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| Comparison the changes of related indexes of different traditional Chinese medicine syndrome types in patients with hepatolenticular degeneration#br# |
| HUANG Peng1,2 DONG Ting1,2 LI Xiang1,2 WANG Han1,2 WANG Meixia1,2 YANG Wenming1,2▲ |
1.The Third Department of Encephalopathy, the First Affiliated Hospital of Anhui University of Chinese Medicine, Anhui Province, Hefei 230031, China;
2.Key Laboratory of Xin’an Medicine Education Ministry, Anhui Province, Hefei 230038, China |
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Abstract Objective To research the changes of related indexes of different traditional Chinese medicine syndrome types in patients with hepatolenticular degeneration (HLD). Methods The clinical medical records of 100 patients with HLD admitted to the First Affiliated Hospital of Anhui University of Traditional Chinese Medicine from January 2018 to March 2021 were retrospectively analyzed. All patients were classified according to traditional Chinese medicine syndrome differentiation, there were 44 cases of internal retention of damp-heat syndrome, 34 cases of intermingled phlegm and blood stasis syndrome, 10 cases of yin deficiency of liver and kidney syndrome and 12 cases of yang deficiency of spleen and kidney syndrome. The results of blood routine, coagulation function, and liver function of patients with different traditional Chinese medicine syndrome types were compared. Results The levels of white blood cell, neutrophil, lymphocyte, red blood cell, hemoglobin, and platelet in yang deficiency of spleen and kidney syndrome were significantly lower than those in internal retention of damp-heat syndrome, intermingled phlegm and blood stasis syndrome, and yin deficiency of liver and kidney syndrome (P ＜ 0.05). The activated partial thromboplastin time, prothrombin time, and thrombin time in yang deficiency of spleen and kidney syndrome were significantly higher than those in internal retention of damp-heat syndrome, intermingled phlegm and blood stasis syndrome, and yin deficiency of liver and kidney syndrome, and the level of fibrinogen was significantly lower than that in internal retention of damp-heat syndrome, intermingled phlegm and blood stasis syndrome, and yin deficiency of liver and kidney syndrome (P ＜ 0.05). The levels of aspartic transaminase, alanine aminotransferase in intermingled phlegm and blood stasis syndrome, and yang deficiency of spleen and kidney syndrome were significantly higher than those in internal retention of damp-heat syndrome, and yin deficiency of liver and kidney syndrome, the levels of albumin in yang deficiency of spleen and kidney syndrome, and intermingled phlegm and blood stasis syndrome were significantly lower than those in yin deficiency of internal retention of damp-heat syndrome, and liver and kidney syndrome, and compared with phlegm-stasis interaction syndrome, the levels of albumin in yang deficiency of spleen and kidney syndrome were significantly decreased, the levels of total bilirubin in yang deficiency of spleen and kidney syndrome were significantly increased (P ＜ 0.05). Conclusion The traditional Chinese medicine syndrome types of HLD patients are related to the changes of liver function, blood routine, and coagulation function indexes. The above examination results can provide a reliable basis for the objectification of traditional Chinese medicine syndrome differentiation.
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