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| Analysis of medication rule of famous old traditional Chinese medicine doctor Song Aili in the treatment of breast cancer bone metastasis |
| XU Jisheng1 SONG Aili2 PU Dongqing1 WANG Jing1 ZHANG Jingyu1 SHI Guangxi2 LI Jingwei2 |
1.The First Clinical Medical College, Shandong University of Traditional Chinese Medicine, Shandong Province, Jinan 250014, China;
2.Department of Breast and Thyroid Surgery, the Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Shandong Province, Jinan 250014, China
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Abstract Objective To analyze the medication rule of Professor Song Aili in the treatment of breast cancer bone metastasis based on data mining. Methods Traditional Chinese medicine prescriptions taken by breast cancer patients with bone metastases treated by Professor Song in the outpatient department and inpatient department of the Affiliated Hospital of Shandong University of Traditional Chinese Medicine from June 2019 to June 2022 were collected, and the traditional Chinese medicine inheritance support system (V2.5) was used to analyze the drug frequency, drug efficacy, four natures, five flavors, channel tropism, and drug use regularity. Results A total of 145 traditional Chinese medicine prescriptions were screened, involving 161 traditional Chinese medicine. The top six drug use frequency were Psoraleae Fructus, Notoginseng Radix Et Rhizoma, Lycii Fructus, Astragali Radix, Codonopsis Radix and Curcumae Rhizoma. The frequency of drug use was highest in tonifying kidney and promoting blood circulation drugs. The drug natures were mainly warm and flat, the drug flavors were mainly sweet and bitter, and the channel tropisms were mainly liver, spleen, and kidney channels. Association rule network analysis showed that ten drugs including Psoraleae Fructus, Lycii Fructus, Notoginseng Radix Et Rhizoma, Hedyotis diffusa Willd., Curcumae Rhizoma, Astragali Radix, Codonopsis Radix, Glycyrrhizae Radix Et Rhizoma, Poria, and Angelicae Sinensis Radix were the core prescriptions for Professor Song’s treatment of breast cancer bone metastases. Three potential new prescriptions were discovered based on entropy clustering core combination of drugs. Conclusion In the treatment of breast cancer bone metastasis, Professor Song takes “tonifying kidney and promoting blood circulation, invigorating qi and nourishing blood” as the core treatment, supplemented by dissipating phlegm and eliminating dampness, regulating qi-flowing, detoxificationk, anti- cancer and other drugs.
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