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2022 Vol. 19, No. 5 Published: 2022-02-15

	4	Exploration of mechanism of “Semen Cuscutae-Herba Epimedii” in the treatment of vitiligo based on network pharmacology#br#
		LYU Kaifeng1 WANG Yuanhong2 ZHANG Wei3 LIU Hongwei2
		Objective To explore the mechanism of “Semen Cuscutae-Herba Epimedii” in the treatment of vitiligo based on network pharmacology. Methods The active components and their targets of “Semen Cuscutae-Herba Epimedii” were screened by traditional Chinese medicine systems pharmacology database and analysis platform, traditional Chinese medicine integrated database, and other databases. The main targets of vitiligo were identified by databases such as GeneCards and online Mendelian inheritance in man, etc. STRING and Cytoscape were used for protein-protein interaction analysis, and David database was used to analyze the obtained targets. Results There were 31 active components and 222 potential targets in “Semen Cuscutae-Herba Epimedii”, and 457 targets in vitiligo, and a total of 47 common targets were extracted. A total of 23 pathways were screened by KEGG enrichment, and 356 entries were obtained by GO analysis. Conclusion “Semen Cuscutae-Herba Epimedii” can treat vitiligo through multi-target and multi-pathway, and provide theoretical basis for its clinical development and utilization.
		2022 Vol. 19 (5): 4-8,17 [Abstract] ( 183 ) HTML (1 KB) PDF (3200 KB) ( 199 )

	9	Analysis of hot spots and frontiers of nested case-control study based on CiteSpace#br#
		MU Ran1 YANG Lin2 LIU Ning3
		Objective To track the hot spots and cutting-edge developments in the field of exploration, CiteSpace software was used to draw knowledge maps for nested case-control related literatures for visual analysis. Methods Nested case-control study papers collected by China National Knowledge Infrastructure from January 2001 to January 2021 were searched and visualized for the number of publications, keywords, analysis of authors and institutions, and literature co-citation. Results A total of 335 articles were included, and the fluctuation of the number of articles increased year by year. The content focused on the research of disease surveillance and inhibitory treatment, with agents, adverse reactions and diabetes as the new research frontier. In terms of publishing institutions and scholars, China Academy of Chinese Medical Sciences and Renmin University of China had close cooperation, while other institutions had published papers independently. Conclusion This paper reveals the research strength, development context, research hotspot and frontier of this field in the past 20 years, and provides reference for future researches.
		2022 Vol. 19 (5): 9-12 [Abstract] ( 192 ) HTML (1 KB) PDF (1452 KB) ( 74 )

	13	Association between triacyl-glucose index and hyperuricemia in males in our hospital#br#
		Mayina Kahaer ZHANG Bei LIANG Meiting CHEN Wujin TIAN Tingting SUN Yuping
		Objective To investigate the relationship between triacylglycerol glucose (TyG) index and hyperuricemia in men. Methods A total of 821 male physical examination population from the First Affiliated Hospital of Xinjiang Medical University from September 2018 to June 2020 were selected as the research subjects for questionnaire survey, physical examination and detection of serum biochemical indicators. According to whether they had hyperuricemia or not, they were divided into hyperuricemia group (314 cases) and control group (507 cases). Results The education level and income level of the hyperuricemia group were lower than those of the control group (P ＜ 0.05); the body weight, waist-hip ratio, body mass index, fasting blood glucose, uric acid, and TyG index of the hyperuricemia group were higher than those of the control group (P ＜ 0.05). According to the quartile analysis of TyG index, with the increase of TyG index, the level of uric acid increased. After adjusting for various confounding factors, the serum uric acid level increased by 21.683 μmol/L for each standard deviation increase of TyG. Compared with the lowest quartile of the adjusted model, serum urate concentrations in the highest quartile increased by 35.804 μmol/L (P ＜ 0.05). Multivariate logistic regression showed that the risk of hyperuricemia increased by 68.9% for each standard deviation increase in the TyG index after adjusting for multiple confounders. The risk in the highest quartile was 0.592 times that in the lowest quartile (P ＜ 0.05). Conclusion Male TyG index has a significant correlation with hyperuricemia, and it has certain validity in assessing the risk of hyperuricemia.
		2022 Vol. 19 (5): 13-17 [Abstract] ( 73 ) HTML (1 KB) PDF (602 KB) ( 65 )

	18	Exploration of moderating effects of Cis-abdominal breathing training on emotional response based on event-related potential P300#br#
		ZHANG Xinzheng1 WANG Ying1 LYU Jiaxuan1 ZHANG Jialei2 DONG Jingjing1 LI Hangyu1 WEI Yulong1
		Objective To explore the regulation effect of Cis-abdominal breathing training on human emotional response. Methods A total of 48 healthy employees of Xinyi Health Technology Co., LTD., ENN group, were recruited and trained from June to September 2020. They were divided into group A and B, according to random number table method, with 24 employees in each group. Group A received body adjustment, and group B received body adjustment combined with Cis-abdominal breathing training. After six weeks of intervention, the peak value of P300 and brain power in both groups under different stimulation were analyzed by event-related potential cerebral electrical activity monitoring technique and cerebral electrical activity map. Results After intervention, in group B, the peak values of P300 in parietal area, occipital area under positive and neutral stimulation and posterior temporal area under neutral stimulation were lower than those in group A, the peak values of P300 in the temporoparietal junction, posterior temporal area, and occipital area under negative stimulation were lower than those in group A, and the differences were statistically significant (P ＜ 0.05). Cerebral electrical activity map showed that after intervention, the power of brain area under each stimulation in group B was lower than that in group A. Conclusion The Cis-abdominal breathing training can adjust and reduce the emotional response of the human body, mainly acting on the right brain, with the function of calming and settling the mind.
		2022 Vol. 19 (5): 18-22 [Abstract] ( 80 ) HTML (1 KB) PDF (1637 KB) ( 330 )

	23	Visual analysis of epilepsy research hotspots and trends in the field of traditional Chinese medicine based on CiteSpace #br#
		MA Wei MO Xueni▲ WU Duo ZHANG Yue LAN Baixin LIU Jiao LIU Na
		Objective To analyze the research hotspot and trend of epilepsy in traditional Chinese medicine by visualization method. Methods The literatures related to epilepsy in the field of traditional Chinese medicine from January 1991 to April 2021 collected on China National Knowledge Infrastructure were searched as objects. CiteSpace 5.7.R2 software was used for bibliometrics analysis to analyze the trend of publication, author cooperation, keywords co-occurrence, clustering and emergence, and the corresponding knowledge map was drew to discuss the research hotspots and trends in this field. Results In the end, 2059 literatures were included, and the overall annual publication volume in this field showed an upward curve. Wang Hao posted the highest number of literatures, but lack of team cooperation, Ma Rong team internal cooperation was relatively close. Keywords co-occurrence hotspots included integrated Chinese and Western medicine therapy, Carbamazepine, clinical observation and clinical research, etc. There were nine types of keywords co-occurrence. The research trend included Chaibei Zhixian Decoction, acupuncture, data mining, traditional Chinese medicine, etc. Conclusion The development prospect of epilepsy research in the field of traditional Chinese medicine is good. It is suggested that researchers and research teams communicate and cooperate with each other to explore higher quality clinical research, so as to improve the curative effect of traditional Chinese medicine on epilepsy.
		2022 Vol. 19 (5): 23-27,31 [Abstract] ( 218 ) HTML (1 KB) PDF (2923 KB) ( 87 )

	28	Expression level of PD-L1 in clinicopathological specimens of oral cancer#br#
		MENG Qingwei
		Objective To investigate the expression of programmed death ligand-1 (PD-1) protein in the pathological tissues of oral cancer, such as oropharyngeal cancer, maxillary sinus cancer and tongue cancer, etc. Methods From January 2015 to January 2020, 20 pathological tissues diagnosed with oral cancer were collected from Beijing Huairou Hospital, and their paraffin sections were stained with PD-L1 by immunohistochemistry method. All sections were photographed in 10 tissue regions randomly selected under an optical microscope, and the proportion of positive cells was calculated and the average value was taken. The positive grade of PD-L1 was qualitatively analyzed according to the evaluation criteria. Results Among the 20 cases of oral cancer pathological tissues collected in this study, six cases (30%) showed strong positive expression of PD-L1, four cases (20%) showed moderate positive expression of PD-L1, four cases (20%) showed weak positive expression of PD-L1, and six cases (30%) showed negative expression of PD-L1. A total of 14 cases (70%) showed positive expression of PD-L1. Conclusion The pathogenesis of oropharyngeal cancer, maxillary sinus cancer, tongue cancer and other oral cancers may also be caused by immune escape caused by high expression of PD-L1 in tumor cells.
		2022 Vol. 19 (5): 28-31 [Abstract] ( 49 ) HTML (1 KB) PDF (1723 KB) ( 54 )

	32	Research progress of immune checkpoint inhibitors in the treatment of non-small cell lung cancer#br#
		HUA Lei WANG Ronglin SU Haichuan
		Lung cancer is one of the most malignant tumor with the highest morbidity and mortality in the world. Currently, it remains to be a challenge to cure the lung cancer. With the advent of immunotherapy, it has brought new hope to lung cancer patients. At present, the research of immunotherapy is developing and advancing rapidly. This article focuses on the present situation of clinical immunotherapy, including the effectiveness and safety. Meanwhile, this article reviews the biomarkers which predict immunotherapy response, and their emergence will further improve the accuracy of immunotherapy. It is expected to provide ideas and clues for optimizing clinical immunotherapy strategies in the future.
		2022 Vol. 19 (5): 32-35,51 [Abstract] ( 112 ) HTML (1 KB) PDF (585 KB) ( 253 )

