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2020 Vol. 17, No. 29
Published: 2020-10-15
 
 
4 Influence of renin angiotensin system biaxial on avascular necrosis of femoral head
SHUAI Bo1 CHEN Shenghao2 SHEN Lin1 YI Jianhua2 MA Chen1 YANG Yanping1 ZHAO Ying3 CAI Xun3

Objective To investigate the influence of renin angiotensin (RAS) biaxial on patients with ischemic necrosis of the femoral head (INFH). Methods From October 2015 to June 2017, 90 patients underwent femoral head replacement in the Department of Orthopedics in Union Hospital Affiliated to Tongji Medical College of Huazhong University of Science and Technology and Suizhou Central Hospital in Hubei Province were selected. Among them, 45 patients with INFH were served as INFH group, and 45 patients with postoperative traumatic femoral neck fracture were served as control group. The expressions of angiotensin converting enzyme (ACE), angiotensin Ⅱ (Ang Ⅱ), angiotensin Ⅱ-1 receptor (AT1R), ACE2, Ang (1-7), Mas receptor (Mas-R) in the circulating blood of two groups were detected before operation, and the expressions of ACE, AngⅡ, AT1R, ACE2, Mas-R, receptor activator of NF-κB ligand (RANKL) and osteoprotegerin (OPG) mRNA in local bone tissue of femoral head were detected after operation, and immunohistochemical analysis was performed. Results There were no significant differences in the expressions of ACE, AngⅡ, AT1R, ACE2, Ang(1-7) and Mas-R between two groups (P > 0.05). The mRNA expression levels of ACE2, Mas-R and OPG in local bone tissue of femoral head in INFH group were lower than those in control group (P < 0.05), while the mRNA expression levels of ACE, AngⅡ, AT1R, RANKL and RANKL mRNA/OPG mRNA were higher in INFH group than those in control group (P < 0.05). Compared with control group, HE staining of bone tissue in INFH group showed hyperplasia of adipocytes, thinning of bone trabeculae, pyknosis and deep staining of bone nucleus, and obvious increase of empty bone lacunae; Masson staining of bone tissue in INFH group showed that dark blue became lighter and more disordered, showing the decrease of collagen structure and obvious hyperplasia of fibrous structure. The results of immunohistochemistry showed that the expressions of ACE and AT1R were higher in INFH group than those in control group, while the expressions of ACE2 and Mas-R were lower than those of control group. There were significant differences in the percentage of positive expression area of ACE, AT1R, ACE2 and Mas-R between two groups (P < 0.05). Conclusion Some components of RAS biaxial in local bone tissue of INFH patients are abnormally expressed, which may be involved in the process of local bone turnover and osteonecrosis, providing new ideas for the follow-up study and diagnosis and treatment.
2020 Vol. 17 (29): 4-8,24 [Abstract] ( 317 ) HTML (1 KB)  PDF (898 KB)  ( 250 )
9 Effect of metformin on cell senescence through IGF-1/PI3K/Akt signaling pathway
HOU Yuli FU Jingxuan WANG Peichang
Objective To explore the effect of metformin (Met) on cell senescence through IGF-1/PI3K/Akt signaling pathway. Methods 2BS cells were selected and divided into four groups, namely control (NC) group, insulin-like growth factor-1 (IGF-1) group, Met group, Met+ IGF-1 group. After drug treatment, SA-β-Gal staining was performed to detect cell senescence, CCK8 test was used to detect cell proliferation ability, EdU test was performed to detect DNA synthesis ability, and Western blot  was used to detect the protein expression of PI3K, p-PI3K, Akt, and p-Akt in each group. Results The positive rate of SA-β-Gal staining in each group was compared, and the difference was statistically significant (P ＜ 0.05). The positive rate of SA-β-Gal staining in Met+IGF-1 group was lower than that in IGF-1 group, and the difference was highly statistically significant (P ＜ 0.01). At the same time point, the OD450 value of the Met+IGF-1 group was higher than that of the IGF-1 group, and the difference was statistically significant (P ＜ 0.05). The staining results at 370 nm after EdU staining showed that the OD370 value of each group was compared with statistical significance (P ＜ 0.05); the OD370 value of the Met+IGF-1 group was higher than that of the IGF-1 group, and the difference was statistically significant (P ＜ 0.05). The expressions of p-PI3K and p-Akt protein in Met group were lower than those in other groups, and the differences were statistically significant (P ＜ 0.05). The expression of p-PI3K and p-Akt protein in IGF-1 group were higher than those in other groups, and the differences were statistically significant (P ＜ 0.05). The expressions of p-PI3K and p-Akt protein in Met+IGF-1 group were lower than those in IGF-1 group, and the differences were statistically significant (P ＜ 0.05). Conclusion Metformin can delay cell senescence by inhibiting IGF-1/PI3K/Akt signaling pathway.
2020 Vol. 17 (29): 9-12 [Abstract] ( 385 ) HTML (1 KB)  PDF (958 KB)  ( 184 )
13 Dynamic changes in brain structure of patients with post-traumatic stress disorder using VBM method
LI Haohao XUE Jinyan HU Min LINAG Xia ZHANG Guiqing
Objective To investigate the dynamic changes in brain structure morphology of patients with post-traumatic stress disorder (PTSD) after experiencing or witnessing a traumatic accident such as car accident. Methods From January to December 2019, a total of 40 patients who experienced traffic accidents such as car accident on roads in Shihezi, Xinjiang Uygur Autonomous Region were selected and admitted to the First Affiliated Hospital, School of Medicine, Shihezi University and the Municipal People′s Hospital of Shihezi, Xinjiang Uygur Autonomous Region. Among them, 17 cases of the patients who experienced a car accident developed PTSD were treated as PTSD group and 23 cases of the patients who experienced a car accident but did not develop PTSD were treated as non-PTSD group. Voxel-based morphological measurement method (VBM) was used to post-process the brain images of the two groups. The brain structure changes in the PTSD group and the non-PTSD group at one week and two months of the traumatic event were compared. The brain structure changes of the first functional magnetic resonance imaging (fMRI) and the second fMRI were compared between the PTSD group and the non-PTSD group. Results No abnormalities were found in brain structure during fMRI examinations of the PTSD group and non-PTSD group at one week of the traumatic event. At two months after the traumatic event, the PTSD group had a smaller volume of the right prefrontal lobe than the non-PTSD group (P ＜ 0.01, GRF adjusted). No abnormalities were found in the brain structure of the non-PTSD group during fMRI examinations at two months after the traumatic event compared with one week. In the PTSD group, the volume of left central sulcus and anterior cingulate gyrus decreased at two months after the traumatic event compared with that at one week. (P ＜ 0.01, GRF adjusted). Conclusion Structural changes in the right frontal lobe, anterior cingulate gyrus, and central sulcus of PTSD patients may be important factors leading to the pathogenesis of PTSD. At the same time, based on whether these changes in brain structure as above may help in the early diagnosis of PTSD.
