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2022 Vol. 19, No. 23
Published: 2022-08-15
 
 
5 Bibliometric analysis on hypertrophic cardiomyopathy based on CiteSpace
ZHANG Xuesong WEI Yi SHI Shuqing SHI Jingjing HU Yuanhui
Objective To visually analyze the scientific achievements in hypertrophic cardiomyopathy (HCM) by searching relevant literature. Methods The data were retrieved from Web of Science core collection database from January 2015 to December 2020. CiteSpace was used to make visual analysis of published HCM related literatures by country, institution, author, and keywords. Results From 2015 to 2020, a total of 6 032 articles related to HCM were published worldwide, and the International Journal of Cardiology had the largest number of articles. The United States had the most publications, the Mayo Clinic was the most influential scientific institution, and author IACOPO OLIVOTTO had the most publications. Key words analysis showed that sudden cardiac death, mutation, prevalence, diagnosis, and cardiovascular magnetic resonance were the current research hotspots. Conclusion The targeted gene therapy of hypertrophic cardiomyopathy is a research hotspot, and the epidemiological research of HCM, especially the genetic research is the research front. Further development in this field also requires increased research and cooperation worldwide.
2022 Vol. 19 (23): 5-8,26 [Abstract] ( 29 ) HTML (1 KB)  PDF (1883 KB)  ( 61 )
9 Relationship between serum hs-CRP, IL-15, and Hp infection in elderly patients with acute cholecystitis and its value in predicting Hp infection
CAI Liuyan JI Qianqian LI Hengjie
Objective To analyze the relationship between serum high-sensitivity C-reactive protein (hs-CRP), interleukin-15 (IL-15), and Helicobacter pylori (Hp) infection in elderly patietns with acute cholecystitis, and their value in predicting Hp infection. Methods The clinical data of 100 elderly patients with acute cholecystitis admitted to Zhejiang Provincial People’s Hospital from April 2017 to May 2019 were analyzed. According to Hp infection, they were divided into infected group and non-infected group. Serum hs-CRP and IL-15 levels were compared between two groups; the metaplasia of gallbladder mucosa and gastric epithelium was observed; the correlation of hs-CRP, IL-15, and Hp positive rate and the efficacy of hs-CRP and IL-15 in predicting Hp infection in elderly patients with acute cholecystitis were analyzed. Results Fifty-three elderly patients with acute cholecystitis were infected with Hp. Serum hs-CRP and IL-15 levels in infected group were higher than those in non-infected group (P < 0.05). The metaplasia rate of gallbladder mucosa and gastric epithelium in infected group was higher than that in non-infected group (P < 0.05). Hp positive rate was positively correlated with hs-CRP and IL-15 (r = 0.694, 0.677, P < 0.05); there was positive correlation between hs-CRP and IL-15 (r = 0.686, P < 0.05). When hs-CRP and IL-15 were combined to predict Hp infection in acute cholecystitis, the area under the curve was 0.870, the sensitivity and specificity were 75.47% and 95.74%, respectively. Conclusion Hp infection in elderly patients with acute cholecystitis can aggravate the local inflammatory response of cholecystitis, and induce release of hs-CRP and IL-15; hs-CRP and IL-15 are highly correlated with Hp infection, which can be used as a basis for preliminary screening of early Hp infection.
2022 Vol. 19 (23): 9-12 [Abstract] ( 22 ) HTML (1 KB)  PDF (932 KB)  ( 25 )
13 Analysis on clinical acupoint selection rules of acupuncture and moxibustion in the treatment of acute ankle sprain based on data mining technology
LIANG Huan1 MA Yufeng2 QI Yinze2 MA Zhanhua2 PAN Xuyue2 CHEN Zhaojun2
Objective To study the acupoint selection rules of acupuncture and moxibustion in the treatment of acute ankle sprain. Methods The clinical data and literature of acupuncture and moxibustion in the treatment of acute ankle sprain in CNKI, Wanfang academic journal full-text database, VIP Chinese scientific and technological journal database, China biomedical literature database, PubMed from inception to May 2021 were searched. The acupoint selection database of acute ankle sprain was established, and descriptive statistics, cluster analysis and association rule analysis were performed on the literature data. Results A total of 123 clinical research literatures were included through retrieval, 73 literatures were excluded from duplication and non-compliance with the inclusion criteria, and finally 50 literatures were included. The acupuncture points with high frequency of acupuncture and moxibustion in the treatment of acute ankle sprain were ashi point, jiěxī, kūnlún. The most frequent selection of channels was the bladder channel of foot taiyang. The acupoint combination with the strongest relevance in the association rules was jiěxī-kūnlún. The selected acupoints were divided into four categories by cluster analysis. Conclusion Acupuncture and moxibustion in treatment of acute ankle sprain is mainly based on five-shu point, combined with bladder channel and kidney channel points. It provides a reference basis for clinical use of acupuncture and moxibustion in the treatment of acute ankle sprain, or precise acupoint selection along the channel.
2022 Vol. 19 (23): 13-17 [Abstract] ( 21 ) HTML (1 KB)  PDF (1112 KB)  ( 276 )
18 Study on medication regularity and difference between abscess stage of granulomatous lobular mastitis and lactation mastitis based on data mining
XU Jisheng1 LIU Miaomiao2 SHI Guangxi3 LIANG Hongyi4 WANG Bo1 ZHANG Mengdi4 CHEN Hanhan3 LI Jingwei3



[Abstract] Objective To discuss the medication regularity and difference between abscess stage of granulomatous lobular mastitis (GLM), lactation mastitis (LM). Methods The literatures on traditional Chinese medicine treatment of the abscess stage of GLM, LM published in Sinomed, CNKI, Wanfang Data, and VIP database from inception to December 2021 were screened, to analyze the medication regularity and difference of the abscess stage of GLM, LM through Traditional Chinese Medicine Inheritance Computing Platform. Results The medication regularity of the abscess stage of GLM, LM, seven of the top ten high-frequency drugs were same and three were different. The comparison of the four nature of drugs, five flavours, and channel tropism showed that at the abscess stage of GLM, LM, cold and warm, mainly bitter and sweet taste drugs were used. The proportion of warm and sweet medicine in abscess stage of GLM was higher than that in abscess stage of LM. The main channel tropism were liver, stomach, and lung channels. Drugs for heat-clearing, tonifying deficiency, dissipating phlegm, promoting blood circulation for removing blood stasis were the main drugs in the classification. The proportion of drugs for tonifying deficiency, dissipating phlegm, promoting blood circulation for removing blood stasis in abscess stage of GLM was higher than that in abscess stage of LM. Futher analysis showed that, six potential drug pairs for abscess stage of GLM and seven potential drug pairs for abscess stage of LM were obtained, and a group of core drug combinations were obtained for each. Conclusion Abscess stage of GLM, LM are treated according to the principle of clearing heat and removing toxicity, expelling pathogens by strengthening vital qi and expelling pus. Abscess stage of LM needs to strengthen the function of strengthening vital qi and tonifying deficiency, accompanied by dissipating phlegm and promoting blood circulation products. Abscess stage of LM needs to strengthen the function of heat-clearing and cooling blood.
2022 Vol. 19 (23): 18-21,31 [Abstract] ( 12 ) HTML (1 KB)  PDF (1384 KB)  ( 12 )
22 Visual analysis of caregiver burden research status and trend based on CiteSpace
YOU Qingqing1 ZHANG Chengcheng1 ZHANG Yuejuan2
Objective To discuss the research status, research hotspots, and development trends of caregiver burden, to provide some reference for the in-depth study of caregiver burden in China. Methods The caregiver burden research literatures collected by CNKI and Web of Science database from inception to April 2021 were searcher by the system, and the perform visual analysis on the author, institution and keywords of caregiver burden research literature in recent ten years were performed by CiteSpace software. Results A total of 4 374 valid English literatures and 1 064 Chinese literatures were retrieved, and the annual number of articles presented an overall upward trend. JOHN and Wang Yuhuan were the most published authors. The University of Hong Kong and the School of Nursing of Central South University are the institutions with the most publications. Alzheimer’s disease and quality of life were the most frequently used keywords. Stroke patients were a persistent feature of the Web of Science. Conclusion There is a gap between domestic research and foreign research. On the basis of learning from research hotspots and research frontiers, we can innovate research ideas and methods and open up a new field of caregiver burden research.
2022 Vol. 19 (23): 22-26 [Abstract] ( 24 ) HTML (1 KB)  PDF (3218 KB)  ( 70 )
27 Analysis on the clinical characteristics and prognosis of elderly patients with high-grade glioma
ZHONG Jiangfen LAI Mingyao CAI Linbo▲
Objective To summarize the clinical features, prognostic factors, and treatment patterns of elderly high-grade gliomas. Methods The clinical data of 84 elderly patients with high-grade glioma (≥65 years old) diagnosed in Guangdong Sanjiu Brain Hospital from January 2008 to January 2021 were collected, and the clinical characteristics and prognostic factors were analyzed. Results Postoperative Karnofsky performance status (KPS) score, histological type, O6-methylguanine-DNA methyltransferase (MGMT) status, surgical method, postoperative treatment mode, whether to maintain chemotherapy, and the number of maintenance chemotherapy cycles were related factors affecting overall survival (P ＜ 0.05). Preoperative KPS score was not related to the completion of radiotherapy (P ＞ 0.05); postoperative KPS score was related to the completion of radiotherapy (P ＜ 0.05). Multivariate Cox regression model showed that negative MGMT immunohistochemistry and ≥six cycles of maintenance chemotherapy were prognostic factors (P ＜ 0.05). Conclusion For elderly high-grade gliomas, the maximum range of safe resection has a survival benefit. It is recommended to perform comprehensive treatment with active radiotherapy after surgery. However, the optimal separation method still needs to be further explored. Negative MGMT immunohistochemistry can benefit from temozolomide treatment, and long-term maintenance chemotherapy can further prolong survival.