	36	Research progress of NGF / TrKA signaling pathway in knee osteoarthritis pain#br#
		LI Mingchao1 WANG Peimin2 YIN Songjiang2 ZHANG Li2 HUANG Zhengquan2 XING Runlin2
		Pain is the main symptom of knee osteoarthritis (KOA), chronic pain seriously affects the quality of life of patients. KOA pain involves pathological changes such as inflammatory environment, cartilage damage, and nerve sensitization. Recent studies have shown that blocking nerve growth factor (NGF) successfully alleviates PAIN in KOA, confirming that NGF is a key mechanism of pain in knee osteoarthritis. This article reviews the research progress of NGF / Tropomyosin receptor kinase A signaling pathway and pathologic changes related to KOA pain.
		2022 Vol. 19 (5): 36-39,55 [Abstract] ( 136 ) HTML (1 KB) PDF (1106 KB) ( 168 )

	40	New progress in the treatment of hypertrophic obstructive cardiomyopathy#br#
		CHEN Meng1 LIU Huihui2 JIANG Zhixin1 SHAN Qijun1
		Hypertrophic cardiomyopathy is a genetic disease, high incidence in the population. Among them, hypertrophic obstructive cardiomyopathy is harmful, in addition to causing chest pain, syncope, and other clinical symptoms, severe cases can cause sudden death. With the further study of the pathogenesis, much progress has been made in the treatment of outflow tract obstruction, both pharmacological and non-pharmacological, such as Mavecamten precision biology drug therapy and apical percutaneous cardiac interventricular radiofrequency ablation. Combined with the latest relevant research, in this paper, drug therapy, interventional therapy, radiofrequency ablation, and gene therapy of hypertrophic obstructive cardiomyopathy were systematically described, in order to improve the understanding of the treatment and research of the disease.
		2022 Vol. 19 (5): 40-43 [Abstract] ( 129 ) HTML (1 KB) PDF (535 KB) ( 178 )

	44	Resecrch progress in the treatment of gouty arthritis#br#
		XU Peng1 LIU Shumin2 YU Donghua2 LU Fang2 WANG Yu2
		Gouty arthritis is one of the most common rheumatic diseases. Patients with purine metabolism disorders or reduced uric acid excretion lead to increased blood uric acid, which leads to monosodium urate crystals and deposition in the joint, characterized by red, swelling, heat, and pain, even joint deformity or functional damage. In recent years, with the gradual improvement of the medical level, the treatment of the gouty arthritis is gradually increasing. The advantages and disadvantages of traditional Chinese medicine therapy and Western medicine treatment coexist, each of them has its own advantages, in different stages of the gouty arthritis shows different treatment characteristics. There are also new research areas to be developed. This paper mainly reviews the latest progress of drug treatment and non drug treatment of gouty arthritis in traditional Chinese medicine and Western medicine.
		2022 Vol. 19 (5): 44-47 [Abstract] ( 160 ) HTML (1 KB) PDF (579 KB) ( 141 )

	48	Research progress of deoxyribonuclease 1 analogue 3 in autoimmune diseases #br#
		OUYANG Bohui
		Autoimmune disease is a disease with high morbidity and fatality rate, since its morbidity is on the rise globally, its early diagnosis is particularly important. Deoxyribonucinase 1 analogue 3 (DNASE1L3) is an endonuclionase that degrades the chromatin of apoptotic or necrotic cells. Its deletion or accumulation leads to disorder in the clearance of apoptotic cells in vivo, triggering autoimmune reactions and causing autoimmune diseases. Especially, its expression level and mechanism in systemic lupus erythematosus, ankylosing spondylitis, dermatomyositis and polymyositis, and other autoimmune diseases have attracted much attention. In addition, the expression of DNASE1L3 is also different in malignant tumors and respiratory diseases. This means that it has a good clinical guiding significance for the diagnosis, treatment and prognosis of these diseases. This article reviews the application and research progress of DNASE1L3 in autoimmune diseases and other diseases in recent years.
		2022 Vol. 19 (5): 48-51 [Abstract] ( 84 ) HTML (1 KB) PDF (496 KB) ( 41 )

	52	Relationship between doctors’ sense of compensation justice and turnover intention in a tertiary hospital #br#
		TAO Mengqi LU Xinyi CHEN Jing▲
		Objective To investigate the current status of compensation justice and turnover intention of clinicians in a tertiary hospital, and to explore the dimensions of salary fairness and influence on turnover intention. Methods In March 2021, a self-made questionnaire was used to investigate the salary fairness and turnover tendency of clinicians in a tertiary hospital. Results A total of 210 copies were issued, 205 copies were recovered, 204 valid questionnaires were issued, and the effective recovery rate was 99.51%. There was no statistically significant difference in the comparison of physicians’ salary fairness, its dimensions, and turnover intention scores with different demographic indicators (P ＜ 0.05). Procedural and interactive fairness (r = -0.440), distribution fairness (r = -0.323) was significantly negatively correlated with turnover intention (P ＜ 0.01). Procedural and interactive fairness was positively correlated with distribution fairness (r = 0.707, P ＜ 0.01). Regression analysis showed that the process and the sense of interaction justice were the influencing factors of turnover intention (P ＜ 0.01), and the explanation rate was 22.5%. Conclusion Physicians’ sense of salary fairness is low, and their turnover tendency is weak. Salary fairness is divided into two dimensions: distribution fairness, procedure and interaction fairness. The sense of fairness of procedures and interactions negatively affects turnover intention. It is recommended to strengthen the fairness of the hospital’s salary system and increase the participation of doctors in the formulation and revision of the salary system.
		2022 Vol. 19 (5): 52-55 [Abstract] ( 27 ) HTML (1 KB) PDF (534 KB) ( 33 )

	56	Status quo and influencing factors of sleep quality among the elderly in military cadre sanitariums in Hefei area#br#
		JIANG Wei1 WANG Nian2 SANG Qiuju3 FAN Qingxuan1 LIU Wenzhu1 HU Xin1
		Objective To investigate and analyze the sleep quality status and related influencing factors of the elderly in the military cadre sanitariums in Hefei area. Methods From January to March 2021, the stratified cluster sampling method was adopted, the general situation questionnaire and the Pittsburgh sleep quality index (PSQI) scale were used to investigate the elderly over 80 years old in Anhui Military Region Hefei No.1 to No.5 Dry cadre sanitariums. Results A total of 230 questionnaires were distributed, 215 valid questionnaires were recovered, and the effective recovery rate was 93.48%. The incidence rate of sleep disorder in 215 elderly people was 57.21%. There were statistically significant differences in sleep quality among elderly people with different gender, marital status, habit of drinking milk before going to bed, frequent outdoor activities, body mass index, number of chronic diseases, history of hypertension, history of stroke, and history of chronic obstructive pulmonary disease (P < 0.05). No spouse (OR = 1.990, 95%CI: 1.097-3.613), history of hypertension (OR = 2.784, 95%CI: 1.428-5.431), history of stroke (OR = 5.545, 95%CI: 1.584-19.416), history of chronic obstructive pulmonary disease (OR = 3.725, 95%CI: 1.233-11.250) were risk factor for sleep disorders (P ＜ 0.05); while the habit of drinking milk before going to bed (OR = 0.539, 95%CI: 0.295-0.984), regular participation in outdoor activities (OR = 0.502, 95%CI: 0.274-0.920) were protective factor for sleep disorders (P ＜ 0.05). Conclusion The incidence of sleep disorders in the elderly in the military cadre sanitarium in Hefei area is high, and the occurrence of sleep disorders is significantly related to a variety of factors.
		2022 Vol. 19 (5): 56-59 [Abstract] ( 225 ) HTML (1 KB) PDF (504 KB) ( 57 )

	60	Reliability and validity analysis and application of MMAS-8 in evaluating the compliance of inhaled DPIs in patients with COPD#br#
		YUAN Ling YANG Qing CAI Ning TONG Deyin
		Objective To evaluate the reliability and validity of the Morisky medication adherence scale (MMAS-8) in investigating the compliance of inhaled DPIs in COPD patients, to analyze the influence of different factors on medication compliance, and to evaluate the effect of medication management services on medication compliance. Methods A total of 110 patients with COPD who were hospitalized in the Department of Respiratory Medicine in a hospital from May to October 2019 were selected for MMAS-8 score and reliability and validity analysis. Drug treatment management services were provided to patients, and MMAS-8 was used to evaluate patients’ medication compliance before and after drug treatment management services. Results Among the 101 patients, the compliance at the time of enrollment was (4.39±2.01) points. There were statistically significant differences in the compliance of different medical insurance, educational level, and inhalation device usage time (P ＜ 0.05). There was a significant difference in the mean scores of the two extreme groups in the top 27% (25 patients) and the bottom 27% (25 patients) of the total scale score (P ＜ 0.05), and the internal consistency coefficient was 0.657. The validity (KMO) value was 0.680, and the Bartlett’s sphericity test value was 119.900. Three common factors were extracted, explaining 60.203% of the total variance. Adherence factors were medical insurance type, educational level, and inhalation device usage time. The patients’ compliance after a year was (6.25±1.06) points after the medication management service. There were statistically significant differences in the total compliance scores, unintentional, and intentional scores before and after medication therapy management service (P ＜ 0.05). Conclusion The MMAS-8 scale has good reliability and validity, and medication management services can help improve the compliance of patients with inhaled DPIs.
		2022 Vol. 19 (5): 60-63 [Abstract] ( 128 ) HTML (1 KB) PDF (510 KB) ( 50 )

