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| Analysis of influencing factors of short-term prognosis of acute ischemic stroke patients with intravenous thrombolysis#br# |
| SHEN Hailin DAI Jie WANG Han ZHU Xiangyang |
| Department of Neurology, Nantong First People’s Hospital the Second Affiliated Hospital of Nantong University, Jiangsu Province, Nantong 226001, China |
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Abstract Objective To investigate the influencing factors of short-term prognosis in acute ischemic stroke patients with intravenous thrombolysis. Methods A retrospective analysis was performed on 318 hospitalized patients who received intravenous recombinant human tissue plasminogen activator from October 2018 to January 2021 in the First People’s Hospital of Nantong, Jiangsu Province. Short-term prognostic index was modified Rankin scale score at three months after onset, including 0-2 scores in 173 cases (good prognosis group) and ≥3 scores in 145 cases (poor prognosis group). Univariate and multivariate analysis were performed on the clinical data of the two groups to explore the influencing factors of short-term prognosis. Results The National Institutes of Health stroke scale (NIHSS) score at admission, proportion of atrial fibrillation, glucose to glycated haemoglobin ratio (GAR), fasting blood glucose, and proportion of hemorrhage conversion in the poor prognosis group were higher than those in the good prognosis group, the uric acid level and the neutrophil to lymphocyte ratio were lower than those in the good prognosis group, the differences were statistically significant (P ＜ 0.05). Multivariate analysis showed that high NIHSS score at admission, atrial fibrillation, and high GAR were independent risk factors for poor short-term prognosis in acute ischemic stroke patients with intravenous thrombolysis (OR ＞ 1, P ＜ 0.05), high uric acid was its protective factor (OR ＜ 1, P ＜ 0.05). Conclusion NIHSS score at admission, GAR, atrial fibrillation, and uric acid level have certain influence on short-term prognosis of acute ischemic stroke patients with intravenous thrombolysis.
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