丁沉扶正汤对消化系统恶性肿瘤术后气滞血瘀型胃肠功能紊乱的疗效和Th1/Th2免疫漂移的影响

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Abstract Objective To investigate the effect of Dingchen Fuzheng Decoction on gastrointestinal function recovery and Th1/Th2 immune drift after operation of digestive system malignant tumor. Methods A total of 120 patients with digestive system malignant tumor who underwent surgical treatment in Hebei General Hospital for Veterans from January 2018 to December 2019 were selected and they were divided into observation group and control group according to random number table method, with 60 cases in each group. The observation group was treated with basic treatment and Dingchen Fuzheng Decoction, while the control group was treated with basic treatment and Motilium. After one month of treatment, the postoperative indexes, motilin, vasoactive intestinal peptide, cytokine levels and type 1 helper T cells/type 2 helper T cells (Th1/Th2) levels of the two groups were observed. Results The recovery time of bowel sound, postoperative first exhaust time, postoperative first defecation time and postoperative total flow recovery time in the observation group were lower than those in the control group (P ＜ 0.01). One month after surgery, motilin levels in both groups were increased and vasoactive peptide levels were decreased compared with one day after surgery, and the motilin level in observation group was higher than that in control group, while vasoactive peptide level was lower than that in control group (P ＜ 0.05). One month after surgery, the levels of interleukin (IL)-2 in the two groups were increased and the levels of IL-4, IL-6, and interferon -γ (IFN-γ) were decreased compared with that one day after surgery, and the level of IL-2 in the observation group was higher than the control group. The levels of IL-4, IL-6, and IFN-γ were lower than those of control group (P ＜ 0.05). The Th1/Th2 level in the observation group was significantly higher than that in the control group one month after surgery (P ＜ 0.05). The total incidence of postoperative complications in the observation group was lower than that in the control group (P ＜ 0.01). Conclusion Dingchen Fuzheng Decoction has a good effect on gastrointestinal dysfunction after operation of digestive system malignant tumor, and can improve Th1/Th2 drift.

Key words： Dingchen Fuzheng Decoction Digestive system malignant tumor Postoperative Gastrointestinal function recovery Type 1 helper T cells/type 2 helper T cells immune drift

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	GAO Xiaojie1 CHEN Juan2 ZHANG Jing1 HAO Jianwen1

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GAO Xiaojie1 CHEN Juan2 ZHANG Jing1 HAO Jianwen1. Effect of Dingchen Fuzheng Decoction on gastrointestinal function recovery and Th1/Th2 immune drift after operation of digestive system malignant tumor#br#[J]. 中国医药导报, 2022, 19(5): 119-123.

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https://www.yiyaodaobao.com.cn/EN/ OR https://www.yiyaodaobao.com.cn/EN/Y2022/V19/I5/119