2020 Vol. 17 (29): 13-16 [Abstract] ( 124 ) HTML (1 KB)  PDF (774 KB)  ( 111 )
17 Discussion on mechanism of prevention and treatment of thrombosis by Buyang Huanwu Decoction based on network pharmacology
FENG Yuenan1 SUN Simiao2 ZHANG Yukun1 BIAN Jingqi1 NIU Wenying1 XIAO Hongbin1
Objective To explore the active components, targets and signal pathways of Buyang Huanwu Decoction in preventing thrombosis by using network pharmacology method. Methods The traditional Chinese medicine system pharmacology database and analysis platform (TCMSP) were used to retrieve drugs, and the active ingredients and corresponding targets of Buyang Huanwu Decoction were selected by combining the two pharmacokinetic parameters of bioavailability and drug-like properties. Genecard and OMIM database were used to find disease-related target genes with the keywords of thrombosis. Drug and disease target genes were intersected, target names were corrected using Uniprot database, and compound-target-disease network was constructed by Cytoscape software. The obtained drug-disease target genes were input into STRING online database to draw PPI network diagram, and the core genes were obtained, and GO and KEGG pathway enrichment analysis were performed. Results Buyang Huanwu Decoction had 61 effective active components, 63 drug-disease intersection genes, 69 biological processes involved and 115 signaling pathways, which were mainly involved in the regulation of tumor necrosis factor (TNF), PI3K-Akt, interleukin (IL)-17 and NF-κB signaling pathways. Conclusion Buyang Huanwu Decoction can regulate multiple genes to regulate multiple signaling pathways to treat thrombotic diseases, reflecting the characteristics of multiple ingredients, multiple targets and multiple pathways of traditional Chinese medicine compound.
2020 Vol. 17 (29): 17-20,28 [Abstract] ( 330 ) HTML (1 KB)  PDF (1414 KB)  ( 125 )
21 Influence of Tangluoning on apoptosis related pathway in diabetic peripheral neuropathy rats
CHEN Feng1 GUO Yuxin1 WANG Liying1 LI Yixiao1 LIU Qin1 ZHANG Taojing2
Objective To observe the regulatory effect of Tangluoning on PI3K/AKT and PERK signaling pathway in sciatic nerve tissue of diabetic peripheral neuropathy (DPN) rats. Methods Eighty eight-week-old male SD rats of clean grade were selected. Fourteen rats were randomly selected as normal group. The other 66 rats were induced hyperglycemia by intraperitoneal injection of streptozotocin 60 mg/kg. Sixty-one rats were randomly divided into model control group (model group, 21 rats), Tangluoning group (traditional Chinese medicine group, 21 rats), α-lipoic acid treatment group (Western medicine group, 19 rats). Traditional Chinese medicine group was given Tangluoning 5 g/(kg·d), Western medicine group was given α-lipoic acid 20 mg/(kg·d) once a day. Model group was given the same amount of distilled water by gavage every day. All groups were treated for eight weeks. After eight weeks, the expression of p-PI3K, p-pPI3K, p-AKT, p-pAKT, p-PERK and p-pPERK protein in sciatic nerve was detected by Western blot. Results The expression of p-PI3K, p-pPI3K, p-AKT, p-pAKT, p-PERK and p-pPERK protein in dorsal root ganglion (DRG) of rats in each group had statistical significance (P < 0.05). Compared with normal group, the protein expressions of p-PI3K, p-pPI3K, p-AKT and p-pAKT in DRG of model group were significantly decreased (P < 0.01), and the protein expressions of p-PERK and p-pPERK were significantly increased (P < 0.01). Compared with model group, the protein expressions of p-PI3K, p-pPI3K, p-AKT and p-pAKT in the DRG of Chinese medicine group and Western medicine group were increased (P < 0.05), and the protein expressions of p-PERK and p-pPERK were decreased (P < 0.05). Conclusion Tangluoning can regulate PI3K/AKT and PERK signaling pathway so as to inhibiting apoptosis and avoid nerve injury.
2020 Vol. 17 (29): 21-24 [Abstract] ( 414 ) HTML (1 KB)  PDF (663 KB)  ( 173 )
25 Expression and correlation of HPV16/18 infection and Rb protein in invasive ductal carcinoma of breast
SHI Zhe1 REN Shan2 DAI Wenbin1 REN Zhanping1
Objective To investigate the expression of human papilloma virus (HPV)16/18 and Rb protein in benign and malignant breast lesions and its correlation. Methods From January 2016 to December 2017, the surgical breast surgically resected specimens in Liuzhou People′s Hospital of Guangxi Zhuang Artonomous Region as the research object, 68 cases with invasive ductal carcinoma (IDC) of IDC group, 30 cases with breast atypical ductal epithelial hyperplasia (ADH) of ADH group, 30 cases with normal breast tissue adjacent to breast fibroadenoma of normal breast group. HPV16/18 DNA was detected by in situ hybridization and Rb protein was detected by immunohistochemistry. Results HPV16/18 DNA positive rate in IDC group was higher than that in normal breast group and ADH group; the positive Rb protein expression rate was lower than that in normal breast group and ADH group（all P ＜ 0.01）. The expression of HPV16/18 DNA in each group was negatively correlated with the expression of Rb protein （r = -0.802, -0.774, -0.802, all P ＜ 0.05）. The expression of HPV16/18 DNA and Rb protein in IDC patients was closely related to histological grade, lymph node metastasis and pTNM stage（P ＜ 0.01）. Conclusion The HPV16/18 infection and Rb protein expression deletion may be involved in the occurrence and development of breast cancer.