	64	Investigation and analysis of the relationship between traditional Chinese medicine constitution and tongue image in 609 children with physical examination in the Affiliated Hospital of Changchun University of Chinese Medicine#br#
		TIAN Tong1 SUN Liping2
		Objective According to the children’s traditional Chinese medicine constitution identification scale, to analyze the distribution of constitution and tongue characteristics of 609 children aged 1-6 who underwent physical examination in Changchun University of Chinese Medicine Hospital (hereinafter referred to as “our hospital”), to explain the relationship and law of the two, and to provide a reference for the judgment and classification of children’s physique. Methods The children (1-6 years old) who underwent physical examination in our hospital from January to December 2020 were taken as the subjects, while the correlation between the two was analyzed by using the tongue image collection instrument and the method of issuing and filling in the scale. Results A total of 620 scales were distributed in this survey, 609 valid scales were recovered, and the effective recovery rate of the scales was 98.23%. There was a highly statistically significant difference in the tongue color of children with different constitution types (P ＜ 0.01). There was a highly statistically significant difference in the tongue shape of children with different constitution types (P ＜ 0.01). Different constitution types were positively correlated with tongue color and tongue shape (r = 0.397, 0.541, P < 0.01). There were highly statistically significant differences in moss of children with different constitution types (P ＜ 0.01). There was a highly statistically significant difference in the moss color of children with different constitution types (P ＜ 0.01). Different physique types were negatively correlated with moss (r = -0.276, P ＜ 0.01); different physique types were positively correlated with moss color (r = 0.305, P ＜ 0.01). Conclusion There is a correlation between traditional Chinese medicine constitution and tongue characteristics of 609 children aged 1-6 years old in our hospital. Tongue characteristics have a certain guiding role in the identification of physical constitution, and tongue characteristics can provide reference for the judgment and classification of children’s constitution.
		2022 Vol. 19 (5): 64-67 [Abstract] ( 109 ) HTML (1 KB) PDF (538 KB) ( 48 )

	68	Changes and clinical significance of serum PCT, CRP, and IL-6 levels in patients with coronary heart disease complicated with pulmonary infection in department of cardiology#br#
		ZHAN Yongzhong1 CHENG Longfei2 LIN Xucheng1
		Objective To investigate the changes and clinical significance of serum procalcitonin (PCT), C-reactive protein (CRP), and interlukin-6 (IL-6) levels in patients with coronary heart disease complicated with pulmonary infection in department of cardiology. Methods The diagnosis and treatment situation of 80 patients with coronary heart disease who were treated in Chaozhou Central Hospital in Guangdong Province (“our hospital” for short) from March 2018 to March 2021 were retrospectively analyzed. According to the diagnostic criteria of pulmonary infection, they were divided into infection group (32 cases) and non-infection group (48 cases), and 50 healthy people who underwent physical examination in our hospital during the same period were selected as control group. Serum levels of PCT, CRP, and IL-6 in each group were detected and compared, and the degree of coronary lesions in the infection group was evaluated according to Gensini score. Pearson linear correlation was used to analyze the correlation between PCT, CRP, IL-6 levels, and Gensini score. Results The serum levels of PCT, CRP, and IL-6 in the infection group and non-infection group were significantly higher than those in the control group, while the serum PCT, CRP, and IL-6 levels in the infection group were higher than those in the non-infection group, and the differences were statistically significant (P ＜ 0.05). There was a statistically significant difference in Gensini score between the two groups (P ＜ 0.01). Pearson linear correlation analysis showed that the levels of serum PCT (r = 0.603), CRP (r = 0.685), IL-6 (r = 0.574) in the infection group were positively correlated with Gensini scores (P ＜ 0.01). Conclusion The serum levels of PCT, CRP, and IL-6 in patients with coronary heart disease complicated with pulmonary infection in the department of cardiology are significantly increased. The detection of the above indicators has certain diagnostic value for coronary heart disease complicated with pulmonary infection.
		2022 Vol. 19 (5): 68-70,78 [Abstract] ( 134 ) HTML (1 KB) PDF (488 KB) ( 150 )

	71	Correlation of cognitive dysfunction with vascular endothelial function, oxidative stress, and white matter changes in patients with posterior circulation ischemia-induced dizziness#br#
		Aotongsha·rehemaiti1 YANG Lijuan1 Abudureheman·mamati2 LI Hongyan1
		Objective To investigate the correlation of cognitive dysfunction with vascular endothelial function, oxidative stress, and white matter changes in patients with posterior circulation ischemia-induced dizziness. Methods A total of 598 patients with posterior circulation ischemia-induced dizziness in Xinjiang Uygur Autonomous Region People’s Hospital from January 2018 to January 2021 were selected as observation subjects. According to the occurrence of cognitive dysfunction, they were divided into cognitive dysfunction group (121 cases) and non-cognitive dysfunction group (477 cases). The age related white matter changes (ARWMC) score was used to assess the severity of white matter change. The levels of vascular endothelial function, oxidative stress index, and ARWMC score were compared between the two groups, and the correlation between these indexes and the occurrence of cognitive dysfunction was analyzed. Results The levels of endothelin-1 (ET-1), malondialdehyde (MDA), and ARWMC score in the cognitive dysfunction group were higher than those in the non-cognitive dysfunction group, and the levels of calcitonin gene-related peptide (CGRP), nitric oxide (NO), and superoxide dismutase (SOD) were lower than those in non-cognitive dysfunction group, the differences were statistically significant (P ＜ 0.05). Spearman correlation analysis showed that ET-1, MDA levels, and ARWMC score were positively correlated with the occurrence of cognitive dysfunction (rs ＞ 0, P ＜ 0.05), CGRP, NO, and SOD levels were negatively correlated with cognitive dysfunction (rs ＜ 0, P ＜ 0.05). Conclusion Patients with posterior circulation ischemia-induced dizziness have a high incidence of cognitive dysfunction, which is related to vascular endothelial function, oxidative stress, and white matter changes. Clinically, cognitive dysfunction in patients with this disease can be prevented from alleviating vascular endothelial injury and oxidative stress, and white matter change can be evaluated for patients to help early recognition of cognitive dysfunction.
		2022 Vol. 19 (5): 71-74 [Abstract] ( 112 ) HTML (1 KB) PDF (589 KB) ( 23 )

	75	Analysis of influencing factors of short-term prognosis of acute ischemic stroke patients with intravenous thrombolysis#br#
		SHEN Hailin DAI Jie WANG Han ZHU Xiangyang
		Objective To investigate the influencing factors of short-term prognosis in acute ischemic stroke patients with intravenous thrombolysis. Methods A retrospective analysis was performed on 318 hospitalized patients who received intravenous recombinant human tissue plasminogen activator from October 2018 to January 2021 in the First People’s Hospital of Nantong, Jiangsu Province. Short-term prognostic index was modified Rankin scale score at three months after onset, including 0-2 scores in 173 cases (good prognosis group) and ≥3 scores in 145 cases (poor prognosis group). Univariate and multivariate analysis were performed on the clinical data of the two groups to explore the influencing factors of short-term prognosis. Results The National Institutes of Health stroke scale (NIHSS) score at admission, proportion of atrial fibrillation, glucose to glycated haemoglobin ratio (GAR), fasting blood glucose, and proportion of hemorrhage conversion in the poor prognosis group were higher than those in the good prognosis group, the uric acid level and the neutrophil to lymphocyte ratio were lower than those in the good prognosis group, the differences were statistically significant (P ＜ 0.05). Multivariate analysis showed that high NIHSS score at admission, atrial fibrillation, and high GAR were independent risk factors for poor short-term prognosis in acute ischemic stroke patients with intravenous thrombolysis (OR ＞ 1, P ＜ 0.05), high uric acid was its protective factor (OR ＜ 1, P ＜ 0.05). Conclusion NIHSS score at admission, GAR, atrial fibrillation, and uric acid level have certain influence on short-term prognosis of acute ischemic stroke patients with intravenous thrombolysis.
		2022 Vol. 19 (5): 75-78 [Abstract] ( 161 ) HTML (1 KB) PDF (475 KB) ( 68 )

	79	Effect of Chaihu plus Longgu Muli Decoction on patients with post-stroke depression with liver qi stasis#br#
		ZHANG Jing YU Lijiao GUO Panpan SHEN Cui FENG Yanmin▲
		Objective To investigate the effect of Chaihu plus Longgu Muli Decoction on patients with post-stroke depression with liver qi stasis. Methods A total of 114 patients with post-stroke depression with liver qi stasis admitted to the Second Hospital of Shijiazhuang from January 2019 to May 2020 were selected and divided into control group and observation group by random number table method, with 57 patients in each group. The control group was treated with Flupentixol and Melitracine Tablets on the basis of conventional treatment, and the observation group was treated with Chaihu plus Longgu Muli Decoction on the basis of conventional treatment. Both groups were treated for four weeks. The clinical efficacy and changes of plasma 5-hydroxytryptamine (5-HT), brain-derived neurotrophic factor (BDNF), and peripheral blood neutrophil to lymphocyte ratio (NLR) before and after treatment were observed. Hamilton depression scale (HAMD) and National Institutes of Health stroke scale (NIHSS) scores were compared between the two groups before and after treatment. Results The total effective rate of observation group was higher than that of control group, and the difference was statistically significant (P ＜ 0.05). After treatment, the levels of plasma 5-HT and BDNF were higher than before treatment, and the NLR in peripheral blood, HAMD, and NIHSS scores in peripheral blood were lower than those before treatment, and the plasma 5-HT and BDNF levels in the observation group were higher than those in the control group, and the NLR in peripheral blood, HAMD, and NIHSS scores were lower than those in the control group, the differences were statistically significant (P ＜ 0.05). Conclusion Chaihu plus Longgu Muli Decoction has a significant effect in the treatment of post-stroke depression with liver qi stasis, which can quickly relieve the clinical symptoms of patients, and is worth promoting.
		2022 Vol. 19 (5): 79-81,85 [Abstract] ( 131 ) HTML (1 KB) PDF (600 KB) ( 54 )

