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2023 Vol. 20, No. 9 Published: 2023-03-25

	7	Analysis and identification of the interaction between TET3 and OGT in the nuclei of rat spinal cord neurons
		WANG Liping* XU Ting* QIU Sheng
		DOI: 10.20047/j.issn1673-7210.2023.09.01
		Objective To analyze and identify the interaction between ten-eleven translocation protein 3 (TET3) and O-linked-β-N-acetylglucosamine transferase (OGT) in the nuclei of rat spinal cord neurons. Methods The spinal cord neurons of rats were primarily cultured and total RNA was extracted, and TET3 and OGT gene fragments were obtained by RT-PCR. The tag proteins of Flag and HA were fused to the carboxyl end of TET3 and OGT protein coding sequences by DNA recombination technology. The recombinant fusion protein plasmids of pcDNA3.0-TET3-Flag-HA and pcDNA3.0-OGT-Flag-HA were verified by double enzyme digestion, and then transfected into the rat spinal cord neurons. The nucleoproteins of spinal cord neurons were extracted 48 hours later. The fusion proteins of TET3-Flag-HA and OGT-Flag-HA were verified by Western blot; the protein complexes bound to TET3 and OGT were enriched by Tandem affinity purification, the candidate proteins interacting with TET3 and OGT were screened by electrophoresis and mass spectrometry, and verified by co-immunoprecipitation. Results It was confirmed that the recombinant fusion protein plasmids of pcDNA3.0-TET3-Flag-HA and pcDNA3.0-OGT-Flag-HA were successfully constructed, and the fusion proteins of TET3-Flag-HA and OGT-Flag-HA were expressed in the nuclei of rat spinal cord neurons. In the nuclei of rat spinal cord neurons, the protein interacting with TET3 was OGT, and the proteins interacting with OGT were TET3 and retinoblastoma binding protein 5. Conclusion TET3 and OGT form a complex in the nuclei of rat spinal cord neurons, which may be involved in regulating the transcriptional and expression of some functional proteins.
		2023 Vol. 20 (9): 7-11 [Abstract] ( 26 ) HTML (1 KB) PDF (1433 KB) ( 83 )

	12	Study on syndrome characteristics of kidney deficiency syndrome during ischemic stroke convalescence based on cluster-factor analysis
		DONG Xinglu1 GAO Ying1 TANG Lu1 GUO Shengnan2 LIU Qiang3 ZHOU Li1
		DOI: 10.20047/j.issn1673-7210.2023.09.02
		Objective To analyze the syndrome characteristics and rules of kidney deficiency syndrome in patients with ischemic stroke convalescence. Methods Based on previous preparation the four diagnostic information collection form of traditional Chinese medicine for kidney deficiency syndrome during ischemic stroke convalescence, a prospective multi-center survey was conducted to collect clinical information in 15 sub-centers including Dongzhimen Hospital, Beijing University of Chinese Medicine from February 2018 to June 2019, and cluster analysis and factor analysis were used to conduct data mining on syndrome characteristics and distribution rules. Results A total of 970 cases of four diagnosis information collection, a total of 33 items of four diagnostic information were analyzed, among which seven items with frequency ≥50% were slow movement, soreness of waist, forgetfulness, weakness of knee, frequent nocturnal urination, soreness of knee, and weakness of waist, respectively. Based on the systematic cluster analysis and expert opinions, it was found that the information dispersion of cluster three categories (kidney qi [essence] deficiency, kidney yang deficiency, kidney yin deficiency) was the best, and the characteristic dimensions of the three categories of clinical symptoms were extracted through factor analysis, and presented in two dimensions of function and form. Conclusion Through cluster-factor analysis, the clinical symptom and dimension characteristics of kidney deficiency syndrome during ischemic stroke convalesce period are initially revealed, and the relevant diagnostic scale is further constructed to provide basis.
		2023 Vol. 20 (9): 12-16 [Abstract] ( 24 ) HTML (1 KB) PDF (1374 KB) ( 129 )

	17	Exploration of the medication rule of Professor Liu Aimin in the treatment of children with psoriasis vulgaris based on the data mining technology
		ZHANG Xiu1 SHI Jiahua1 ZHANG Hui1 ZHANG Yao1 LIU Aimin2 ZHANG Buxin2
		DOI: 10.20047/j.issn1673-7210.2023.09.03
		Objective To explore the medical experience of Liu Aimin, a famous Chinese doctor, in treating children with psoriasis vulgaris. Methods Clinical medical records of Professor Liu’s treatment of children with psoriasis vulgaris from June 2017 to June 2022 were collected. Excel 2021, SPSS, and R software were used to conduct statistical analysis with medication frequency, nature, flavour, channel tropism, correlation association rules, complex network, and clustering results as observation indicators. Results A total of 134 prescriptions were included, including 95 traditional Chinese medicines, and 20 drugs with drug frequency ≥20. The four nature of drugs were mainly cold and slightly cold, and the five flavrurs were bitter, mainly to the heart, lung, liver, spleen, and stomach channels. A core formula was obtained by combining association rules and complex network analysis, and two prescriptions were obtained by cluster analysis. Conclusion Professor Liu Aimin treats children with psoriasis vulgaris from the heart and the lung, taking into account the spleen and stomach. In the treatment, heat-clearing drugs, deficient-tonifying drugs, and heat-removing drugs are often used to clear heat and remove toxicity, cool blood for removing macula spots.
		2023 Vol. 20 (9): 17-20,37 [Abstract] ( 23 ) HTML (1 KB) PDF (1774 KB) ( 37 )

	21	Scientific knowledge map analysis of pain management after spinal cord injury based on CiteSpace
		YANG Xiangyu1 ZHOU Binbin2 SU Ting1 MO Qilin1 XIA Weihua1 XIONG Yihe1
		DOI: 10.20047/j.issn1673-7210.2023.09.04
		Objective To analyze the scientific knowledge map in the field of pain treatment after spinal cord injury use CiteSpace. Methods Literature on pain treatment after spinal cord injury was retrieved from CNKI and Web of Science core collection database from January 2011 to May 2022, CiteSpace software was used to draw the knowledge map of author, institution, and key words. Results A total of 348 literatures on CNKI and 1 398 literatures on Web of Science were included in the core collection. Domestic core scholars mainly include Li Yongjie, Ni Jiaxiang, Hu Yongsheng, and Tao Wei, and the foreign core scholars mainly include MICHAEL G FEHLINGS, MARK P JENSEN, BRUCE PARSONS, and JAMES W GRAU. The largest domestic institution was the Guangdong Industrial Injury Rehabilitation Hospital, while the core foreign institutions were the University of Miami, the University of Wisconsin, the University of Toronto, Harvard Medical School and Texas A&M University. The key words with high frequency were cell therapy, stem cell, rehabilitation, electroacupuncture, stimulation therapy. Keywords electroacupuncture and cell therapy have the highest intensity of emergence. Conclusion Cell therapy, electroacupuncture, and electrical stimulation are still the latest research hotspots, and the research heat is still not decreasing, with an increasing trend. Baclofen, botulinum toxin, traditional Chinese medicine fumigation, acupuncture and cupping have good clinical effects in recent years, which may be one of the new research hotspots and new trends in the future.
		2023 Vol. 20 (9): 21-27 [Abstract] ( 30 ) HTML (1 KB) PDF (3255 KB) ( 220 )

	28	Optimization of extraction process of Qinkou Huashi Mixture based on entropy weight method combined with Box-Behnken design-response surface methodology
		FAN Runyong XU Wei ZHANG Ming ZHONG Baiming ZHOU Qian
		DOI: 10.20047/j.issn1673-7210.2023.09.05
		Objective To optimize the extraction process parameters of Qinkou Huashi Mixture based on entropy weight method combined with Box-Behnken design-response surface methodology. Methods Using high performance liquid chromatography and ultraviolet-visible spectrophotometry, the amount of baicalin, total flavonoids， and total solids were used as evaluation indexes, extraction times, extraction time， and water addition multiple were used as investigation factors. The weight coefficients of each index were analyzed by entropy weight method, and Box-Behnken design-response surface method was used to optimize the optimum extraction parameters of Qinkou Huashi Mixture. Results The contents of baicalin and total flavonoids showed a good linear relationship in the range of 6.06-193.68 and 1.96-31.25 μg/ml (r=0.999 8, 0.999 5). The weight coefficients Wj of baicalin, total flavonoids, and total solids were 0.467 9, 0.287 1, and 0.245 0. The optimal extraction process of Qinkou Huashi Mixture was determined as follows: extraction times were 2 times, extraction 33 min and each time was addition 7.8-fold water. Conclusion The optimized extraction process is stable, reliable, and reproducible, which can be used for mass production.
		2023 Vol. 20 (9): 28-32 [Abstract] ( 32 ) HTML (1 KB) PDF (1666 KB) ( 35 )

