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| Discussion on medication rule of Lou Xien in treating type two diabetic peripheral neuropathy based on data mining#br# |
| YAN Qingping LI Min WEN Qiao CHEN Jinfeng LOU Xien |
| The Third Clinical Medical College, Beijing University of Chinese Medicine, Beijing 100029, China |
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Abstract Objective To analyze the medication rule of Professor Lou Xien in the treatment of type two diabetic peripheral neuropathy based on data mining. Methods The prescriptions of type two diabetic peripheral neuropathy in Outpatient Department of the Third Affiliated Hospital of Beijing University of Chinese Medicine from June 2010 to June 2020 were collected. Traditional Chinese medicine inheritance auxiliary system (V2.5) was adopted. Association rules, frequency analysis and improved mutual information method were used to analyze the properties, tastes, meridians and the relationship between prescription drugs. Results A total of 229 prescriptions for the treatment of type two diabetic peripheral neuropathy by Professor Lou Xien were excavated, involving 256 drugs and 18 types of drugs. Among the four qi of drugs, warm, flat and cold were the main ones; among the five flavors of drugs, sweet taste was the highest; the meridian of drugs was mainly liver, spleen and kidney meridian. High frequency drugs included Salviae Miltiorrhizae Radix et Rhizoma, Carthami Flos, Pheretima, Gastrodiae Rhizoma, Fried Bombyx Batryticatus, and other 30 drugs. The top five drugs were tonifying deficiency drugs, promoting blood circulation and removing blood stasis drugs, promoting water and dampness drugs, clearing heat drugs and calming liver and calming wind drugs. The drug combinations with the top five use frequencies were Chuanxiong Rhizoma-Salviae Miltiorrhizae Radix et Rhizoma, Salviae Miltiorrhizae Radix et Rhizoma-Dioscoreae Rhizoma, Dioscoreae Rhizoma-Poria, Carthami Flos-Chuanxiong Rhizoma, Corni Fructus-Salviae Miltiorrhizae Radix et Rhizoma. The combination with the highest confidence was Carthami Flos, Salviae Miltiorrhizae Radix et Rhizoma→Chuanxiong Rhizoma. The top three combinations of drug correlation were Rehmanniae Radix Praeparata-Chuanxiong Rhizoma, Chuanxiong Rhizoma-Astragali Radix Praeparata Cum Melle, Salviae Miltiorrhizae Radix et Rhizoma-Carthami Flos. Conclusion In the treatment of this disease, Professor Lou Xien has the characteristics of “tonifying deficiency, reducing standard”, “harmonizing cold and heat, calming yin and yang”, “five tastes are sweet, and returning to meridians and three viscera”. On the basis of replenishing deficiency, stress blood stasis and internal wind pathological factors, flexibly use Salviae Miltiorrhizae Radix et Rhizoma-Carthami Flos and other drugs to promote blood circulation and remove blood stasis, and other drugs to calm liver and reduce wind such as Gastrodiae Rhizoma, Pheretima and Fried Bombyx Batryticatus.
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