	82	Correlation analysis of serum uric acid, CysC, and Hcy with the course and severity of disease in elderly patients with Parkinson disease#br#
		ZHANG Jiahe1 KE Kaifu2 SHI Jiansheng2 ZHANG Qi1
		Objective To analyze the correlation of blood uric acid (UA), cystatin C (CysC), and homocysteine (Hcy) with the course and severity of disease in elderly patients with Parkinson disease. Methods Eighty-six elderly Parkinson disease patients admitted to Affiliated Ruici Hospital of Nantong University from January 2018 to January 2021 were selected. They were divided into <6 years group (45 cases), 6-10 years group (28 cases), and >10 years group (13 cases) according to the course of the disease; they were divided into mild group (25 cases), moderate group (43 cases), and severe group (48 cases) according to the Hoehn-Yahr grading scale. Serum UA, CysC, and Hcy levels in patients with different courses of disease and different severity of disease were compared, and the correlation between serum UA, CysC, and Hcy levels and the course of disease and severity of disease were analyzed by Spearman correlation analysis. Results The serum UA level in >10 years group was lower than that in 6-10 years group and <6 years group; the serum UA level in 6-10 years group was lower than that in <6 years group, and the differences were statistically significant (P < 0.05). The levels of serum CysC and Hcy in >10 years group were higher than those in 6-10 years group and <6 years group; and the levels of serum CysC and Hcy in 6-10 years group were higher than those in <6 years group, and the differences were statistically significant (P < 0.05). The serum UA level in severe group was lower than that in moderate group and mild group; the serum UA level in moderate group was lower than that in mild group, and the differences were statistically significant (P < 0.05). The levels of serum CysC and Hcy in severe group were higher than those in moderate group and mild group; and the levels of serum CysC and Hcy in moderate group were higher than those in mild group, and the differences were statistically significant (P < 0.05). Serum UA level was negatively correlated with the course of disease (P < 0.05); serum CysC and Hcy levels were positively correlated with the course of disease and severity of disease (P < 0.05). Conclusion The changes of serum UA, CysC, and Hcy levels in elderly patients with Parkinson disease with different course and severity of disease are significant, clinical monitoring of the changes of serum UA, CysC, and Hcy levels is of great importance for prevention and treatment and control of disease development.
		2022 Vol. 19 (5): 82-85 [Abstract] ( 74 ) HTML (1 KB) PDF (520 KB) ( 15 )

	86	Effect of Butylphthalide in the treatment of acute ischemic stroke and its influence on serum factors#br#
		GU Wei ZHU Zhengping CHEN Yulan LI Rongping HU Ting▲ XUE Xingxin
		Objective To investigate the effect of Butylphthalide on acute ischemic stroke (AIS) and its effect on serum neuron-specific enolase (NSE) and C-reactive protein (CRP). Methods A total of 100 AIS patients admitted to Nanjing Pukou District Hospital of Traditional Chinese Medicine from December 2017 to September 2019 were selected as research objects, they were divided into the control group (50 cases) and the observation group (50 cases) according to the random number table method. Control group was treated with conventional drug therapy, and observation group was treated with Butylphthalide on the basis of control group. The clinical efficacy of two groups was compared; NSE and CRP levels were compared between two groups before and after treatment; National Institutes of Health stroke scale (NIHSS), mini mental state examination (MMSE) and Montreal cognitive assessment scale (MoCA) scores were compared between two groups. Results The clinical efficacy of observation group was better than control group (P < 0.05). After treatment, serum NSE and CRP levels in two groups were lower than those before treatment, and observation group was lower than control group (P < 0.05). After treatment, NIHSS scores in both groups were lower than those before treatment, MMSE and MoCA scores were higher than those before treatment; NIHSS score of observation group was lower than that of control group, MMSE and MoCA scores were higher than those of control group (P < 0.05). Conclusion Butylphthalide treatment of AIS has significant clinical effect, which can significantly reduce the level of inflammatory factors, protect nerve cells, and effectively improve the neurological deficit of AIS patients.
		2022 Vol. 19 (5): 86-88,92 [Abstract] ( 124 ) HTML (1 KB) PDF (618 KB) ( 16 )

	89	Influencing factors of ineffective treatment of hyperbaric oxygen in patients with persistent vegetative state after craniocerebral injury#br#
		ZOU Yuting LUO Chaojin
		Objective To investigate the influencing factors of ineffective treatment of hyperbaric oxygen in patients with persistent vegetative state (PVS) after craniocerebral injury. Methods A retrospective analysis was performed on 55 patients with PVS after craniocerebral injury who had ineffective treatment of hyperbaric oxygen in West China Hospital, Sichuan University (hereinafter referred to as “our hospital”) from March 2019 to March 2021 were ineffective group; 55 patients with PVS after craniocerebral injury who had effective treatment of hyperbaric oxygen in our hospital during the same period were collected as effective group, the clinical data of all patients were consulted, baseline data of two groups were counted and compared, the influencing factors of ineffective treatment of hyperbaric oxygen in patients with PVS after craniocerebral injury were analyzed. Results The proportion of age≥60 years old, severe craniocerebral injury, hyperbaric oxygen intervention time ≥30 d, intracranial hematoma in ineffective group were higher than those in effective group, and the differences were statistically significant (P < 0.05). Age ≥60 years old, severe craniocerebral injury, hyperbaric oxygen intervention time ≥30 d, intracranial hematoma were risk factors of ineffective treatment of hyperbaric oxygen in patients with PVS after craniocerebral injury (OR > 1, P < 0.05). Conclusion The ineffective treatment of hyperbaric oxygen in patients with PVS after craniocerebral injury may be affected by advanced age, severe craniocerebral injury, hyperbaric oxygen intervention time, intracranial hematoma, and other factors.
		2022 Vol. 19 (5): 89-92 [Abstract] ( 58 ) HTML (1 KB) PDF (545 KB) ( 80 )

	93	Strategies for assisting pregnancy with traditional Chinese medicine for elderly couples in three-child era#br#
		JIA Zhicheng1 LI Ran1 GUO Ying2
		With the promulgation of three-child policy, the willingness of elderly couples to bear children has increased significantly, and they are also facing multiple difficulties in fertility. Traditional Chinese medicine has systematic theories and rich clinical experience in cognition of the physical and mental characteristics of elderly couples and strategies for assisting pregnancy. This paper explores the reproductive characteristics of elderly couples in the age of three-child era, discusses their physical and mental states from the aspects of “shape” and “spirit” of traditional Chinese medicine, grasps the constitution of elderly couples from the “holistic concept” in traditional Chinese medicine; based on the classic syndrome differentiation of zang-fu organs, syndrome differentiation and treatment, legislation along with syndrome, according to the the theory of health preservation with the characteristics of traditional Chinese medicine, abstinence to preserve the essence and pre-cultivation of the damage, the combination of traditional Chinese medicine and modern assisted reproductive technology, from the multidimensional perspective of the guidance of traditional Chinese medicine theory of strategies for assisting pregnancy for elderly couples.
		2022 Vol. 19 (5): 93-96,100 [Abstract] ( 149 ) HTML (1 KB) PDF (769 KB) ( 43 )

	97	Analysis of influencing factors of relaceration after lateral episiotomy for primiparas vaginal delivery#br#
		TANG Beibei DING Weiwei ZHANG Yuanyuan XUE Mei▲
		Objective To explore the influencing factors of relaceration after lateral episiotomy for primiparas vaginal delivery. Methods The clinical data of 86 primiparas who underwent vaginal delivery in the Department of Obstetrics, the First Affiliated Hospital of Nanjing Medical University from January to July 2018 were retrospectively analyzed. They were divided into control group and laceration group according to the absence or presence of relaceration after lateral episiotomy. The influencing factors of relaceration after lateral episiotomy were analyzed. Results Among 86 primiparas, 10 cases （11.63%） suffered from relaceration, including 8 cases with grade Ⅰ laceration and 2 cases with grade Ⅱ laceration. The proportion of newborn weight≥ 4000 g and working years of midwife ＜ 5 years in laceration group were higher than those in control group（P < 0.05）. Newborn weight≥4000 g, working years of midwife＜5 years were independent risk factors for relaceration after lateral episiotomy (OR > 1, P < 0.05). Conclusion The incidence of relaceration after lateral episiotomy is increased in primiparas with newborn weight≥4000 g and working years of midwife ＜5 years.
		2022 Vol. 19 (5): 97-100 [Abstract] ( 149 ) HTML (1 KB) PDF (552 KB) ( 45 )

	101	Clinical effect of self-made Qingpen Recipe for internal administration combined with external in the treatment of damp-heat stasis type pelvic inflammatory #br#
		LI Weiwei LI Rui
		Objective To explore the clinical effect of self-made Qingpan Recipe for internal administration combined with external in the treatment of damp-heat stasis type pelvic inflammatory. Methods A total of 200 patients with damp-heat stasis type pelvic inflammatory treated in Taihe Hospital of Traditional Chinese Medicine Affiliated to Anhui Vniversity of Chinese medicine, from January 2018 to December 2020 were selected as the research subjects. According to the random number table method, they were divided into observation group and control group, with 100 cases in each group. Control group was treated with Levofloxacin and Metronidazole, and observation group was treated with self-made Qingpen Recipe for internal administration combined with external enema on the basis of control group. All patients were treated for 14 days. The therapeutic effects of two groups were compared; the scores of traditional Chinese medicine syndromes, pelvic effusion, inflammatory mass diameter, inflammatory factors and immune factors levels were compared between two groups before and after treatment; the incidence of adverse reactions in two groups were recorded. Results Observation group actually enrolled 96 cases, and control group actually enrolled 95 cases. The clinical efficacy of observation group was better than that of control group, and the difference was statistically significant (P < 0.05). After treatment, the scores of lumbosacral pain, lower band weight, lower abdominal pain, and fatigue were lower than those before treatment, and observation group was lower than control group, and the differences were statistically significant (P < 0.05). After treatment, pelvic effusion, inflammatory mass diameter, and inflammatory factors levels in two groups were lower than before treatment, and observation group was lower than control group, and the differences were statistically significant (P < 0.05). After treatment, CD4+ and CD4+/CD8+ in both groups were higher than before treatment, and observation group was higher than control grou; CD8+ in observation group was lower than before treatment, and observation group was lower than control group, and the differences were statistically significant (P < 0.05). There was no significant difference in the total incidence of adverse reactions between two groups (P > 0.05). Conclusion Self-made Qingpen Recipe is safe and effective for damp-heat stasis type pelvic inflammatory, and can enhance immune function.
		2022 Vol. 19 (5): 101-104 [Abstract] ( 97 ) HTML (1 KB) PDF (593 KB) ( 16 )