2022 Vol. 19 (23): 27-31 [Abstract] ( 21 ) HTML (1 KB)  PDF (910 KB)  ( 21 )
32 Analysis of epidemiological status and risk factors of allergic rhinitis among primary and secondary school students in Hohhot area
LIU Chang CHI Baofeng
Objective To understand the prevalence and risk factors of allergic rhinitis among primary and secondary school students in Hohhot. Methods A cross-sectional survey method was used to conduct a questionnaire survey among primary and secondary school students aged 7 to 18 in six schools in Hohhot. The research subjects were divided into allergic rhinitis (AR) group and non AR group. The related data of the two groups were compared, and logistic regression analysis was used for multivariate analysis. Results A total of 5 747 primary and secondary school students were investigated, and the reported rate of AR among primary and secondary school students in Hohhot was 18.51%. Univariate analysis showed that there were significant differences in gender, age, ethnicity, body mass index, place of residence, parents with allergic rhinitis, mode of delivery, breastfeeding, neonatal jaundice, mother drinking alcohol during pregnancy, living in a city, having pets at home, having flowers or plants at home, someone smoking at home, and plush toys at home between AR group and non AR (P ＜ 0.05). Multivariate logistic regression analysis showed that females, household flowers and plants were protective factors for allergic rhinitis in primary and secondary school students (OR ＜ 1, P ＜ 0.05); Mongolian nationality, obesity, living in the city, parents suffering from AR, cesarean section, neonatal jaundice, keeping pets at home, and someone smoking at home were risk factors for AR in primary and middle school students (OR ＞ 1, P ＜ 0.05). Conclusion The reported rate of AR among primary and secondary school students in Hohhot is at a high level. Students and parents should pay attention, find the reasons and take corresponding countermeasures.
2022 Vol. 19 (23): 32-35 [Abstract] ( 22 ) HTML (1 KB)  PDF (464 KB)  ( 44 )
36 Analysis of influencing factors of HIV positive in blood donor population in Guangxi Zhuang Autonomous Region
LIN Guokui
Objective To investigate and analyze the influencing factors of human immunodeficiency virus (HIV) positivity among blood donors in Guigang City, Guangxi Zhuang Autonomous Region, to provide a basis for controlling HIV transmission through blood transfusion. Methods The blood HIV screening and confirmation results of 131 430 unpaid blood donors were analyzed in Central Blood Station of Guigang in Guangxi Zhuang Autonomous Region from January 2018 to June 2021. The blood donors were divided into two groups according to whether they were HIV-positive or not, and the risk factors of HIV-positive people were analyzed and determined. Results Among the 131 430 blood donors, 46 were confirmed positive, and the confirmed positive rate was 35/10 000; among the 46 confirmed positive blood donors, the positive rate in Qintang District was the highest, and the positive rate in Gangbei District was the lowest. Univariate data analysis showed that the proportion of males, age, junior high school education and below, farmers, blood donation times 0 to 3 times, Qintang District and Guiping City in the positive group were significantly higher than those in the negative group, and the differences were statistically significant (P ＜ 0.05). Logistic regression analysis showed that the number of blood donations (OR = 1.800), occupation (OR = 1.578), and education (OR = 1.937) were independent influencing factors of HIV positivity (P ＜ 0.05). Conclusion From 2018 to 2021, the HIV-positive infection rate of blood donors in Guigang City, Guangxi Zhuang Autonomous Region is significantly higher than the national average. Occupation, blood donation frequency and education are independent risk factors, and focus on high-risk groups and increase publicity efforts to ensure blood safety.
2022 Vol. 19 (23): 36-39 [Abstract] ( 21 ) HTML (1 KB)  PDF (548 KB)  ( 44 )
40 Correlation analysis of dignity with hope level and negative emotion in middle-aged and elderly maintenance hemodialysis patients
CHEN Xinru1 DONG Caimei2 CAO Fei1
Objective To explore the status of dignity in middle-aged and elderly maintenance hemodialysis (MHD) patients and its correlation with hope level and negative emotion. Methods A questionnaire survey was conducted among 182 middle-aged and elderly MHD patients in a blood purification center of a tertiary hospital in Hunan Province from May to July 2021. They were were investigated by using the patient’s general information questionnaire, the Chinese version of the dignity scale, the Herth hope scale, and the hospital anxiety and depression scale. Results The total score of the patient’s dignity was (41.72±10.83) points, which indicated that there was widespread damage to dignity. There were significant differences in the total scores of dignity among patients with different educational levels, marital status, self-care ability, and average monthly family income (P ＜ 0.05). The total scores of dignity in middle-aged and elderly MHD patients were negatively correlated with the total score of hope (r = -0.646, P ＜ 0.01), and positively correlated with the total score of anxiety and depression (r = 0.502, 0.467, P ＜ 0.01). Conclusion The degree of impaired dignity in middle-aged and elderly MHD patients is closely related to their level of hope and negative emotions. It is suggested that medical staff should pay attention to the patient’s dignity, actively take intervention measures, improve the hope level of middle-aged and elderly MHD patients, relieve their negative emotions of anxiety and depression, so as to improve the patient’s dignity level, improve the quality of life of patients, and enhance the meaning of life.
2022 Vol. 19 (23): 40-43,48 [Abstract] ( 18 ) HTML (1 KB)  PDF (644 KB)  ( 64 )
44 The correlation of thyroid function with coronary heart disease and lesion numbers
LI Jiadan1,2 PAN Liming1,2 WANG Jun1,2 XU Yong3
Objective To investigate the correlation of thyroid function in normal range of thyroid stimulating hormone (TSH) with coronary heart disease and the number of lesion vessel. Methods A total of 258 inpatients in the Department of Cardiaology, Mentougou District Hospital of Beijing from January to Decmber in 2018 were retrospectively studied. According to the results of angiography, they were divided into coronary heart disease group(172 cases) and non-coronary heart disease group (86 cases). According to the number of stenosed coronary vessels, they were divided into 0 vessel group (86 cases), 1 vessel group (60 cases), 2 vessels group (56 cases) and 3 vessels group (56 cases). Fasting blood was collected to detect thyroid function related indicators total triiodothyronine (TT3), free T3 (FT3), free thyroxine (FT4) and TSH. and the differences and correlation analysis of each index between groups were compared. Results The level of TSH in coronary heart disease group was higher than that in non-coronary heart disease group, the difference was statistically significant (P ＜ 0.05). Univariate regression analysis showed that TSH (OR = 1.385, 95%CI:1.068-1.797, P ＜ 0.05), and multivariate regression analysis showed that TSH (OR = 1.362, 95%CI: 1.049-1.768, P ＜ 0.05) was an independent risk factor for coronary heart disease. There were statistically significant differences in TSH among groups with 0, 1, 2 and 3 vessel lesions groups (P ＜ 0.05). In univariate linear regression analysis, TSH (β=0.303, 95%CI: 0.172-0.433, P ＜ 0.001) and the number of coronary artery lesions. Multiple linear regression analysis showed that the regression equation was: the number of coronary artery lesions =0.669+0.316×TSH. Conclusion TSH level in the normal range is an independent risk factor for CHD, and has a linear correlation with the number of coronary artery lesions
2022 Vol. 19 (23): 44-48 [Abstract] ( 18 ) HTML (1 KB)  PDF (556 KB)  ( 20 )
49 Predictive value of aVR lead of electrocardiogram combined with precursor brain natriuretic peptide level in heart failure after acute anterior myocardial infarction#br#
AN Dongmei1 CAO Li2▲ LIU Jie1 RUI Daorong3
Objective To investigate the predictive value of AVR lead of electrocardiogram combined with pro-brain natriuretic peptide (pro-BNP) level in predicting heart failure after acute anterior myocardial infarction (AAMI). Methods From February 2019 to May 2020, a total of 97 patients with AAMI who underwent percutaneous coronary intervention (PCI) were selected as the research objects. Patients were divided into heart failure group and non-heart failure group according to whether they have heart failure within three months after surgery. The logistic multivariate regression method was used to analyze the influencing factors of heart failure in patients with AAMI within three months after PCI. Receiver operating characteristic (ROC) curve was used to analyze the preoperative ST segment elevation in aVR lead electrocardiogram, preoperative plasma pro-BNP level and their combined predictive value in AAMI patients with heart failure within three months after PCI. Results The time window of treatment after onset, the degree of preoperative stenosis, the number of preoperative vascular lesions, the proportion of ST segment elevation in aVR lead, the preoperative serum creatinine and plasma pro-BNP levels in the heart failure group were higher than those in the non-heart failure group (P ＜ 0.05). Logistic multivariate analysis showed that preoperative ST-segment elevation in aVR lead electroacrdiogram, and preoperative plasma pro-BNP level were the influencing factors for AAMI patients with heart failure within three months after PCI (P ＜ 0.05). The sensitivity and specificity of preoperative ST segment elevation in aVR lead electroacrdiogram in diagnosing AAMI patients with heart failure within three months after PCI were 82.69% and 82.22%, respectively. The ROC curve results showed that preoperative plasma pro-BNP level and the combination of the two predicted the AUC values of AAMI patients with heart failure within three months after PCI were 0.728, 0.866, respectively (P ＜ 0.05). Conclusion Preoperative ST-segment elevation in aVR lead and preoperative plasma pro-BNP levels have certain value in predicting AAMI patients with heart failure within three months after PCI, and the combined detection has a higher predictive value.
2022 Vol. 19 (23): 49-52,61 [Abstract] ( 15 ) HTML (1 KB)  PDF (882 KB)  ( 28 )
53 Correlation of fragmented QRS waves with autonomic function and left ventricular remodeling in patients with acute myocardial infarction
HU Yanli1 SHAN Qing2 XIAO Sa1 HAN Yuhua1
Objective To investigate the correlation between fragmented QRS (fQRS) waves and autonomic function and left ventricular remodeling in patients with acute myocardial infarction (AMI). Methods A total of 114 patients with AMI admitted to Hospital of Beijing Armed Police Corps from January 2015 to June 2021 were selected and they were divided into fQRS group (51 cesea) and non-fQRS group (63 cases) according to the presence or absence of fQRS. The baseline data, heart rate variability parameters, and left ventricular function indexes were compared between the two groups, and the correlation of fQRS with heart rate variability parameters and left ventricular function indexes were analyzed. Results The proportion of ST-segment elevation myocardial infarction, total cholesterol, low density lipoprotein cholesterol, serum creatinine, blood urea nitrogen, blood uric acid, cardiac troponin I, creatine phosphokinase, creatine kinase isozyme, ventricular septal thickness (IVST), and left ventricular posterior wall thickness (LVPW) in fQRS group were higher than those in non-fQRS group. High density lipoprotein cholesterol, low spectral power, very low spectral power, low spectral power to high spectral power ratio (LF/HF), standard deviation of 24 h normal sinus R-R interval (SDNN), mean deviation of every five minutes sinus R-R interval (SDANN), and left ventricular ejection fraction (LVEF) were lower than those in the non-fQRS group, the differences were statistically significant (P < 0.05). fQRS was negatively correlated with low spectral power, very low spectral power, LF/HF, SDNN, SDANN and LVEF (r = -0.364, -0.409, -0.365, -0.428, -0.355, -0.423, P < 0.001), it was positively correlated with IVST and LVPW (r = 0.457, 0.544, P < 0.001). FQRS had no correlation with high spectral power (r = -0.141, P ＞ 0.05). Conclusions Cardiac autonomic dysfunction is evident in AMI patients with fQRS and is closely associated with left ventricular remodelling.