2020 Vol. 17 (29): 25-28 [Abstract] ( 353 ) HTML (1 KB)  PDF (645 KB)  ( 105 )
29 Progress in the mechanism of pericytes in ischemic stroke
PENG Yongjun1 LI Wenqian1 LYU Hequn2 XU Shuying1 WU Xu1 ZHU Bingmei3
Cerebral pericytes are an important part of neurovascular units. In recent years, the focus of research on cerebral ischemia has gradually shifted from neurons to neurovascular units. Pericytes are located in the center of neurovascular units and have become the focus of new research fields in recent years. Pericerebral cells perform a variety of functions by integrating and processing the signals of neighboring cells, including regulating the blood-brain barrier, regulating cerebral blood flow, regulating immune inflammatory response, participating in angiogenesis, regulating stem cell activity and epigenetic regulation. By reviewing the relevant literature at home and abroad in recent years, this paper discusses the function and mechanism of pericytes in ischemic stroke, so as to provide reference for the study of the mechanism of ischemic stroke and provide ideas for the discovery of new therapeutic targets.
2020 Vol. 17 (29): 29-32 [Abstract] ( 161 ) HTML (1 KB)  PDF (610 KB)  ( 103 )
33 Progress of metabolomics in the study of anti hepatic fibrosis of traditional Chinese medicine
YANG Ni1* XU Jianliang1,2* SHENG Guoguang2 XIAO Mingzhong1,2
Metabolomics can reveal the nature of disease and look for disease markers through accurate qualitative and quantitative analysis of small molecular metabolites in the body, and analyze the relationship between metabolites and physiological and pathological changes. At present, no specific and effective Western medicine has been found in the treatment of liver fibrosis. The clinical use of traditional Chinese medicine and Chinese patent medicine has a significant effect on liver fibrosis. In recent years, metabolomics technology has developed rapidly, which provides a new technology platform for the research of traditional Chinese medicine treatment of liver fibrosis. This article mainly reviews the research progress of metabolomics in the treatment of liver fibrosis with traditional Chinese medicine in recent five years.
2020 Vol. 17 (29): 33-36 [Abstract] ( 150 ) HTML (1 KB)  PDF (609 KB)  ( 181 )
37 The role of microglia in the development of white matter damage
XU Manman CHAO Bin CUI Hanming PAN Juhua ZHANG Qiuyan HUANG Shijing
Microglia is widely distributed in the central nervous system and is the inherent immune cells. The nerve inflammation mediated by microglia is an important factor that cause white matter damage. More and more evidences show that the activation pathways of microglia in different white matter damage diseases are different, which is the basis of their complex role in the central nervous system. The typical manifestation of white matter damage is demyelination, which is a common pathological stage in multiple diseases including multiple sclerosis, Alzheimer′s disease, vascular cognitive impairment and dementia. In this article, the medical mechanism for microglia playing biological role through different activation pathways under various disease types and different brain regions is discussed. In addition, microglia can play a biphasic role in brain white matter damage, such as proinflammatory and immunomodulatory effects, therefore further research on these microglial subtypes may lead to new treatments that promote the repair of white matter damage.
2020 Vol. 17 (29): 37-39,44 [Abstract] ( 110 ) HTML (1 KB)  PDF (623 KB)  ( 46 )
40 Review of the diagnosis of chronic heart failure syndrome based on metabonomics
ZHONG Senjie LI Jing LI Lin HUANG Shumin YANG Meng QIU Hong CHENG Bin HU Zhixi
The pathological process of chronic heart failure is accompanied by a series of complex changes of metabolic function. Metabolomics can grasp the metabolic function changes of the body from the overall level through advanced detection technology and statistical algorithms, which has now become a common means of experimental research on heart failure. This article summarizes metabonomics technology in the diagnosis of chronic heart failure disease research, based on the theory of “metabolic remodeling”, the metabolic characteristics of chronic heart failure are expounded, and the metabonomics change rules of different syndromes of chronic heart failure are discussed. It is believed that metabonomics technology has certain diagnostic value for the assessment of heart failure and the discrimination of syndrome types of heart failure. In addition, the key problems in the study are discussed, and the corresponding ideas such as standardized and unified research standards, reasonable design of controlled experiments, and emphasis on the dynamic process research of heart failure syndrome are put forward, so as to provide reference for subsequent studies.
2020 Vol. 17 (29): 40-44 [Abstract] ( 310 ) HTML (1 KB)  PDF (618 KB)  ( 145 )
45 Research progress of circular RNA in nervous system diseases
GAO Yongchao WANG Shuang WANG Jing TAI Xiantao
Circular RNA (circRNA) is a long-chain non-coding RNA molecule, which is widely found in eukaryotic cells. It is highly conserved in expression and has the functions of sponge adsorption, protein binding and protein translation. CircRNA can be involved in the regulation of a variety of diseases, such as tumors, cardiovascular diseases and nervous system diseases. Recent studies have found that circRNA is highly expressed in the nervous system and has tissue specificity, especially in the brain tissue. It is involved in the development and signal transmission of the nervous system and regulates the complex functions and various neural activities of the brain. CircRNA is closely associated with the development of nervous system diseases, and it has been found to be involved in cerebral palsy, alzheimer′s disease, and stroke. CircRNA is stable in structure, has a long half-life in exosomes, and is not easily degraded. Therefore, circRNA is considered as an ideal biomarker for monitoring a variety of nervous system diseases. This paper reviews the biological functions of circRNA and its application in nervous system diseases.
2020 Vol. 17 (29): 45-47 [Abstract] ( 315 ) HTML (1 KB)  PDF (601 KB)  ( 77 )
48 Research progress of microRNA-1290 in digestive system tumors
MO Hui XU Min
MicroRNAs (microRNAs, miRNAs) are a type of short non-coding RNA. A large number of studies have shown that they are closely related to the occurrence and development of malignant tumors. As a member of the microRNAs family, microRNA-1290 has been increasingly researched in recent years and found in various digestive system tumors (including esophageal cancer, gastric cancer, pancreatic cancer, colorectal cancer, liver tumor, etc.) The expression is abnormal, and may be closely related to tumor proliferation, invasion, migration, apoptosis and poor prognosis. This article reviews the research progress of microRNA-1290 in various digestive system tumors, hoping to provide new ideas for anti-tumor therupy research based on microRNA-1290.
