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| Study on medication regularity and difference between abscess stage of granulomatous lobular mastitis and lactation mastitis based on data mining |
| XU Jisheng1 LIU Miaomiao2 SHI Guangxi3 LIANG Hongyi4 WANG Bo1 ZHANG Mengdi4 CHEN Hanhan3 LI Jingwei3 |
1.First Clinical Medical College, Shandong University of Traditional Chinese Medicine, Shandong Province, Jinan 250014, China;
2.Department of Breast and Thyroid Surgery, Yanzhou Hospital, Affiliated Hospital of Jining Medical College, Shandong Province, Jining 272100, China; 3.Department of Breast and Thyroid Surgery, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Shandong Province, Jinan 250014, China;
4.College of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Shandong Province, Jinan 250014, China |
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Abstract
[Abstract] Objective To discuss the medication regularity and difference between abscess stage of granulomatous lobular mastitis (GLM), lactation mastitis (LM). Methods The literatures on traditional Chinese medicine treatment of the abscess stage of GLM, LM published in Sinomed, CNKI, Wanfang Data, and VIP database from inception to December 2021 were screened, to analyze the medication regularity and difference of the abscess stage of GLM, LM through Traditional Chinese Medicine Inheritance Computing Platform. Results The medication regularity of the abscess stage of GLM, LM, seven of the top ten high-frequency drugs were same and three were different. The comparison of the four nature of drugs, five flavours, and channel tropism showed that at the abscess stage of GLM, LM, cold and warm, mainly bitter and sweet taste drugs were used. The proportion of warm and sweet medicine in abscess stage of GLM was higher than that in abscess stage of LM. The main channel tropism were liver, stomach, and lung channels. Drugs for heat-clearing, tonifying deficiency, dissipating phlegm, promoting blood circulation for removing blood stasis were the main drugs in the classification. The proportion of drugs for tonifying deficiency, dissipating phlegm, promoting blood circulation for removing blood stasis in abscess stage of GLM was higher than that in abscess stage of LM. Futher analysis showed that, six potential drug pairs for abscess stage of GLM and seven potential drug pairs for abscess stage of LM were obtained, and a group of core drug combinations were obtained for each. Conclusion Abscess stage of GLM, LM are treated according to the principle of clearing heat and removing toxicity, expelling pathogens by strengthening vital qi and expelling pus. Abscess stage of LM needs to strengthen the function of strengthening vital qi and tonifying deficiency, accompanied by dissipating phlegm and promoting blood circulation products. Abscess stage of LM needs to strengthen the function of heat-clearing and cooling blood.
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