2022 Vol. 19 (23): 53-56,78 [Abstract] ( 12 ) HTML (1 KB)  PDF (660 KB)  ( 33 )
57 Predictive value of cardiac troponin I, high sensitivity-C-reactive protein, and N-terminal brain natriuretic peptide precursors for major adverse cardiovascular events in patients with acute ST-segment elevation myocardial infarction after percutaneous coronary intervention
TAO Hongzhi YU Guozhong
Objective To analyze the predictive value of cardiac troponin I (cTnI), high sensitivity C-reactive protein (hs-CRP), and N-terminal brain natriuretic peptide precursor (NT-proBNP) for major adverse cardiovascular events (MACE) in patients with acute ST-segment elevation myocardial infarction (STEMI) after percutaneous coronary intervention (PCI). Methods From October 2017 to May 2021, 77 patients with STEMI who received PCI and treated successfully in Tongling Municipal Hospital were selected. According to whether MACE occurred within six months after surgery, they were divided into occurrence group (15 cases) and non-occurrence group (62 cases). Serum levels of cTnI, hs-CRP, and NT-proBNP were detected in all patients before PCI. Logistic multivariate regression was used to analyze risk factors, and the receiver operating characteristic (ROC) curve was used to analyze the predictive value. Results The age, proportion of pathological vessels≥2 cases, b-type natriuretic peptide, serum cTnI, hs-CRP, and NT-proBNP levels in the occurrence group were higher than those in the non-occurrence group (P ＜ 0.05). Logistic multivariate analysis showed that age (OR = 3.271, 95%CI:1.346-7.949, P ＜ 0.05) and proportion of pathological vessels≥2 cases (OR = 3.463, 95%CI:0.425-8.415, P ＜ 0.05), preoperative serum cTnI level (OR = 2.766, 95%CI:1.142-6.747, P ＜ 0.05), preoperative serum hs-CRP level (OR = 2.757, 95%CI:1.134-6.699, P < 0.05), and preoperative serum NT-proBNP level (OR = 3.846, 95%CI: 1.582-9.347, P < 0.05) were the influencing factors of MACE in STEMI patients within six months after PCI. ROC curve results showed that preoperative serum cTnI, hS-CRP, and NT-proBNP levels predicted the AUC values of MACE six months after PCI in STEMI patients were 0.811, 0.681 and 0.718, respectively. Conclusion The serum levels of cTnI, hs-CRP, and NT-proBNP have good value in predicting the occurrence of MACE in STEMI patients after PCI.
2022 Vol. 19 (23): 57-61 [Abstract] ( 12 ) HTML (1 KB)  PDF (714 KB)  ( 204 )
62 Effect observation and safety evaluation of Bivalrudine on slow blood flow/no-reflow treatment in elderly patients with coronary heart disease after PCI
FAN Linglong ZHANG Yilin▲
Objective To investigate the effect of Bivalrudin on the treatment of slow blood flow/no-reflow in elderly patients with coronary heart disease after percutaneous coronary intervention (PCI). Methods A total of 146 elderly patients with coronary heart disease with slow blood flow/no-reflow during emergency PCI who were admitted to Hangzhou Ninth People’s Hospital from August 2019 to October 2021 were collected, and theye were divided into the study group (treated with Bivalrudine, 73 cases) and control group (treated with unfractionated heparin, 73 cases) by digital parity method. Coronary artery TIMI blood flow classification and coagulation function (prothrombin time [PT], activated partial thromboplastin time [APTT], thrombin time [TT], the maximum platelet aggregation rate (MPAR) and related indicators of microcirculation function (coronary artery blood flow reserve [CFR], microcirculation resistance index [IMR]) in two groups after PCI were compared. Major adverse cardiac events (MACE) and bleeding events within 30 days after PCI were compared between the two groups. Results Blood flow grading in the study group was better than that in the control group (P ＜ 0.05). After treatment, PT, APTT, and TT increased in both groups, while MPAR decreased. PT, APTT, and TT in the study group were higher than those in the control group, while MPAR was lower than that in the control group (P ＜ 0.05). After treatment, CFR and IMR in the two groups were increased, and CFR in the study group were higher than those in the control group, and IMR was lower than the control group (P ＜ 0.05). The total incidence and bleeding rate of MACE in the study group were lower than those in the control group (P ＜ 0.05). Conclusion The application of Bivalrudin during PCI in elderly patients with coronary heart disease can improve patients’ slow blood flow/no-reflow, coagulation function and microcirculation function, regulate MPAR, and reduce the incidence of MACE and bleeding after surgery.
2022 Vol. 19 (23): 62-65 [Abstract] ( 18 ) HTML (1 KB)  PDF (521 KB)  ( 121 )
66 Changes of circulating extracellular DNA in patients with venous thromboembolism and its clinical significance
ZHANG Yuanli1 LU Caixia2 DONG Sumin3 SUN Meilan4
Objective To investigate the changes of circulating extracellular deoxyribonucleic acid (DNA) in patients with venous thromboembolism and its clinical significance. Methods A total of 107 patients with venous thromboembolism treated in Shijiazhuang People’s Hospital (“our hospital” for short) from May 2019 to May 2021 were selected as the disease group, in the same period, 110 healthy people in the Department of Physical Examination of our hospital were selected as the control group. Peripheral venous blood was collected and the plasma DNA concentration was detected by fluorescence quantitative polymerase chain reaction. The plasma circulating extracellular DNA levels of the control group and disease group and the patients with different severity in disease group were compared. The relationship between circulating extracellular DNA level and the severity of venous thromboembolism was analyzed by Spearman rank correlation. Results The level of circulating extracellular DNA in the disease group was higher than that in the control group (P ＜ 0.05). There were significant differences in circulating extracellular DNA levels with different degrees of embolism (P ＜ 0.05), the levels of circulating extracellular DNA in the moderate group and the severe group were higher than those in the mild group (P ＜ 0.05), and the level of circulating extracellular DNA in the severe group was higher than that in the moderate group (P ＜ 0.05). The level of circulating extracellular DNA was positively correlated with the severity of venous thromboembolism (r = 0.866, P ＜ 0.05). Conclusion The level of circulating extracellular DNA in patients with venous thromboembolism is higher than that in healthy people, which is positively correlated with the severity of venous thromboembolism. The more severe the venous thromboembolism, the higher the circulating extracellular DNA level, which can provide a reference basis for the evaluation of the severity of venous thromboembolism.
2022 Vol. 19 (23): 66-69 [Abstract] ( 13 ) HTML (1 KB)  PDF (518 KB)  ( 69 )
70 Correlation analysis of disease severity and anti-thyroid antibody level in patients with Guillain-Barré syndrome
LIU Zhiwei LI Yimeng ZHANG Haifeng LIAN Yajun CHENG Xuan
Objective To analyze the correlation of disease severity with antithyroid antibody and thyroid hormone in patients with Guillain-Barré syndrome (GBS). Methods A total of 163 GBS patients admitted to the First Affiliated Hospital of Zhengzhou University from October 2013 to March 2021 were selected. They were classified as mild group (50 cases) and severe group (113 cases) according to the Hughes functional grading scale score. Clinical data of patients were collected, and the correlation between disease severity and antithyroid antibody and thyroid hormone, and the risk factors influencing disease severity were analyzed. Results The course of disease before admission in severe group was shorter than that in mild group, and age, the levels of anti-thyroid peroxidase autoantibody (aTPOAb), and anti-thyroid globulin antibody (aTGAb) were higher than those in mild group, and the differences were statistically significant (P < 0.05). The disease severity of GBS patients was positively correlated with serum aTPOAb and aTGAb levels (r =0.366, 0.394, P < 0.05), but not with thyroid-stimulating hormone level (P > 0.05). Age and aTGAb level were the influencing factors of disease severity (OR > 1, P < 0.05). Conclusion ATGAb is an independent risk factor for disease severity in GBS patients. The older the age, the higher the level of aTGAb, and the more severe the disease of GBS patients.
2022 Vol. 19 (23): 70-73 [Abstract] ( 16 ) HTML (1 KB)  PDF (597 KB)  ( 13 )
74 Comparison for recurrence of cerebral infarction and cerebral hemorrhage in one year and analysis of risk factors
ZHUO Yuanyuan1 WANG Xinru2 HUANG Congcong2 PI Min1 YUAN Weiqu1 LI Kailin2 YU Haibo1
Objective To compare the recurrence risk of cerebral infarction and cerebral hemorrhage within one year and to analyze the clinical risk factors. Methods Eight hundred and sixteen stroke patients (592 cases of cerebral infarction and 224 cases of cerebral hemorrhage) hospitalized in the Department of Acupuncture and Moxibustion, Shenzhen Traditional Chinese Medicine Hospital from September 2017 to June 2019 were included. The demographic characteristics and control of risk factor of stroke were collected and followed up for one year. The recurrence risk of cerebral infarction and cerebral hemorrhage were compared by Kaplan-Meier method. The risk factors of cerebral infarction and cerebral hemorrhage recurrence were analyzed by single factor analysis, and then the Cox proportional risk regression model related to recurrence was established by stepwise regression method. Results After correction of age and gender，comparison of K-M curves between two groups showed statistically significant difference (P < 0.05). For cerebral infarction, the risk of recurrence was 1.872 times higher in patients with family history of stroke than patients without family history of stroke (95%CI: 1.063-3.311, P = 0.031), and 1.464 times higher in patients with poor blood pressure control than in patients with good blood pressure control (95%CI: 1.058-2.018, P = 0.020). For intracerebral hemorrhage, patients with family history of stroke had 4.685 times higher risk of recurrence than those without family history of stroke (95%CI: 1.372-16.003, P = 0.014), and patients with poor blood glucose control had 2.961 times higher risk of recurrence than those with good blood glucose control (95%CI: 1.459-6.010, P = 0.003), the risk of recurrence in patients who still drank alcohol was 2.719 times that of those who did not drink alcohol (95%CI: 1.223-6.046, P = 0.014). Conclusion The recurrence rate of cerebral infarction is higher than that of cerebral hemorrhage in stroke patients with one-year onset. Poor blood pressure control is an independent risk factor for recurrence of cerebral infarction, while poor glycemic control and alcohol consumption behavior are independent risk factors for recurrence of cerebral hemorrhage, and interventions targeting these factors are needed to reduce the risk of stroke recurrence.