2020 Vol. 17 (29): 48-51 [Abstract] ( 185 ) HTML (1 KB)  PDF (611 KB)  ( 64 )
52 Application progress of “all manic and all belong to fire” in the treatment of hyperthyroidism
LI Chaolin1 JIANG Deyou2
“All manic and all belong to fire” comes from the nineteenth items of pathogenesis in Huangdi Neijing, which is still an important theoretical basis for the analysis of pathogenesis. According to clinical characteristics of hyperthyroidism, the pathogenesis is closely related to fire pathogen. Fire pathogen is the disease in the early stage of hyperthyroidism, and it damages yin for a long time. It is the syndrome of deficiency and excess, and fire evil is involved in the whole pathogenesis. This paper analyzes and summarizes the methods of treating hyperthyroidism by many doctors in recent years. All of them take the theory of “all manic and all belong to fire” as the pathogenesis theory to guide the treatment of hyperthyroidism. Whether it is classified and treated by stages, or by the treatment of prescriptions, all of them are based on the principle of clearing away heat and reducing firenourishing yin and reducing fire, which provides a reference for the future clinical treatment of hyperthyroidism by fire.
2020 Vol. 17 (29): 52-55 [Abstract] ( 303 ) HTML (1 KB)  PDF (688 KB)  ( 119 )
56 Analysis on the outpatient and emergency prescriptions of probiotics for the treatment of functional dyspepsia in children
YU Yuncui1▲ DU Saifei2▲ ZHANG Li3 WEI Ting2 JIA Lulu1 MA Jinjing4 JIN Yan2 WANG Xiaoling4
Objective To understand the current status and problems of the clinical application of microecological preparations in the treatment of children with functional dyspepsia (FD) in China, and to provide the basis for the rational application of microecological preparations in the treatment of children with FD. Methods A retrospective selection of five Grade A children′s hospitals across the country (Beijing Children′s Hospital of Capital Medical University, Harbin Children′s Hospital, He′nan Children′s Hospital, Hu′nan Children′s Hospital, Jiangxi Provincial Children′s Hospital) would use microecological preparations to treat children from January to March 2019, while all outpatient/emergency prescriptions for FD were extracted. At the same time, the relevant guidelines/consensus of probiotics and FD at home and abroad were sorted out, and the treatment of children with FD by probiotics were investigated and analyzed. Results A total of 14 099 FD prescriptions for the treatment of children with microecological preparations were drawn, of which 56.43% were males (7956/14 099) and females accounted for 43.57% (6143/14 099). The proportion of children aged one to three years was the highest, reaching 28.58%. A total of 17 kinds of microecological preparations were involved in the prescriptions. Among them, the prescription number of Clostridium Butyricum Duojun San was the highest, reaching 64.65% (9115/14 099). The proportion of prescriptions with combined drugs accounted for 59.69% (8415/14 099). The combined drugs mainly included Chinese patent medicines for strengthening the spleen and eliminating food, Chinese patent medicines for clearing away heat and detoxification, and antibacterial drugs. The incidence of off-label medication prescriptions was 27.68% (3903/14 099), and there were mainly cases of over-indications, over-population, over-usage and dosage. A total of 15 domestic and foreign microecological preparations and FD-related clinical guidelines/consensus have been sorted out. In terms of effectiveness, only two domestic expert consensus suggested that probiotics can be used as adjuvant drugs for the treatment of FD. The recommended varieties mainly include double Fidobacterium, Lactobacillus, etc. In terms of safety, the seven guidelines and consensus mention and generally affirm the safety of probiotics, however none of them separately mentions the safety of probiotics in treating children with FD. Conclusion The application of microecological preparations to treat children with FD is common clinically, but there are still cases of off-label use of drugs, and there is little evidence-based medicine. Clinicians should standardize their prescription behavior. At the same time, a large number of multi-center prospective studies based on pediatric groups are still needed in the future to provide more support for the rational application of probiotics in the treatment of children with FD.
2020 Vol. 17 (29): 56-61 [Abstract] ( 166 ) HTML (1 KB)  PDF (466 KB)  ( 186 )
62 Symptom analysis of SCL-90 in parents of phenylketonuria in our hospital
HAN Zonglan
Objective To describe the mental health status of parents of children with phenylketonuria (PKU) and to provide background information for the development of relevant intervention strategies. Methods From December 2014 to December 2016, a total of 76 parents of children with PKU (the main guardians of the parents) who were admitted to Tangshan Maternal and Child Health Hospital were selected as the research objects, while symptom check list 90 (SCL-90) was used to evaluate the psychiatric symptoms of the children′s parents and compared them with the national norm. Results The total mean score of SCL-90 symptoms of children′s parents was higher than that of the Chinese norm, and the difference was statistically significant (P ＜ 0.05). The score results of all dimensions showed that the parents of children with PKU score in compulsive, depression, anxiety, phobia, paranoia, and psychosis were significantly higher than those of the Chinese norm, and the differences were statistically significant (P ＜ 0.05). In addition, the positive and negative item scores in the parents of children with PKU were higher than those in the Chinese norm, and the difference was statistically significant (P ＜ 0.05). The comparison of the SCL-90 scores of parents of children with PKU in different situations showed that the total average score of SCL-90 were higher than those with younger age, mothers, lower educational level, and lower monthly household income, and the differences were statistically significant (P ＜ 0.05). Conclusion The degree of abnormality of 90 symptoms of the parents of children with PKU is significantly higher than the national norm. The main abnormalities are concentrated in the mental and psychological fields. Parents with younger parents, lower education level, and lower monthly family income have higher levels of mental abnormalities.
