加味茵陈四逆颗粒联合西医综合疗法治疗乙型肝炎病毒感染相关慢性肝衰竭的效果

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Abstract Objective To observe the effect of modified Yinchen Sini Granules combined with comprehensive therapy of Western medicine in treating HBV-related chronic liver failure. Methods One hundred and forty patients with HBV-related chronic liver failure hospitalized in Department of Hepatology of the First Affiliated Hospital of Guangxi University of Chinese Medicine from January 2019 to January 2021 were selected and divided into control group and treatment group according to the random number table method, with 70 cases in each group. Control group was treated with comprehensive Western medicine, and treatment group was treated with modified Yinchen Sini Granules combined with comprehensive Western medicine. Both groups were treated for eight weeks. The ascites efficacy, ascites depth, abdominal circumference, body weight, 24-hour urine volume, total bilirubin (TBil), albumin (ALB), prothrombin activity (PTA), model for end-stage liver disease combined with serum sodium (MELD-Na) score and adverse reactions were compared between the two groups. Results Total effective rate of ascites in treatment group was significantly higher than that in control group, the difference was statistically significant (P < 0.05). After treatment, the ascites depth, abdominal circumference, body weight of the two groups were lower than those before treatment, and 24-hour urine volume of two groups were higher than those before treatment, and the improvement degree of treatment group was significantly higher than that of control group (P < 0.05). After treatment, the TBil, MELD-Na scores in two groups were lower than those before treatment, ALB, PTA were higher than those before treatment, and the degree of improvement in treatment group was significantly higher than that in control group, the differences were statistically significant (P < 0.05). Conclusion Modified Yinchen Sini Granules combined with Western medicine comprehensive therapy can restore liver function, promote the regression of ascites complications and improve the prognosis through the effect of reinforcing yang from collapse.

Key words： Chronic liver failure Reinforcing yang from collapse Yuanyang deficiency and decline Modified Yinchen Sini Granules Clinical outcomes

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	MENG Yinjie1 QIU Hua2 LI Wang1 WANG Zigong1 ZHU Wenshuang1 HUANG Peng1

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MENG Yinjie1 QIU Hua2 LI Wang1 WANG Zigong1 ZHU Wenshuang1 HUANG Peng1. Effect of modified Yinchen Sini Granules combined with comprehensive therapy of Western medicine in treating HBV-related chronic liver failure#br#[J]. 中国医药导报, 2022, 19(5): 146-149,166.

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https://www.yiyaodaobao.com.cn/EN/ OR https://www.yiyaodaobao.com.cn/EN/Y2022/V19/I5/146

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