2022 Vol. 19 (23): 74-78 [Abstract] ( 13 ) HTML (1 KB)  PDF (853 KB)  ( 280 )
79 Meta-analysis of the association between APOE e4 allele and mental behavioral symptoms in Alzheimer’s disease
MA Suya1 WEI Mingqing2 NI Jingnian2 LI Ting2 WANG Xu2 XU Xiaoqing2 LI Xiaohong3
Objective To systematically assess the association of APOE e4 allele with mental and behavioral symptoms of Alzheimer’s disease. Methods PubMed, Web of Science, Cochrane, Embase, and CNKI databases were searched, clinical study of screening mental behavioral symptoms and APOE e4 allele in Alzheimer’s disease. Self-built database until September 2020. Two researchers independently completed literature retrieval, quality evaluation, and data extraction, and Stata 15 software was used for data analysis. Results A total of 4 937 patients were included in 13 literatures. Agitation (Z = 0.31, P = 0.760), depression (Z = 1.71, P = 0.086), hallucinations (Z = 0.75, P = 0.456), delusions (Z = 1.80, P = 0.072), indifference (Z = 1.52, P = 0.128), nocturnal behavior abnormalities (Z = 1.70, P = 0.09) were not correlated with APOE e4 allele. Anxiety (Z = 4.38, P = 0.000) and abnormal behavior movement (Z = 2.16, P = 0.031) were correlated with APOE e4 allele. Conclusion The APOE e4 allele may be a risk gene for anxiety and abnormal behavior movement in psychobehavioral symptoms.
2022 Vol. 19 (23): 79-84 [Abstract] ( 13 ) HTML (1 KB)  PDF (1646 KB)  ( 38 )
85 Evaluation value of clinical outcome in patients with acute ischemic stroke by glomerular filtration rate monitoring
ZHANG Jin1 LI Jie1 FAN Wei2▲ YU Yan1 ZONG Huihua1
Objective To explore the evaluation value of clinical outcome in patients with acute ischemic stroke by glomerular filtration rate (GFR). Methods A total of 96 patients with acute ischemic stroke admitted to Yixing People’s Hospital, Jiangsu Province from January 2019 to January 2021 were selected. According to the modified Rankin scale score at six months after discharged, they were divided into poor group (mRS score ≥3 points, 39 cases) and good group (mRS score ＜ 3 points, 57 cases). The general data and laboratory indicators of the two groups at admission were compared, and the factors influencing the outcome of patients with acute ischemic stroke were analyzed by multivariate analysis, and the value of GFR in predicting the outcome of patients with acute ischemic stroke was analyzed by receiver operating characteristic (ROC) curve. Results The score of National Institutes of Health stroke scale (NIHSS) in the poor group was higher than that in the good group, and serum uric acid, glutamic-pyruvic transaminase, and GFR were lower than those in the good group (P ＜ 0.05). Multivariate analysis showed that scores of NIHSS, serum uric acid, and GFR were all influencing factors for the outcome of patients with acute ischemic stroke (P ＜ 0.05). ROC curve analysis showed that GFR had a cut-off value of 98.87 ml/(min·1.73m2), a sensitivity of 84.62%, a specificity of 92.98%, and an area under curve of 0.925 in predicting the outcome of acute ischemic stroke patients (P ＜ 0.05). Conclusion The GFR of patients with poor outcome of acute ischemic stroke is abnormally reduced, clinical monitoring of GFR can be used as a sensitive indicator to predict the poor outcome of patients with acute ischemic stroke.
2022 Vol. 19 (23): 85-88 [Abstract] ( 15 ) HTML (1 KB)  PDF (629 KB)  ( 33 )
89 Effect of different doses of glucocorticoid combined with Clarithromycin in the treatment of severe Mycoplasma pneumoniae pneumonia in children
DUAN Nana1 RONG Weiqiang2 ZHENG Maodong1 YAN Juan1 ZUO Luguang3▲
Objective To study the effect of different doses of glucocorticoid combined with Clarithromycin in the treatment of severe Mycoplasma pneumoniae pneumonia in children. Methods A total of 156 children with severe Mycoplasma pneumoniae pneumonia treated in the First Affiliated Hospital of Hebei North University from June 2019 to August 2021 were selected as research objects. They were divided into the control group (36 cases), the observation group (40 cases), the constant group (43 cases), and the small dose group (37 cases) according to the random number table method. The control group was treated with Azithromycin, the observation group was treated with Clarithromycin, the constant group was treated with Clarithromycin combined with conventional dose glucocorticoid [1.0 mg/(kg·d)], and the small dose group was treated with Clarithromycin combined with low dose glucocorticoid [2.0 mg/(kg·d)]. Clinical indexes, peripheral blood inflammatory indexes, and adverse reactions of each group were compared. Results The days of antipyretic, cough remission, and disappearance of pulmonary murmur in the observation group were shorter than those in the control group (P < 0.05); and the days of antipyretic, cough remission and disappearance of pulmonary murmur in the constant group and small dose group were shorter than those in the observation group (P < 0.05); the days of cough remission in the small dose group were shorter than those in the constant group (P < 0.05). After treatment, the levels of hypersensitive C-reactive protein (hs-CRP), serum amyloid A (SAA), and interleukin-6 (IL-6) in control group and observation group were lower than before treatment (P < 0.05); SAA level in observation group was lower than that in control group (P < 0.05). After treatment, the levels of Hs-CRP, SAA, and IL-6 in the observation group, constant group, and small dose group were lower than those before treatment (P < 0.05); there was statistical significance in hs-CRP level among all groups (P < 0.05); SAA level in the constant group was higher than that in the observation group (P < 0.05); SAA level in the small dose group was lower than that in the constant group (P < 0.05). There was no significant difference in the total incidence of adverse reactions between the observation group and the control group (P > 0.05); the total incidence of adverse reactions in the constant group and the small dose group were lower than that the in observation group (P > 0.05). Conclusion Clarithromycin has advantages over Azithromycin in the treatment of severe Mycoplasma pneumoniae pneumonia in children. Glucocorticoid combined with Clarithromycin in the treatment of severe Mycoplasma pneumoniae pneumonia in children can be applied and popularized.
2022 Vol. 19 (23): 89-92,103 [Abstract] ( 17 ) HTML (1 KB)  PDF (685 KB)  ( 151 )
93 Analysis of the detection results of ferritin level, thyroid function, and pancreatic function in early pregnant women with minor thalassemia
ZHOU Xiaoping1 DENG Yuping2 YANG Xin2 XU Ying1
Objective To investigate the changes of ferritin(Fer) level, thyroid function, and pancreatic function in pregnant women with minor thalassemia. Methods A total of 160 pregnant women with minor thalassemia at the gestational age of three months who underwent prenatal examinations in the First Affiliated Hospital of Chengdu Medical College from January 2018 to October 2021 were selected as the thalassemia group, and 200 healthy pregnant women in the same period were selected as the control group. The levels of thyroid stimulating hormone (TSH), free triiodothyronine (FT3), free thyroid hormone (FT4), thyroglobulin antibody (Tg-Ab), thyroperoxidase antibody (TPO-Ab), fasting plasma glucose (FPG), fasting plasma insulin (FINS), Fer, and hemoglobin (Hb) were measured between the two groups. Results There were no significant differences in TSH, FT3, FT4, Tg-Ab, and TPO-Ab between the two groups （P > 0.05）. There was no significant difference in the prevalence of thyroid dysfunction between the two groups (P > 0.05). There were no significant differences in FPG, FINS, and the homeostasis model assessment of insulin resistance between the two groups (P > 0.05). Hb in the thalassemia group was lower than that in the control group, Fer was higher than that in the control group, and the differences were statistically significant (P < 0.05). Conclusion Thyroid function and pancreas function of pregnant women with mild thalassemia do not change significantly in early pregnancy, but Fer and Hb levels are affected.
2022 Vol. 19 (23): 93-96 [Abstract] ( 14 ) HTML (1 KB)  PDF (524 KB)  ( 46 )
97 The incidence and influencing factors of hematoma after EnCor minimally invasive rotatectomy in patients with benign breast lymp
WANG Pei LIU Shangjun ZHANG Ruhui
Objective To analyze the incidence and influencing factors of hematoma in benign breast lymp patients after EnCor minimally invasive rotatectomy. Methods A total of 80 patients with benign breast lymps admitted to 17th Metallurgical Hospital from January 2019 to June 2021 were selected. All patients were treated with EnCor minimally invasive rotatectomy. The occurrence of postoperative hematoma was recorded, and the influencing factors of postoperative hematoma were analyzed. Results Postoperative hematoma occurred in six cases of the 80 patients, with an incidence of 7.50%. Univariate analysis showed that there were statistically significant differences in the incidence of hematoma among patients with different number of lumps, depth of lumps, number of incisions, Adler blood supply grade, and postoperative bandage compression time (P < 0.05). The multivariate analysis showed that the number of lumps, the depth of lumps, the number of incisions, the Adler blood supply grade, and postoperative bandage compression time were all influencing factors for the occurrence of hematoma after EnCor minimally invasive rotatectomy (OR ＞ 1, P < 0.05). Conclusion The number of lumps, the depth of lumps, the number of incisions, the Adler blood supply grading, and postoperative bandage compression time are important risk factors for the occurrence of hematoma after EnCor minimally invasive rotatectomy in patients with benign breast lymps.
2022 Vol. 19 (23): 97-99,108 [Abstract] ( 20 ) HTML (1 KB)  PDF (520 KB)  ( 26 )
100 Effect of Morphine Sulfate Sustained-release Tablets as background medication combined with Morphine Hydrochloride Injection on moderate and severe cancerous pain
WANG Pengyuan DONG Xueru LIU Zhi SHANG Nana
Objective To investigate the effect of Morphine Sulfate Sustained-release Tablets as background medication combined with Morphine Hydrochloride Injection on moderate and severe cancerous pain. Methods A total of 100 patients with moderate and severe cancerous pain admitted to Xuchang Central Hospital Affiliated to Henan University of Science and Technology from September 2018 to September 2019 were selected as the study subjects. They were divided into observation group and control group by random number table method, with 50 patients in each group. The observation group was treated with Morphine Sulfate Sustained-release Tablets as background medication combined with Morphine Hydrochloride Injection, while the control group was treated with Morphine Hydrochloride Injection only. The pain number rating scale (NRS) scores before (T0) and 3 h (T1), 24 h after medication (T2) were compared between the two groups, and the pain relief effect was compared between the two groups. The incidence of adverse reactions in the two groups was recorded. Results Pain NRS scores in both groups at 3, 24 h after medication were lower than T0, and T2 was lower than T1 (P ＜ 0.05). Pain NRS scores at T1, T2 in observation group were lower than control group at the same time (P ＜ 0.05). The pain relief in observation group was better than that in control group (P < 0.05). There was no significant difference in the total incidence of adverse reactions between the two groups (P > 0.05). Conclusion The efficacy of Morphine Sulfate Sustained-release Tablets as the background medication combined with Morphine Hydrochloride Injection in relieving moderate and severe cancerous pain is good and worthy of further clinical study.