	33	Effects of Mifepristone combined with Xiaoliu Prescription on hemorheology and GPR30-EGFR signaling pathway in uterine fibroid patients with syndrome of qi stagnation and blood stasis
		LI Qin1 RUAN Chengjuan2 ZHANG Ruiwen2 ZHANG Yanni2 CHEN Dongqiong3▲
		DOI: 10.20047/j.issn1673-7210.2023.09.06
		Objective To investigate the effects of Mifepristone combined with Xiaoliu Prescription on clinical efficacy, hemorheology, and GPR30-EGFR signaling pathway in intermyowall uterine fibroids patients with syndrome of qi stagnation and blood stasis. Methods Eighty intermyowall uterine fibroids patients with syndrome of qi stagnation and blood stasis admitted to the First Affiliated Hospital of Yunnan University of Chinese Medicine from December 2021 to March 2022 were selected and divided into control group (40 cases) and experimental group (40 cases) according to random number table method. The control group was treated with Mifepristone, and the experimental group was treated with Mifepristone combined with Xiaoliu Prescription. The treatment course of both groups was three months (withdrawal of the drug during menstrual period). The clinical efficacy and uterine volume, fibroid area, hemorheology indexes before and after treatment were compared between the two groups. Real-time quantitative PCR and Western blot were used to detect the mRNA and protein expression levels of G-protein-coupled receptor 30 (GPR30) and epidermal growth factor receptor (EGFR) in two groups. Results Four cases fell off in the experimental group. In the control group, five cases were shed and one case was eliminated. The clinical effect of experimental group was better than that of control group (P＜0.05). After treatment, uterine volume, fibroid area, and plasma viscosity in two groups were lower than those before treatment, and experimental group was lower than control group (P＜0.05). After treatment, the whole blood high and low shear viscosity values of experimental group were lower than those of experimental group before treatment and control group (P＜0.05). After treatment, the mRNA and protein expression levels of GPR30 and EGFR in experimental group were lower than those in control group (P＜0.05). There was no significant difference in the total incidence of adverse reactions between the two groups (P＞0.05). No abnormal changes of liver and kidney function were observed in both groups during treatment. Conclusion Mifepristone combined with Xiaoliu Prescription can effectively treat intermyowall uterine fibroids, reduce uterine volume and uterine fibroid area, improve hemorheology indexes, reduce GPR30 and EGFR expression, with high safety.
		2023 Vol. 20 (9): 33-37 [Abstract] ( 19 ) HTML (1 KB) PDF (759 KB) ( 21 )

	38	Research progress on the mechanism of traditional Chinese medicine protecting liver injury
		SUN Yibin1 ZHU Mingxing2 LIU Yueyang3 ZHAO Ruowei1 HUANG Mingqing1 CHENG Zaixing1 ZHENG Yanfang1 LIN Yanxiang1
		DOI: 10.20047/j.issn1673-7210.2023.09.07
		The incidence of liver injury is increasing year by year, it is urgent to develop high quality hepatoprotective drugs. Traditional Chinese medicine has unique advantages and potential in liver protection, and has therapeutic effect in a variety of liver injury caused by chemical, drug, alcohol, and immunity reasons. Traditional Chinese medicine can alleviate liver injury by improving liver antioxidant capacity, inhibiting hepatocyte apoptosis, regulating hepatocyte autophagy, regulating liver metabolism, and improving liver inflammation. It acts on Nrf2, PI3K, TGF-β1, NF-κB and other targets, and related signaling pathways. Some drugs or active ingredients can act through multiple pathways and multiple targets. Traditional Chinese medicine has a good application prospect in liver protection, but there are many components of the compound and unclear mechanism interaction. Further research is needed to provide reference for clinical application.
		2023 Vol. 20 (9): 38-40,45 [Abstract] ( 27 ) HTML (1 KB) PDF (512 KB) ( 345 )

	41	Current situation and prospect of exosomes application in tumor diagnosis and treatment
		ZHU Xiaoxian1 CHEN Huizhi1 CUI Kuiyan1 ZHONG Wen2 PENG Xinsheng1 ZHOU Yubin1
		DOI: 10.20047/j.issn1673-7210.2023.09.08
		Exosomes are membranous vesicles with a size of 30-150 nm that are produced by the endovascular process of the endocytic membrane. Exosomes contain a large number of biological macromolecules, such as various enzymes, proteins, mRNA, and non-coding RNA, which make them increasingly regarded as important carriers in intercellular communication and substance exchange. Exosomes are closely related to the processes of tumor growth, angiogenesis, and tumor immune escape, and metastasis, and the research on exosomes in the field of tumors is one of the current hotspots. Because exosomes contain numerous information of donor cells and carry a variety of important biomolecules, they can be applied as biomarkers, drug carriers, or immunomodulators for tumor diagnosis and treatment. In this review, the basic concept, formation and elemental composition, isolation and characterization of exosomes, as well as their applications in tumor diagnosis (as biomarkers) and treatment (as drug carriers and as immunomodulatory substances) are reviewed, and their prospects are discussed.
		2023 Vol. 20 (9): 41-45 [Abstract] ( 40 ) HTML (1 KB) PDF (633 KB) ( 254 )

	46	Research progress of immune regulation mechanism of traditional Chinese medicine on spinal tuberculosis based on the theory of “killing insects and replenishing deficiency”
		LIANG Jian1 KANG Wenting1 FENG Jing2 PU Feifei2 XIA Ping1
		DOI: 10.20047/j.issn1673-7210.2023.09.09
		In traditional Chinese medicine, tuberculosis is mainly caused by “the deficiency of the body and the external sensation of tuberculosis”, and “killing insects and replenishing deficiency” is the general treatment principle of traditional Chinese medicine in the treatment of tuberculosis. Spinal tuberculosis is mostly secondary to pulmonary tuberculosis and digestive tract tuberculosis. Modern medical studies have shown that the pathogenesis and outcome of spinal tuberculosis are closely related to the immune status of the host and the growth and inhibition of Mycobacterium tuberculosis. In the treatment of spinal tuberculosis, single traditional Chinese medicine components, extracts, and traditional Chinese medicine compounds can play an important auxiliary role by regulating the immune function of the body, destroying and inhibiting the generation of pathogenic bacteria, regulating autophagy and apoptosis of cells, and other different immune axes. Based on the theory of “killing insects and replenishing deficiency”, this paper discusses the research progress of the immune regulation mechanism of traditional Chinese medicine on spinal tuberculosis.
		2023 Vol. 20 (9): 46-49,57 [Abstract] ( 27 ) HTML (1 KB) PDF (664 KB) ( 74 )

	50	Research progress on the basic pathway of ferroptosis and the possible regulatory mechanism of ferroptosis and osteoarthritis
		XU Limei XU Fangyuan XIA Jing LUO Fangfang LIN Munan
		DOI: 10.20047/j.issn1673-7210.2023.09.10
		Ferroptosis is a new type of iron-dependent programmed cell death. Iron, lipid, and amino acid metabolism are major pathways regulating ferroptosis. Osteoarthritis (OA) is a common degenerative joint disease. Its pathogenesis is complex and has not been completely clarified. However, iron metabolism disorder, oxidative stress, and lipid metabolism are common pathological characteristics of OA, which are closely related to the pathogenesis of OA. In this article, the basic mechanism of ferroptosis will be briefly described, and the role of ferroptosis in the pathogenesis of OA will be analyzed from the perspectives of iron metabolism disorder, amino acid metabolism and lipid metabolism, in order to provide a new direction for the clinical treatment of OA and new ideas for its prevention and treatment.
		2023 Vol. 20 (9): 50-53 [Abstract] ( 20 ) HTML (1 KB) PDF (485 KB) ( 130 )

	54	Research progress on the assessment tools and influencing factors of stigma for patients with psoriasis
		ZHANG Luyu ZHAO Qianqian ZHUANG Miaoqing LIU Yue WANG Jiayi CHEN Hongfang
		DOI: 10.20047/j.issn1673-7210.2023.09.11
		Patients with psoriasis are prone to stigma. Timely and effective evaluation of stigma in patients with psoriasis and the adoption of targeted intervention strategies are of great significance for improving the outcome of rehabilitation and quality of life. Based on the literature review, this paper systematically reviewed five kinds of stigma assessment tools for psoriasis patients, including the feelings of stigmatization questionnaire, the questionnaire on experience with skin complaints, the 6-item stigmatization scale, the internalized stigma of mental illness, and the perceived stigmatization questionnaire, the influencing factors of stigma in patients psoriasis with were summarized from the aspects of social demography, disease, psychology and social support, in order to provide reference for the development of localized stigma assessment tools for patients with psoriasis, scientific application assessment tools and relevant interventions.
		2023 Vol. 20 (9): 54-57 [Abstract] ( 36 ) HTML (1 KB) PDF (457 KB) ( 212 )