2020 Vol. 17 (29): 62-64 [Abstract] ( 201 ) HTML (1 KB)  PDF (416 KB)  ( 35 )
65 Clinical study on the evaluation of cardiac function in patients with decompensated cirrhosis by tissue Doppler myocardial composite index and plasma B-type natriuretic peptide
CHEN Xi WANG Likun WANG Yicheng
Objective To evaluate the cardiac function in patients with decompensated cirrhosis by tissue Doppler myocardial performance index (Tei index) combined with plasma B-type natriuretic peptide (BNP). Methods A total of 100 patients with cirrhosis diagnosed and hospitalized in the Department of Gastroenterology, the First Affiliated Hospital of Hebei North University (“our hospital” for short) from June 2014 to June 2016 were selected, and they were divided into the compensated cirrhosis group and the decompensated cirrhosis group according to Child-Pugh grading of liver function and clinical symptoms, with 50 cases in each group. In addition, 40 healthy people who underwent physical examination in our hospital during the same period were selected as the normal control group. Tei index, plasma BNP level and liver function indexes among three groups were compared. The correlation between left and right ventricular Tei indexes and plasma BNP levels in patients with decompensated cirrhosis in different grading were analyzed. Tei index and plasma BNP levels of patients with decompensated cirrhosis in different grading were compared. Results The levels of alanine aminotransferase and aspartate aminotransferase in the decompensated cirrhosis group were higher than those in the normal control group, the levels of total bilirubin (TBil) were higher than those in the normal control group and the compensated cirrhosis group, and the levels of albumin (ALB) were lower than those in the normal control group and the compensated cirrhosis group; the levels of TBil in the compensated cirrhosis group were higher than those in the normal control group and the levels of ALB in the compensated cirrhosis group were lower than those in the normal control group (all P < 0.05). Left and right ventricle Tei indexes and BNP levels in the decompensated cirrhosis group were higher than those in the normal control group and the compensated cirrhosis group; left and right ventricle Tei indexes and BNP levels of in the compensated cirrhosis group were higher than those in the normal control group (all P < 0.05). Left and right ventricular Tei indexes were positively correlated with plasma BNP level in patients with decompensated cirrhosis (r = 0.717, 0.618, all P < 0.01). Left and right ventricular Tei indexes and plasma BNP levels in patients with grade C decompensated cirrhosis were higher than those in patients with grade B decompensated cirrhosis (all P < 0.05). Conclusion Tei index and plasma BNP level were significantly correlated with cardiac function in patients with decompensated cirrhosis, and the combination can quantitatively evaluate the decompensated stage of cirrhosis.
2020 Vol. 17 (29): 65-68 [Abstract] ( 134 ) HTML (1 KB)  PDF (481 KB)  ( 33 )
69 Effect of low dose Atorvastatin Calcium combined with Amlodipine Besylate on elderly patients with hypertension
LU Xin1 ZHAO Guifeng2▲
Objective To investigate the effect of low dose Atorvastatin Calcium combined with Amlodipine Besylate on elderly patients with hypertension. Methods From January 2016 to June 2019, 180 elderly patients with hypertension admitted to Rocket Army Characteristic Medical Center were selected and they were divided into the control group (90 cases) and the combined treatment group (90 cases) according to the random number table method. The control group was given Amlodipine Besylate orally and the combined treatment group was given Amlodipine Besylate+Atorvastatin Calcium orally. The changes of blood pressure, blood lipid and inflammatory factors between the two groups were compared. Results The average systolic blood pressure, average diastolic blood pressure, total cholesterol, triglyceride, low-density lipoprotein cholesterol, apolipoprotein a, homocysteine, high-sensitivity C-reactive protein, angiotensin Ⅱ levels after one, three months of treatment in the combined treatment group were lower than those in the control group, while high-density lipoprotein cholesterol level was higher than that of the control group (all P < 0.01). Conclusion The effect of adding low dose Atorvastatin Calcium on reducing blood pressure, blood lipid and inflammatory factors in patients with hypertension is significantly better than that of simple antihypertensive drug therapy, and low dose Atorvastatin Calcium and antihypertensive drugs have synergistic antihypertensive effect.
2020 Vol. 17 (29): 69-72 [Abstract] ( 172 ) HTML (1 KB)  PDF (410 KB)  ( 122 )
73 CEUS evaluation of the relationship between neovascularization in carotid atherosclerotic plaque and NIHSS and mRs scores in patients with cerebral infarction
HUANG Hui SHENG Wenwei▲
Objective To investigate the relationship between contrast-enhanced ultrasound (CEUS) evaluation of neovascularization in carotid atherosclerotic plaques and the National Institutes of Health stroke scale (NIHSS) score and the modified Rankin scale (mRs) score in patients with acute cerebral infarction. Methods The clinical data of 148 patients with acute ischemic cerebral infarction admitted to the Huai′an First Hospital Affiliated to Nanjing Medical University from October 2016 to October 2019 were retrospectively analyzed. According to the presence or absence of carotid atherosclerotic plaque, those without plaque were admitted to group A (41 cases). The other 107 patients had plaque and received CEUS. According to the results of CEUS (plaque classification), the patients were divided into group B (stable plaque, plaque classification of 0-Ⅰ, 19 cases) and group C (vulnerable plaque, plaque classification of Ⅱ-Ⅲ, 88 cases). The both sides of angiography grade of carotid artery plaques in patients with acute cerebral infarction with carotid atherosclerotic plaque were observed, and the NIHSS and mRs scores of the three groups and their correlation with the grade of neovascularization in carotid atherosclerotic plaque were analyzed. Results Comparison of both sides of the angiographic grading of carotid artery plaques in patients with carotid atherosclerotic plaque showed no statistically significant difference (P ＞ 0.05). Comparison of NIHSS and mRs scores between groups A and B showed no statistically significant differences (P ＞ 0.05). NIHSS and mRs scores in groups A and B were lower than those in group C, and the differences were statistically significant (P ＜ 0.05). NIHSS and mRs scores in patients with acute cerebral infarction were positively correlated with the grade of neovascularization in carotid atherosclerotic plaque (r = 0.448, 0.406, all P ＜ 0.05). Conclusion CEUS evaluation of neovascularization in carotid atherosclerotic plaques is closely related to NIHSS and mRs scores in patients with acute cerebral infarction.
2020 Vol. 17 (29): 73-76 [Abstract] ( 130 ) HTML (1 KB)  PDF (371 KB)  ( 85 )
77 Analysis of influencing factors of bone mineral density in perimenopausal women
GU Hong1 GENG Xiaoli2 YU Na3
Objective To analyze the influencing factors of bone mineral density in perimenopausal women. Methods A total of 620 perimenopausal women who saw a doctor and had physical examination in the Department of Gynaecology and Obstetrics, Baogang Hospital of Inner Mongolia Autonomous Region from January 2018 to May 2019 were selected as the study subjects. According to bone mineral density, the subjects were divided into the low bone mass group (482 cases) and the normal bone mass group (138 cases). Bone mineral density, levels of serum estradiol (E2), follicle-stimulating hormone (FSH) and parathyroid hormone (PTH) of the enrolled subjects were measured, and the relationship between bone mineral density and age, body mass index (BMI), E2, FSH and PTH were analyzed. Results The differences in age, levels of BMI, E2, FSH and PTH between the two groups were statistically significant (all P ＜ 0.05), while the differences in pregnancy times and smoking rates between the two groups were not statistically significant (P ＞ 0.05). In perimenopausal women, bone mineral density was negatively correlated with age, levels of FSH and PTH (r = -0.402, -0.421, -0.357, all P ＜ 0.05), and positively correlated with BMI and E2 levels (r = 0.387, 0.408, all P ＜ 0.05). Age (>50 years old), BMI (<24 kg/m2), FSH (≥20 IU/L), E2 (<20 pg/mL), and PTH (≥30 pg/mL) were risk factors for bone mineral density in perimenopental women (OR = 2.061, 2.100, 2.765, 2.818, 2.748, all P ＜ 0.05). Conclusion Bone mineral density in perimenopausal women is closely related to age, levels of FSH, BMI, E2 and PTH. Among them, advanced age, high FSH, high PTH, low BMI and low E2 levels are independent risk factors of bone mineral density.
