APOE e4等位基因与阿尔茨海默病精神行为症状关联的meta分析

Abstract
Figure/Table
References (25)
Related Citation (15)

Download: PDF (1646 KB) HTML (1 KB)
Export: BibTeX | EndNote (RIS)

Abstract Objective To systematically assess the association of APOE e4 allele with mental and behavioral symptoms of Alzheimer’s disease. Methods PubMed, Web of Science, Cochrane, Embase, and CNKI databases were searched, clinical study of screening mental behavioral symptoms and APOE e4 allele in Alzheimer’s disease. Self-built database until September 2020. Two researchers independently completed literature retrieval, quality evaluation, and data extraction, and Stata 15 software was used for data analysis. Results A total of 4 937 patients were included in 13 literatures. Agitation (Z = 0.31, P = 0.760), depression (Z = 1.71, P = 0.086), hallucinations (Z = 0.75, P = 0.456), delusions (Z = 1.80, P = 0.072), indifference (Z = 1.52, P = 0.128), nocturnal behavior abnormalities (Z = 1.70, P = 0.09) were not correlated with APOE e4 allele. Anxiety (Z = 4.38, P = 0.000) and abnormal behavior movement (Z = 2.16, P = 0.031) were correlated with APOE e4 allele. Conclusion The APOE e4 allele may be a risk gene for anxiety and abnormal behavior movement in psychobehavioral symptoms.

Key words： APOE e4 allele Alzheimer’s disease Behavioral and psychological symptoms of dementia Meta-analysis

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	MA Suya1 WEI Mingqing2 NI Jingnian2 LI Ting2 WANG Xu2 XU Xiaoqing2 LI Xiaohong3

Cite this article:

MA Suya1 WEI Mingqing2 NI Jingnian2 LI Ting2 WANG Xu2 XU Xiaoqing2 LI Xiaohong3. Meta-analysis of the association between APOE e4 allele and mental behavioral symptoms in Alzheimer’s disease[J]. 中国医药导报, 2022, 19(23): 79-84.

URL:

https://www.yiyaodaobao.com.cn/EN/ OR https://www.yiyaodaobao.com.cn/EN/Y2022/V19/I23/79