	58	Investigation on cleaning and disinfection of flexible endoscope in 42 tertiary hospitals in Beijing
		CUI Yanhua1 LI Jing2 XIE Xiaoyue3 YU Lei1 QIN Xiaoping4
		DOI: 10.20047/j.issn1673-7210.2023.09.12
		Objective To understand the cleaning and disinfection status of endoscope room in Beijing hospitals. Methods From March to August 2021, questionnaire survey method with convenient sampling was adopted to investigate the layout facilities, system construction, training, occupational safety protection, cleaning and disinfection (sterilization) process, monitoring, and recording of endoscopy centers (rooms) in 42 tertiary hospitals in Beijing. Results A total of 42 questionnaires were collected, with an effective recovery rate of 100%. Among them 10 institutions had no office room, 12 institutions had no anesthesia recovery room, and 6 institutions had no emergency plan, and there was still a big gap in training. The cleaning and disinfection tank was fully equipped, power pump and ultrasonic cleaner are 76.2% and 69.0% respectively, and 73.8% of the endoscopic automatic cleaning machines were configured. 30.9% of hospitals were equipped with ethylene oxide sterilizers, 9.5% with low temperature formaldehyde sterilization, and 59.5% with hydrogen peroxide low-temperature plasma sterilizers. Phthalaldehyde was used in 59.5% of hospitals, and compound chlorine-containing disinfectant was used in 40.5% of hospitals. 42 hospitals had provided protective equipment for disinfection workers. Natural ventilation was used in 15 hospitals (35.7%), and mechanical ventilation was installed in 27 hospitals (64.3%), and 5 (18.5%) of the installation locations were on the ceiling, which did not meet the requirements. There were still some gaps in the pretreatment, leak detection, flushing water and equipment. Conclusion All medical institutions are able to comply with the basic requirements of standardized cleaning and disinfection. However, there are still some gaps in the configuration of facilities and equipment and the implementation of cleaning and disinfection details. Medical institutions should constantly improve against the new norms to reduce the incidence of nosocomial infections.
		2023 Vol. 20 (9): 58-61,66 [Abstract] ( 19 ) HTML (1 KB) PDF (699 KB) ( 59 )

	62	Analysis of hospitalization costs of acute leukemia patients in Beijing from 2015 to 2019
		CHEN Yin1 HU Guangyu2 GUO Moning1▲
		DOI: 10.20047/j.issn1673-7210.2023.09.13
		Objective To analyze the trend of hospitalization expenses and its expense structure in acute leukemia inpatients, and to provide the data-based evidence for policy-making. Methods Descriptive, variance, and trend analyses of acute leukemia inpatient costs, cost structure were performed using inpatient case home data from 77 secondary and tertiary hospitals in Beijing from 2015 to 2019. Results The average cost of acute leukemia hospitalization in Beijing showed an increasing trend from 2015 to 2019 (P＜0.05), the differences were statistically significant when comparing the average hospitalization subcosts among different age groups (P＜0.05). The main treatment modality of hospitalization for patients with acute leukemia was chemotherapy, and there was a statistically significant difference in the average cost of hospitalization and the average cost of drugs among patients with chemotherapy at different ages (P＜0.05). Conclusion The burden of hospitalization costs for acute leukemia patients in Beijing is still relatively high, and the cost of drugs and consumables contributes highly to the hospitalization burden but is on a decreasing trend. It is necessary to pay attention to the hospitalization cost burden of key populations such as children and the elderly, and to make separate calculations of their payment rates in combination with the characteristics of childhood leukemia.
		2023 Vol. 20 (9): 62-66 [Abstract] ( 28 ) HTML (1 KB) PDF (1021 KB) ( 34 )

	67	Current situation analysis of hospital staff’s willingness to participate in hospital reform and management
		YUAN Zheng1 ZHANG Yuqing2 WANG Cunliang3 LI Yan3 LI Huan3 LI Jun1
		DOI: 10.20047/j.issn1673-7210.2023.09.14
		Objective To analyze the current situation of hospital staff’s willingness to participate in hospital reform and hospital management, and to provide directions for promoting democratic management. Methods From November 2020 to January 2021, employee representatives from 22 municipal public hospitals in Beijing were selected and a questionnaire survey was conducted. The survey objects were identified by single-blind and cluster sampling methods, and two indicators of willingness to actively participate in hospital reform and willingness to hospital management were selected in combination with the demographic information of employees. Results In this study, 2 975 questionnaires were distributed and 2 293 valid questionnaires were received with effective recovery of 77.1%. There was statistical significance in the willingness of employees of different gender, age, political status, and job category to actively participate in hospital reform (P＜0.05). There was statistical significance in the willingness of employees of different ages, political status, and job categories to actively participate in hospital management (P＜0.05). Conclusion According to the different influencing factors, taking corresponding measures can improve the enthusiasm of workers to participate in democratic management.
		2023 Vol. 20 (9): 67-70 [Abstract] ( 26 ) HTML (1 KB) PDF (623 KB) ( 178 )

	71	Effect of Pregabalin combined with Lipoic acid on patients with diabetic painful neuropathy
		FU Xiaojuan1 LI Xunjun2 YU Jian3 YANG Zongfa1 JIANG Yuqin1
		DOI: 10.20047/j.issn1673-7210.2023.09.15
		Objective To investigate the effect of Pregabalin combined with Lipoic acid on patients with diabetic painful neuropathy. Methods A total of 86 patients with diabetic painful neuropathy admitted to the Seventh People’s Hospital of Chongqing from July 2019 to December 2020 were selected and divided into control group (43 cases) and experimental group (43 cases) according to random number table method. Both groups received conventional treatment, the control group was treated with Lipoic acid combined with Gabapentin, and the experimental group was treated with Lipoic acid combined with Pregabalin, the course of treatment was four weeks. The efficacy, numerical rating scale (NRS) score, Michigan diabetic neuropathy score (MDNS), and nerve conduction velocity before and after treatment were compared between the two groups. The occurrence of adverse drug reaction (ADR) was recorded in the two groups. Results After treatment, the therapeutic effect of experimental group was better than that of control group, and the difference was statistically significant (P＜0.05). After treatment, NRS scores and MDNS in two groups were lower than those before treatment, and experimental groups were lower than those of control group, and the differences were statistically significant (P＜0.05). After treatment, the motor nerve conduction velocity and sensory nerve conduction velocity of median nerve and common peroneal nerve in two groups were higher than before treatment, the differences were statistically significant (P＜0.05). There was no significant difference in the total incidence of ADR between the two groups (P＞0.05). Conclusion The treatment effect of Pregabalin combined with Lipoic acid is better than that of Lipoic acid combined with Gabapentine in patients with diabetic painful neuropathy, and the incidence of ADR is lower.
		2023 Vol. 20 (9): 71-74,79 [Abstract] ( 22 ) HTML (1 KB) PDF (668 KB) ( 85 )

	75	Influence of vitamin D assisted reduced glutathione on hepatic lipidosis and intestinal flora in patients with type 2 diabetes mellitus complicated with non-alcoholic fatty liver disease
		Reyihannisha·Yakeya Zulipiya·Nuermaimaiti Yilimire·Nuermaimaiti
		DOI: 10.20047/j.issn1673-7210.2023.09.16
		Objective To investigate the effect of vitamin D assisted reduced glutathione in the treatment of type 2 diabetes mellitus (T2DM) complicated with non-alcoholic fatty liver disease (NAFLD) and its influence on hepatic lipidosis and intestinal flora. Methods A total of 168 patients with T2DM complicated with NAFLD admitted to the Department of Endocrinology of the First People’s Hospital of Kashgar, Xinjiang Uygur Autonomous Region from July 2019 to October 2020 were selected as the study objects. According to the random number table method, they were divided into control group and observation group, with 84 cases in each group. The control group received conventional treatment and reduced glutathione, and the observation group received vitamin D assisted therapy on the basis of the control group. The treatment course of both groups was three months. The efficacy of NAFLD was compared between the two groups, and the liver function, liver fat deposition, intestinal flora, and blood glucose indexes before and after treatment were compared between the two groups. Results There were two cases in the control group and four cases in the observation group during the treatment. The efficacy of NAFLD in the observation group was better than that in the control group (P＜0.05). After treatment, glutamic pyruvic transaminase (GPT), glutamic oxaloacetic aminotransferase (GOT), γ-glutamyltransferase (GGT), controlled attenuation parameter (CAP), liver stiffness measurement (LSM), liver fat content, and levels of Escherichia coli, fasting blood glucose (FPG), 2 h postprandial blood glucose (2hPG), glycosylated hemoglobin (HbA1c) of two groups were lower than those before treatment, while levels of Bifidobacterium and Lactobacillus in two groups were higher than those before treatment (P＜0.05). After treatment, GPT, GOT, GGT, CAP, LSM, liver fat content, and levels of Escherichia coli, FPG, 2hPG, HbA1c in observation group were lower than those in control group, while levels of Bifidobacterium and Lactobacillus were higher than those in control group (P＜0.05). Conclusion Vitamin D-assisted reduced glutathione has a good effect in the treatment of T2DM patients with NAFLD, which can improve clinical effect, improve liver function, reduce liver lipidosis, and regulate intestinal flora.
		2023 Vol. 20 (9): 75-79 [Abstract] ( 27 ) HTML (1 KB) PDF (643 KB) ( 26 )