2022 Vol. 19 (23): 100-103 [Abstract] ( 18 ) HTML (1 KB)  PDF (580 KB)  ( 31 )
104 Analysis of the influencing factors of postoperative recurrence of colonic polyps
GAO Jingjing LU Shiyu DU Shengnan YUAN Yifu JIANG Yuanye▲ CAO Qin▲
Objective To retrospectively analyze the influencing factors of postoperative recurrence of colonic polyps after treatment. Methods A total of 416 patients with colonic polyps hospitalized and received endoscopic treatment in Putuo Hospital Affiliated to Shanghai University of Traditional Chinese Medicine from May 2014 to May 2019 were selected. The patients were divided into the recurrence group (216 cases) and the non-recurrence group (200 cases) according to the postoperative recurrence. The clinical data of the patients were retrospectively collected to analyze the influencing factors of postoperative recurrence of colonic polyps. Results The proportion of male, age ≥60 years, non-alcoholic fatty liver disease, hypertension, type 2 diabetes mellitus, operation method of argon-plasma coagulation (APC) and APC combined with high frequency electrical polypectomy, number of polyps ≥3, diameter of polyps ≥10 mm, multiple sites, adenoma, and the levels of body mass index (BMI), uric acid (UA), triglyceride (TG), high density lipoprotein (HDL) in the recurrence group were all higher than those in the non-recurrence group, and the differences were statistically significant (P ＜ 0.05). Multivariate analysis showed that age ≥60 years, non-alcoholic fatty liver disease, hypertension, high BMI, number of polyps ≥3, diameter of polyps ≥10 mm, multiple sites, and adenoma were independent risk factors for colon polyp recurrence (OR ＞ 1, P ＜ 0.05). Conclusion Age ≥60 years, non-alcoholic fatty liver disease, hypertension, number of polyps ≥3, diameter of polyps ≥10 mm, multiple sites, adenoma, high BMI are independent influence factors of recurrence of colonic polyps, may be closely related with the recurrence of colonic polyps, for domestic clinicians guide patients with colonic polyps of follow-up work provide certain reference value.
2022 Vol. 19 (23): 104-108 [Abstract] ( 18 ) HTML (1 KB)  PDF (623 KB)  ( 77 )
109 Clinical study on the relationship between frailty and prognosis of severe patients with respiratory function injury
XU Jie YAO Xiujuan LIU Guangjie SHENG Haiyan WANG Xinmao PANG Jian LIU Xiaofang▲
Objective To explore the relationship between frailty and prognosis of severe patients with respiratory function injury. Methods The clinical data of 508 severe patients with respiratory function injury (partial pressure of oxygen ＜ 80 mmHg) (1 mmHg=0.133 kPa) were retrospectively analyzed in Beijing Tongren Hospital, Capital Medical University from January 2016 to December 2021. According to the prognosis, they were divided into survival group (431 cases) and death group (77 cases). The basic data of the two groups were collected, and the clinical frailty scale score, acute renal failure, respiratory failure, and time of admission to the respiratory intensive care unit were recorded. Acute physiology and chronic health evaluationⅡ (APACHEⅡ) scores were calculated at 24 h after admission (APACHEⅡ-1), and APACHEⅡ scores were calculated again at 48-72 h after initial diagnosis and treatment (APACHEⅡ-3). The data of the two groups were compared and the influencing factors of the prognosis of severe patients with respiratory function injury were analyzed and the predictive value of frailty on death of patients was futher analyzed. Results Age, APACHEⅡ-1, APACHEⅡ-3, clinical frailty scale score, and proportion of acute renal failure and respiratory failure in death group were higher than those in survival group, the differences were statistically significant (P ＜ 0.05). Age, clinical frailty scale score, acute renal failure, respiratory failure, and APACHEⅡ-3 were the influencing factors for the prognosis of severe patients with respiratory function injury (P ＜ 0.05). Age, clinical frailty scale score, and APACHEⅡ-3 combined had moderate ability to predict the prognosis of severe patients with respiratory impairment. The area under the receiver operating characteristic curve (AUC) combined with age, clinical frailty scale score, and APACHEⅡ-3 was higher than that of age, clinical frailty scale score, and APACHEⅡ-3 alone (P ＜ 0.05). The AUC of clinical frailty scale score was higher than that of age (P ＜ 0.05). Conclusion Frailty is an independent risk factor in predicting the prognosis for severe patients with respiratory impairment. Clinical frailty scale score for severe patients with respiratory impairment can assist in the evaluation of prognosis.
2022 Vol. 19 (23): 109-112 [Abstract] ( 48 ) HTML (1 KB)  PDF (605 KB)  ( 37 )
113 Effect of percutaneous radiofrequency thermocoagulation in the treatment of fingertip subnail glomus tumor
LI Jing HUANG Ying ZHU Tong MA Chao TAO Gaojian
Objective To investigate the efficacy and safety of percutaneous radiofrequency thermocoagulation in the treatment of fingertip subnail glomus tumor. Methods A total of seven patients with fingertip subnail glomus tumor admitted to the Outpatient of Department of Pain Medicine, Nanjing Drum Tower Hospital, the Affiliated Hospital of Nanjing University Medical College from October 2018 to May 2021 were selected and numbered in chronological order (No.1-7). All patients underwent ultrason-guided percutaneous radiofrequency thermocoagulation, and follow-up was completed after surgery (≥six months). Changes of visual analog scale (VAS) score were observed before and six months after surgery, and the appearance of the affected finger, cold sensitivity test, and Love test were recorded. Results No.1 patient developed skin scald during treatment and recovered two months after surgery. In order to prevent this situation, the operation was modified with normal saline, and no obvious adverse reactions were observed during the treatment of No.2-7 patients. VAS scores of all patients six months after surgery were higher than those before surgery, the difference was statistically significant (P ＜ 0.05). Cold sensitivity test results were negative in all patients six months after surgery. The Love test results of No.4 patient were suspicious six months after surgery, the results of other patients were negative. The pain of No.4 patient recurred 12 months after surgery, and the pain was completely relieved after surgical resection of the tumor. All patients had no damage to the skin and nail bed of the affected finger six months after surgery, and the appearance of the affected finger was normal. Conclusion Percutaneous radiofrequency thermocoagulation in the treatment of subungual glomus tumor of fingertips is easy to operate, which can effectively relieve pain, and has no complications such as nail bed injury or postoperative deformity. It can be used as a supplementary treatment in addition to surgical resection.
2022 Vol. 19 (23): 113-116 [Abstract] ( 130 ) HTML (1 KB)  PDF (777 KB)  ( 20 )
117 Application value of serum uric acid / creatinine ratio and N-terminal pro-brain natriuretic peptide level in prognosis of patients with acute exacerbation of chronic obstructive pulmonary disease
WANG Libing1 ZHANG Xiaodong1 ZHANG Guirong1 DING Yihong2
Objective To explore the application value of serum uric acid (UA) / creatinine (CR) ratio and N-terminal pro-brain natriuretic peptide (NT-proBNP) levels in predicting the prognosis of patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD). Methods A total of 82 patients with AECOPD admitted to Tianchang Hospital of Traditional Chinese Medicine, Anhui Province from October 2018 to October 2020 were selected as the study object, all patients were followed up for 12 months. According to the prognosis, they were divided into death group (10 cases) and survival group (72 cases). Serum UA / Cr and NT-proBNP levels of the two groups were compared to analyze the factors influencing the prognosis of AECOPD patients, and the value of serum UA / Cr and NT-proBNP levels in evaluating the prognosis of AECOPD. Results The mortality rate of AECOPD patients in this study was 12.20%. The levels of acute physiology and chronic health evaluation Ⅱ(APACHE Ⅱ) score, NT-proBNP, serum UA / Cr, and the proportion of Grade Ⅳ in death group were higher than those in survival group (P ＜ 0.05). Multivariate analysis showed that APACHE Ⅱ score, NT-proBNP, serum UA / Cr, and Grade Ⅳ were the influencing factors of death in AECOPD patients (P ＜ 0.05). Serum UA / Cr and NT-proBNP levels combined to predict the death of AECOPD patients had a higher area under the receiver operating characteristic curve than those predicted separately (P ＜ 0.05). Conclusion Serum UA / Cr and NT-proBNP are closely related to the severity and prognosis of AECOPD patients. Both alone and combined tests have high prognostic efficacy, and serum UA / Cr combined with NT-proBNP have higher prognostic efficacy.
2022 Vol. 19 (23): 117-120 [Abstract] ( 15 ) HTML (1 KB)  PDF (698 KB)  ( 222 )
121 Analysis of the effect of peripheral blood CD4+ T cell count on the evaluation of drug treatment effect in patients with immune thrombocytopenia
WANG Qiong WANG Yong WU Yuling▲
Objective To analyze the effect of peripheral blood CD4+ T cell count on the evaluation of drug treatment effect in patients with immune thrombocytopenia (ITP). Methods A total of 80 ITP patients admitted to Huangshan People’s Hospital, Anhui Province (hereinafter referred to as “our hospital”) from January 2018 to December 2020 who received glucocorticoid treatment after admission were selected as the study group, and 30 healthy volunteers who underwent physical examination in our hospital during the same period were selected as the control group. Difference in peripheral blood CD4+T cell count before the treatment of stndy group were compared between the two groups. The changes of peripheral blood CD4+T cell count before and after treatment were compared in the study group. The study group was divided into the effective group (62 cases) and the ineffective group (18 cases) according to the treatment effect. The disease-related indicators of the effective group and the ineffective group were compared, and the factors influencing the treatment effect were analyzed, as well as the predictive value of peripheral blood CD4+T cell count on the treatment effect. Results Before the treatment of study group, the peripheral blood CD4+T cell count of the study group was lower than that of the control group, the difference was statistically significant (P ＜ 0.05). After treatment, the peripheral blood CD4+T cell count of the study group was higher than that before treatment, the difference was statistically significant (P ＜ 0.05). The megakaryocytes count and peripheral blood CD4+T cell count of effective group were higher than those of ineffective group, and the differences were statistically significant (P ＜ 0.05). Multivariate analysis showed that megakaryocyte count and peripheral blood CD4+T cell count were the influencing factors of drug treatment effect in ITP patients (P ＜ 0.05). The area under the receiver operating characteristic curve of peripheral blood CD4+T cell count on drug treatment effect of ITP patients was 0.765 (P ＜ 0.05). Conclusion Abnormal expression of peripheral blood CD4+T cell count in ITP patients is a factor affecting the efficacy of drug treatment in ITP patients, and has certain predictive value for the efficacy of drug trextment in ITP patients.
