轻型地中海贫血孕妇孕早期铁蛋白水平、甲状腺功能及胰腺功能检测结果分析

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Abstract Objective To investigate the changes of ferritin(Fer) level, thyroid function, and pancreatic function in pregnant women with minor thalassemia. Methods A total of 160 pregnant women with minor thalassemia at the gestational age of three months who underwent prenatal examinations in the First Affiliated Hospital of Chengdu Medical College from January 2018 to October 2021 were selected as the thalassemia group, and 200 healthy pregnant women in the same period were selected as the control group. The levels of thyroid stimulating hormone (TSH), free triiodothyronine (FT3), free thyroid hormone (FT4), thyroglobulin antibody (Tg-Ab), thyroperoxidase antibody (TPO-Ab), fasting plasma glucose (FPG), fasting plasma insulin (FINS), Fer, and hemoglobin (Hb) were measured between the two groups. Results There were no significant differences in TSH, FT3, FT4, Tg-Ab, and TPO-Ab between the two groups （P > 0.05）. There was no significant difference in the prevalence of thyroid dysfunction between the two groups (P > 0.05). There were no significant differences in FPG, FINS, and the homeostasis model assessment of insulin resistance between the two groups (P > 0.05). Hb in the thalassemia group was lower than that in the control group, Fer was higher than that in the control group, and the differences were statistically significant (P < 0.05). Conclusion Thyroid function and pancreas function of pregnant women with mild thalassemia do not change significantly in early pregnancy, but Fer and Hb levels are affected.

Key words： Pregnant women with thalassemia Thyroid hormone Ferritin Insulin resistance

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	ZHOU Xiaoping1 DENG Yuping2 YANG Xin2 XU Ying1

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ZHOU Xiaoping1 DENG Yuping2 YANG Xin2 XU Ying1. Analysis of the detection results of ferritin level, thyroid function, and pancreatic function in early pregnant women with minor thalassemia[J]. 中国医药导报, 2022, 19(23): 93-96.

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https://www.yiyaodaobao.com.cn/EN/ OR https://www.yiyaodaobao.com.cn/EN/Y2022/V19/I23/93

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