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| Research progress of immune regulation mechanism of traditional Chinese medicine on spinal tuberculosis based on the theory of “killing insects and replenishing deficiency” |
| LIANG Jian1 KANG Wenting1 FENG Jing2 PU Feifei2 XIA Ping1 |
1.Clinical College of Traditional Chinese Medicine, Hubei University of Chinese Medicine, Hubei Province, Wuhan 430065, China;
2.Department of Spinal Surgery, Wuhan Hospital of Integrated Traditional and Western Medicine, Hubei Province, Wuhan 430000, China
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Abstract In traditional Chinese medicine, tuberculosis is mainly caused by “the deficiency of the body and the external sensation of tuberculosis”, and “killing insects and replenishing deficiency” is the general treatment principle of traditional Chinese medicine in the treatment of tuberculosis. Spinal tuberculosis is mostly secondary to pulmonary tuberculosis and digestive tract tuberculosis. Modern medical studies have shown that the pathogenesis and outcome of spinal tuberculosis are closely related to the immune status of the host and the growth and inhibition of Mycobacterium tuberculosis. In the treatment of spinal tuberculosis, single traditional Chinese medicine components, extracts, and traditional Chinese medicine compounds can play an important auxiliary role by regulating the immune function of the body, destroying and inhibiting the generation of pathogenic bacteria, regulating autophagy and apoptosis of cells, and other different immune axes. Based on the theory of “killing insects and replenishing deficiency”, this paper discusses the research progress of the immune regulation mechanism of traditional Chinese medicine on spinal tuberculosis.
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[1] Garg D，Goyal V. Spinal tuberculosis treatment：an enduring bone of contention [J]. Ann Indian Acad Neurol，2020，23（4）：441-448.
[2] Chakaya J，Khan M，Ntoumi F，et al. Global tuberculosis report 2020-reflections on the global TB burden，treatment and prevention efforts [J]. Int J Infect Dis，2021，113 Suppl 1：S7-S12.
[3] Vilchèze C，Kim J，Jacobs WR. Vitamin C potentiates the killing of mycobacterium tuberculosis by the first-line tuberculosis drugs isoniazid and rifampin in mice [J]. Antimicrob Agents Chemother，2018，62（3）：e02165-17.
[4] Ghiraldi-Lopes LD，Campanerut-Sa P，Evaristo G，et al. New insights on ethambutol targets in Mycobacterium tuberculosis [J]. Infect Disord Drug Targets，2019，19（1）：73-80.
[5] Singh V，Chibale K. Strategies to combat multi-drug resistance in tuberculosis [J]. Acc Chem Res，2021，54（10）：2361- 2376.
[6] Oh JH，Yun J，Yang MS，et al. Reintroduction of antituberculous drugs in patients with antituberculous drug-related drug reaction with eosinophilia and systemic symptoms [J]. J Allergy Clin Immunol Pract，2021，9（9）：3442-3449.
[7] 王和鸣.中医骨伤科学[M].北京：中国中医药出版社，2017.
[8] 于首元，王珂，何礼营，等.常规抗痨结合中医综合疗法治疗脊椎结核临床观察[J].中医临床研究，2017，9（22）：88-89.
[9] 王新刚，卫建民，杨俊松，等.加味清骨散联合抗结核药物治疗阴虚内热型脊柱结核的临床疗效观察[J].辽宁中医药大学学报，2023，25（1）：143-147.
[10] 戴赢杰，魏建，石仕元.阳和汤联合抗结核药治疗阳虚寒凝型脊柱结核短期疗效观察[J].浙江中西医结合杂志，2022，32（5）：421-423.
[11] 虞抟等明.医学正传[M].大连：中医古籍出版社，2002.
[12] 乔杰.基于扶正祛邪法探讨阳和汤治疗脊柱结核作用机制的临床和实验研究[D].武汉：湖北中医药大学，2022.
[13] 陈稚，吴都督，郑博丹，等.黄连素抗结核影响因素研究[J].广东化工，2015，42（21）：27-28.
[14] Ozturk M，Chia JE，Hazra R，et al. Evaluation of berberine as an adjunct to TB treatment [J]. Front Immunol，2021， 12：656419.
[15] 熊友谊，杨长水.猫爪草石油醚提取物抗多药耐药结核菌株活性研究[J].安徽科技学院学报，2017，31（2）：27- 30.