2022 Vol. 19 (23): 121-124 [Abstract] ( 15 ) HTML (1 KB)  PDF (619 KB)  ( 31 )
125 Treatment of sleep-wake disorder from gallbladder
ZHANG Ming1 LI Guixia2 ZHANG Jinhua2 WANG Weidong2
The most common abnormal manifestations of sleep-wake disorder are insomnia and drowsiness. The recognition and treatment are usually based on zangfu dysfunction, in which few of them is from gallbladder. Inspired by the theory of “all the eleven zang depend on gallbladder”, here is a tentative discussion on the relationship between gallbladder and sleep-wake disorder and a systematic review of ideas about traditional Chinese medicine treatment of sleep-wake disorder from gallbladder. From the perspective of gallbladder being the pivot, gallbladder managing decision and gallbladder liking tranquility, it is summed up that gallbladder dysfunction leads to sleep-wake disorder in three ways: disharmony between yin and yang because of dysfunction of shaoyang pivot; emotional disorder because of deficiency of gallbladder and decision dysfunction; dredging failure because of impurity of gallbladder invaded by evil. This article ulteriorly enriches the theoretical and clinical study of traditional Chinese medicine in sleep-wake disorder.
2022 Vol. 19 (23): 125-127,136 [Abstract] ( 15 ) HTML (1 KB)  PDF (597 KB)  ( 59 )
128 Effect of taiyang point venous blood draw combined with micro fire needle acupuncture at fēngchí and fēngfǔ points in the treatment of angioneurotic headache with blood stasis blocking cerebral collaterals type
TIAN Liuqing1 KANG Guanghua2 LIU Fubiao3 CHEN Zedong4 SONG Jinping5 LING Shujuan6



[Abstract] Objective To compare the effect of taiyang point venous blood draw combined with micro fire needle acupuncture at fēngchí and fēngfǔ points in the treatment of angioneurotic headache with blood stasis blocking cerebral collaterals type. Methods A total of 120 patients with angioneurotic headache with blood stasis blocking cerebral collaterals type in Sanhe Hospital of Hebei Province from September 2019 to June 2021 were selected as the research objects, and they were divided into control group one, control group two and treatment group according to the random number table method, with 40 cases in each group. Control group one was treated with oral Flunarizine Hydrochloride Capsules combined with taiyang point venous blood draw, control group two was treated with oral Flunarizine Hydrochloride Capsules combined with micro fire needle acupuncture at fēngchí and fēngfǔ points, the treatment group was treated with taiyang point venous blood draw combined with micro fire needle acupuncture at fēngchí and fēngfǔ points on the basis of oral administration of Flunarizine Hydrochloride Capsules. The levels of calcitonin gene related peptide (CGRP), C-reactive protein (CRP), homocysteine (Hcy) and the curative effect of traditional Chinese medicine were compared among the three groups. Results After treatment, the CGRP levels of the three groups were lower than those before treatment, and the CGRP level of the treatment group was lower than that of the control group one and the control group two, the differences were statistically significant (P < 0.05). After treatment, the levels of Hcy and CRP of the three groups were lower than those before treatment, and the levels of Hcy and CRP in the treatment group were lower than those in control group one and control group two, the differences were statistically significant (P < 0.05). After treatment, the curative effect of traditional Chinese medicine in the treatment group was better than that in the control group one and the control group two, and the differences were statistically significant (P < 0.05). Conclusion The effect of taiyang point venous blood draw combined with micro fire needle acupuncture at fēngchí and fēngfǔ points in the treatment of angioneurotic headache with blood stasis blocking cerebral collaterals type is significant, which can alleviate the symptoms of angioneurotic headache in patients.
2022 Vol. 19 (23): 128-131,141 [Abstract] ( 13 ) HTML (1 KB)  PDF (746 KB)  ( 48 )
132 Analysis and compilation of coronary heart disease daoyin method in Za Bing Yuan Liu Xi Zhu
WANG Chengchao TAN Tianyang WEI Yulong
With the continuous enrichment of material living conditions in today’s society and the influence of aging population, the incidence and mortality of coronary heart disease in China is on the rise, which brings great burden to the family and society. Besides regular medication and healthy living habits, qigong exercise is also a good method of rehabilitation and health care for patients with coronary heart disease. But now, there are few qigong methods for the rehabilitation of coronary heart disease. The qigong method selected in this paper comes from Za Bing Yuan Liu Xi Zhu. It contains many daoyin methods, which can reach beyond acupuncture and medicine. But this book was written in a long time, and the description of the practical operation of the methods is obscure. So this paper analyzes the cardiac disease daoyin methods in Za Bing Yuan Liu Xi Zhu. Based on the perspective of three tunes of qigong and qi-blood and meridian of traditional Chinese medicine, and the habits of modern people, this paper explains and integrates a set of qigong exercises for the coronary heart disease daoyin. It has five types, such as starting position, raising arms and punching fists, pushing palms and cling to knees, guiding qi to be unobstructed and closing position.
2022 Vol. 19 (23): 132-136 [Abstract] ( 24 ) HTML (1 KB)  PDF (823 KB)  ( 61 )
137 Effect of traditional Chinese medicine fumigation method combined with Longdan Xiegan Decoction in the treatment of recurrent urinary tract infection in adult female
GE Shulong CHEN Lei YANG Xiaolei
Objective To explore the effect of traditional Chinese medicine fumigation method combined with Longdan Xiegan Decoction in the treatment of recurrent urinary tract infection in adult female. Methods A total of 108 adult female patients with recurrent urinary tract infection admitted to Shandong Provincial Third Hospital from January 2019 to January 2021 were selected, and they were divided into fumigation group, decoction group and combined group according to the random number table method, with 36 cases in each group. All patients were treated with first-line drugs. On this basis, the fumigation group was treated with traditional Chinese medicine fumigation, the decoction group was treated with Longdan Xiegan Decoction, and the combined group was treated with traditional Chinese medicine fumigation and Longdan Xiegan Decoction for four weeks. The clinical efficacy, urinary bacterial negative conversion rate, disappearance time of main symptoms, traditional Chinese medicine syndrome score and inflammatory factor level of the three groups were compared, and the adverse reactions of the three groups during treatment were observed. Results The total effective rate and the negative conversion rate of urine bacteria in the combined group were higher than those in the fumigation group and the decoction group, and the differences were statistically significant (P < 0.05). The disappearance times of frequency of urination, urgency of urination, astringent pain of urination, hematuria and lower thigh pain in the combined group were shorter than those in the fumigation group and the decoction group, and the differences were statistically significant (P < 0.05). After treatment, the syndrome scores of the three groups were lower than those before treatment, and the traditional Chinese medicine syndrome scores of the combined group were lower than those of the fumigation group and the decoction group, the differences were statistically significant (P < 0.05). After treatment, hypersensitivity C-reactive protein (hs-CRP), interleukin (IL)-6, IL-8, tumor necrosis factor-α (TNF-α), and procalcitonin (PCT) levels of the three groups were lower than those before treatment, and hs-CRP, IL-6, IL-8, TNF-α, and PCT levels of the combined group were lower than those of fumigation group and decoction group, and the differences were statistically significant (P < 0.05). No obvious adverse reactions were found in the three groups during treatment, with normal liver and kidney functions, no shock and diarrhea. Conclusion Traditional Chinese medicine fumigation method combined with Longdan Xiegan Decoction in the treatment of recurrent urinary tract infection in adult female can effectively improve the clinical symptoms and signs of patients, improve the negative rate of urinary bacteria, shorten the disappearance time of main symptoms, adjust the level of inflammatory factors, and there are no obvious adverse reactions during the treatment, ensuring the safety during the treatment.
2022 Vol. 19 (23): 137-141 [Abstract] ( 24 ) HTML (1 KB)  PDF (739 KB)  ( 12 )
142 Professor Chen Yiping’s experience in the treatment of IgA nephropathy with the “woxuan sanjiao”
ZHANG Quan CHEN Yiping ZHANG Xianwen SHENG Lingli WANG Lin▲
The treatment of IgA nephropathy is a research problem in the world. Professor Chen Yiping, a famous traditional Chinese medicine in Shanghai and the founder of the nephrology discipline of integrated traditional Chinese and western medicine in China, believes that the occurrence and development of IgA nephropathy are closely related to the sanjiao, and puts forward the treatment method of “woxuan sanjiao, divide and rule”. The secret of its treatment lies in dredging the qi and blood of the sanjiao, and the clinical syndrome attaches importance to the methods of reconciling shaoyang and benefiting qi for activating blood circulation. At the same time, in the different stages of IgA nephropathy, he proposed to apply reasonable methods such as dispersing the lung and relieving throat disorder, invigorating spleen for eliminating dampness, clearing heat and promoting diuresis to focus therapeutic goal on the different parts of the upper, middle and lower sanjiao, and eliminate the diffuse evil poison of the sanjiao. Professor Chen has accumulated rich clinical experience and outstanding curative effect by creating prescription and selecting drugs, combining Chinese and western ingredients, and paste prescription in sequence, and regulating the sanjiao and quenching “the kidney wind”.
2022 Vol. 19 (23): 142-145,161 [Abstract] ( 17 ) HTML (1 KB)  PDF (828 KB)  ( 40 )
146 Professor Sun Zhanxue’s experience in the treatment of lichen planus from stagnant fire
WANG Shiwen1 SUN Zhanxue2 FAN Ziyi1 ZHANG Huili1 CHENG Jing1
Lichen planus is a chronic inflammatory skin disease characterized by polygonal purplish red flat papules of skin damage and easily involving mucous membranes. Professor Sun Zhanxue believes that the occurrence of lichen planus and the characteristics of lingering and difficult to heal are closely related to stagnant fire. In clinic, relieving depression and dispelling fire is the treatment method with definite curative effect. Based on the pathogenesis evolution characteristics of “stagnant fire in sanjiao caused by stagnation of various evils”, “stagnant fire for a long time leads to blood stasis and yin injury”, “overuse of cold medicine will hinder the positive”, combined with classical and modern theories, this paper systematically expounds the treatment of lichen planus from stagnant fire. In terms of treatment, Professor Sun advocates evacuating the stagnant fire of sanjiao from the three levels of “cool the upper, smooth the middle, and purge the lower”, and stresses that the drugs with cold, moisturizing, purging and nourishing should be used to promote blood circulation and nourish yin, and the wind medicine with pungent flavor should be used to invigorate depression and to strengthen the body, and to avoid excessive use of bitter cold, at the same time, pay attention to syndrome differentiation according to the characteristics of the disease.