	105	Expression and clinical significance of LncRNA ROR and TGF-β1 in patients with breast cancer#br#
		ZHANG Yujuan YE Huirong YUAN Huiling WANG Yongxia
		Objective To investigate the expression and clinical significance of long noncoding RNA ROR (LncRNA ROR) and transforming growth factor-β1 (TGF-β1) in breast cancer patients. Methods A total of 73 patients with breast cancer who were first diagnosed by pathology in Dongguan People’s Hospital of Guangdong Province (hereinafter referred to as “our hospital”) from January 2018 to June 2019 were selected as group A, 37 patients with benign breast lesions treated in our hospital during the same period were selected as group B and 37 healthy subjects who underwent physical examination were selected as group C. Serum LncRNA ROR levels were detected by real time fluorescence quantitative reverse transcription polymerase chain reaction (qRT-PCR), serum TGF-β1 levels were detected by enzyme-linked immunoadsordent assay, and serum carbohydrate antigen 153 (CA153) and carcinoembryonic antigen (CEA) levels were detected by electrochemiluminescence. The expression differences of LncRNA ROR, TGF-β1, CA153, and CEA of subjects in the three groups were observed, and the clinical value of LncRNA ROR, TGF-β1, CA153, and CEA in the diagnosis of breast cancer. The effects of age, degree of differentiation, clinical stage, lymph node metastasis, and phenotype on the expression of LncRNA ROR, TGF-β1, CA153, and CEA were observed. Results LncRNA ROR and TGF-β1 in group A were higher than those in group B and group C, the differences were statistically significant (P ＜ 0.05). Spearman correlation analysis showed that LncRNA ROR was positively correlated with TGF-β1 (r = 0.897, P < 0.05). The levels of CA153 and CEA in group A were higher than those in group B and group C, and the differences were statistically significant (P ＜ 0.05). The levels of CA153 and CEA in group B were higher than those in group C, and the differences were statistically significant (P ＜ 0.05). There was no significant difference between LncRNA ROR and TGF-β1 in predicting area under the curve (AUC) of breast cancer (P ＞ 0.05). LncRNA ROR and TGF-β1 predicted higher AUC than CA153 and CEA, the differences were statistically significant (P ＜ 0.05). There were statistically significant differences in LncRNA ROR and TGF-β1 levels among breast cancer patients with different clinical tumor stages (P ＜ 0.05). Serum LncRNA ROR and TGF-β1 levels in breast cancer patients with lymph node metastasis were higher than those in patients without lymph node metastasis, the differences were statistically significant (P ＜ 0.05). Conclusion Serum LncRNA ROR and TGF-β1 may be potential markers for breast cancer diagnosis. The expression of serum LncRNA ROR and TGF-β1 is correlated with tumor stage and lymph node metastasis, which has certain reference value for prognosis.
		2022 Vol. 19 (5): 105-109,123 [Abstract] ( 183 ) HTML (1 KB) PDF (870 KB) ( 26 )

	110	Expression and clinical significance of miR-340-5p, c-Myc, and TCF-4 in laryngeal cancer tissues
		ZHOU Haiting ZHAO Yu QIU Ying
		Objective To study the expression of microRNA (miR)-340-5p, proto-oncogene c-Myc and transcription factor-4 (TCF-4) in laryngeal cancer tissues, and to analyze the correlation between the expression of them and the clinicopathological characteristics of laryngeal cancer. Methods A total of 102 patients with laryngeal cancer treated in Panjin Liaoyou Baoshihua Hospital from February 2015 to November 2020 were selected as the research subjects. The expressions of miR-340-5p, c-Myc, TCF-4 in cancer tissues and para-cancer tissue of 102 patients with laryngeal cancer were detected by real time fluorescence quantitative reverse transcription polymerase chain reaction. The correlation between the expressions of them and clinicopathological characteristics was statistically analyzed, and the correlation between the expressions of them was analyzed by Pearson linear correlation. Results Compared with para-cancer tissues, the relative expression levels of miR-340-5p in cancer tissues were significantly lower, while the relative expression levels of c-Myc and TCF-4 were significantly higher (P ＜ 0.05). There were statistically significant differences in the expressions of miR-340-5p, c-Myc, and TCF-4 in laryngeal cancer tissues with different tumor stages (P ＜ 0.05), while there were no statistically significant differences in gender, age, parting, tumor differentiation degree and whether or not lymph node metastasis (P ＜ 0.05). The expression of miR-340-5p was negatively correlated with c-Myc and TCF-4 (r = -0.549, -0.452, P < 0.05). Conclusion The expression of miR-340-5p is decreased in laryngeal cancer tissues, while the expression of c-Myc and TCF-4 is up-regulated. miR-340-5p, c-Myc, and TCF-4 are all related to the tumor stages of laryngeal cancer and are involved in the occurrence and development of laryngeal cancer.
		2022 Vol. 19 (5): 110-114 [Abstract] ( 33 ) HTML (1 KB) PDF (809 KB) ( 33 )

	115	Effects of MDT nutritional intervention on the efficacy and immune function of elderly patients with radical radiotherapy and chemotherapy for gastric cancer#br#
		DAI Kejun1 LIU Yongping2▲ HUANG Xue2 CHENG Jing2 FANG Mingming2
		Objective To investigate the effects of multidisciplinary team (MDT) nutritional intervention on the efficacy and immune function of elderly patients with radical radiotherapy and chemotherapy for gastric cancer. Methods A total of 118 elderly patients with radical radiotherapy and chemotherapy for gastric cancer admitted to the Third Affiliated Hospital of Soochow University from December 2017 to December 2019 were selected as the research subjects. They were divided into control group and nutritional intervention group by random envelope method, with 59 patients in each group. Both groups received radical radiotherapy and chemotherapy. The control group did not receive nutritional education guidance and systematic nutritional support, while the nutritional intervention group received MDT nutritional intervention, which lasted for 14 weeks in both groups. The patient-generated subjective global assessment (PG-SGA) grading, immunoglobulin M (IgM), Beck depression inventory (BDI) and health promoting lifestyle profile-Ⅱ (HPLP-Ⅱ) were compared between two groups before and after intervention. Results Before intervention, there was no significant difference in PG-SGA grading between the two groups (P ＞ 0.05). After intervention, the PG-SGA grading of the nutritional intervention group was better than that of the control group, and the difference was statistically significant (P ＜ 0.05). Before intervention, there were no significant differences in IgM, BDI scores and HPLP-Ⅱ scores between the two groups (P ＞ 0.05). After intervention, IgM and BDI scores of both groups were decreased before intervention, and IgM and BDI scores of nutritional intervention group were lower than those of control group, the differences were statistically significant (P ＜ 0.05). After intervention, HPLP-Ⅱ scores in both groups were higher than before intervention, and nutritional intervention group was higher than control group, the differences were statistically significant (P ＜ 0.05). Conclusion MTD nutritional intervention can improve nutritional status, immune function, depression mood and quality of life in elderly patients with gastric cancer who underwent radical radiotherapy and chemotherapy.
		2022 Vol. 19 (5): 115-118 [Abstract] ( 174 ) HTML (1 KB) PDF (552 KB) ( 22 )

	119	Effect of Dingchen Fuzheng Decoction on gastrointestinal function recovery and Th1/Th2 immune drift after operation of digestive system malignant tumor#br#
		GAO Xiaojie1 CHEN Juan2 ZHANG Jing1 HAO Jianwen1
		Objective To investigate the effect of Dingchen Fuzheng Decoction on gastrointestinal function recovery and Th1/Th2 immune drift after operation of digestive system malignant tumor. Methods A total of 120 patients with digestive system malignant tumor who underwent surgical treatment in Hebei General Hospital for Veterans from January 2018 to December 2019 were selected and they were divided into observation group and control group according to random number table method, with 60 cases in each group. The observation group was treated with basic treatment and Dingchen Fuzheng Decoction, while the control group was treated with basic treatment and Motilium. After one month of treatment, the postoperative indexes, motilin, vasoactive intestinal peptide, cytokine levels and type 1 helper T cells/type 2 helper T cells (Th1/Th2) levels of the two groups were observed. Results The recovery time of bowel sound, postoperative first exhaust time, postoperative first defecation time and postoperative total flow recovery time in the observation group were lower than those in the control group (P ＜ 0.01). One month after surgery, motilin levels in both groups were increased and vasoactive peptide levels were decreased compared with one day after surgery, and the motilin level in observation group was higher than that in control group, while vasoactive peptide level was lower than that in control group (P ＜ 0.05). One month after surgery, the levels of interleukin (IL)-2 in the two groups were increased and the levels of IL-4, IL-6, and interferon -γ (IFN-γ) were decreased compared with that one day after surgery, and the level of IL-2 in the observation group was higher than the control group. The levels of IL-4, IL-6, and IFN-γ were lower than those of control group (P ＜ 0.05). The Th1/Th2 level in the observation group was significantly higher than that in the control group one month after surgery (P ＜ 0.05). The total incidence of postoperative complications in the observation group was lower than that in the control group (P ＜ 0.01). Conclusion Dingchen Fuzheng Decoction has a good effect on gastrointestinal dysfunction after operation of digestive system malignant tumor, and can improve Th1/Th2 drift.
		2022 Vol. 19 (5): 119-123 [Abstract] ( 95 ) HTML (1 KB) PDF (683 KB) ( 64 )