	80	Effect of Guben Ziyin Decoction and Yiqi Tongluo Decoction in treating elderly patients with type 2 diabetes mellitus peripheral neuropathy with syndrome of deficiency of both qi and yin complicated by stasis
		SHEN Jinhua XIA Jing
		DOI: 10.20047/j.issn1673-7210.2023.09.17
		Objective To explore the effect of Guben Ziyin Decoction and Yiqi Tongluo Decoction on elderly patients with type 2 diabetes mellitus peripheral neuropathy with syndrome of deficiency of both qi and yin complicated by stasis. Methods A total of 83 elderly patients with type 2 diabetes mellitus peripheral neuropathy with syndrome of deficiency of both qi and yin complicated by stasis admitted to Jiangyin Hospital of Traditional Chinese Medicine in Jiangsu Province from June 2019 to June 2022 were selected and divided into Mecobalamine group (41 cases, Mecobalamine Tablets) and experimental group (42 cases, on the basis of Mecobalamine group plus Guben Ziyin Decoction and Yiqi Tongluo Decoction) by random number table method. Both groups were treated continuously for two months. Traditional Chinese medicine syndrome score, fasting blood glucose level, nerve conduction velocity, and nerve defect score (NDS) of the two groups before and after treatment were analyzed. The clinical efficacy of the two groups was compared, and the occurrence of adverse reactions during treatment was recorded. Results After treatment, traditional Chinese medicine syndrome scores, NDS, and fasting blood glucose levels of the two groups were lower than those before treatment, the sensory and motor nerve conduction velocity of common peroneal nerve and median nerve was higher than those before treatment, traditional Chinese medicine syndrome scores, NDS, and fasting blood glucose levels of experimental group were lower than those of Mecobalamine group, the sensory and motor nerve conduction velocity of common peroneal nerve and median nerve was higher than those of Mecobalamine group, the differences were statistically significant (P＜0.05). The therapeutic effect of experimental group was better than that of Mecobalamine group, and the difference was statistically significant (P＜0.05). There was no adverse reaction occurred in both groups during treatment. Conclusion The effect of Gubenziyin Decoction and Yiqi Tongluo Decoction in the treatment of elderly patients with type 2 diabetes mellitus peripheral neuropathy with syndrome of deficiency of both qi and yin complicated by stasis is exact, which can improve clinical symptoms and promote the recovery of peripheral nerve conduction velocity, with high safety, so it is recommended to be popularized and used in clinic.
		2023 Vol. 20 (9): 80-83 [Abstract] ( 21 ) HTML (1 KB) PDF (570 KB) ( 64 )

	84	Meta-analysis of the efficacy and safety of Tamsulosin combined with Butylscopolammonium Bromide assisted extracorporeal shock wave lithotripsy in the treatment of urinary calculi
		ZHONG Bin1 ZOU Junrong2 PENG Peng3 WANG Xiaoning3 ZHANG Guoxi3 XIE Tianpeng3
		DOI: 10.20047/j.issn1673-7210.2023.09.18
		To systematically evaluate the efficacy and safety of Tamsulosin combined with Butylscopolammonium Bromide assisted extracorporeal shock wave lithotripsy (ESWL) in the treatment of urinary calculi. Methods CNKI, Wanfang, VIP, CBM, PubMed, Cochrane Library, and Web of Science core collection databases were searched by computer, the search period was from establishment to April 2022. The randomized controlled trials of Tamsulosin combined with Butylscopolammonium Bubromine assisted ESWL for urinary calculi was found, the experimental group was given Tamsulosin + Butylscopolammonium Bromide after ESWL, and control group was given Butylscopolammonium Bromide after ESWL. Meta-analysis was performed using RevMan 5.4 software, the effective rate, stone discharge time, disappearance time of renal colic, pain score, and adverse reactions between two groups were analyzed. According to the stone discharge time, it can be divided into hour group and day group; according to the rating scale select, it can be divided into visual analog scale (VAS) group and numerical pain rating scale (NPRS) group. Results A total of eight articles with 1 762 patients were included. The effective rate of experimental group was higher than that of control group (RR=1.21, 95%CI:1.16 to 1.26, P＜0.000 01). The stone discharge time of hour group was shorter than that of control group (SMD=-5.50, 95%CI:-6.59 to -4.41, P＜0.000 01). The stone discharge time of day group was shorter than that of control group (SMD=-4.21, 95%CI:-6.40 to -2.03, P=0.000 2). The disappearance time of renal colic in experimental group was shorter than that in control group (SMD=-2.04, 95%CI:-2.18 to -1.91, P＜0.000 01). The degree of pain in VAS group was lower than that in control group (SMD=-0.65, 95%CI:-0.90 to -0.39, P＜0.000 01). The degree of pain in NPRS group was lower than that in control group (SMD=-1.59, 95%CI:-1.80 to -1.38, P＜0.000 01). There was no significant difference in adverse reactions between the two groups (P＞0.05). Conclusion Tamsulosin combined with Butylscopolammonium Bromide assisted ESWL treatment of urinary calculi can improve the effective rate of treatment, promote the discharge of calculi, shorten the pain time, and relieve the pain symptoms of patients, which is a safe and effective method.
		2023 Vol. 20 (9): 84-88 [Abstract] ( 29 ) HTML (1 KB) PDF (3054 KB) ( 114 )

	89	Clinical effect of Cui’s back massage six methods in the treatment of non-specific low back pain
		LU Guoming1 ZHOU Kelin2 CUI Shusheng1
		DOI: 10.20047/j.issn1673-7210.2023.09.19
		Objective To observe the clinical efficacy of Cui’s back massage six methods in the treatment of non-specific low back pain. Methods A total of 84 patients who visited Beijing Gulou Hospital from October 2018 to October 2020 were divided into control group and treatment group by random number table method, with 42 cases in each group. The treatment group was treated by Cui’s back massage six methods, and the control group was treated with the conventional massage treatment, treated for 2 weeks. The clinical efficacy of the two groups was compared after treatment, Roland Morris disability questionnaire (RMDQ) scale scores, and McGill pain questionnaire (MPQ) scale were scored before and after treatment, at 4 and 8 weeks of follow-up. Results The clinical effect of the treatment group was better than that of the control group, and the difference was statistically significant (P＜0.05). The overall analysis showed that there were significant differences among groups, time points and interactions (P＜0.01). Comparison within groups, the RMDQ score and McGill score in the treatment group were lower after treatment, 4 weeks of follow-up and 8 weeks of follow-up than before, and the differences were statistically significant (P＜0.01). Comparison between groups: RMDQ score and McGill score in the treatment group were lower than those in the control group after treatment, 4 weeks of follow-up and 8 weeks of follow-up, and the differences were statistically significant (P＜0.05). Conclusion Cui’s back massage six methods can significantly alleviate the pain and dysfunction symptoms of patients with non-specific low back pain.
		2023 Vol. 20 (9): 89-92 [Abstract] ( 27 ) HTML (1 KB) PDF (481 KB) ( 42 )

	93	Clinical effect of Fu’s acupuncture combined with meridian acupuncture for treatment of lumbar intervertebral disc herniation
		MENG Xianyu CHENG Yun LYU Zhigang HOU Weilin
		DOI: 10.20047/j.issn1673-7210.2023.09.20
		Objective To observe the clinical effect of Fu’s acupuncture combined with meridian acupuncture on lumbar intervertebral disc herniation. Methods A total of 60 patients with lumbar disc herniation diagnosed clearly in the outpatient Department of Rehabilitation, Changzhou Hospital of Traditional Chinese Medicine Affiliated to Nanjing University of Chinese Medicine from November 2020 to November 2021 were selected, and they were divided into control group and treatment group by random number table method, with 30 cases in each group. The treatment group was treated with Fu’s acupuncture combined with meridian acupuncture, and the control group was treated with conventional acupuncture. After three weeks of treatment, the clinical efficacy, Japanese Orthopaedic Society score, Oswestry disability index, and serum inflammatory factors were observed and analyzed statistically. Results After treatment, the score of Japanese Orthopaedic Society score in the two groups was higher than before treatment, and the treatment group was higher than the control group, the differences were statistically significant (P＜0.05). After treatment, the Oswestry disability index and serum inflammatory factors of the two groups were lower than before treatment, and the treatment group was lower than the control group, the differences were statistically significant (P＜0.05). The therapeutic effect of the treatment group was better than that of the control group, the difference was statistically significant (P＜0.05). Conclusion Fu’s acupuncture combined with meridian acupuncture can obviously improve lumbar intervertebral disc herniation, and its curative effect is better than ordinary acupuncture, which can be popularized in clinic.
		2023 Vol. 20 (9): 93-96 [Abstract] ( 24 ) HTML (1 KB) PDF (626 KB) ( 41 )

