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Clinical effect of self-made Qingpen Recipe for internal administration combined with external in the treatment of damp-heat stasis type pelvic inflammatory #br# |
LI Weiwei LI Rui |
Department of Obstetrics and Gynecology, Taihe Hospital of Traditional Chinese Medicine Affiliated to Anhui University of Chinese Medicine, Anhui Province, Taihe 236600, China |
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Abstract Objective To explore the clinical effect of self-made Qingpan Recipe for internal administration combined with external in the treatment of damp-heat stasis type pelvic inflammatory. Methods A total of 200 patients with damp-heat stasis type pelvic inflammatory treated in Taihe Hospital of Traditional Chinese Medicine Affiliated to Anhui Vniversity of Chinese medicine, from January 2018 to December 2020 were selected as the research subjects. According to the random number table method, they were divided into observation group and control group, with 100 cases in each group. Control group was treated with Levofloxacin and Metronidazole, and observation group was treated with self-made Qingpen Recipe for internal administration combined with external enema on the basis of control group. All patients were treated for 14 days. The therapeutic effects of two groups were compared; the scores of traditional Chinese medicine syndromes, pelvic effusion, inflammatory mass diameter, inflammatory factors and immune factors levels were compared between two groups before and after treatment; the incidence of adverse reactions in two groups were recorded. Results Observation group actually enrolled 96 cases, and control group actually enrolled 95 cases. The clinical efficacy of observation group was better than that of control group, and the difference was statistically significant (P < 0.05). After treatment, the scores of lumbosacral pain, lower band weight, lower abdominal pain, and fatigue were lower than those before treatment, and observation group was lower than control group, and the differences were statistically significant (P < 0.05). After treatment, pelvic effusion, inflammatory mass diameter, and inflammatory factors levels in two groups were lower than before treatment, and observation group was lower than control group, and the differences were statistically significant (P < 0.05). After treatment, CD4+ and CD4+/CD8+ in both groups were higher than before treatment, and observation group was higher than control grou; CD8+ in observation group was lower than before treatment, and observation group was lower than control group, and the differences were statistically significant (P < 0.05). There was no significant difference in the total incidence of adverse reactions between two groups (P > 0.05). Conclusion Self-made Qingpen Recipe is safe and effective for damp-heat stasis type pelvic inflammatory, and can enhance immune function.
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[1] Lewis J,Horner PJ,White PJ. Incidence of Pelvic Inflammatory Disease Associated With Mycoplasma genitalium Infection:Evidence Synthesis of Cohort Study Data [J]. Clin Infect Dis,2020,71(10):2719-2722.
[2] 张亚敏,张立然,时思毛.大柴胡汤治疗急性盆腔炎的临床疗效及对患者血清分泌型免疫球蛋白A CRP的影响[J].河北医学,2021,27(2):326-330.
[3] 余梦黎,金芳和.祛湿清热方联合盐酸左氧氟沙星治疗湿热蕴结型盆腔炎的临床疗效观察[J].山西医药杂志,2020,49(9):1147-1149.
[4] 王艳,焦波,吉文倩,等.小金丸联合左氧氟沙星和甲硝唑对盆腔炎性包块患者的临床疗效[J].中成药,2020,42(3):644-647.
[5] 李雪纯,苏晓红.生殖支原体耐药机制及治疗方案的研究进展[J].临床皮肤科杂志,2020,49(8):506-508.
[6] 霍素明.中药塌渍结合补气化瘀方治疗老年慢性盆腔炎疗效观察[J].辽宁中医药大学学报,2020,22(5):202-205.
[7] 马建芳.中药内服联合塌渍灌肠治疗湿热瘀阻型慢性盆腔炎疗效观察[J].四川中医,2016,34(9):126-129.
[8] 李姣,林洁.龙胆泻肝汤治疗湿热瘀阻型盆腔炎性不孕的疗效及作用机制[J].中国实验方剂学杂志,2020,26(6):85-90.
[9] 谢幸,苟文丽.妇产科学[M].8版,北京:人民卫生出版社,2013:258-263.
[10] 乐杰,谢幸.妇产科学[M].8版,北京:人民卫生出版社,2004:274-275.
[11] 郑筱萸.中药新药临床研究指导原则[M].北京:中国医药科技出版社,2002:243
[12] Akhter M. Effect of Urinalysis on the Role of Pelvic Examination in Patients With Possible Genitourinary Infection [J]. Ann Emerg Med,2019,74(1):163-164.
[13] 中华医学会妇产科学分会感染性疾病协作组.盆腔炎症性疾病诊治规范(2019修订版)[J].中华妇产科杂志,2019,54(7):433-437.
[14] 林巧红,李思华,刘庆标.红藤解毒汤灌肠联合西药对慢性盆腔炎的疗效观察[J].四川中医,2016,34(6):182-184.
[15] 杨通飞.慢性盆腔炎的临床治疗研究进展综述[J].实用妇科内分泌杂志:电子版,2018,5(30):16-23.
[16] 刘春思,张春雷.四位一体疗法治疗湿热瘀阻型慢性盆腔炎临床研究[J].新中医,2020,52(11):73-75.
[17] 江佳琳,何静玲,黎小斌.基于数据挖掘及网络药理学探讨中药灌肠治疗慢性盆腔炎的核心中药及机制[J].广州中医药大学学报,2021,38(2):379-385.
[18] 纪宝玉,范崇庆,裴莉昕,等.白花蛇舌草的化学成分及药理作用研究进展[J].中国实验方剂学杂志,2014,20(19):235-240.
[19] 夏晓杰,丁宁,王昕.温针灸联合中药保留灌肠治疗气滞血瘀型慢性盆腔炎及其对血清炎性因子的影响[J].辽宁中医药大学学报,2020,22(1):163-166.
[20] 宋霞.中医辨证施护对输液式中药保留灌肠治疗慢性盆腔炎患者心理状态及临床疗效的影响[J].护士进修杂志,2019,34(9):834-836.
[21] 庄晓丹,顾志钰,彭燕.中药灌肠联合脐灸辨证治疗慢性盆腔炎的临床效果与安全性评价[J].中国现代医生,2021,59(28):150-153.
[22] 黄远芹.清热活血消癥汤灌肠配合微波治疗慢性盆腔炎80例[J].陕西中医,2013,34(6):714-715.
[23] 王小蓉,张亚娜.化瘀除湿止痛方保留灌肠治疗慢性盆腔炎疗效及对炎症因子、盆空包块的影响[J].四川中医,2020,38(4):171-173.
[24] Okamoto K,Kurita M,Yamaguchi H,et al. Effect of tadalafil on chronic pelvic pain and prostatic inflammation in a rat model of experimental autoimmune prostatitis [J]. Prostate,2018,78(10):707-713.
[25] 迟晓君,季飞宏,吴海超,等.蒲公英咀嚼片研发及抑菌作用分析[J].食品科技,2020,45(10):111-117.
[26] 李晓娟,邱育红.红藤汤保留灌肠对慢性盆腔炎患者疗效及对免疫-炎症因子的调节作用[J].中医药学报,2020, 48(10):26-31. |
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