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| Effects of MDT nutritional intervention on the efficacy and immune function of elderly patients with radical radiotherapy and chemotherapy for gastric cancer#br# |
| DAI Kejun1 LIU Yongping2▲ HUANG Xue2 CHENG Jing2 FANG Mingming2 |
1.Department of Radiotherapy, the Third Affiliated Hospital of Soochow University, Jiangsu Province, Changzhou 213001, China;
2.Cancer Center, Changzhou Tumor Hospital, Jiangsu Province, Changzhou 213001, China |
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Abstract Objective To investigate the effects of multidisciplinary team (MDT) nutritional intervention on the efficacy and immune function of elderly patients with radical radiotherapy and chemotherapy for gastric cancer. Methods A total of 118 elderly patients with radical radiotherapy and chemotherapy for gastric cancer admitted to the Third Affiliated Hospital of Soochow University from December 2017 to December 2019 were selected as the research subjects. They were divided into control group and nutritional intervention group by random envelope method, with 59 patients in each group. Both groups received radical radiotherapy and chemotherapy. The control group did not receive nutritional education guidance and systematic nutritional support, while the nutritional intervention group received MDT nutritional intervention, which lasted for 14 weeks in both groups. The patient-generated subjective global assessment (PG-SGA) grading, immunoglobulin M (IgM), Beck depression inventory (BDI) and health promoting lifestyle profile-Ⅱ (HPLP-Ⅱ) were compared between two groups before and after intervention. Results Before intervention, there was no significant difference in PG-SGA grading between the two groups (P ＞ 0.05). After intervention, the PG-SGA grading of the nutritional intervention group was better than that of the control group, and the difference was statistically significant (P ＜ 0.05). Before intervention, there were no significant differences in IgM, BDI scores and HPLP-Ⅱ scores between the two groups (P ＞ 0.05). After intervention, IgM and BDI scores of both groups were decreased before intervention, and IgM and BDI scores of nutritional intervention group were lower than those of control group, the differences were statistically significant (P ＜ 0.05). After intervention, HPLP-Ⅱ scores in both groups were higher than before intervention, and nutritional intervention group was higher than control group, the differences were statistically significant (P ＜ 0.05). Conclusion MTD nutritional intervention can improve nutritional status, immune function, depression mood and quality of life in elderly patients with gastric cancer who underwent radical radiotherapy and chemotherapy.
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