2020 Vol. 17 (29): 77-80 [Abstract] ( 185 ) HTML (1 KB)  PDF (472 KB)  ( 142 )
81 Effect of acupoint application of Bushen Gutai Cream on serum sex hormone levels and cytokines in early threatened abortion patients with kidney deficiency
ZHENG Na WANG Ting YANG Lijuan
Objective To observe the effect of acupoint application of Bushen Gutai Cream on serum sex hormone levels and cytokines in early threatened abortion patients with kidney deficiency. Methods A total of 74 pregnant women diagnosed as early threatened abortion with kidney deficiency were selected from Department of Gynecology, Yunnan Provincial Hospital of Traditional Chinese Medicine from January 2017 to December 2018. According to the order in which the patient was treated, the patients were sorted from one, and then according to the random number table, the patients were divided into the observation group and the control group with 37 cases each. The control group was given progesterone injection of 40 mg intramuscular injection plus Shoutai Wan orally. On this basis, the observation group was given Bushen Gutai Cream applied to shenque point for treatment. After two weeks of treatment, the improvement of the traditional Chinese medicine symptom scores in the two groups, the patients′ hormone levels, expression of cytokines in T-helper 1 cells (Th1) and T-helper 2 cells (Th2) were observed, and safety evaluation was performed. Results After two weeks of treatment, the scores of traditional Chinese medicine symptoms in the observation group were significantly lower than those in the control group (all P ＜ 0.01). The hormone levels of the observation group were significantly higher than those of the control group (P ＜ 0.01), the levels of cytokines in Th1 were lower than those of the control group, and the levels of cytokines in Th2 were higher than those of the control group (P ＜ 0.01). No obvious adverse reactions occurred in both groups. Conclusion Acupoint application of Bushen Gutai Cream can significantly increase the hormone level of patients, improve the imbalance of cytokines, relieve clinical symptoms, which is safe and effective.
2020 Vol. 17 (29): 81-84 [Abstract] ( 416 ) HTML (1 KB)  PDF (470 KB)  ( 97 )
85 Expression and significance of IL-17 and IL-38 in triple negative breast cancer
WU Jiang1 YE Biaofei2 MENG Qingjie3 FAN Jing1 LI Nanlin1 LING Rui1
Objective To detect the expression of IL-17 and IL-38 in triple negative breast cancer (TNBC) patients, and to explore their possible role in the pathogenesis of breast cancer. Methods From November 2017 to March 2019, 71 cases with breast cancer admitted to Xijing Hospital (“our hospital”for short) were selected as study subjects, including 36 cases in the TNBC group and 35 cases in the ductal carcinoma in situ (DCIS) group, and 33 patients with fibroadenoma who admitted to our hospital at the same time were selected as the control group. The expression of interleukin (IL-17) mRNA and IL-38 mRNA in tissue samples were detected by real-time RT-PCR; and the protein expression of IL-17 and IL-38 were detected by immunohistochemistry. The correlation between IL-17 mRNA expression and IL-38 mRNA expression in the TNBC group was further analyzed. Results The expression IL-17 mRNA in TNBC group and DCIS group were higher than those in control group, and the differences were statistically significant (all P < 0.05). While the expression of IL-38 mRNA in TNBC group and DCIS group were lower than those in control group, and the differences were statistically significant (all P < 0.05). The protein positive expression of IL-17 in TNBC group was higher than that in DCIS group and control group, and the differences were statistically significant (all P < 0.05). While the protein positive expression of IL-38 in TNBC group and DCIS group were lower than those in control group, and the differences were statistically significant (all P < 0.05). The relative expression of IL-17 mRNA and IL-38 mRNA was negatively correlated in TNBC(r = -0.685, P < 0.01). Conclusion The expression of IL-17 is increased and IL-38 is decreased in TNBC. There is a negative correlation between IL-17 mRNA and IL-38 mRNA. They may play an opposite role in the pathogenesis of TNBC.
2020 Vol. 17 (29): 85-88,105 [Abstract] ( 154 ) HTML (1 KB)  PDF (639 KB)  ( 50 )
89 Meta analysis of the predictive value of preoperative ALBI grade for postoperative prognosis of hepatocellular carcinoma patients
LUO Hao1 ZHOU Jing2 HUANG Jun1
Objective To evaluate the association between preoperative albumin-bilirubin (ALBI) grade and postoperative prognosis of hepatocellular carcinoma (HCC) patients with hepatocellular carcinoma. Methods PubMed, the Cochrane Library, EMbase, Web of Science, CNKI, WanFang, VIP database were searched by computer, the studies on the correlation between ALBI grade and hepatectomy prognosis of HCC were collected. The retrieval time was from create database to August 2019. The data was analyzed by RevMan 5.3 and Stata 12.0 and published bias was evaluated by funnel graph. Results A total of 16 articles and 8820 casess were enrolled in the study. Meta analysis showed that postoperative overall surviva with preoperative high ALBI grade patients were lower than those with preoperative low ALBI grade patients (HR = 1.47, 95%CI:1.33-1.62, P ＜ 0.00 001). Disease free survival with preoperative high ALBI grade patients were lower than those with preoperative low ALBI grade patients (HR = 1.67, 95%CI:1.12-2.50, P = 0.01). Conclusion Preoperative ALBI grade is a biomarker that can be used to predict hepatectomy prognosis of patients with hepatocellular carcinoma.