[1] DeMichele-Sweet MA，Sweet RA. Genetics of Psychosis in Alzheimer’s Disease：A Review [J]. J Alzheimers Dis，2010，19（3）：761-780.
[2] 魏翠柏.精神行为症状与阿尔茨海默病[J].中国实用内科杂志，2016，36（11）：935-937.
[3] Rosenberg PB，Lanctot KL，Herrmann N，et al. Changes in Neuropsychiatric Inventory Associated with Semagacestat Treatment of Alzheimer’s Disease [J]. J. Alzheimers Dis，2016，54（1）：373-381.
[4] Polito L，Prato F，Rodilossi S，et al. A Novel Study and Meta-Analysis of the Genetic Variation of the Serotonin Transporter Promoter in the Italian Population Do Not Support a Large Effect On Alzheimer’s Disease Risk [J]. Int J Alzheimers Dis，2011，2011：312341.
[5] 曾宪涛，刘慧，陈曦，等.Meta分析系列之四：观察性研究的质量评价工具[J].中国循证心血管医学杂志，2012， 4（4）：297-299.
[6] 周青，刘帅妹，张瑞金，等.MTHFR基因多态性与宫颈癌关系的Meta分析[J].中国医药导报，2019，16（24）：99-102.
[7] 赵丽丽，张硕，姜立刚.帕金森病冻结步态临床特征Meta分析[J].中风与神经疾病杂志，2019，36（5）：430-437.
[8] 查莉，赵斌，刘洋毅，等.“全面二孩”政策下中国育龄妇女二孩生育意愿的Meta分析[J].中国循证医学杂志，2020， 20（11）：1301-1307.
[9] 顾文明，陈美娟，高哲石，等.阿尔茨海默病载脂蛋白E基因多态性研究[J].临床精神医学杂志，2003（3）：131-133.
[10] Craig D，Hart DJ，McCool K，et al. Apolipoprotein E E4 Allele Influences Aggressive Behaviour in Alzheimer’s Disease [J]. J Neurol Neurosurg Psychiatry，2004，75（9）：1327-1330.
[11] Craig D，Hart DJ，McIlroy SP，et al. Association Analysis of Apolipoprotein E Genotype and Risk of Depressive Symptoms in Alzheimer’s Disease [J]. Dement Geriatr Cogn Disord，2005，19（2/3）：154-157.
[12] Monastero R，Mariani E，Camarda C，et al. Association Between Apolipoprotein E Epsilon4 Allele and Apathy in Probable Alzheimer’s Disease [J]. Acta Psychiatr Scand，2006，113（1）：59-63.
[13] Pritchard AL，Harris J，Pritchard CW，et al. The Effect of the Apolipoprotein E Gene Polymorphisms and Haplotypes On Behavioural and Psychological Symptoms in Probable Alzheimer’s Disease [J]. J Neurol Neurosurg Psychiatry，2007，78（2）：123-126.
[14] Flirski M，Sieruta M，Golanska E，et al. PRND 3’UTR Polymorphism May be Associated with Behavioral Disturbances in Alzheimer’s Disease [J]. Prion，2012，6（1）：73-80.
[15] Michels A，Multhammer M，Zintl M，et al. Association of Apolipoprotein E Epsilon4 （ApoE Epsilon4） Homozygosity with Psychiatric Behavioral Symptoms [J]. J Alzheimers Dis，2012，28（1）：25-32.
[16] Christie D，Shofer J，Millard SP，et al. Genetic Association Between APOE e4 and Neuropsychiatric Symptoms in Patients with Probable Alzheimer’s Disease is Dependent On the Psychosis Phenotype [J]. Behav. Brain Funct，2012，8：62.
[17] 伍力，王燕，余发春，等.阿尔茨海默病精神症状与载脂蛋白E基因多态性相关性研究[J].中国健康心理学杂志，2008（10）：1168-1170.
[18] Xing Y，Tang Y，Jia J. Sex Differences in Neuropsychiatric Symptoms of Alzheimer’s Disease：The Modifying Effect of Apolipoprotein E epsilon4 Status [J]. Behav Neurol，2015，2015：275256.
[19] Park HK，Choi SH，Park SA，et al. Cognitive Profiles and Neuropsychiatric Symptoms in Korean Early-Onset Alzheimer’s Disease Patients：A CREDOS Study [J]. J Alzheimers Dis，2015，44（2）：661-673.
[20] Pink A，Stokin GB，Bartley MM，et al. Neuropsychiatric Symptoms，APOE Epsilon4，and the Risk of Incident Dementia：A Population-Based Study [J]. Neurology，2015， 84（9）：935-943.
[21] Scassellati C，Ciani M，Maj C，et al. Behavioral and Psychological Symptoms of Dementia （BPSD）：Clinical Characterization and Genetic Correlates in an Italian Alzheimer’s Disease Cohort [J]. J Pers Med，2020，10（3）.
[22] Pritchard AL，Harris J，Pritchard CW，et al. Role of 5HT 2A and 5HT 2C Polymorphisms in Behavioural and Psychological Symptoms of Alzheimer’s Disease [J]. Neurobiol. Aging，2008，29（3）：341-347.
[23] Frieden C，Wang H，Ho C. A Mechanism for Lipid Binding to apoE and the Role of Intrinsically Disordered Regions Coupled to Domain-Domain Interactions [J]. Proc Natl Acad Sci USA，2017，114（24）：6292-6297.
[24] Wei TS，Si NY，Bernice XL，et al. Impacts of Apolipoprotein E Disclosure On Healthy Asian Older Adults：A Cohort Study [J]. Int Psychogeriatr，2019，31（10）.
[25] Rosenberg PB，Nowrangi MA，Lyketsos CG. Neuropsychiatric Symptoms in Alzheimer’s Disease：What Might be Associated Brain Circuits? [J]. Mol Aspects Med，2015，43/44：25-37.