老年急性胆囊炎患者血清hs-CRP、IL-15与Hp感染的关系及其预测Hp感染的价值

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Abstract Objective To analyze the relationship between serum high-sensitivity C-reactive protein (hs-CRP), interleukin-15 (IL-15), and Helicobacter pylori (Hp) infection in elderly patietns with acute cholecystitis, and their value in predicting Hp infection. Methods The clinical data of 100 elderly patients with acute cholecystitis admitted to Zhejiang Provincial People’s Hospital from April 2017 to May 2019 were analyzed. According to Hp infection, they were divided into infected group and non-infected group. Serum hs-CRP and IL-15 levels were compared between two groups; the metaplasia of gallbladder mucosa and gastric epithelium was observed; the correlation of hs-CRP, IL-15, and Hp positive rate and the efficacy of hs-CRP and IL-15 in predicting Hp infection in elderly patients with acute cholecystitis were analyzed. Results Fifty-three elderly patients with acute cholecystitis were infected with Hp. Serum hs-CRP and IL-15 levels in infected group were higher than those in non-infected group (P < 0.05). The metaplasia rate of gallbladder mucosa and gastric epithelium in infected group was higher than that in non-infected group (P < 0.05). Hp positive rate was positively correlated with hs-CRP and IL-15 (r = 0.694, 0.677, P < 0.05); there was positive correlation between hs-CRP and IL-15 (r = 0.686, P < 0.05). When hs-CRP and IL-15 were combined to predict Hp infection in acute cholecystitis, the area under the curve was 0.870, the sensitivity and specificity were 75.47% and 95.74%, respectively. Conclusion Hp infection in elderly patients with acute cholecystitis can aggravate the local inflammatory response of cholecystitis, and induce release of hs-CRP and IL-15; hs-CRP and IL-15 are highly correlated with Hp infection, which can be used as a basis for preliminary screening of early Hp infection.

Key words： Acute cholecystitis Helicobacter pylori High-sensitivity C-reactive protein Interleukin-15 Infection

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CAI Liuyan JI Qianqian LI Hengjie. Relationship between serum hs-CRP, IL-15, and Hp infection in elderly patients with acute cholecystitis and its value in predicting Hp infection[J]. 中国医药导报, 2022, 19(23): 9-12.

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https://www.yiyaodaobao.com.cn/EN/ OR https://www.yiyaodaobao.com.cn/EN/Y2022/V19/I23/9

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