2020 Vol. 17 (29): 89-93 [Abstract] ( 199 ) HTML (1 KB)  PDF (1207 KB)  ( 79 )
94 Risk factors of deep vein thrombosis before clinical intervention in ovarian malignant tumors
LIANG Lingyun ZHAO Junda LIN Lin
Objective To explore the risk factors of deep vein thrombosis before clinical intervention in ovarian malignant tumor. Methods A total of 110 ovarian malignant tumor patients in the First Affiliated Hospital of Xinjiang Medical University from January 2017 June to 2019 March were selected. Before clinical intervention, the ovarian tumor marker carbohydrate antigen CA125, human epididymal protein HE4, plasma D-dimer (DD), and gynecological B-ultrasound and other related examinations were compared. The occurrence and risk factors of deep venous thrombosis in untreated ovarian malignant tumors were analyzed. Results Before the clinical intervention, the study population developed deep vein thrombosis in 17 patients, seven cases of ovarian serous adenocarcinoma, three cases of clear cell carcinoma, and three cases of undifferentiated cancer were included. Among them, advanced ovarian malignant tumors accounted for 94.2%, and 52.9% of patients were accompanied by a large amount of ascites, and 88.2% of patients with deep vein thrombosis had no obvious clinical symptoms. When the plasma DD level was ≥2000 ng/mL, the incidence of thrombosis was significantly higher than that of the other groups, and the differences were statistically significant (P ＜ 0.05). There were no significant differences in the occurrence of deep vein thrombosis in different ages, nationalities, body mass index and ascites, tumor markers and special pathological types (P ＞ 0.05); comparisons of large tumor size, late tumor stage and high levels of plasma DD showed statistical differences significance (P ＞ 0.05). In multivariate analysis, plasma DD level ≥1000 ng/mL was a risk factor for deep vein thrombosis in untreated ovarian malignant tumors (OR ＞ 1, P ＜ 0.05). Conclusion The risk factor for deep vein thrombosis in untreated malignant ovarian tumors is significantly increased the levels of DD.
2020 Vol. 17 (29): 94-97,114 [Abstract] ( 167 ) HTML (1 KB)  PDF (888 KB)  ( 99 )
98 Analysis of breast cancer screening results of 24 693 people of physical examination combined with ultrasound and selective complementary mammography
DING Songtao MA Xiangjun▲ HE Xiangping CHEN Si ZHANG Yi QIN Jing
Objective To evaluate the application value of physical examination combined with ultrasound and selective supplemental mammography for breast cancer screening. Methods From June 2013 to December 2016, 24 693 women of appropriate age who underwent breast cancer screening in Maternal and Child Health Hospital of Haidian District of Beijing were selected as the study subjects. Mammography rate, detection rate of breast cancer and early breast cancer, recall rate of biopsy, rate of biopsy, biopsy compliance rate, biopsy positive predictive value (PPV) were analyzed. The detection rate of breast cancer and early breast cancer before and after supplementary mammography were compared. The correlation between the detection rate of early breast cancer and the rate of mammography examination and biopsy compliance were analyzed. Results A total of 7211 (29.20%) people underwent supplementary mammography. Before supplemental mammography, 54 cases (bilateral breast cancer were recorded two cases) of breast cancer were detected, and the detection rate of breast cancer was about 218.69/100 000. Among them, 33 cases of early stage breast cancer and the detection rate of it was about 133.64/100 000. Ten cases of breast cancer were detected after supplemental mammography, including nine cases of early breast cancer, the detection rate of breast cancer was about 259.18/100 000, and the detection rate of early breast cancer was about 170.09/100 000. There were no significant differences between the detection rate of breast cancer and early breast cancer before and after supplemental mammography (P > 0.05). A total of 460 people(1.86%) were recalled for biopsy after the screening, and the actual biopsy was 121 people (0.49%), the biopsy compliance rate was about 26.30%, and the biopsy PPV was about 52.89%. The detection rate of early breast cancer was significantly positively correlated with the biopsy compliance rate (r = 0.996, P < 0.01), but not with the mammography detection rate (P > 0.05). Conclusion The screening mode of physical examination combined with ultrasound and selective supplement mammography for breast cancer screening is effective and feasible, but the standards of supplementary mammography should be optimized. The biopsy compliance rate after screening need to be improved.
2020 Vol. 17 (29): 98-101 [Abstract] ( 126 ) HTML (1 KB)  PDF (656 KB)  ( 36 )
102 Significance of ZEB2 and E-cadherin in the occurrence and development of prostate cancer
WANG Yingbin1 LI Dandan2 FU Yuhuan3 YU Xuenong1
Objective To study the expression significance of zinc-finger E-box binding protein 2 (ZEB2) and E-cadherin in the occurrence and development of prostate cancer. Methods A total of 88 prostate specimens from Tangshan Union Medical College Hospital from January 2016 to March 2019 were selected. Among them, a total of 60 prostate cancer tissues were in the observation group and a total of 28 benign prostate hyperplasia tissues were in the control group. The immunohistochemical SP method was used to detect ZEB2 and E-cadherin protein in the two groups. The relationship between ZEB2 and E-cadherin protein expression and clinicopathological parameters of prostate cancer were analyzed. Results The positive expression rate of ZEB2 and E-cadherin between the two groups were compared, and the differences were highly statistically significant (P ＜ 0.01). The expression of ZEB2 and E-cadherin protein were closely related to the TNM staging and bone metastasis of prostate cancer patients (P ＜ 0.05 or P ＜ 0.01), but had nothing to do with age and Gleason grade (P ＞ 0.05). Spearman rank correlation analysis showed that ZEB2 and E-cadherin protein expression in prostate cancer tissue were negatively correlated (r = -0.377, P ＜ 0.01). Conclusion The high expression of ZEB2 protein and the reduced expression of E-cadherin protein may play an important role in the occurrence and development of prostate cancer.
2020 Vol. 17 (29): 102-105 [Abstract] ( 141 ) HTML (1 KB)  PDF (640 KB)  ( 128 )
106 Systematic evaluation of the prevalence of hyperuricemia in the elderly in China
YANG Ting1 WANG Shurui1 WANG Ruirui1 WEI Wentong1 YANG Xueshi1 ZHANG Chunmei2
Objective To systematically evaluate the incidence of hyperuricemia (HUA) in the elderly in China from 2010 to 2019. Methods PubMed, EMbase, Web of Science, CNKI, WanFang Data, VIP and CBM databases were electronically searched to collect cross-sectional studies on the prevalence of HUA of Chinese elderly from January 2010 to December 2019. Two reviewers independently screened literature, extracted data and assessed risk of bias of included studies. Then, meta analysis was performed by using Stata 12.0 software. Results A total of 31 cross-sectional studies and 110 103 elderly were included. Meta-analysis showed that the overall prevalence of HUA in Chinese elderly was 21% (95%CI[18%, 24%]), in which 22% (95%CI[20%, 25%]) was male and 19% (95%CI[15%, 22%]) was female. The prevalence of HUA was 19% (95%CI[14%, 24%]) in the elderly aged 60, <70, 26% (95%CI[20%, 31%]) in the elderly aged 70, <80 and 29% (95%CI[20%, 38%]) in the elderly aged ≥80. The prevalence of HUA was 22% (95%CI[19%, 26%]) in coastal areas, and 18% (95%CI[13%, 23%]) in inland areas. By using the diagnostic criteria proposed by Chinese expert consensus on hyperuricemia and gout treatment, the prevalence of HUA was 28% (95%CI[19%, 38%]), and was 18% (95%CI[10%, 26%]) using the criteria of the eighth edition of Internal Medicine. Conclusion The prevalence of HUA in the elderly in China is relatively high. The prevalence of HUA is different in the elderly with different gender, age and geographical location, and the prevalence of HUA is significantly different with different diagnostic criteria.
