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| Meta-analysis of the efficacy and safety of Tamsulosin combined with Butylscopolammonium Bromide assisted extracorporeal shock wave lithotripsy in the treatment of urinary calculi |
| ZHONG Bin1 ZOU Junrong2 PENG Peng3 WANG Xiaoning3 ZHANG Guoxi3 XIE Tianpeng3 |
1.The First Clinical Medical College, Gannan Medical University, Jiangxi Province, Ganzhou 341000, China;
2.Urological Research Institute, Gannan Medical University, Jiangxi Province, Ganzhou 341000, China;
3.Department of Urology, the First Affiliated Hospital of Gannan Medical University, Jiangxi Province, Ganzhou 341000, China
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Abstract To systematically evaluate the efficacy and safety of Tamsulosin combined with Butylscopolammonium Bromide assisted extracorporeal shock wave lithotripsy (ESWL) in the treatment of urinary calculi. Methods CNKI, Wanfang, VIP, CBM, PubMed, Cochrane Library, and Web of Science core collection databases were searched by computer, the search period was from establishment to April 2022. The randomized controlled trials of Tamsulosin combined with Butylscopolammonium Bubromine assisted ESWL for urinary calculi was found, the experimental group was given Tamsulosin + Butylscopolammonium Bromide after ESWL, and control group was given Butylscopolammonium Bromide after ESWL. Meta-analysis was performed using RevMan 5.4 software, the effective rate, stone discharge time, disappearance time of renal colic, pain score, and adverse reactions between two groups were analyzed. According to the stone discharge time, it can be divided into hour group and day group; according to the rating scale select, it can be divided into visual analog scale (VAS) group and numerical pain rating scale (NPRS) group. Results A total of eight articles with 1 762 patients were included. The effective rate of experimental group was higher than that of control group (RR=1.21, 95%CI:1.16 to 1.26, P＜0.000 01). The stone discharge time of hour group was shorter than that of control group (SMD=-5.50, 95%CI:-6.59 to -4.41, P＜0.000 01). The stone discharge time of day group was shorter than that of control group (SMD=-4.21, 95%CI:-6.40 to -2.03, P=0.000 2). The disappearance time of renal colic in experimental group was shorter than that in control group (SMD=-2.04, 95%CI:-2.18 to -1.91, P＜0.000 01). The degree of pain in VAS group was lower than that in control group (SMD=-0.65, 95%CI:-0.90 to -0.39, P＜0.000 01). The degree of pain in NPRS group was lower than that in control group (SMD=-1.59, 95%CI:-1.80 to -1.38, P＜0.000 01). There was no significant difference in adverse reactions between the two groups (P＞0.05). Conclusion Tamsulosin combined with Butylscopolammonium Bromide assisted ESWL treatment of urinary calculi can improve the effective rate of treatment, promote the discharge of calculi, shorten the pain time, and relieve the pain symptoms of patients, which is a safe and effective method.
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