	97	Diagnostic value of ultrasound scoring method combined with plasma human placental prolactin level for placenta previa combined with placenta accreta
		SHI Mingfang CHANG Shujuan ZHANG Congyi
		DOI: 10.20047/j.issn1673-7210.2023.09.21
		Objective To investigate the diagnostic value of ultrasound scoring method combined with plasma human placental prolactin (hPL) level for placenta previa combined with placenta accreta. Methods A total of 128 patients with placenta previa who were admitted to the Second People’s Hospital of Hengshui, Hebei Province from September 2019 to October 2021 were selected as the research subjects. According to the pathological results, they were divided into implanted group and non-implanted group. The clinical data, ultrasound scores, and plasma hPL mRNA levels of patients were compared between implanted group and non-implanted group. Receiver operating characteristic curve was drawn to evaluate the diagnostic performance of ultrasound scoring method, plasma hPL mRNA level and their combination detected in the diagnosis of placenta previa combined with placenta accreta by area under the curve (AUC). Results There were 68 cases of placenta previa combined with placenta implantation in 128 cases. The ultrasonic score, plasma hPL mRNA level of implanted group was higher than that of non-implanted group (P＜0.05). The proportion of placental tissue thickness ≥3 cm, the proportion of postplacental hypogyrus vocal cord deletion, the proportion of the thinnest myometrium thickness＜1 mm, the proportion of rough bladder surface, the proportion of increased blood flow at the base of the placenta, and the proportion of blood flow signal in cervix and surrounding of implantation group were higher than those in non-implanted group (P＜0.05). Ultrasound score method and plasma hPL mRNA level were the influencing factors of patients with placenta accreta combined with placenta previa (OR＞1, P＜0.05). The AUC of ultrasound scoring method combined with plasma hPL mRNA level in the diagnosis of placenta previa combined with placenta accreta was higher than that of ultrasound scoring method and plasma hPL mRNA level alone (P＜0.05). Conclusion Ultrasound scoring method combined with plasma hPL mRNA level have high diagnostic performance for placenta previa combined with placenta accreta.
		2023 Vol. 20 (9): 97-100 [Abstract] ( 21 ) HTML (1 KB) PDF (756 KB) ( 89 )

	101	Relationship between maternal disease uncertainty and family care of very low birth weight premature infants
		WU Yan ZHOU Jingxin WANG Liwei▲
		DOI: 10.20047/j.issn1673-7210.2023.09.22
		Objective To analyze the relationship between maternal disease uncertainty and family care of very low birth weight preterm infants, and to expand the intervention channels for improving maternal disease uncertainty. Methods A total of 115 mothers of very low birth weight preterm infants who were treated in the neonatal intensive care unit of Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine from June 2020 to December 2021 were investigated by cross-sectional investigation. The survey items included the uncertainty of disease, family care, anxiety, and depression; the relationship between maternal disease uncertainty and family care of very low birth weight premature infant were analyzed; a linear regression model was constructed to analyze the effect of family care on the maternal disease uncertainty of very low birth weight preterm infants. Results A total of 115 questionnaires were distributed, and 108 were effectively received, with effective recovery of 93.91%. The Mishel’s uncertainty in illness scale-family member form (MUIS-FM) score of 108 preterm mothers was (74.58±11.64) points. The family caring index questionnaire (APGAR) score was 7.00 (6.00, 7.00) points. self-rating anxiety scale (SAS) and self-rating depressive scale (SDS) scores were (55.78±4.24) points and (53.49±4.15) points respectively. There was a negative correlation between MUIS-FM score and APGAR score (r＜0, P＜0.05), and positively correlated with SAS and SDS scores (r＞0, P＜0.05); APGAR score was negatively correlated with SAS and SDS scores (r＜0, P＜0.05). There were significant differences in MUIS-FM score among different ages and gestational history in mothers of very low birth weight preterm infants (P＜0.05). APGAR score, age, and pregnancy history had an impact on the maternal disease uncertainty of very low birth weight premature infants (P＜0.05), linear regression equation: Y=78.998-1.529×APGAR score+10.470×age+7.189×pregnancy history. Conclusion The maternal disease uncertainty of very low birth weight premature infants is related to family care. Lack of family care, advanced maternal age, and first-time maternal age care can increase maternal disease uncertainty.
		2023 Vol. 20 (9): 101-104 [Abstract] ( 30 ) HTML (1 KB) PDF (571 KB) ( 36 )

	105	Allocation study of health resources of different districts in Beijing based on quantitative evaluation method
		YANG Yurun1 DU Tianyi2 WANG Zhi1 LIU Liming1 JIANG Yan1 CHENG Wei1
		DOI: 10.20047/j.issn1673-7210.2023.09.23
		Objective To analyze the allocation of health resources in 16 districts of Beijing in 2020, and to provide suggestions for optimizing the allocation of health resources. Methods Principal component analysis, factor analysis, and cluster analysis were carried out for 9 major indicators that had significant influence on the allocation of health resources in 16 districts of Beijing (Dongcheng District, Xicheng District, Chaoyang District, Fengtai District, Shijingshan District, Haidian District, Mentougou District, Fangshan District, Tongzhou District, Shunyi District, Changping District, Daxing District, Huairou District, Pinggu District, Miyun District, and Yanqing District) from January to December 2020, the status quo and difference of the allocation of health resources in different districts were compared. Results The resource allocation of medical and health institutions was influenced by two principal components. The health resource factors and institutional allocation factors were obtained by factor analysis, which were consistent with the results of principal component analysis. The 16 districts were divided into four types through clustering, namely core district, economic district, development district, and suburban district. Conclusion The 16 districts need to plan the allocation of health resources rationally, and strengthen the input of health human resources and the construction of medical alliances, improving the allocation of resources and the quality of medical care, so as to promote the improvement of the overall quality of health resources in Beijing.
		2023 Vol. 20 (9): 105-108,118 [Abstract] ( 32 ) HTML (1 KB) PDF (1072 KB) ( 146 )

	109	Research on the law of traditional Chinese medicine in the differentiation and treatment of apoplexy based on ancient and modern medical cases
		XU Jingwen1 JU Yuanhong2 WANG Shutong1 LYU Shuzhen1 MU Dongmei2
		DOI: 10.20047/j.issn1673-7210.2023.09.24
		Objective To mine the data of ancient and modern medical cases of apoplexy by using statistical analysis and social network analysis, and to analyze the law of their identification and treatment of apoplexy. Methods The medical case data were retrieved, collected, and organized from the super star electronic book database, and the retrieval period was from inception to December 2022, while the medical case data were screened and extracted in conjunction with the National Joint Catalogue of Chinese Medicine Books, and statistical analysis and data mining were performed on the high incidence syndrome type, nature and flavour of traditional Chinese medicine, channel tropism of apoplexy and so on. Results A total of 404 medical cases of apoplexy were included, involving 48 medical case collections, 340 Chinese herbal medicines, 4 937 total medication frequencies, three high frequency symptom types (syndrome of blood stasis due to qi deficiency, syndrome of wind-phlegm obstructing collateral, syndrome of stirring wind due to yin deficiency). The drug natures were usually warm, plain, and cold. The drug flavours were mainly sweet, bitter, and pungent. The drug channel tropisms were liver, spleen, and heart channels. There were ten high centrality value drugs. The results of the social network analysis showed that there was a strong association between the type of symptoms and the formulas and herbal medicines. The treatment was mainly composed of Buyang Huanwu Decoction, Dihuang Yinzi, and other prescriptions. Conclusion Ancient and modern medical cases suggest that apoplexy is closely related to the liver, spleen, and heart. Syndrome of blood stasis due to qi deficiency, syndrome of wind-phlegm obstructing collateral, syndrome of stirring wind due to yin deficiency are the core syndrome types. There is an obvious trend of concentration in the use of drugs, such as invigorating qi, promoting blood circulation for removing blood stasis, and suppressing hyperactive liver for calming endogenous wind, which can provide certain reference for clinical prescription drug use.
		2023 Vol. 20 (9): 109-113 [Abstract] ( 19 ) HTML (1 KB) PDF (3118 KB) ( 24 )

	114	Visual analysis of Wuling Powder research literatures based on CiteSpace
		CHI Dongbo GUO Zhichao YAN Meiling YAN Zhonghong
		DOI: 10.20047/j.issn1673-7210.2023.09.25
		Objective To analyze the research status and development trend of Wuling Powder research literatures through the visualization software CiteSpace. Methods Wuling Powder-related literatures were retrieved from CNKI. From January 2000 to March 2022, visualized analysis was conducted with journal distribution, research institutions, authors, and keywords of the literatures through CiteSpace 5.6 R5 and Excel. Results A total of 1 804 literatures were included and the average number of literatures presented an upward trend year by year. The authors were mainly from Liu Tian’s team, and formed a stable core team. The research institutions were represented by Tianjin University of Traditional Chinese Medicine, Liaoning University of Traditional Chinese Medicine, and Chengdu University of Traditional Chinese Medicine. Key words analysis showed that the research hotspot of Wuling Powder was famous medical records and clinical application, such as related diseases chronic heart failure, renal edema, diabetic nephropathy, etc. Conclusion In recent years, Wuling Powder has attracted more attention, and the research focuses on clinical study, the mechanism of action. The cooperation between different teams needs to be strengthened.
		2023 Vol. 20 (9): 114-118 [Abstract] ( 23 ) HTML (1 KB) PDF (2912 KB) ( 169 )