2022 Vol. 19 (23): 146-149 [Abstract] ( 24 ) HTML (1 KB)  PDF (668 KB)  ( 26 )
150 Effect of self-made Huatan Huoxue Tongluo Decoction in the treatment of cerebral infarction with phlegm and blood stasis obstructing collateral syndrome during early recovery
DENG Di XU Qiqi WANG Shaomin LI Zhen▲
Objective To explore the effect of self-made Huatan Huoxue Tongluo Decoction in the treatment of cerebral infarction with phlegm and blood stasis obstructing collateral syndrome during early recovery. Methods A total of 80 patients with cerebral infarction with phlegm and blood stasis obstructing collateral syndrome in the early recovery period treated in Bozhou Hospital of Traditional Chinese Medicine, Anhui Province from October 2018 to September 2021 were selected, and they were divided into control group and study group according to the random number table method, with 40 cases in each group. The control group was treated with routine treatment, and the study group was treated with self-made Huatan Huoxue Tongluo Decoction on the basis of the control group. After two months of treatment, the clinical efficacy, neurological impairment, degree of neurological dysfunction, ability of daily living activities and incidence of adverse reactions were compared between the two groups. Results The clinical efficacy of the study group was better than that of the control group, the difference was statistically significant (P < 0.05). After treatment, National Institutes of Health stroke scale (NIHSS) scores and modified Rankin scale (mRS) scores of the two groups were lower than those before treatment, the Barthel index (BI) scores of the two groups were higher than those before treatment, and the NIHSS scores and mRS scores of the study group were lower than those of the control group, and the BI scores of the study group were higher than those of the control group, the differences were statistically significant (P < 0.05). There was no significant difference in the total incidence of adverse reactions between the two groups (P > 0.05). Conclusion Self-made Huatan Huoxue Tongluo Decoction is effective in treating cerebral infarction patients with phlegm and blood stasis obstructing collateral syndrome during early recovery, which can significantly improve the patient’s nerve function and the ability of daily living activities.
2022 Vol. 19 (23): 150-153 [Abstract] ( 18 ) HTML (1 KB)  PDF (549 KB)  ( 24 )
154 Study on the intervention of health science popularization activities in prevention and management of herpes zoster neuralgia in community residents
CAO Lijing1 PAN Xinxin2 WU Ruilian1 CHEN Yiwen1 YAN Jianjun3


[Abstract] Objective To explore the effect of health science popularization activities in prevention and management of herpes zoster neuralgia in community residents. Methods From October 2020 to September 2021, residents in the permanent community of Jinqiao Medical Association of Pudong Xinqu, Shanghai were selected as the research objects. According to the order of inclusion, there were 321 cases in experimental group and 317 cases in control group. Then, according to gender, age, knowledge level, and education level of herpes zoster neuralgia, 1∶1 matching, 80 cases in each of two groups were matched. The control group adopted routine health education program, and the experimental group adopted science popularization practice research mode. The scores of prevention and management knows, belief, and behavior of herpes zoster neuralgia, pain, and quality of life between two groups were compared; and the satisfaction levels of two groups were compared. Results The scores of prevention and management knows, belief, and behavior of herpes zoster neuralgia, and quality of life in experimental group were higher than those in control group (P < 0.05). The pain score in experimental group was lower than that of the control group (P < 0.05). The satisfaction of experimental group was higher than that of control group (P < 0.05). Conclusion The practice science popularization of herpes zoster neuralgia prevention and management can effectively improve the prevention and management of knowledge, belief, and behavior level of herpes zoster neuralgia of community residents, improve the pain level, quality of life, and health science popularization satisfaction.
2022 Vol. 19 (23): 154-157 [Abstract] ( 14 ) HTML (1 KB)  PDF (597 KB)  ( 182 )
158 Application and effect analysis of pre-prescription review system in pediatric outpatient and emergency department clinical medication
XU Hui1 HE Tingting2 LIU Jia1 LU Qiang1 JI Ning1▲
Objective To explore the application and effect of pre-prescription review system in pediatric outpatient and emergency department clinical medication. Methods A retrospective analysis was conducted on 185 857 prescriptions of pediatric outpatient and emergency department prescriptions without pre-prescription review system from January to December 2018 and 103 432 prescriptions of pediatric outpatient and emergency department were reviewed by pre-prescription review system from January to December 2020 in North Jiangsu People’s Hospital. The qualified rate of prescriptions in 2018 and 2020 was analyzed, and the types of unreasonable prescriptions in 2018 and 2020 were analyzed. Results The qualified rate of prescriptions in 2020 was higher than that in 2018 (P < 0.05). From January to December 2020, the qualified rate of prescriptions was higher than 97.00%. No indications of drug use and interactions accounted for a high proportion of irrational prescriptions in 2018 and 2020; there were statistically significant differences between irrational prescription types in 2018 and 2020 (P < 0.05). Conclusion The pre-prescription review system can effectively improve the level of clinical rational drug use in pediatric outpatient and emergency department and it is worthy of promotion.
2022 Vol. 19 (23): 158-161 [Abstract] ( 27 ) HTML (1 KB)  PDF (552 KB)  ( 41 )
162 Application effects of humanistic care based on Watson’s theory of care in elderly patients with chronic obstructive pulmonary disease
SONG Chanjuan ZHAO Di CHEN Huijuan
Objective To explore the application effect of humanistic care based on Watson’s theory of care in elderly patients with chronic obstructive pulmonary disease (COPD). Methods A total of 107 elderly COPD patients admitted to Xuancheng People’s Hospital of Anhui Province from January 2019 to December 2020 were selected and they were divided into the experimental group with 54 cases and the control group with 53 cases according to the random number table method. The control group was given routine nursing intervention, while the experimental group was given humanistic care based on Watson’s theory of care. After six months of intervention, the self-perceived burden, self-management ability, and quality of life were compared between the two groups. Results After six months of intervention, the scores of physical burden, emotional burden, economic burden, and self-perceived burden in the two groups were lower than those before the intervention, while those of the experimental group were lower than those of the control group, and the differences were statistically significant (P ＜ 0.05). After six months of intervention, the total scores of symptom management, daily life management, emotion management, self-efficacy management, and self-management ability in the two groups were higher than those before intervention, while those of the experimental group were higher than those of the control group, and the differences were statistically significant (P ＜ 0.05). After six months of intervention, the scores of respiratory symptoms, activity limitation, disease impact on life, and quality of life between the two groups were lower than those before intervention, while those of the experimental group were lower than those of the control group, with statistically significant differences (P ＜ 0.05). Conclusion Humanistic care based on Watson’s theory of care can help relieve the self-perceived burden of elderly COPD patients, enhance self-management ability, and improve the quality of life.
2022 Vol. 19 (23): 162-165 [Abstract] ( 13 ) HTML (1 KB)  PDF (559 KB)  ( 126 )
166 Influence of stroke emergency nurses’ participation in management on the treatment effect and doctor’s satisfaction of patients with acute ischemic stroke
CHEN Xiufang ZHAO Qiumei LUO Guoying XIANG Songfei
Objective To observe the effect of stroke emergency nurses’ participation in management on the treatment effect and doctor’s satisfaction of patients with acute ischemic stroke. Methods A total of 150 patients with acute ischemic stroke who met the inclusion criteria and were to undergo intravenous alteplase thrombolysis in Shaoxing People’s Hospital of Zhejiang Province were selected. They were divided into control group and observation group by random number table method, with 75 cases in each group. The control group was treated according to the conventional green channel for acute ischemic stroke, while the observation group was provided with stroke emergency nurses to participate in the whole process management on the basis of the control group. The up-to-standard rate of the time from admission to medication (DNT), hospitalization time, hospitalization expenses, treatment process, and the survey doctor’s satisfaction with nursing work in the two groups were observed and recorded. Results The hospitalization time and hospitalization expenses of the observation group were lower than those of the control group, while the DNR compliance rate was higher than that of the control group, and the differences were statistically significant (P ＜ 0.05). The time from admission to diagnosis, time from diagnosis to specialist treatment, time from rescue to CT examination, time from family decision-making, time from doctor visit to thrombolytic administration or intravascular rescue, time from CT to thrombolysis, and vascular rescue in the observation group were shorter than those in the control group, and the differences were statistically significant (P ＜ 0.05). The doctor’s satisfaction in the observation group was higher than that in the control group, and the difference was statistically significant (P ＜ 0.05). Conclusion The participation of stroke emergency nurses in management is conducive to improving the treatment effect of AIS patients, enhancing the satisfaction of doctors, and saving medical expenses, which is worthy of clinical application.
2022 Vol. 19 (23): 166-169,193 [Abstract] ( 14 ) HTML (1 KB)  PDF (724 KB)  ( 934 )
170 Effect of nursing intervention mode based on broken window effect in the incidence of CRBSI in patients with traumatic brain injury
ZHANG Ping XU Shaohong SUN Cunqin▲
Objective To explore the effect of nursing intervention mode based on broken window effect in the incidence of catheter-related bloodstream infection (CRBSI) in patients after traumatic brain injury. Methods A total of 80 patients with craniocerebral trauma who received surgical treatment from April 2018 to April 2021 in the East Campus of the Second People’s Hospital of Lianyungang, Jiangsu Province (hereinafter referred to as “our hospital”) were selected. They were divided into experimental group and reference group by random number table method, with 40 cases in both groups. The reference group was given routine nursing intervention, while the experimental group was given the nursing intervention mode based on the broken window effect. The CRBSI infection rate, nutritional status and levels of related inflammatory factors were compared between the two groups. Results The infection rate of CRBSI in the experimental group was lower than that in the reference group, and the difference was statistically significant (P ＜ 0.05). After nursing, the levels of various nutritional indicators in the two groups were higher than those before nursing, while those of the experimental group were higher than those of the reference group, and the differences were statistically significant (P ＜ 0.05). After nursing, the levels of inflammatory factors in the two groups were lower than those before nursing, while those of the experimental group were lower than those of the reference group, and the differences were statistically significant (P ＜ 0.05). Conclusion Nursing intervention mode based on broken window effect has important application value in patients after craniocerebral trauma, it can improved the nutritional status of the patients, decreased the CRBIS infection rate and the levels of pro-inflammatory factors.