	124	Application of the shortest diameter of lymph nodes in enhanced CT and SCC-Ag predicting pre-operation lymph node metastasis in cervical squamous cell carcinoma#br#
		QIN Lin WU Yumei WANG Ming WEI Jiahui
		Objective To investigate the application value of the shortest diameter of lymph nodes in enhanced CT and squamous cell carcinoma antigen (SCC-Ag) in diagnosing lymph node metastasis pre-operation in cervical squamous cell cancer. Methods Patients with cervical squamous cell carcinoma ⅠA1-ⅢCr stage who underwent radical cervical surgery in Beijing Obstetrics and Gynecology Hospital, Capital Medical University from October 2019 to December 2020 were selected. By single factor analysis and evaluation of the factors related to lymph node metastasis, the prediction model of lymph node metastasis was established and the predictive value of the model was evaluated. Results A total of 189 patients were included, including 30 in the lymph node metastasis group. There were statistically significant differences in maximum diameter, clinical stage, cell differentiation, preoperative serum SCC-AG and enhanced CT lymph node short diameter between the two groups (P ＜ 0.001), but there were no statistically significant differences in age and HPV infection (P ＞ 0.05). The best truncation value was 0.625cm, area under curve (AUC) value was 0.827 cm (P ＜ 0.001), sensitivity was 66.7%, and specificity was 83.0%, respectively. The optimal cut-off value of SCC-AG in predicting cervical squamous cell carcinoma lymph node metastasis was 1.88 ng/ml, AUC value was 0.733 (P ＜ 0.001), sensitivity was 66.7%, and specificity was 73.6%. The AUC value of the combined detection was 0.802 (P ＜ 0.001), the sensitivity was 66.7%, and the specificity was 84.3%. Conclusion SCC-Ag and the shortest diameter of lymph nodes in enhanced CT can be used to evaluate lymph node metastasis in patients with cervical squamous cell carcinoma,and the diagnostic value of the shortest diameter of lymph nodes in enhanced CT is higher,which provides a reference for clinical treatment planning.
		2022 Vol. 19 (5): 124-128 [Abstract] ( 41 ) HTML (1 KB) PDF (653 KB) ( 41 )

	129	Effect of modified Ivor-Lewis operation and Mckeown operation in the treatment of esophageal cancer and its influence on lung function and inflammatory indexes#br#
		REN Qiang1 YANG Dabin1 WU Kai1 ZHOU Qianhua2
		Objective To study the effect of modified Ivor Lewis operation and Mckeown operation in the treatment of esophageal cancer and its influence on lung function and inflammatory indexes. Methods A total of 80 patients with esophageal cancer treated in Huaibei Coal Miners General Hospital of Anhui Province from March 2017 to February 2021 were selected and they were divided into group A and group B by random number table method, with 40 patients in each group. Group A was treated with modified Ivor-Lewis and group B was treated with Mckeown. The changes of perioperative indexes, forced vital capacity (FVC), forced expiratory volume per second /FVC (FEV1/FVC), procalcitonin (PCT), C-reactive protein (CRP), tumor necrosis factor-α (TNF-α), and the incidence of postoperative complications were compared between the two groups. Results The operative time and hospital stay of group A were shorter than that of group B, and the amount of intraoperative blood loss was less than that of group B (P ＜ 0.05). The levels of FVC, FEV1/FVC in group A were higher than those in group B, and the levels of PCT, CRP and TNF-α in serum were lower than those in group B (P ＜ 0.05). The total incidence of complications in group A was lower than that in group B (P ＜ 0.05). Conclusion Compared with Mckeown surgery, the modified Ivor-Lewis surgery have less impact on lung function and inflammatory indexes in patients with esophageal cancer.
		2022 Vol. 19 (5): 129-132 [Abstract] ( 197 ) HTML (1 KB) PDF (578 KB) ( 60 )

	133	Reporting quality of randomized controlled trials of Xiaozhiling Injection for rectal prolapse based on CONSORT statement#br#
		LI Yingqian BAO Wenliang LI Huashan
		Objective To evaluate the reporting quality of randomized controlled trials (RCT) on the treatment of rectal prolapse by Xiaozhiling Injection. Methods The RCTs of Xiaozhiling Injection in the treatment of rectal prolapse were systematically searched by PubMed, Cochrane Library, CNKI, VIP, Wanfang dara and CBM from the database establishment to July 2021, and the included literature was evaluated by CONSORT statement (2010 edition). Results A total of 18 articles were included. Among them, 8 articles (44%) described the purpose or hypothesis of the study, 5 articles (28%) reported the method of generating random sequence, 1 articles (6%) gave the type of random method, 1 articles (6%) mentioned the allocation hidden mechanism, 8 articles (44%) referred to adverse events, and 2 articles (11%) described the limitations of the study. The writing of the topic was not in accordance with the standard, and blind method was not applied in all the literature, and there was a lack of description of the trial design, sample size estimation, auxiliary analysis, extensibility, trial registration, funding, and other aspects. Conclusion There are some deficiencies in the report quality of Xiaozhiling Injection in the treatment of rectal prolapse RCTs. It is suggested that the researchers refer to CONSORT statement to design, implement and write RCT, so as to improve the research quality.
		2022 Vol. 19 (5): 133-137 [Abstract] ( 40 ) HTML (1 KB) PDF (889 KB) ( 30 )

	138	Clinical effect of Bromocriptine Mesylate combined with Xiaoyong Sanjie Decoction in the treatment of non-lactation mastitis#br#
		SHEN Weijuan ZHANG Yi▲ YU Weijia
		Objective To explore the effect of Bromocriptine Mesylate combined with Xiaoyong Sanjie Decoction on non-lactation mastitis. Methods A total of 62 non-lactation mastitis patients admitted to Changzhou Wujin People’s Hospital, Jiangsu Province, from May 2017 to May 2020 were selected as the research subjects, the subjects were random drawing into control group (Bromocriptine Mesylate was used for treatment) and study group (Bromoyinting Mesylate combined with Xiaoyong Sanjie Decoction was used for treatment), with 31 cases in each group. The efficacy was evaluated after three weeks of continuous treatment. The time when the symptoms disappeared and the incidence of adverse reactions during treatment were observed. Results After three weeks of treatment, There was no significant difference in the therapeutic effect between the two group (P ＞ 0.05). The regression time of breast pain, breast redness and pus in the study group was shorter than that in the control group, the differences were statistically significant (P ＜ 0.05); the levels of hypersensitive C-reactive protein (hs-CRP), interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α) in both groups were decreased, and the levels of hs-CRP, IL-6, and TNF-α in the study group were lower than those in the control group, the differences were statistically significant (P ＜ 0.05). There was no significant difference in the incidence of adverse reactions between two groups during treatment (P ＞ 0.05). Conclusion Bromoyinting Mesylate combined with Xiaoyong Sanjie Decoction can speed up the improvement of symptoms, relieve inflammatory response, improve the efficacy and safety.
		2022 Vol. 19 (5): 138-141 [Abstract] ( 35 ) HTML (1 KB) PDF (599 KB) ( 37 )

	142	Discussion on medication rule of Lou Xien in treating type two diabetic peripheral neuropathy based on data mining#br#
		YAN Qingping LI Min WEN Qiao CHEN Jinfeng LOU Xien
		Objective To analyze the medication rule of Professor Lou Xien in the treatment of type two diabetic peripheral neuropathy based on data mining. Methods The prescriptions of type two diabetic peripheral neuropathy in Outpatient Department of the Third Affiliated Hospital of Beijing University of Chinese Medicine from June 2010 to June 2020 were collected. Traditional Chinese medicine inheritance auxiliary system (V2.5) was adopted. Association rules, frequency analysis and improved mutual information method were used to analyze the properties, tastes, meridians and the relationship between prescription drugs. Results A total of 229 prescriptions for the treatment of type two diabetic peripheral neuropathy by Professor Lou Xien were excavated, involving 256 drugs and 18 types of drugs. Among the four qi of drugs, warm, flat and cold were the main ones; among the five flavors of drugs, sweet taste was the highest; the meridian of drugs was mainly liver, spleen and kidney meridian. High frequency drugs included Salviae Miltiorrhizae Radix et Rhizoma, Carthami Flos, Pheretima, Gastrodiae Rhizoma, Fried Bombyx Batryticatus, and other 30 drugs. The top five drugs were tonifying deficiency drugs, promoting blood circulation and removing blood stasis drugs, promoting water and dampness drugs, clearing heat drugs and calming liver and calming wind drugs. The drug combinations with the top five use frequencies were Chuanxiong Rhizoma-Salviae Miltiorrhizae Radix et Rhizoma, Salviae Miltiorrhizae Radix et Rhizoma-Dioscoreae Rhizoma, Dioscoreae Rhizoma-Poria, Carthami Flos-Chuanxiong Rhizoma, Corni Fructus-Salviae Miltiorrhizae Radix et Rhizoma. The combination with the highest confidence was Carthami Flos, Salviae Miltiorrhizae Radix et Rhizoma→Chuanxiong Rhizoma. The top three combinations of drug correlation were Rehmanniae Radix Praeparata-Chuanxiong Rhizoma, Chuanxiong Rhizoma-Astragali Radix Praeparata Cum Melle, Salviae Miltiorrhizae Radix et Rhizoma-Carthami Flos. Conclusion In the treatment of this disease, Professor Lou Xien has the characteristics of “tonifying deficiency, reducing standard”, “harmonizing cold and heat, calming yin and yang”, “five tastes are sweet, and returning to meridians and three viscera”. On the basis of replenishing deficiency, stress blood stasis and internal wind pathological factors, flexibly use Salviae Miltiorrhizae Radix et Rhizoma-Carthami Flos and other drugs to promote blood circulation and remove blood stasis, and other drugs to calm liver and reduce wind such as Gastrodiae Rhizoma, Pheretima and Fried Bombyx Batryticatus.
		2022 Vol. 19 (5): 142-145 [Abstract] ( 216 ) HTML (1 KB) PDF (597 KB) ( 30 )