[1] 胡叶，李萌，王毛毛，等.消化系统恶性肿瘤术后胃肠道功能紊乱的中药治疗方法分析[J].现代中医临床，2017， 24（1）：48-52.
[2] Yiyi H，Jie LI，Oncology DO，et al. The Prevention and Treatment of Gastrointestinal Dysfunction in Digestive System Malignant Tumor：Based on The Anus Is Regulated by Five-zang Viscera [J]. J Tradit Chin Med，2019，3（6）：45-49.
[3] 李向英，马银琴，常风.辨证施护对胃癌患者营养状态、胃肠道反应及疼痛程度的影响[J].中医药导报，2019，25（3）：103-106.
[4] 吴易超，侯俊明.中药穴位注射对胃肠道恶性肿瘤术后胃肠功能恢复的临床研究[J].长春中医药大学学报，2019，35（1）：85-87.
[5] Artinyan A，Nunoo-Mensah JW，Balasubramaniam S，et al. Prolonged postoperative ileus-definition，risk factors，and predictors after surgery [J]. World J Surg，2008，32（7）：1495-1500.
[6] 陈贵廷，杨思澍.实用中西医结合诊断治疗学[M].2版.北京：中国医药科技出版社，1994：135-137．
[7] Song Z，Wu Y，Yang J，et al. Progress in the treatment of advanced gastric cancer [J]. Tumour Biol，2017，39（7）：1-7.
[8] Holmes GM，Blanke EN. Gastrointestinal dysfunction after spinal cord injury [J]. Exp Neurol，2019，3（20）：113009-113012.
[9] Jiawei C，Tian L，Zhang L，et al. Nalbuphine on postoperative gastrointestinal tract dysfunction after laparoscopic surgery for gynaecological malignancies：A randomized controlled trial[J]. Clin Exp Pharmacol P，2020，45（5）：120-126.
[10] 王一同，周琴，郑俊超，等.基于调畅中焦枢机探讨经方论治消化系统肿瘤术后胃肠功能紊乱[J].环球中医药，2019，12（10）：1533-1535.
[11] 邱书瑾，张晓炜.四磨汤口服液联合枳术宽中胶囊治疗消化系统恶性肿瘤术后胃肠功能紊乱的临床疗效观察[J].现代消化及介入诊疗，2019，8（7）：77-79.
[12] 朱广辉，李杰.基于“遗邪内伏”探讨中医药防治恶性肿瘤术后复发转移[J].中医杂志，2020，61（6）：42-46.
[13] Zhang W，Pan Y，Gou P，et al. Effect of xanthohumol on Th1/Th2 balance in a breast cancer mouse model [J]. Oncol Rep，2018，34（22）：56-61.
[14] 王蕾，张颖，王立彬，等.肠内免疫营养在胃肠道肿瘤围手术期的临床应用[J].中华临床医师杂志：电子版，2020， 14（6）：465-468.
[15] 蔡蓉，朱瑜，王开放，等.褪黑素体内外对胃癌Th1/Th2/Th17型细胞因子表达的影响[J].解剖学报，2019，50（4）：471-476.
[16] 李素素，濮文渊，凌云，等.三物白散通过影响FXR表达逆转Th1/Th2漂移发挥抗肝癌免疫应答作用[J].中医学报，2021，36（5）：1021-1028.
[17] 张典.胃肠道恶性肿瘤患者外周血淋巴细胞与肠道菌群相关性研究[D].邯郸：河北工程大学，2020.
[18] 宋献美，吴晓东，杨亮，等.雷酚内酯对IgA肾病大鼠肾间质纤维化和Th1/Th2漂移的调控[J].中国免疫学杂志，2020，36（7）：789-793.
[19] 袁权利，王毅刚，唐宇杰，等.溃疡性结肠炎相关性结直肠癌大鼠Th1/Th2漂移与微血管密度的关系[J].现代免疫学，2020，40（3）：226-232.
[20] 孔琦，黄强，陈斌，等.尼美舒利对胆管癌细胞Th1/Th2细胞因子分泌的影响[J].肿瘤基础与临床，2018，31（4）： 16-18.
[21] 孔琦，朱家胜，芮景.Th1/Th2偏移与肿瘤免疫研究进展[J].现代肿瘤医学，2010，18（8）：1653-1655.
[22] 赛星月，李晓红，杜蓉.宫颈病变患者外周血中TH1/TH2漂移状态与T-bet/GATA-3的表达及意义[J].中国医药导报，2020，17（11）：76-79.
[23] 柏涛，王静丽，胡旭东，夏冰，程海林，王娟.肝细胞癌患者肝动脉化疗栓塞术后外周血长链非编码RNA TINCR水平与Th1/Th2平衡及预后的相关性分析[J].临床肝胆病杂志，2021，37（1）：79-83.
[24] 季菲，何艳，杨丽，等.宫颈癌患者Th1/Th2细胞因子的表达及其预后意义[J].重庆医学，2018，47（33）：4229-4233.
[25] 张汯.阿帕替尼结合替吉奥对晚期胃癌患者血清肿瘤标志物、Th1及Th2类细胞因子水平的影响[J].中国当代医药，2020，27（29）：77-79.
[26] 林秀清，黄智铭，陈新，等.胃癌患者外周血中CD4~+CD25~+调节性T细胞和Th17细胞的表达和临床意义[J].中国现代医生，2018，56（13）：21-24.
[27] 房灿，房英，刘辉.STAT3信号通路对胃癌患者外周血调节性T细胞的作用机制分析[J].临床和实验医学杂志，2021，20（12）：1252-1256.
[28] Yang C，Wu S，Mou Z，et al. Transcriptomic Analysis Identified ARHGAP Family as a Novel Biomarker Associated With Tumor-Promoting Immune Infiltration and Nanomechanical Characteristics in Bladder Cancer [J]. Front Cell Dev Biol，2021，9：657219.
[29] 阳柳，范先基，宁雪坚，等.葶苈泽漆汤对肺癌恶性胸腔积液患者生存期及Th1、Th2细胞因子失衡的影响[J].解放军预防医学杂志，2019，37（7）：150-151.