[16] 黄华靖，江洁怡，肖观林，等.猫爪草的化学成分、药理作用研究进展及其质量标志物的预测分析[J].中药材，2022，45（3）：752-759.
[17] Zhao BQ，Peng S，He WJ，et al. Antitubercular and cytotoxic tigliane-type diterpenoids from Croton tiglium [J]. Bioorg Med Chem Lett，2016，26（20）：4996-4999.
[18] Huang F，Li W，Xu H，et al. Cordycepin kills Mycobacterium tuberculosis through hijacking the bacterial adenosine kinase [J]. PLoS One，2019，14（6）：e218449.
[19] 谢玉瑾，宋雪云，马永春.甲基莲心碱通过miR-3619- 5p调控结核分枝杆菌诱导的THP-1凋亡及炎性反应的分子机制[J].河北医药，2022，44（1）：46-49.
[20] 肖红侠，张喜霞，邵世峰，等.黄芩苷对结核分枝杆菌抑菌作用的研究[J].临床检验杂志，2017，35（4）：291-292.
[21] Zhang Q，Sun J，Wang Y，et al. Antimycobacterial and anti-inflammatory mechanisms of baicalin via induced autophagy in macrophages infected with Mycobacterium tuberculosis [J]. Front Microbiol，2017，8：2142.
[22] Bai X，Oberley-Deegan RE，Bai A，et al. Curcumin enhances human macrophage control of Mycobacterium tuberculosis infection [J]. Respirology，2016，21（5）：951-957.
[23] 刘莉，刘锦程，牛国强，等.姜黄素在结核分枝杆菌脂蛋白P19所致巨噬细胞炎症和凋亡中的作用[J].中华结核和呼吸杂志，2014，37（6）：421-426.
[24] 刘婷婷，欧阳建军，伍参荣，等.月华丸（胶囊）对耐多药结核菌感染自噬相关蛋白LC3的影响[J].湖南中医杂志，2019，35（3）：129-131.
[25] 范俊，秦世炳，董伟杰，等. 脊柱结核外周血T细胞亚群的检测及临床意义[C]//全国结核病诊疗与防控暨第四届中西医结合治疗基础与临床新进展研讨会、中国医疗保健国际交流促进会结核病防治分会基础与临床专业第四届学术年会资料汇编，2019：147.
[26] Sun J，Zhang Q，Yang G，et al. The licorice flavonoid isoliquiritigenin attenuates Mycobacterium tuberculosis- induced inflammation through Notch1/NF-kappaB and MAPK signaling pathways [J]. J Ethnopharmacol，2022，294：115368.
[27] Wang W，Yang B，Cui Y，et al. Isoliquiritigenin attenuates spinal tuberculosis through inhibiting immune response in a New Zealand white rabbit model [J]. Korean J Physiol Pharmacol，2018，22（4）：369-377.
[28] Li Y，Fu Y，Sun J，et al. Tanshinone ⅡA alleviates NLRP3 inflammasome-mediated pyroptosis in Mycobacterium tuberculosis-（H37Ra-） infected macrophages by inhibiting endoplasmic reticulum stress [J]. J Ethnopharmacol，2022， 282：114595.
[29] Dwivedi VP，Bhattacharya D，Singh M，et al. Allicin enhances antimicrobial activity of macrophages during Mycobacterium tuberculosis infection [J]. J Ethnopharmacol，2019，243：111634.
[30] 秦蕊.夏枯草提取物对MDR-TB感染小鼠细胞免疫的调节作用[D].淮南：安徽理工大学，2013.
[31] 陆军，秦蕊，叶松，等.夏枯草提取物对MDR-MTB感染小鼠细胞免疫功能的影响[J].临床检验杂志，2012，30（1）：49-51.
[32] 梁健，冯晶，乔杰，等.阳和汤加味对早期胸腰椎结核患者炎症因子和骨代谢的影响[J].湖南中医药大学学报，2022，42（10）：1772-1776.
[33] 杨国强，张靳，廖伟，等.阳和汤联合西药抗结核药物治疗骨结核的临床效果观察[J].现代生物医学进展，2015， 15（33）：6487-6490.
[34] 李军杰.加味清骨散用于阴虚内热型胸腰椎结核术后疗效及对T淋巴细胞亚群的影响[D].兰州：甘肃中医药大学，2019. |
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