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| Effect of traditional Chinese medicine fumigation method combined with Longdan Xiegan Decoction in the treatment of recurrent urinary tract infection in adult female |
| GE Shulong CHEN Lei YANG Xiaolei#br# |
| Department of Traditional Chinese Medicine, Shandong Provincial Third Hospital, Shandong Province, Jinan 250031, China |
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Abstract Objective To explore the effect of traditional Chinese medicine fumigation method combined with Longdan Xiegan Decoction in the treatment of recurrent urinary tract infection in adult female. Methods A total of 108 adult female patients with recurrent urinary tract infection admitted to Shandong Provincial Third Hospital from January 2019 to January 2021 were selected, and they were divided into fumigation group, decoction group and combined group according to the random number table method, with 36 cases in each group. All patients were treated with first-line drugs. On this basis, the fumigation group was treated with traditional Chinese medicine fumigation, the decoction group was treated with Longdan Xiegan Decoction, and the combined group was treated with traditional Chinese medicine fumigation and Longdan Xiegan Decoction for four weeks. The clinical efficacy, urinary bacterial negative conversion rate, disappearance time of main symptoms, traditional Chinese medicine syndrome score and inflammatory factor level of the three groups were compared, and the adverse reactions of the three groups during treatment were observed. Results The total effective rate and the negative conversion rate of urine bacteria in the combined group were higher than those in the fumigation group and the decoction group, and the differences were statistically significant (P < 0.05). The disappearance times of frequency of urination, urgency of urination, astringent pain of urination, hematuria and lower thigh pain in the combined group were shorter than those in the fumigation group and the decoction group, and the differences were statistically significant (P < 0.05). After treatment, the syndrome scores of the three groups were lower than those before treatment, and the traditional Chinese medicine syndrome scores of the combined group were lower than those of the fumigation group and the decoction group, the differences were statistically significant (P < 0.05). After treatment, hypersensitivity C-reactive protein (hs-CRP), interleukin (IL)-6, IL-8, tumor necrosis factor-α (TNF-α), and procalcitonin (PCT) levels of the three groups were lower than those before treatment, and hs-CRP, IL-6, IL-8, TNF-α, and PCT levels of the combined group were lower than those of fumigation group and decoction group, and the differences were statistically significant (P < 0.05). No obvious adverse reactions were found in the three groups during treatment, with normal liver and kidney functions, no shock and diarrhea. Conclusion Traditional Chinese medicine fumigation method combined with Longdan Xiegan Decoction in the treatment of recurrent urinary tract infection in adult female can effectively improve the clinical symptoms and signs of patients, improve the negative rate of urinary bacteria, shorten the disappearance time of main symptoms, adjust the level of inflammatory factors, and there are no obvious adverse reactions during the treatment, ensuring the safety during the treatment.
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