2022 Vol. 19 (23): 170-173 [Abstract] ( 13 ) HTML (1 KB)  PDF (618 KB)  ( 35 )
174 Effect of the concept of enhanced recovery after surgery combined with preoperative 3DVT on the surgical outcome and rehabilitation process of hepatolithiasis
GAO Jingyun1 CHEN Chuang1 XIE Yongfeng1 QI Yunfeng2 LYU Fei3▲
Objective To observe the effect of the concept of enhanced recovery after surgery(ERAS) combined with preoperative three-dimensional visualization technology (3DVT) on the surgical outcome and rehabilitation process of hepatolithiasis. Methods A total of 160 patients with hepatolithiasis admitted to Huaian Second People’s Hospital from August 2018 to August 2021 were selected as the subjects, and they were divided into control group (80 cases) and observation group (80 cases) by random number table method. The control group was given 3DVT preoperative evaluation combined with traditional perioperative treatment, and the observation group was given 3DVT preoperative evaluation combined with ERAS perioperative treatment. Preoperative CT examination, 3DVT evaluation, operation plan and perioperative situation of the two groups were recorded. Serum biochemical indexes including albumin (ALB), alanine aminotransferase (ALT), aspartate aminotransferase (AST), hemoglobin (Hb), and the total incidence of postoperative complications were compared between the two groups before and seven days after operation. Results Comparison of preoperative CT examination and intraoperative consistency rate, 3DVT preoperative evaluation, and intraoperative consistency rate and operation type between the two groups (P ＞ 0.05). The amount of intraoperative blood loss in the observation group was lower than that in the control group, and the postoperative hospital stay was shorter than that in the control group (P ＜ 0.05). On seven days after operation, ALB and Hb in both groups were lower than those before operation and higher in observation group than those in control group, while ALT and AST were higher than those before operation and lower in observation group than in those control group (P ＜ 0.05). The total incidence of complications in observation group was lower than that in control group (P ＜ 0.05). Conclusion 3DVT preoperative evaluation combined with ERAS perioperative management can effectively reduce intraoperative blood loss in patients with hepatolithiasis, shorten hospital stay, and promote liver function recovery.
2022 Vol. 19 (23): 174-177 [Abstract] ( 26 ) HTML (1 KB)  PDF (525 KB)  ( 114 )
178 Effect of social support combined with perioperative nursing on postoperative gastrointestinal function and sleep quality of patients with hysteromyoma
WU Lingling QIU Lingqiao WANG Ying
Objective To explore the effect of social support combined with perioperative nursing on postoperative gastrointestinal function and sleep quality of patients with hysteromyoma. Methods A total of 100 patients with hysteromyoma treated in Xuancheng People’s Hospital of Anhui Province from January 2019 to December 2020 were selected as the research subjects. Patients were divided into two groups by ball-touching method, with 50 cases in each group, with odd numbers as the control group, and even numbers as the observation group. The control group received perioperative nursing, and the observation group received social support combined with perioperative nursing. Postoperative gastrointestinal function, sleep quality, and social support scores were compared between the two groups. Results After nursing, sleep quality scores of both groups were lower than before nursing, and observation group was lower than control group, the differences were statistically significant (P ＜ 0.05); the score of social support in the observation group was higher than before nursing, and the observation group was higher than the control group, the difference was statistically significant (P ＜ 0.05); the recovery time of bowel sound, first exhaust time, and first defecation time in the observation group were shorter than those in the control group, the differences were high statistically significant (P ＜ 0.01). Conclusion Good social support and perioperative nursing can improve the patient’s psychological state, improve sleep, improve social support, promote the recovery of gastrointestinal function, promote postoperative recovery of patients.
2022 Vol. 19 (23): 178-181 [Abstract] ( 22 ) HTML (1 KB)  PDF (682 KB)  ( 76 )
182 Effect of MTP intervention mode on the heart function, mental state, and ability of daily living in patients with dilated cardiomyopathy complicated with heart failure
YIN Jiao WANG Juan LIU Ning SHI Min QIN Haihong LIU Xiaoyang▲
Objective To investigate the impact of monitoring-training-planning (MTP) intervention model in patients with dilated cardiomyopathy (DCM) and heart failure (HF). Methods Eighty patients with DCM complicated with HF admitted to the Second Affiliated Hospital of Air Force Military Medical University from July 2020 to July 2021 were prospectively selected as the study subjects. The patients were divided into group A and group B by simple random coin-flipping method. Finally, 47 cases in group A and 33 cases in group B were included. Group A received MTP intervention mode on the basis of routine nursing, and group B received simple routine nursing, intervention lasted for three months. The changes of heart function before and after intervention were compared between the two groups, the psychological state before and after intervention was evaluated by self-rating anxiety scale (SAS) and self-rating depression scale (SDS), the living ability before and after intervention was evaluated by activity of daily living scale (ADL), and the nursing satisfaction between the two groups was compared. Results After three months of intervention, the levels of left ventricular ejection fraction in both groups were higher than before intervention, and those of the group A were higher than group B, the levels of left ventricular end-systolic diameter and left ventricular diastolic diameter were lower than before intervention, and those of the group A were lower than group B, the differences were statistically significant (P ＜ 0.05). SAS and SDS scores of the two groups were lower than before intervention, and those of the group A were lower than group B, the differences were statistically significant (P ＜ 0.05); ADL scale scores of both groups were higher than before intervention, and group A was higher than group B, the differences were statistically significant (P ＜ 0.05). The scores of nursing quality, nursing attitude, nursing specialty, nursing procedure, and nursing satisfaction in group A were higher than those in group B, the differences were high statistically significant (P ＜ 0.01). Conclusion MTP intervention mode has significant intervention effect on patients with DCM combined with HF, which can improve their cardiac function, psychological state, and enhance daily living ability.
2022 Vol. 19 (23): 182-185 [Abstract] ( 15 ) HTML (1 KB)  PDF (560 KB)  ( 21 )
186 Effect of psychological education intervention on acute pain, anxiety, and quality of life after laparoscopic cholecystectomy
PAN Kefang1 XIA Dengzhi2
Objective To analyze the effect of psychological education intervention on acute pain, anxiety, and quality of life after laparoscopic cholecystectomy. Methods A total of 112 patients with laparoscopic cholecystectomy were selected from the Department of Hepatobiliary Surgery, Chaohu Hospital of Anhui Medical University from July 2020 to February 2021. They were divided into observation group and control group by random number table method, with 56 cases in each group. The control group received general health education, and the observation group received psychological education intervention on this basis. Numeric rating scale (NRS), self-rating anxiety scale (SAS), self-rating depression scale (SDS), 36-item short-form (SF-36) scores, analgesia, opioid side effects and postoperative adverse reactions were compared between the two groups. Results After intervention, SAS, SDS, and NRS scores in both groups were lower than before intervention, SF-36 scores were higher than before intervention, and SAS, SDS, and NRS scores in observation group were lower than control group, SF-36 scores were higher than intervention group, the differences were statistically significant (P ＜ 0.05). The postoperative supplementary analgesia rate and the incidence of drug side effects in the observation group were lower than those in the control group, and the differences were statistically significant (P ＜ 0.05). There was no significant difference in postoperative adverse reactions between the two groups (P ＞ 0.05). Conclusion Psychological education intervention for patients after laparoscopic cholecystectomy can reduce postoperative acute pain and opioid-related side effects and improve patients’ anxiety and quality of life.
2022 Vol. 19 (23): 186-189 [Abstract] ( 13 ) HTML (1 KB)  PDF (607 KB)  ( 361 )
190 Effects of path health education management combined with children’s entertaining nursing on the disease awareness rate and compliance behavior of parents of children with Henoch Schönlein purpura
LI Jingjing QIAO Jianyun YI Man AN Lu LIANG Juan▲
Objective To explore the effects of path health education management combined with children’s entertaining nursing on the disease awareness rate and compliance behavior of parents of children with Henoch-Schönlein purpura. Methods A total of 108 parents of children with Henoch-Schönlein purpura treated in the Department of Pediatrics of the First Affiliated Hospital of Air Force Military Medical University from January 2020 to June 2021 were selected as the research subjects, they were divided into control group and observation group by random number table method, with 54 in each group. The control group was managed by path health education, and the observation group was combined with children’s entertaining nursing on this basis. Parents’ self-rating anxiety scale (SAS) score, self-rating depression scale (SDS) score, disease awareness rate and compliance behavior were compared between the two groups. Results After intervention, SAS and SDS scores of the two groups were lower than before intervention, and observation group was lower than control group, the differences were statistically significant (P ＜ 0.05). The disease awareness rate of observation group was better than that of control group, and the difference was statistically significant (P ＜ 0.05). The compliance rate of observation group was higher than that of control group, and the difference was statistically significant (P ＜ 0.05). Conclusion The application of path health education management combined with children’s entertaining nursing can improve the psychological status of children with Henoch-Schönlein purpura, and improve the parents’ disease awareness rate and compliance rate, which is worthy of promotion and application.
2022 Vol. 19 (23): 190-193 [Abstract] ( 21 ) HTML (1 KB)  PDF (609 KB)  ( 22 )
194 Analysis and countermeasures of common problems in ethical review of scientific research fund projects
CHEN Yu1 PAN Changqing2 ZHANG Wei2 LI Yiying1
Ethical declaration and review is an important part in the application and implementation of scientific research fund projects. This paper is based on the main ethical problems existing in the scientific research projects launched by Beijing Neurosurgical Institute in 2020, such as incomplete materials submitted for examination, the content of informed consent is unreasonable, and incomplete and wrong filling of the application form for ethical review etc., through the standardized training for researchers, improve the researchers’ understanding and attention to ethical declaration. At the same time, the Ehics Committee should also further understand the basic process and characteristics of the scientific research projects carried out by Beijing Neurosurgical Institute, so as to better find out the problems in the process of ethical review. It is emphasized that medical research institutes should formulate an ethical review system suitable for their own institutions according to their own characteristics under the condition of following the principles of medical ethics, so as to truly play the role of ethical review and ensure the safety of subjects and the scientificity of clinical research.
2022 Vol. 19 (23): 194-封三 [Abstract] ( 15 ) HTML (1 KB)  PDF (638 KB)  ( 69 )
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