	119	Professor Chen Ruixue’s experience in treating thin endometrium infertility based on the theory of “deficiency of qi and stagnation”
		GUO Li1 SUI Juan2 REN Mengxue2 ZHOU Lin2 CHEN Ziwei1 BI Hong2 CHEN Ruixue2
		DOI: 10.20047/j.issn1673-7210.2023.09.26
		This article summarizes Professor Chen Ruixue’s experience in treating thin endometrium infertility based on the theory of “deficiency of qi and stagnation”. Professor Chen believes that “deficiency of qi” and “stagnation” are the main causes of thin endometrial infertility. Among them, “deficiency of qi” is mainly responsible for kidney deficiency and spleen deficiency, and “stagnation” includes qi stagnation, phlegm obstruction, and collaterals stasis. In terms of treatment, Professor Chen advocates that tonifying the kidney and strengthening the spleen to regulate the deficiency qi, soothing liver qi, removing phlegm and dampness, and dissipating blood stasis to smooth the stagnation, especially emphasizes that tonifying kidney and raising the Yuan and promoting blood circulation for removing obstruction in collaterals are the core treatment principles of this disease. Clinically, Professor Chen uses Bushen Yangxue Zhuyun Prescription add or subtract medicine, stages medicine according to the menstrual cycle, combines internal and external application, and the efficacy is outstanding.
		2023 Vol. 20 (9): 119-122,130 [Abstract] ( 24 ) HTML (1 KB) PDF (776 KB) ( 64 )

	123	Professor Zhou Hua’s experience in treating atrial fibrillation based on staged dialectical theory
		TANG Qiaolin QU Huiyan LIU Wenrui YANG Tianshu YANG Tao ZHOU Hua
		DOI: 10.20047/j.issn1673-7210.2023.09.27
		Atrial fibrillation is one of the most common arrhythmias characterized with high morbidity, disability, and mortality in the clinical field. Professor Zhou Hua believes that atrial fibrillation is the syndrome of deficiency of root case and excess of manifestation. The deficiency of root case is mainly caused by deficiency of qi, blood, yin and yang, the excess of manifestation is mainly phlegm and blood stasis. In terms of treatment, it is emphasized that treatment should be carried out by three stages, including early stage, middle stage, and late stage. At the early stage, the heart’s qi and yin injuries are the key to its pathogenesis, and the treatment is mainly to replenish qi and nourish yin. In the middle stage, phlegm and blood stasis are caused by deficiency of heart and spleen, which should be treated by resolving phlegm, removing blood stasis, and strengthening the spleen. In the later stage, the deficiency of heart and kidney yang caused by the injury of kidney qi is an important reason for the disease to persist and worsen, treat with warming yang and tonifying kidney.
		2023 Vol. 20 (9): 123-126 [Abstract] ( 19 ) HTML (1 KB) PDF (633 KB) ( 335 )

	127	View of inheritance and development of folk traditional Chinese medicine from the protection of traditional Chinese medicine knowledge
		QIN Peijie LIU Qian WANG Liuqing AN Hong SHI Xueqin WANG Shiheng LIU Jianfeng
		DOI: 10.20047/j.issn1673-7210.2023.09.28
		Traditional Chinese medicine is an important part of traditional Chinese medicine and an important object of traditional Chinese medicine knowledge protection. It is highly valued for its “simplicity, convenience, cheapness, and efficacy”, and has made great contributions to improving the health level of Chinese people. Inheriting and developing traditional Chinese medicine is of great significance to the development of traditional Chinese medicine. This paper analyzes the reasons that restrict the inheritance and development of folk traditional Chinese medicine, and discusses the significance of traditional Chinese medicine protection to the inheritance and development of folk traditional Chinese medicine from the practical point of view of traditional Chinese medicine protection in China.
		2023 Vol. 20 (9): 127-130 [Abstract] ( 24 ) HTML (1 KB) PDF (563 KB) ( 47 )

	131	Analysis of medication rule of famous old traditional Chinese medicine doctor Song Aili in the treatment of breast cancer bone metastasis
		XU Jisheng1 SONG Aili2 PU Dongqing1 WANG Jing1 ZHANG Jingyu1 SHI Guangxi2 LI Jingwei2
		DOI: 10.20047/j.issn1673-7210.2023.09.29
		Objective To analyze the medication rule of Professor Song Aili in the treatment of breast cancer bone metastasis based on data mining. Methods Traditional Chinese medicine prescriptions taken by breast cancer patients with bone metastases treated by Professor Song in the outpatient department and inpatient department of the Affiliated Hospital of Shandong University of Traditional Chinese Medicine from June 2019 to June 2022 were collected, and the traditional Chinese medicine inheritance support system (V2.5) was used to analyze the drug frequency, drug efficacy, four natures, five flavors, channel tropism, and drug use regularity. Results A total of 145 traditional Chinese medicine prescriptions were screened, involving 161 traditional Chinese medicine. The top six drug use frequency were Psoraleae Fructus, Notoginseng Radix Et Rhizoma, Lycii Fructus, Astragali Radix, Codonopsis Radix and Curcumae Rhizoma. The frequency of drug use was highest in tonifying kidney and promoting blood circulation drugs. The drug natures were mainly warm and flat, the drug flavors were mainly sweet and bitter, and the channel tropisms were mainly liver, spleen, and kidney channels. Association rule network analysis showed that ten drugs including Psoraleae Fructus, Lycii Fructus, Notoginseng Radix Et Rhizoma, Hedyotis diffusa Willd., Curcumae Rhizoma, Astragali Radix, Codonopsis Radix, Glycyrrhizae Radix Et Rhizoma, Poria, and Angelicae Sinensis Radix were the core prescriptions for Professor Song’s treatment of breast cancer bone metastases. Three potential new prescriptions were discovered based on entropy clustering core combination of drugs. Conclusion In the treatment of breast cancer bone metastasis, Professor Song takes “tonifying kidney and promoting blood circulation, invigorating qi and nourishing blood” as the core treatment, supplemented by dissipating phlegm and eliminating dampness, regulating qi-flowing, detoxificationk, anti- cancer and other drugs.
		2023 Vol. 20 (9): 131-134,143 [Abstract] ( 27 ) HTML (1 KB) PDF (1183 KB) ( 42 )

	135	Summary of Professor Cai Lianxiang’s experience in treating unruptured ectopic pregnancy
		GAO Shanfeng CHEN Yanxia HUANG Yuxiao▲
		DOI: 10.20047/j.issn1673-7210.2023.09.30
		Ectopic pregnancy is one of the common acute abdominal diseases in obstetrics and gynecology. Clinically, it is often divided into unruptured type and ruptured type, and the unruptured stage is the best time for traditional Chinese medicine intervention. Professor Cai Lianxiang believes that the pathogenesis of unruptured ectopic pregnancy in traditional Chinese medicine always belongs to the deficiency of root cause and the excess of manifestation, and intermingled deficiency and excess, in which the deficiency of qi and blood is the root cause and the blood stasis and heat is the manifestation. In terms of treatment, the unruptured ectopic pregnancy was treated by stages. In the first stage, the treatment was mainly to promote blood circulation and kill embryos; in the later stage, the treatment was mainly to eliminate symptoms and resolving hard mass. At the same time, in the later stage of treatment, on the basis of internal decoction, external application or enema of traditional Chinese medicine for removing stasis and clearing collaterals was often used to promote lump absorption, prevent pelvic adhesion, and promote fallopian tube recovery patency. Professor Cai is good at combining modern pharmacological research and drug use to provide psychological counseling for patients with ectopic pregnancy, and the idea of strengthening vital qi to eliminate pathogenic factor and protecting and maintaining vital qi throughout the treatment, so as to restore and retain the fertility function of patients to the greatest extent.
		2023 Vol. 20 (9): 135-138,149 [Abstract] ( 31 ) HTML (1 KB) PDF (798 KB) ( 124 )

	139	Comments on the Abridged English Versions of Qian Jin Yao Fang
		YANG Guangyi1 WANG Shanshan2 ZHANG Sijie2 BAI Bing2
		DOI: 10.20047/j.issn1673-7210.2023.09.31
		Qian Jin Yao Fang, one of the classics of Sun Simiao in Tang Dynasty, has high academic value. Till now, only three abridged English versions have been officially published, which are translated by scholar Ms. Sabine Wilms at Arizona State University in the United States. This paper analyzes the three versions, finding they are characterized by reasonable compilation, various translation, and detailed annotation. As to translation strategies, both “domestication” and “foreignization” are taken into account with specific translation methods such as transliteration, literal translation, and liberal translation, etc. Annotation methods like in-text citations, footnotes, and endnotes are also included. Despite occasional mistranslations and other considerable issues, these versions still retain important academic value. Through the analysis of translation ideas, strategies and methods of the three versions, this paper aims to offer references for the subsequent complete translation work on Qian Jin Yao Fang and the overseas dissemination of traditional Chinese medicine classics.
		2023 Vol. 20 (9): 139-143 [Abstract] ( 38 ) HTML (1 KB) PDF (847 KB) ( 151 )