	146	Effect of modified Yinchen Sini Granules combined with comprehensive therapy of Western medicine in treating HBV-related chronic liver failure#br#
		MENG Yinjie1 QIU Hua2 LI Wang1 WANG Zigong1 ZHU Wenshuang1 HUANG Peng1
		Objective To observe the effect of modified Yinchen Sini Granules combined with comprehensive therapy of Western medicine in treating HBV-related chronic liver failure. Methods One hundred and forty patients with HBV-related chronic liver failure hospitalized in Department of Hepatology of the First Affiliated Hospital of Guangxi University of Chinese Medicine from January 2019 to January 2021 were selected and divided into control group and treatment group according to the random number table method, with 70 cases in each group. Control group was treated with comprehensive Western medicine, and treatment group was treated with modified Yinchen Sini Granules combined with comprehensive Western medicine. Both groups were treated for eight weeks. The ascites efficacy, ascites depth, abdominal circumference, body weight, 24-hour urine volume, total bilirubin (TBil), albumin (ALB), prothrombin activity (PTA), model for end-stage liver disease combined with serum sodium (MELD-Na) score and adverse reactions were compared between the two groups. Results Total effective rate of ascites in treatment group was significantly higher than that in control group, the difference was statistically significant (P < 0.05). After treatment, the ascites depth, abdominal circumference, body weight of the two groups were lower than those before treatment, and 24-hour urine volume of two groups were higher than those before treatment, and the improvement degree of treatment group was significantly higher than that of control group (P < 0.05). After treatment, the TBil, MELD-Na scores in two groups were lower than those before treatment, ALB, PTA were higher than those before treatment, and the degree of improvement in treatment group was significantly higher than that in control group, the differences were statistically significant (P < 0.05). Conclusion Modified Yinchen Sini Granules combined with Western medicine comprehensive therapy can restore liver function, promote the regression of ascites complications and improve the prognosis through the effect of reinforcing yang from collapse.
		2022 Vol. 19 (5): 146-149,166 [Abstract] ( 122 ) HTML (1 KB) PDF (740 KB) ( 69 )

	150	Visual analysis on knowledge graph of massage in treating insomnia based on CiteSpace#br#
		MU Sisi1 MA Liangliang1 WANG Yiqiong1 YANG Lulu1 GUO Lisheng1 WANG Zheng1 LI Jie1 ZHOU Yunfeng2
		Objective To provide directions for future research, knowledge map visualization based on CiteSpace is used to analyze the literature, authors, institutions and keywords of massage in the treatment of insomnia in the past 20 years. Methods The literatures on massage therapy for insomnia published in the CNKI database from January 1999 to January 2021 were used as the research object. Scientific visual analysis based on CiteSpace 5.7.R4 was used to discuss the amount of literature, authors, keywords, institutions, research hotspots and trends. Results The most influential authors were Zhou Yunfeng, Lei Longming and Pang Jun. The institution with the largest number of papers was Department of Massage, Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine. Keywords and emergent words showed that the most concerne was the quality of sleep, it showed that the research direction at this stage was the clinical efficacy, combination therapy and mechanism of massage in the treatment of insomnia. Conclusion In the past 20 years, massage treatment for insomnia has developed well, and it is in a period of steady development. The research hotspots tend to be the combination therapy of massage in the treatment of insomnia, clinical efficacy and the mechanism of insomnia. But the cooperation between different regions should be established.
		2022 Vol. 19 (5): 150-154,178 [Abstract] ( 201 ) HTML (1 KB) PDF (2898 KB) ( 65 )

	155	Bibliometric analysis of traditional Chinese medicine in the treatment of bone metastasis#br#
		YU Chengfeng1 ZHU Shijie1 MAO Yun2 LI Linlu2 JIANG Pengyuan2 CHEN Zheng2 SU Yixin1 ZHANG Xin2 ZHOU Lei1
		Objective To understand the research status of traditional Chinese medicine (TCM) in the treatment of bone metastasis (BM) by using bibliometric analysis, and to provide a reference for clinical and scientific research. Methods The related literatures of BM treated by TCM were selected from CNKI, Wanfang, VIP, and CBM databases from the establishment of the databases to December 2020, statistical analysis was carried out from the aspects of distributive age, author distribution, drug distribution rule, and curative effect evaluation. Results A total of 600 literatures were included, although the number of published literatures fluctuated, it showed an overall upward trend; the literatures were mainly published on Hunan journal of traditional Chinese medicine, journal of traditional Chinese medicine, journal of emergency in traditional Chinese medicine, and so on; the primary researchers were Liu Sheng, Jia Liqun, and Feng Li, etc. The main intervention measures of traditional Chinese medicine were oral decoction, there were relatively few studies on acupoint application and acupuncture; pain assessment and Kanofsky performance score were commonly used to evaluate the effect of BM treated by TCM. Conclusion The research content of TCM in the treatment of BM is mainly clinical research, with relatively few basic research and theoretical discussion, and the lack of unified standard for efficacy evaluation, which is a difficult problem to be solved at present.
		2022 Vol. 19 (5): 155-158 [Abstract] ( 216 ) HTML (1 KB) PDF (461 KB) ( 53 )

	159	Study on the regularity of drug use of Chinese Medical Code in the treatment of pulmonary fibrosis based on data mining#br#
		XIAO Siyao1,2 YU Yang2 XIONG Yimin1,2 LIU Yingfang1,2 ZHANG Shunan2
		Objective To explore the drug use characteristics and prescription regularity in the treatment of pulmonary fibrosis in Chinese Medical Code. Methods “Lung atrophy” “Pulmonary arthralgia” “dyspnea syndrome” as the key words, the prescriptions about the treatment of pulmonary fibrosis in Chinese Medical Code were searched, and the prescriptions were screened by reading the literatures. Excel 2010 was used to extract the data of the prescriptions and to establish the drug database, SPSS Statistics 20.0 and SPSS Molder 18.0 were used to mine the rules of prescription medication. Results The study finally included 102 prescriptions, 108 Chinese herbs, the total frequency of drugs was 813, and the use drugs with the frequency ≥10% were 24. The core compatibility drugs in the prescription include Radix Glycyrrhizae, Radix Ginseng, Poria, Radix Platycodonis, Bulbus Fritillariae Cirrhosae, Radix Asteris, Flos Farfarae, and so on. Conclusion Taking tonifying lung and spleen as the core, combined with warming or clearing heat, supplemented by relieving asthma, reducing qi, resolving phlegm, relieving cough, and other treatment are the prescription regularity for the treatment of pulmonary fibrosis in Chinese Medical Code.
		2022 Vol. 19 (5): 159-162 [Abstract] ( 191 ) HTML (1 KB) PDF (972 KB) ( 161 )

	163	Comparison the changes of related indexes of different traditional Chinese medicine syndrome types in patients with hepatolenticular degeneration#br#
		HUANG Peng1,2 DONG Ting1,2 LI Xiang1,2 WANG Han1,2 WANG Meixia1,2 YANG Wenming1,2▲
		Objective To research the changes of related indexes of different traditional Chinese medicine syndrome types in patients with hepatolenticular degeneration (HLD). Methods The clinical medical records of 100 patients with HLD admitted to the First Affiliated Hospital of Anhui University of Traditional Chinese Medicine from January 2018 to March 2021 were retrospectively analyzed. All patients were classified according to traditional Chinese medicine syndrome differentiation, there were 44 cases of internal retention of damp-heat syndrome, 34 cases of intermingled phlegm and blood stasis syndrome, 10 cases of yin deficiency of liver and kidney syndrome and 12 cases of yang deficiency of spleen and kidney syndrome. The results of blood routine, coagulation function, and liver function of patients with different traditional Chinese medicine syndrome types were compared. Results The levels of white blood cell, neutrophil, lymphocyte, red blood cell, hemoglobin, and platelet in yang deficiency of spleen and kidney syndrome were significantly lower than those in internal retention of damp-heat syndrome, intermingled phlegm and blood stasis syndrome, and yin deficiency of liver and kidney syndrome (P ＜ 0.05). The activated partial thromboplastin time, prothrombin time, and thrombin time in yang deficiency of spleen and kidney syndrome were significantly higher than those in internal retention of damp-heat syndrome, intermingled phlegm and blood stasis syndrome, and yin deficiency of liver and kidney syndrome, and the level of fibrinogen was significantly lower than that in internal retention of damp-heat syndrome, intermingled phlegm and blood stasis syndrome, and yin deficiency of liver and kidney syndrome (P ＜ 0.05). The levels of aspartic transaminase, alanine aminotransferase in intermingled phlegm and blood stasis syndrome, and yang deficiency of spleen and kidney syndrome were significantly higher than those in internal retention of damp-heat syndrome, and yin deficiency of liver and kidney syndrome, the levels of albumin in yang deficiency of spleen and kidney syndrome, and intermingled phlegm and blood stasis syndrome were significantly lower than those in yin deficiency of internal retention of damp-heat syndrome, and liver and kidney syndrome, and compared with phlegm-stasis interaction syndrome, the levels of albumin in yang deficiency of spleen and kidney syndrome were significantly decreased, the levels of total bilirubin in yang deficiency of spleen and kidney syndrome were significantly increased (P ＜ 0.05). Conclusion The traditional Chinese medicine syndrome types of HLD patients are related to the changes of liver function, blood routine, and coagulation function indexes. The above examination results can provide a reliable basis for the objectification of traditional Chinese medicine syndrome differentiation.
		2022 Vol. 19 (5): 163-166 [Abstract] ( 116 ) HTML (1 KB) PDF (539 KB) ( 113 )

