铁死亡的基本途径及其与骨关节炎可能调控机制的研究进展

doi:10.20047/j.issn1673-7210.2023.09.10

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Abstract Ferroptosis is a new type of iron-dependent programmed cell death. Iron, lipid, and amino acid metabolism are major pathways regulating ferroptosis. Osteoarthritis (OA) is a common degenerative joint disease. Its pathogenesis is complex and has not been completely clarified. However, iron metabolism disorder, oxidative stress, and lipid metabolism are common pathological characteristics of OA, which are closely related to the pathogenesis of OA. In this article, the basic mechanism of ferroptosis will be briefly described, and the role of ferroptosis in the pathogenesis of OA will be analyzed from the perspectives of iron metabolism disorder, amino acid metabolism and lipid metabolism, in order to provide a new direction for the clinical treatment of OA and new ideas for its prevention and treatment.

Key words： Ferroptosis Osteoarthritis Iron metabolism Amino acid metabolism Lipid metabolism

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	XU Limei XU Fangyuan XIA Jing LUO Fangfang LIN Munan

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XU Limei XU Fangyuan XIA Jing LUO Fangfang LIN Munan. Research progress on the basic pathway of ferroptosis and the possible regulatory mechanism of ferroptosis and osteoarthritis[J]. 中国医药导报, 2023, 20(9): 50-53.

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https://www.yiyaodaobao.com.cn/EN/10.20047/j.issn1673-7210.2023.09.10 OR https://www.yiyaodaobao.com.cn/EN/Y2023/V20/I9/50

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