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| Effect of Guben Ziyin Decoction and Yiqi Tongluo Decoction in treating elderly patients with type 2 diabetes mellitus peripheral neuropathy with syndrome of deficiency of both qi and yin complicated by stasis |
| SHEN Jinhua XIA Jing |
Department of Endocrinology, Jiangyin Hospital of Traditional Chinese Medicine, Jiangsu Province, Jiangyin 214400, China
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Abstract Objective To explore the effect of Guben Ziyin Decoction and Yiqi Tongluo Decoction on elderly patients with type 2 diabetes mellitus peripheral neuropathy with syndrome of deficiency of both qi and yin complicated by stasis. Methods A total of 83 elderly patients with type 2 diabetes mellitus peripheral neuropathy with syndrome of deficiency of both qi and yin complicated by stasis admitted to Jiangyin Hospital of Traditional Chinese Medicine in Jiangsu Province from June 2019 to June 2022 were selected and divided into Mecobalamine group (41 cases, Mecobalamine Tablets) and experimental group (42 cases, on the basis of Mecobalamine group plus Guben Ziyin Decoction and Yiqi Tongluo Decoction) by random number table method. Both groups were treated continuously for two months. Traditional Chinese medicine syndrome score, fasting blood glucose level, nerve conduction velocity, and nerve defect score (NDS) of the two groups before and after treatment were analyzed. The clinical efficacy of the two groups was compared, and the occurrence of adverse reactions during treatment was recorded. Results After treatment, traditional Chinese medicine syndrome scores, NDS, and fasting blood glucose levels of the two groups were lower than those before treatment, the sensory and motor nerve conduction velocity of common peroneal nerve and median nerve was higher than those before treatment, traditional Chinese medicine syndrome scores, NDS, and fasting blood glucose levels of experimental group were lower than those of Mecobalamine group, the sensory and motor nerve conduction velocity of common peroneal nerve and median nerve was higher than those of Mecobalamine group, the differences were statistically significant (P＜0.05). The therapeutic effect of experimental group was better than that of Mecobalamine group, and the difference was statistically significant (P＜0.05). There was no adverse reaction occurred in both groups during treatment. Conclusion The effect of Gubenziyin Decoction and Yiqi Tongluo Decoction in the treatment of elderly patients with type 2 diabetes mellitus peripheral neuropathy with syndrome of deficiency of both qi and yin complicated by stasis is exact, which can improve clinical symptoms and promote the recovery of peripheral nerve conduction velocity, with high safety, so it is recommended to be popularized and used in clinic.
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