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| Correlation of cognitive dysfunction with vascular endothelial function, oxidative stress, and white matter changes in patients with posterior circulation ischemia-induced dizziness#br# |
| Aotongsha·rehemaiti1 YANG Lijuan1 Abudureheman·mamati2 LI Hongyan1 |
1.Department of Neurology, Xinjiang Uygur Autonomous Region People’s Hospital, Xinjiang Uygur Autonomous Region, Urumqi 830000, China;
2.Department of Medical Record Quality, Xinjiang Uygur Autonomous Region People’s Hospital, Xinjiang Uygur Autonomous Region, Urumqi 830000, China |
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Abstract Objective To investigate the correlation of cognitive dysfunction with vascular endothelial function, oxidative stress, and white matter changes in patients with posterior circulation ischemia-induced dizziness. Methods A total of 598 patients with posterior circulation ischemia-induced dizziness in Xinjiang Uygur Autonomous Region People’s Hospital from January 2018 to January 2021 were selected as observation subjects. According to the occurrence of cognitive dysfunction, they were divided into cognitive dysfunction group (121 cases) and non-cognitive dysfunction group (477 cases). The age related white matter changes (ARWMC) score was used to assess the severity of white matter change. The levels of vascular endothelial function, oxidative stress index, and ARWMC score were compared between the two groups, and the correlation between these indexes and the occurrence of cognitive dysfunction was analyzed. Results The levels of endothelin-1 (ET-1), malondialdehyde (MDA), and ARWMC score in the cognitive dysfunction group were higher than those in the non-cognitive dysfunction group, and the levels of calcitonin gene-related peptide (CGRP), nitric oxide (NO), and superoxide dismutase (SOD) were lower than those in non-cognitive dysfunction group, the differences were statistically significant (P ＜ 0.05). Spearman correlation analysis showed that ET-1, MDA levels, and ARWMC score were positively correlated with the occurrence of cognitive dysfunction (rs ＞ 0, P ＜ 0.05), CGRP, NO, and SOD levels were negatively correlated with cognitive dysfunction (rs ＜ 0, P ＜ 0.05). Conclusion Patients with posterior circulation ischemia-induced dizziness have a high incidence of cognitive dysfunction, which is related to vascular endothelial function, oxidative stress, and white matter changes. Clinically, cognitive dysfunction in patients with this disease can be prevented from alleviating vascular endothelial injury and oxidative stress, and white matter change can be evaluated for patients to help early recognition of cognitive dysfunction.
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