	144	Clinical effect on treatment of ARCO stage Ⅰ and Ⅱ femoral head necrosis with pivot channel needleknife
		LIN Xueting1 YANG Peipei2 FU Weiyan1 NI Lixin1 ZHANG Yunyu1 ZHU Shanjia1 WANG Kailong2
		DOI: 10.20047/j.issn1673-7210.2023.09.32
		Objective To observe the clinical effect on treatment of ARCO stage Ⅰand Ⅱ ostecnecrosis of the femoral head (ONFH) with pivot channel needleknife. Methods A total of 60 patients with ONFH were selected from the Department of Rehabilitation Medicine, the First Affiliated Hospital of Guangxi University of Chinese Medicine from September 2019 to December 2020, and they were divided into treatment group and control group, with 30 patients in each group. The treatment group was treated with pivot channel needleknife combined with Osteoking, and the control group was treated with common acupuncture combined with Osteoking for three months, with a follow-up visit at the 12th month after the end of treatment. The outcome measures were Harris hip score (HHS), visual analogue scale (VAS) and quality of life scale (short form, SF-36). Results Shedding occurred in two patients in the treatment group; one case fell out in the control group and those cases were excluded, resulting in a final outcome analysis of 57 cases. The clinical effect of the treatment group was better than that of the control group, and the difference was statistically significant (P＜0.05). Comparison between groups, comparison at time point and interaction of VAS were statistically significant (P＜0.05). Further pair comparison and intra-group comparison: VAS scores of the two groups were lower after treatment and at follow-up than before treatment (P＜0.05); comparison between groups: after treatment and at follow-up, VAS score of the treatment group was lower than that of the control group, the differences were statistically significant (P＜0.05). There were significant differences in the total score of HHS, functional activities, and deformities among groups, time points and interaction (P＜0.05). The time point comparison and interaction differences of pain score were statistically significant (P＜0.05), but there was no statistical significance between groups (P＞0.05); the interaction of joint activcty score was statistically significant (P＜0.05). Further pairwise comparison and intra-group comparison: after treatment and at follow-up, the total score of HHS, pain, functional activity and joint activity scores of the two groups were higher than before treatment, the differences were statistically significant (P＜0.05), the deformity score of the treatment group was higher than before treatment (P＜0.05), the deformity score of the control group was not statistically significant before and after treatment (P＞0.05). Comparison between groups: after treatment and at follow-up, the total score of HHS, functional activities and malformation scores in the treatment group were higher than those in the control group, the differences were statistically significant (P＜0.05). The quality of life scores of the two groups were higher after treatment than before treatment, the differences were statistically significant (P＜0.05). After treatment, the scores of physiological function, physical pain, general health status, energy, social function, and mental health in the treatment group were higher than those in the control group, and the differences were statistically significant (treatment group). There was no significant difference in physiological function and emotional function scores between the two groups (P＞0.05). Conclusion It is effective to treat ONFH patients with ARCO stages Ⅰ and Ⅱwith pivot channel needleknife and common acupuncture, but the pivot channel needleknife is superior to the common acupuncture in the degree of improvement.
		2023 Vol. 20 (9): 144-149 [Abstract] ( 24 ) HTML (1 KB) PDF (818 KB) ( 157 )

	150	Application of self-management education based on cognitive behavioral therapy in patients after mechanical heart valve replacement
		GENG Dandan GUAN Yuzhen▲ ZHOU Jingxin
		DOI: 10.20047/j.issn1673-7210.2023.09.33
		Objective To explore the application effect of self-management education based on cognitive behavioral therapy in patients after mechanical heart valve replacement (MHVR). Methods A total of 93 MHVR patients in the Department of Cardiac Great Vascular Surgery Ward, Jiangsu Provincial People’s Hospital from July 2018 to July 2020 were selected as the study subjects, and they were divided into control group 46 cases and experimental group 47 cases by random number table method. The control group received conventional self-management education, and the experimental group received self-management education based on cognitive behavioral therapy. After six months of intervention, disease uncertainty, self-management ability and complications were compared between the two groups. Results After intervention, the scores disease of uncertainty, inconsistency, complexity, unpredictability and disease uncertainty total score in two groups were lower than those before intervention, and the experimental group was lower than the control group, and the differences were statistically significant (P＜0.05); the scores of symptom management, treatment compliance management, daily life management, emotion management, information management, self-efficacy management and self-management ability total score of the two groups were higher than those before intervention, and the scores of symptom management, daily life management, emotion management, information management, self-efficacy management and self-management ability of the experimental group were higher than those of the control group, and the differences were statistically significant (P＜0.05); the total incidence of postoperative complications in experimental group was lower than that in control group, and the difference was statistically significant (P＜0.05). Conclusion Cognitive behavioral therapy is helpful to alleviate the uncertainty of MHVR patients, promote the cultivation of self-management ability and reduce the incidence of postoperative complications.
		2023 Vol. 20 (9): 150-155 [Abstract] ( 18 ) HTML (1 KB) PDF (783 KB) ( 95 )

	156	Effect of traditional Chinese medicine emotional nursing combined with fine nursing on self-efficacy and quality of life of patients after breast cancer surgery
		ZHANG Si
		DOI: 10.20047/j.issn1673-7210.2023.09.34
		Objective To analyze the effect of traditional Chinese medicine emotional nursing combined with fine nursing on self-efficacy and quality of life of patients after breast cancer surgery. Methods A total of 104 breast cancer patients treated in Nanjing Hospital Integrated of Traditional Chinese and Western Medicine from July 2019 to August 2021 were selected as the research objects. The control group was given fine nursing, while the observation group was given traditional Chinese medicine emotional nursing combined with fine nursing. The self-efficacy, quality of life and nursing satisfaction were compared between the two groups. Results After nursing, the scores of general self-efficacy sensing scale in the two groups were higher than those before nursing, and the observation group was higher than the control group, and the differences were statistically significant (P＜0.05). After nursing, the quality of life scores of the two groups were higher than those before nursing, and the observation group was higher than the control group, and the differences were statistically significant (P＜0.05). There was no significant difference in nursing satisfaction between the two groups (P＞0.05). Conclusion Breast cancer patients after the intervention of traditional Chinese medicine emotional nursing combined with fine nursing, the effect is significant, can effectively enhance patients’ self-efficacy, improve the quality of life.
		2023 Vol. 20 (9): 156-159 [Abstract] ( 26 ) HTML (1 KB) PDF (588 KB) ( 103 )

	160	Application of discharge planning based on IMB model in the elderly patients with chronic heart failure
		LU Xuan1 YIN Wei2 ZHANG Jianwei3
		DOI: 10.20047/j.issn1673-7210.2023.09.35
		Objective To explore the application effect of discharge planning based on IMB model in the elderly patients with chronic heart failure. Methods A total of 82 elderly patients with chronic heart failure admitted to the Department of Geriatric, Nanjing Drum Tower Hospital, the Affiliated Hospital of Nanjing University Medical School from September 2020 to September 2021 were selected as the research objects. The patients were divided into control group and observation group by random number table method, with 41 cases in each group. The control group was given routine nursing and discharge guidance, and on the basis of the control group, the observation group was given IMB model-based service plan for discharge preparation. Comparison of self-care ability (EHFSCB-9 score), cardiac function indicators (cardiac output [CO], left ventricular ejection time [LVET], B-type urinary natriuretic peptide [BNP]), 6-min walking distance (6MWD), and minnesota living with heart failure questionnaire (MLHFQ) score between the two groups before intervention and three months after discharge. Results After intervention, the EHFSCB-9 score of the observation group was lower than before intervention, and the observation group was lower than the control group, and the differences were statistically significant (P＜0.05). 6MWD in the control group was higher than that before intervention, BNP was lower than that before intervention, 6MWD, CO and LVET in the observation group were higher than those before intervention, BNP was lower than that before intervention, and 6MWD, CO, and LVET in the observation group were higher than those in control group, BNP was lower, and the differences were statistically significant (P＜0.05). MLHFQ scores in both groups were lower than those before intervention, and observation group was lower than control group, and the differences were statistically significant (P＜0.05). Conclusion The discharge planning based on IMB model can effectively improve the self-care ability, exercise endurance, and cardiac function of elderly patients with heart failure, and improve the quality of life of patients.
		2023 Vol. 20 (9): 160-164 [Abstract] ( 20 ) HTML (1 KB) PDF (717 KB) ( 74 )

	165	Effect of full-time follow-up on medication compliance, self-care ability, and quality of life of thyroid cancer patients discharged after iodine-131 treatment
		YAN Shouzhen XU Feng▲
		DOI: 10.20047/j.issn1673-7210.2023.09.36
		Objective To investigate the effect of full-time follow-up on medication compliance, self-care ability, and quality of life of patients with thyroid cancer after discharge after iodine-131 treatment. Methods Ninety-two patients with thyroid cancer who received iodine-131 treatment in Suqian First People’s Hospital from June 2020 to May 2022 were selected and divided into control group and observation group according to random number table method, with 46 cases in each group. The control group was given routine continuous intervention after discharge, and the observation group was given full-time follow-up nursing intervention mode. Medication compliance, self-care ability, and quality of life were compared between the two groups before intervention and three months after intervention. Results After three months of follow-up, the medication compliance of the observation group was better than that of the control group, and the difference was statistically significant (P＜0.05). After intervention, the self-skill, self-care responsibility, self-concept, health knowledge level, and the exercise of self-care agency scale total score of the two groups were higher than before intervention, while those of the observation group were higher than those of the control group, and the differences were statistically significant (P＜0.05). After intervention, the social function, physical symptoms, emotion management, disease cognition, role adaptation, and overall health of two groups were higher than before intervention, while those of the observation group were higher than those of the control group, and the differences were statistically significant (P＜0.05). Conclusion Full-time follow-up nursing intervention mode can effectively improve the self-care ability of discharged patients treated with iodine-131 for thyroid cancer, improve their medication compliance, and improve the quality of life.
		2023 Vol. 20 (9): 165-168,180 [Abstract] ( 25 ) HTML (1 KB) PDF (605 KB) ( 164 )

