外泌体在肿瘤诊断和治疗中的应用现状与展望

doi:10.20047/j.issn1673-7210.2023.09.08

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Abstract Exosomes are membranous vesicles with a size of 30-150 nm that are produced by the endovascular process of the endocytic membrane. Exosomes contain a large number of biological macromolecules, such as various enzymes, proteins, mRNA, and non-coding RNA, which make them increasingly regarded as important carriers in intercellular communication and substance exchange. Exosomes are closely related to the processes of tumor growth, angiogenesis, and tumor immune escape, and metastasis, and the research on exosomes in the field of tumors is one of the current hotspots. Because exosomes contain numerous information of donor cells and carry a variety of important biomolecules, they can be applied as biomarkers, drug carriers, or immunomodulators for tumor diagnosis and treatment. In this review, the basic concept, formation and elemental composition, isolation and characterization of exosomes, as well as their applications in tumor diagnosis (as biomarkers) and treatment (as drug carriers and as immunomodulatory substances) are reviewed, and their prospects are discussed.

Key words： Exosomes Extracellular vesicles Tumor diagnosis Tumor treatment Drug delivery Tumor immune regulation

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	ZHU Xiaoxian1 CHEN Huizhi1 CUI Kuiyan1 ZHONG Wen2 PENG Xinsheng1 ZHOU Yubin1

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ZHU Xiaoxian1 CHEN Huizhi1 CUI Kuiyan1 ZHONG Wen2 PENG Xinsheng1 ZHOU Yubin1. Current situation and prospect of exosomes application in tumor diagnosis and treatment[J]. 中国医药导报, 2023, 20(9): 41-45.

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https://www.yiyaodaobao.com.cn/EN/10.20047/j.issn1673-7210.2023.09.08 OR https://www.yiyaodaobao.com.cn/EN/Y2023/V20/I9/41

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