	167	Zhou Yongming’s experience in the maintenance treatment of aggressive lymphoma with Chinese medicine from “phlegmatic toxin”#br#
		ZHANG Fupeng LI Jiekai BAO Jizhang ZHOU Yongming▲
		Aggressive lymphoma is a kind of malignant lymphoma with high degree of malignant and rapid clinical advance. Maintenance therapy is an important mean to delay its replase and improve refractory disease. Traditional Chinese medicine treatment has a certain role, but maintenance therapy is rarely reported at present. Professor Zhou Yongming, who has been practicing medicine for more than 40 years and has rich clinical experience, believes that the maintenance treatment of aggressive lymphoma should start with “phlegmatic toxin” and focus on “attacking evil”, modifies according to symptoms. This paper expounds that Professor Zhou Yongming makes good use of the rule of “toxin herbs”, and summarizes his academic thought and experience from the aspects of resolving phlegm and toxicity, eliminating toxicity and resolving hard mass, seeking the source of poison, helping the viscera to expel toxicity, eliminating poison and resolving dampness, and following the toxicology. In addition, typical case report is attached.
		2022 Vol. 19 (5): 167-170 [Abstract] ( 175 ) HTML (1 KB) PDF (748 KB) ( 35 )

	171	Exploration on the medication rule of Zhang Wei in the treatment of insomnia based on the traditional Chinese medicine inheritance assistant platform#br#
		WANG Ying1 CHEN Jie2 LIU Dongling2 HAN Zucheng2 WANG Jin2 ZHANG Wei3
		Objective To explore the medication rule of insomnia patients in Dr Zhang Wei’s outpatient department and inpatient department through the traditional Chinese medicine inheritance assistant platform. Methods A total of 174 cases of insomnia patients and 416 visits from January 2017 to December 2020 in Xi’an Hospital of Traditional Chinese Medicine were selected. Traditional Chinese medicine inheritance assistant platform V2.5 was used to summarized and analyzed. Results Syndrome of water retention due to qi deficiency was the most widely used syndrome type in clinic. Buzhong Yiqi Decoction were the main basal prescriptions. There were 21 Chinese herbs with frequencies ＞80; 22 groups of common drug pairs; the further evolved into six core medicine combinations, and three new prescriptions. Conclusion Dr Zhang Wei’s treatment of insomnia is mainly focuses on replenishing qi and invigorating spleen, strengthening spleen and eliminating dampness, harmonizing yingfen and weifen, combined with the products of regulating qi, promoting blood circulation, and tranquillization, provids new ideas and new plans for the clinical treatment of insomnia, which has strong clinical guiding significance.
		2022 Vol. 19 (5): 171-174 [Abstract] ( 154 ) HTML (1 KB) PDF (810 KB) ( 33 )

	175	Effect of constructing anesthetic and psychopharmaceutical service system in general hospitals#br#
		JI Ning PAN Jun XU Hui▲
		Objective To explore the construction and application effect of anesthetic and psychopharmaceutical service system in general hospitals. Methods According to the management principles of anesthetic and psychotropic drugs in China, combined with the actual situation of the Department of Pharmacy, Subei People’s Hospital of Jiangsu Province, the anesthetic and psychotropic service system was constructed, the anesthetic and psychotropic drug prescriptions of 116 patients who were prescribed within one year before (September 1, 2018 to September 1, 2019) the construction were selected and recorded as pre-implementation, and the anesthetic and psychotropic drug prescriptions of 124 patients who were prescribed within one year after (January 1, 2020 to January 1, 2021) the construction were selected and recorded as the post-implementation. The standardization of distribution and storage of narcotic psychotropic drugs before and after implementation, drug prescription turnover time, and the incidence of drug prescription related problems during treatment were compared. Results After the implementation, the scores of the distribution and custody practices of narcotic psychotropic drugs were higher than those before the implementation (P ＜ 0.01). The quarter turnaround time and average turnaround time of narcotic psychotropic drugs prescription after implementation were shorter than before implementation (P ＜ 0.01). The total incidence of problems related to narcotic and psychotropic drugs prescription after the implementation was lower than before the implementation (P ＜ 0.01). Conclusion The anesthetic and pharmaceutical psychotropic service system realizes systematic and information-based management, effectively improves the standardization and management efficiency of the distribution and storage of anesthetic psychotropic drugs, and make patients’ medication more reasonable.
		2022 Vol. 19 (5): 175-178 [Abstract] ( 35 ) HTML (1 KB) PDF (569 KB) ( 87 )

	179	Application of based on AS-NZS4360 risk management standard in patients with esophageal cancer with enteral-intestinal nutrition tube#br#
		QIAN Jinyu1 ZHU Yuan1 ZHANG Qin2 LUO Yiqing1 ZENG Shiying1 LIU Chang1
		Objective To evaluate the application of AS-NZS4360 risk management standard in esophageal cancer patients with enteral-intestinal nutrition tube. Methods From April 2020 to April 2021, 240 patients with esophageal cancer diagnosed by pathology or imaging from Shanghai Chest Hospital were selected. The subjects were divided into control group and intervention group by ramdon number table method, with 120 cases in each group. The control group was given routine nursing measures of nasal feeding, and the intervention group was given routine nursing measures of nasal feeding plus targeted nursing measures after risk assessment of AS-NZS4360 risk management standard. The incidence of adverse reactions, catheter slippage, catheter blockage, malnutrition, and nursing complaints were compared between the two groups. Results The incidence of enteral nutrition tube blockage, patients’ malnutrition, pipeline complaints, diarrhea, reflux, and nasal mucosal injury in the intervention group was lower than that in the control group, the differences were statistically significant (P ＜ 0.05). There were no significant differences in the incidence of pipeline complaints, nutritional tube slippage, and gastric retention (P ＞ 0.05). Conclusion Application of AS-NZS4360 in patients with esophageal cancer with enteral nutrition tube can effectively control the incidence of risk in each group.
		2022 Vol. 19 (5): 179-183 [Abstract] ( 113 ) HTML (1 KB) PDF (753 KB) ( 37 )

	184	Effect of health education based on Six Sigma theory on elderly patients with coronary heart disease and angina pectoris#br#
		LYU Peinan1 MA Yingrui1 KONG Dezhao2
		Objective To explore and analyze the application of health education based on Six Sigma theory in elderly patients with coronary heart disease and angina pectoris. Methods A total of 120 elderly patients with coronary heart disease and angina pectoris were treated in Affiliated Hospital of Liaoning University of Traditional Chinese Medicine selected from June 2019 to June 2021, they were divided into control group and observation group by random number table method, with 60 cases in each group. The control group was given regular health education, the observation group was given a health education intervention based on the Six Sigma theory, disease-related cognitive scores before and after health education, the Seattle angina questionnaire (SAQ) total score, Herth hope scale (HHI) score were compared between the two groups. Results After education, the cognitive scores of reasonable diet, reasonable work and rest, exercise, emotional control, and compliance with medical medicine in the two groups were higher than those before education, and the observation group was higher than the control group, the differences were statistically significant (P ＜ 0.05); the stability, disease cognition, satisfaction, attack, physical activity, and total score of SAQ scale in the two groups were higher than those before education, and the observation group was higher than the control group, the differences were statistically significant (P ＜ 0.05); the intimate relationship, life attitude, positive action, and total score of health HHI scale in both groups were higher than those before education, and the observation group was higher than the control group, the differences were statistically significant (P ＜ 0.05); the compliance of both groups to treatment was better than before education, and the observation group was better than the control group, the differences were statistically significant (P ＜ 0.05). Conclusion Health education based on Six Sigma theory has significantly improved patients with coronary heart disease and angina pectoris, their awareness of the disease, improved their quality of life, and increased their hope and compliance with disease improvement.
		2022 Vol. 19 (5): 184-187 [Abstract] ( 215 ) HTML (1 KB) PDF (568 KB) ( 18 )

	188	Relevant research status of clinical practice guidelines in nursing field in China#br#
		HU Baoling1 LI Yaling2 WANG Jieyu3 ZHANG Jing4
		Objective To explore the relevant research status of clinical practice guidelines in nursing field in China. Methods The search terms of Keywords such as “guide” “consensus” and “nursing” were searched in CNKI, VIP, Wanfang Data, and CBM, the retrieval time was from June 24, 2011 to August 31, 2020. Descriptive analysis was conducted on the basic information, research types, topics, research methods, and findings of the literature using the Australian Evidence-based Care Centre scope review guidelines framework. Results A total of 151 literatures were included, of which 15.9% were related to the construction of nursing clinical practice guidelines, of which 75.0% referred to a certain guideline to construct a theoretical framework; the category of guideline application accounted for 62.9%, among which, 28.6% of the literatures based on guideline construction applied some evidence-based practice mode; content analysis (content analysis method was adopted) and quality evaluation (guideline research evaluation Ⅱ was the main evaluation tool) accounted for 21.2%. Conclusion There are various research types related to nursing clinical practice guidelines in China, and there is room for further improvement in methodological research of guideline construction and application. Methodological guidance should be improved to promote the construction and application of high-quality clinical nursing guidelines.
		2022 Vol. 19 (5): 188-191,196 [Abstract] ( 172 ) HTML (1 KB) PDF (1102 KB) ( 90 )

	192	Strategy research in the “machine translation + post-editing” of medical academic texts from the perspective of translator’s subjectivity #br#
		GUO Zikai CHEN Chen LIU Manling
		In order to explore how the translator exerts his subjectivity under the “machine translation + post-editing” mode in medical translation, this paper selected medical academic texts containing both difficult language and background knowledge, and adopted the research method of comparing machine-translated texts and human-translated texts. We found several advantages of machine translation and the necessity of post-editing, and put forward specific strategies under the “machine translation + post-editing” mode: translators should resort to machine translation proactively; they should return to translation skills and other core skills to correct the mistakes in the texts translated by the machine; and they can use computer-aided translation or corpus resources to improve the expression of terms or other words and sentences.
		2022 Vol. 19 (5): 192-196 [Abstract] ( 57 ) HTML (1 KB) PDF (662 KB) ( 255 )

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