	169	Application of staged rehabilitation guidance under the guidance of PAC elasticity theory in patients with systemic lupus erythematosus
		WANG Yu1 LIU Yajie2 ZHAO Huan3▲
		DOI: 10.20047/j.issn1673-7210.2023.09.37
		Objective To analyze the application of staged rehabilitation guidance under the guidance of PAC elasticity theory in patients with systemic lupus erythematosus (SLE). Methods A total of 80 SLE patients admitted to Qingdao Municipal Hospital, Shandong Province, from November 2019 to November 2021 were selected, and they were divided into control group and experimental group by envelope random method, with 40 cases in each group. The control group was given basic nursing care, and the experimental group was given staged rehabilitation guidance under the guidance of PAC elasticity theory. The effects of anxiety, depression, connor-davidson resilience scale (CD-RICS) scores, intervention effects and safety were compared between the two groups. Results After four weeks of nursing, the scores of self-rating anxiety scale and self-rating depression scale in experimental group were lower than those in control group, and the scores in experimental group were lower than those in control group (P＜0.05); the score and total score of CD-RICS in two groups were higher than those before nursing, and the experimental group was higher than the control group (P＜0.05). The healing time of ulcerated skin in experimental group was shorter than that in control group (P＜0.05); the complication rate of experimental group was lower than that of control group (P＜0.05). Conclusion In the nursing of SLE patients, the phased rehabilitation guidance under the guidance of PAC elasticity theory has a significant effect, which has a relatively obvious improvement effect on negative emotions. The speed of erythema fading is accelerated, the psychological resilience of patients is stronger, and the complications are reduced, which is worth promoting.
		2023 Vol. 20 (9): 169-172 [Abstract] ( 29 ) HTML (1 KB) PDF (557 KB) ( 92 )

	173	Application effect of hierarchical responsibility nursing under CICARE communication model in patients with diabetic retinopathy
		ZHANG Jing WEN Mingxia WANG Shanshan▲
		DOI: 10.20047/j.issn1673-7210.2023.09.38
		Objective To observe the application effect of hierarchical responsibility nursing under CICARE communication model in patients with diabetic retinopathy. Methods A total of 280 patients with diabetic retinopathy admitted to the Second Affiliated Hospital of Air Force Military Medical University from December 2020 to December 2021 were selected as the study objects. They were divided into the conventional group and the research group according to the lottery method, with 140 cases in each group. The routine group was given routine nursing, and the research group was given hierarchical responsibility nursing cooperation under CICARE communication mode. Self-efficacy, self-care ability, treatment compliance, glycolipid metabolism, and vision loss were compared between the two groups before intervention and three months after intervention. Results After three months intervention, the self-efficacy and self-care ability of the two groups were higher than those before intervention, and the research group was higher than the conventional group, and the differences were statistically significant (P＜0.05); the treatment compliance of the study group was better than that of the conventional group, and the difference was statistically significant (P＜0.05); the indexes of glucose and lipid metabolism in both groups were lower than those before intervention, and the study group was lower than the conventional group, and the differences were statistically significant (P＜0.05); the visual impairment rate of the study group was lower than that of the conventional group, and the difference was statistically significant (P＜0.05). Conclusion The implementation of stratified responsibility nursing intervention measures based on CICARE communication mode can further enhance the self-efficacy and self-care ability of patients with diabetes retinopathy, and prevent their vision decline.
		2023 Vol. 20 (9): 173-176 [Abstract] ( 21 ) HTML (1 KB) PDF (565 KB) ( 42 )

	177	A case report of Rett syndrome and literature review
		CHANG Qian1 DING Xia2 ZHOU Bingbo3 ZHANG Qiaoli1 WANG Fan1▲ YIN Liqin1
		DOI: 10.20047/j.issn1673-7210.2023.09.39
		A 3-month-old infant with microcephaly was reported, high-throughput sequencing of growth retardation genes, the results confirmed frameshift mutation in MECP2 gene, and a rare male child diagnosed with Rett syndrome combined with the clinical phenotype. Normal early development and age greater than six months of age are no longer necessary for diagnosis of classic Rett syndrome. This case report will provide some reference for the diagnosis of Rett syndrome, and improve the knowledge of clinical workers, in order to reduce the rate of misdiagnosis and missed diagnosis.
		2023 Vol. 20 (9): 177-180 [Abstract] ( 24 ) HTML (1 KB) PDF (857 KB) ( 276 )

	181	Research on the mechanism of central fatigue and analysis of animal model construction methods
		WANG Ruochong1 WU Fengzhi2 YU Qingxi1 LI Jie1 YANG Xingzhe1 LI Feng1 ZHANG Weiyue3
		DOI: 10.20047/j.issn1673-7210.2023.09.40
		With the change of life style and rhythm, central fatigue has become the main fatigue type of modern people. In this paper, the etiology, mechanism, animal model, and application of traditional Chinese medicine are analyzed. It is found that the occurrence of central fatigue is related to excessive mental and physical exertion, sleep disorders, and so on. The main mechanism hypotheses include neurotransmitter hypothesis, stress system reaction mechanism hypothesis, immune inflammation mechanism hypothesis, fatigue chain hypothesis, and mitochondrial biosynthesis hypothesis. Animal model construction methods include excessive exercise method, sleep deprivation method, neurotransmitter injection method, immune inflammation method, and genetic engineering method. Syndromes and anti-fatigue agents of traditional Chinese medicine are the focus of research.
		2023 Vol. 20 (9): 181-185，封三 [Abstract] ( 25 ) HTML (1 KB) PDF (1177 KB) ( 153 )

	186	Construction present situation and practice of medical virtual simulation experiment course
		ZHU Jianyi1 WU Zheng2 ZHANG Min3 WANG Qianwei1 JI Li1 LIU Wei4 JIANG Yi5
		DOI: 10.20047/j.issn1673-7210.2023.09.41
		The construction of national-level virtual simulation courses has been developed until today, the software research and development technology, course system design, course application model, and other aspects are being continuously optimized. This paper reviewes the development history of medical virtual simulation courses, the problems faced, and the characteristics of national-level courses in recent years, discusses how to combine the current advanced technology of virtual reality to design virtual simulation experiment course, to meet the new needs of medical experiment teaching; how to make more practical and vivid virtual simulation experiment course, improve students’ interest in learning, cultivate self-adaptive learning ability; and further explore the future development prospects of national-level virtual simulation courses. This paper also introduces the experience of constructing organ system virtual simulation experiment courses at Shanghai Jiao Tong University Medical School for discussion.
		2023 Vol. 20 (9): 186-189 [Abstract] ( 22 ) HTML (1 KB) PDF (1827 KB) ( 150 )

	190	Study on negative public opinion of Beijing public hospitals based on text mining
		DU Mengkai1 WANG Lei1 DI Yang1 SHAN Yue2 YUE Xiaolin3
		DOI: 10.20047/j.issn1673-7210.2023.09.42
		Objective To analyze the negative public opinions of municipal public hospitals in Beijing based on text mining and topic modeling. Methods All the negative public opinions of 22 municipal public hospitals in Beijing on the mainstream online media platforms from January 1 to December 31, 2021 were collected. Python 3.9 was used for text mining and corpus building. While the latent dirichlet allocation (LDA) topic model was adopted for linguistic data clustering and explaining the meaning of each cluster according to its keywords. Results A total of 3 083 pieces of linguistic data were collected, and 6 topics were extracted, forming 5 types of problems by keywords, including problems related to registration and fees, problems related to public health emergencies, problems with waiting times and service accessibility, problems in service attitude and experience of the medical process, and problems in patients’ experience of surgery and prognosis as well as hospital admissions. Conclusion Negative public opinions about public hospitals are an important source of information reflecting social conditions and public opinions. Through text mining and research on negative public opinions, management loopholes can be found effectively and improvement measures proposed, so as to enhance public opinion management in hospitals and improve medical services.
		2023 Vol. 20 (9): 190-193 [Abstract] ( 22 ) HTML (1 KB) PDF (769 KB) ( 203 )

	194	New thinking on strengthening archives management and promoting hospital culture construction
		LIU Wei1 YIN Lu2▲ WANG Xiaopin2
		DOI: 10.20047/j.issn1673-7210.2023.09.43
		Hospital culture is the basis of the core competitiveness of the hospital, which is a booster to improve the cohesion of the hospital and empower the high-quality development of the hospital. The construction of hospital culture is a vital job for the current constant development of the hospital. The relationship between the archive management and the cultural construction of the hospital has been interpreted, and the positive rule of archive management on the cultural construction of the hospital has been discussed in the paper via the analysis of the new connotation of the cultural construction of the hospital. It has proposed that the archive management of the hospital is an important part of the cultural construction in the hospital, the methods and paths to innovate the archive management in the hospital has been proposed targeted.
		2023 Vol. 20 (9): 194-封三 [Abstract] ( 23 ) HTML (1 KB) PDF (591 KB) ( 86 )

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