丁苯酞治疗急性缺血性脑卒中的效果及对血清因子的影响

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Abstract Objective To investigate the effect of Butylphthalide on acute ischemic stroke (AIS) and its effect on serum neuron-specific enolase (NSE) and C-reactive protein (CRP). Methods A total of 100 AIS patients admitted to Nanjing Pukou District Hospital of Traditional Chinese Medicine from December 2017 to September 2019 were selected as research objects, they were divided into the control group (50 cases) and the observation group (50 cases) according to the random number table method. Control group was treated with conventional drug therapy, and observation group was treated with Butylphthalide on the basis of control group. The clinical efficacy of two groups was compared; NSE and CRP levels were compared between two groups before and after treatment; National Institutes of Health stroke scale (NIHSS), mini mental state examination (MMSE) and Montreal cognitive assessment scale (MoCA) scores were compared between two groups. Results The clinical efficacy of observation group was better than control group (P < 0.05). After treatment, serum NSE and CRP levels in two groups were lower than those before treatment, and observation group was lower than control group (P < 0.05). After treatment, NIHSS scores in both groups were lower than those before treatment, MMSE and MoCA scores were higher than those before treatment; NIHSS score of observation group was lower than that of control group, MMSE and MoCA scores were higher than those of control group (P < 0.05). Conclusion Butylphthalide treatment of AIS has significant clinical effect, which can significantly reduce the level of inflammatory factors, protect nerve cells, and effectively improve the neurological deficit of AIS patients.

Key words： Butylphthalide Acute ischemic stroke Effect Serum neuron-specific enolase C-reactive protein

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	GU Wei ZHU Zhengping CHEN Yulan LI Rongping HU Ting▲ XUE Xingxin

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GU Wei ZHU Zhengping CHEN Yulan LI Rongping HU Ting▲ XUE Xingxin. Effect of Butylphthalide in the treatment of acute ischemic stroke and its influence on serum factors#br#[J]. 中国医药导报, 2022, 19(5): 86-88,92.

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https://www.yiyaodaobao.com.cn/EN/ OR https://www.yiyaodaobao.com.cn/EN/Y2022/V19/I5/86

[1] 吕立峰，亓爱芹，李秀芹.温脾通络开窍汤联合丁苯酞治疗老年血管性痴呆的疗效及对高血浆同型半胱氨酸、炎症因子的影响[J].中华中医药学刊，2018，36（5）：1262-1265.
[2] 黄骏文，李浪.丁苯酞对心肌细胞保护作用机制的研究进展[J].山东医药，2021，61（4）：80-83.
[3] 袁庆芳，李欣欣，张剑平，等.丁苯酞氯化钠注射液联合依达拉奉治疗新发脑梗死的疗效及神经功能和CRP水平分析[J].中国新药杂志，2017，25（23）：2818-2821.
[4] 王新德.各类脑血管疾病诊断要点[J].中华神经外科杂志，1997，13（1）：1-2.
[5] 常思远，许予明.NIHSS的再评价[J].神经损伤与功能重建，2011，6（4）：305-308.
[6] 周小炫.中文版简易智能精神状态检查量表在脑卒中患者中的信效度初步研究[D].福建：福建中医药大学，2015.
[7] 王炜，王鲁宁.“蒙特利尔认知评估量表”在轻度认知损伤患者筛查中的应用[J].中华内科杂志，2007，46（5）：414-416.
[8] 杨璟，李凤，石长青.丁苯酞治疗进展性脑梗死患者疗效及对血清白细胞介素6和S100B蛋白表达的影响[J].中国新药杂志，2020，29（9）：1018-1022.
[9] 孙明英，陈超，李月春，等.长期丁苯酞预处理通过Nrf2通路减轻永久性大脑中动脉远端闭塞小鼠缺血性脑损伤[J].国际脑血管病杂志，2021，29（3）：194-200.
[10] 明子歆.阿替普酶联合氯吡格雷在急性缺血性轻型脑卒中患者中的应用[J].中国当代医药，2020，27（18）：146-148.
[11] 喻蕾，郝新斌，玄红雷.急性缺血性脑卒中的micro RNA-16表达水平及其对预后的影响[J].中国急救复苏与灾害医学杂志，2021，16（9）：1000-1003.
[12] Dieplinger B，Bocksrucker C，Egger M，et al. Prognostic value of inflammatory and cardiovascular biomarkers for prediction of 90-day all-cause mortality after acuteischemic stroke-results from the linz stroke unit study [J]. Clin Chem，2017，63（6）：1101-1109.
[13] 宋祺，孙西庆.红花黄色素注射液联合丁苯酞氯化钠注射液治疗急性脑梗死的效果观察[J].山东医药，2021， 61（13）：72-75.
[14] 张多斌，陈后勤，蔡红星，等.缺血性脑卒中患者脑微出血的危险因素及血清CysC、NLR与脑微出血的关系[J].中国医药导报，2020，17（35）：38-41.
[15] 张雪海，周少珑，孙鹏，等.丁苯酞氯化钠注射液对进展性脑卒中患者微栓子清除机制的影响[J].中国老年学杂志，2020，40（19）：4070-4072.
[16] Zhang C，Zhao S，Zang Y，et al. The efficacy and safety of Dl-3n-butylphthalide on progressive cerebral infarction：A randomized controlled STROBE study [J]. Medicine（Baltimore），2017，96（30）：e7257.
[17] 刘维婕，刘丹，刘坤，等.复方丹参注射液联合丁苯酞注射液治疗老年急性脑梗死的临床分析[J].中华中医药学刊，2019，37（5）：1274-1277.
[18] 叶佳媚，林青，彭飞飞.丁苯酞注射液联合双重抗血小板对急性进展性脑梗死的疗效及其机制探讨[J].中国现代医学杂志，2021，31（9）：60-66.
[19] 余晖，宋哲.重复经颅磁刺激联合认知康复训练治疗脑卒中后认知障碍的临床效果[J].中国医药科学，2021， 11（4）：31-34.
[20] 杨东娜，张涤，于佳佳.丁苯酞注射液联合依达拉奉对老年急性脑梗死患者细胞因子、血管内皮功能和氧化应激的影响[J].中国老年学杂志，2021，41（3）：477-480.
[21] Osei E，den Hertog HM，Berkhemer OA，et al. Admission Glucose and Effect of Intra-Arterial Treatment in Patients With Acute Ischemic Stroke [J]. Stroke，2017，48（5）：1299-1305.
[22] 陈宗胜，陈祥攀，费世早，等.丹参川芎嗪联合丁苯酞注射液治疗急性缺血性脑卒中患者的疗效及对脑钠肽、Chemerin的影响[J].中国老年学杂志，2021，41（3）：480-483.
[23] 苏晓丽.循证护理联合丁苯酞及依达拉奉对急性脑梗死患者炎性因子和氧化应激的影响[J].河北医药，2019， 47（12）：1278-1280.
[24] 孟琳琳，孙瑞兴，刘娜.丁苯酞注射液联合银杏叶提取物治疗rt-PA溶栓后急性脑梗死的疗效和安全性研究[J].中国实用神经疾病杂志，2021，24（2）：143-147.
[25] 苏小明，王立忠.氢溴酸樟柳碱联合丁苯酞治疗进展性脑梗死对患者D-二聚体、同型半胱氨酸、脂蛋白相关磷脂酶A2水平及血液流变学的影响[J].中国医刊，2021，56（3）：296-300.
[26] 陈瑶，周德生，颜思阳，等.三七通舒胶囊联合丁苯酞治疗脑梗死的通用分子机制研究[J].世界中医药，2021， 16（7）：1045-1053.