Application of the shortest diameter of lymph nodes in enhanced CT and SCC-Ag predicting pre-operation lymph node metastasis in cervical squamous cell carcinoma#br#
QIN Lin WU Yumei WANG Ming WEI Jiahui
Department of Gynecology and Oncology, Beijing Obstetrics and Gynecology Hospital, Capital Medical University Beijing Maternal and Child Health Care Hospital, Beijing 100006, China
Abstract Objective To investigate the application value of the shortest diameter of lymph nodes in enhanced CT and squamous cell carcinoma antigen (SCC-Ag) in diagnosing lymph node metastasis pre-operation in cervical squamous cell cancer. Methods Patients with cervical squamous cell carcinoma ⅠA1-ⅢCr stage who underwent radical cervical surgery in Beijing Obstetrics and Gynecology Hospital, Capital Medical University from October 2019 to December 2020 were selected. By single factor analysis and evaluation of the factors related to lymph node metastasis, the prediction model of lymph node metastasis was established and the predictive value of the model was evaluated. Results A total of 189 patients were included, including 30 in the lymph node metastasis group. There were statistically significant differences in maximum diameter, clinical stage, cell differentiation, preoperative serum SCC-AG and enhanced CT lymph node short diameter between the two groups (P ＜ 0.001), but there were no statistically significant differences in age and HPV infection (P ＞ 0.05). The best truncation value was 0.625cm, area under curve (AUC) value was 0.827 cm (P ＜ 0.001), sensitivity was 66.7%, and specificity was 83.0%, respectively. The optimal cut-off value of SCC-AG in predicting cervical squamous cell carcinoma lymph node metastasis was 1.88 ng/ml, AUC value was 0.733 (P ＜ 0.001), sensitivity was 66.7%, and specificity was 73.6%. The AUC value of the combined detection was 0.802 (P ＜ 0.001), the sensitivity was 66.7%, and the specificity was 84.3%. Conclusion SCC-Ag and the shortest diameter of lymph nodes in enhanced CT can be used to evaluate lymph node metastasis in patients with cervical squamous cell carcinoma,and the diagnostic value of the shortest diameter of lymph nodes in enhanced CT is higher,which provides a reference for clinical treatment planning.
QIN Lin WU Yumei WANG Ming WEI Jiahui. Application of the shortest diameter of lymph nodes in enhanced CT and SCC-Ag predicting pre-operation lymph node metastasis in cervical squamous cell carcinoma#br#[J]. 中国医药导报, 2022, 19(5): 124-128.
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