硫酸吗啡缓释片为背景用药联合盐酸吗啡针对中重度癌性疼痛的影响

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Abstract Objective To investigate the effect of Morphine Sulfate Sustained-release Tablets as background medication combined with Morphine Hydrochloride Injection on moderate and severe cancerous pain. Methods A total of 100 patients with moderate and severe cancerous pain admitted to Xuchang Central Hospital Affiliated to Henan University of Science and Technology from September 2018 to September 2019 were selected as the study subjects. They were divided into observation group and control group by random number table method, with 50 patients in each group. The observation group was treated with Morphine Sulfate Sustained-release Tablets as background medication combined with Morphine Hydrochloride Injection, while the control group was treated with Morphine Hydrochloride Injection only. The pain number rating scale (NRS) scores before (T0) and 3 h (T1), 24 h after medication (T2) were compared between the two groups, and the pain relief effect was compared between the two groups. The incidence of adverse reactions in the two groups was recorded. Results Pain NRS scores in both groups at 3, 24 h after medication were lower than T0, and T2 was lower than T1 (P ＜ 0.05). Pain NRS scores at T1, T2 in observation group were lower than control group at the same time (P ＜ 0.05). The pain relief in observation group was better than that in control group (P < 0.05). There was no significant difference in the total incidence of adverse reactions between the two groups (P > 0.05). Conclusion The efficacy of Morphine Sulfate Sustained-release Tablets as the background medication combined with Morphine Hydrochloride Injection in relieving moderate and severe cancerous pain is good and worthy of further clinical study.

Key words： Morphine Sustained-release Tablets Cancerous pain Injection

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	WANG Pengyuan DONG Xueru LIU Zhi SHANG Nana

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WANG Pengyuan DONG Xueru LIU Zhi SHANG Nana. Effect of Morphine Sulfate Sustained-release Tablets as background medication combined with Morphine Hydrochloride Injection on moderate and severe cancerous pain[J]. 中国医药导报, 2022, 19(23): 100-103.

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https://www.yiyaodaobao.com.cn/EN/ OR https://www.yiyaodaobao.com.cn/EN/Y2022/V19/I23/100

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