2020 Vol. 17 (29): 106-110,122 [Abstract] ( 291 ) HTML (1 KB)  PDF (913 KB)  ( 108 )
111 Effect of Terlipressin in the treatment of ascites-related acute kidney injury in liver cirrhosis
XU Aijing1* KONG Deliang2* LI Shuangxi2 YIN Wei1 HUANG Qianyun1 LI Chengzhong1
Objective To analyze the efficacy and recurrence rate of Terlipressin in the treatment of ascites-related acute renal injury (AKI) stage Ⅰ patients with cirrhosis. Methods Clinical data of 123 patients with AKI stage Ⅰ cirrhosis ascites treated in Changhai Hospital from January 2014 to February 2018 were collected and randomly divided into control group (n = 56) and observation group (n = 67) according to random number table method. Control group was given conventional treatment, and observation group was given Terlipressin on this basis. All patients were followed up for six months. Clinical efficacy of two groups was evaluated. The levels of total bilirubin (TBil), alanine aminotransferase (ALT), albumin, serum creatinine (Scr), serum sodium, international normalized ratio (INR), end-stage liver disease (MELD) score, MELD-Na score and estimated glomerular filtration rate (eGFR) were compared between two groups before treatment and after follow-up. The recurrence rate was compared between two groups. Results There were no significant differences in TBil, ALT, albumin, Scr, serum sodium, blood urea nitrogon (BUN), INR, MELD-Na score between two groups before treatment (P > 0.05). But eGFR of observation group was lower than that of control group before treatment (P < 0.05). TBil, ALT, Scr and INR of two groups after follow-up were lower than those before treatment, while albumin, MELD score, MELD-Na score and EGFR were higher than those before treatment (P < 0.05). TBil, Scr and BUN of observation group were lower than those of control group after follow-up, while albumin, MELD-Na score and eGFR of observation group were higher than those of control group (P < 0.05). The length of stay in observation group was significantly shorter than that in control group, and treatment response rate was significantly higher than that in control group (P < 0.05). There were no significant differences in recurrence rate and total recurrence rate between two groups after one, three and six months of follow-up (P > 0.05). Conclusion Terlipressin in the treatment of cirrhotic ascites AKI stage Ⅰ patients can effectively reduce Scr, BUN, albumin and eGFR, improve renal function, shorten the length of hospital stay, but has no significant effect on reducing the recurrence rate of AKI.
2020 Vol. 17 (29): 111-114 [Abstract] ( 145 ) HTML (1 KB)  PDF (530 KB)  ( 62 )
115 Correlation study between renal injury and humoral immunity in patients with rheumatoid arthritis, systemic lupus erythematosus and primary Sjogren′s syndrome
GUO Huijuan1 TIAN Bingchao2 TANG Jinyang3 LI Qi1
Objective To explore the correlation between renal injury and humoral immune in patients with rheumatoid arthritis (RA), systemic lupus erythematosus (SLE) and primary Sjogren′s syndrome (pSS). Methods Eighty-three cases of RA as RA group, 40 cases of SLE as SLE group and 50 cases of pSS as pSS group treated in Department of Rheumatology, Xiyuan Hospital, Chinese Academy of Traditional Chinese Medicine from March 2018 to November 2018. Another 50 healthy persons in the same period were selected as control group. Serum immunoglobulin (IgG, IgA), urinary β2-microglobulin (β2-MG), α1-microglobulin (α1-MG), microalbumin (mALB), creatinine (Cr) and ACR were detected. Pearson analysis was used to analyze the correlation between renal injury index and humoral immunity. Results The levels of serum IgG, IgA, urinary β2-MG and α1-MG in pSS group, SLE group and RA group were higher than those in control group (P < 0.05). Urine Cr of pSS group and RA group was lower than that of control group, and ACR was higher than that of control group (P < 0.05). There was no significant difference in urine mALB level among four groups (P > 0.05). Serum IgA, β2-MG and IgG were positively correlated in RA group (P < 0.05). Serum IgA, mALB, α1-MG, β2-MG were positively correlated with IgG in SLE group (P < 0.05). There was a positive correlation between serum IgA, β2-MG and IgG in pSS group (P < 0.05). Conclusion The immunological indexes of RA, SLE and pSS patients are significantly increased, which indicated that humoral immunity might be activated in different degrees, leading to immune dysfunction. The increase of renal injury index indicates that RA, SLE and pSS may have different degrees of renal injury. The positive correlation between renal injury index and immunologic index indicates that serum immunoglobulin (IgG, IGA) may participate in the pathological process of renal injury, which can provide certain reference value for clinical diagnosis and treatment of patients.
2020 Vol. 17 (29): 115-118 [Abstract] ( 239 ) HTML (1 KB)  PDF (631 KB)  ( 170 )
119 Effect of local vibration therapeutic apparatus on lower limb spasticity and three-dimensional gait parameters in patients with hemiplegia
SHI Fang1 LI Fuliang1 LYU Zeping2
Objective To explore the effect of local vibration therapeutic apparatus on lower limb spasticity and three-dimensional gait parameters in patients with hemiplegia. Methods A total of 82 patients with hemiplegia (stable and convalescent) admitted to the First People′s Hospital of Dongcheng District, Beijing from March 2018 to June 2019 were selected as study subjects. The patients were divided into control group and experimental group by random number table method, with 41 cases each group. The control group were given routine rehabilitation training, and on this basis, the experimental group were treated with local vibration therapeutic apparatus. The degree of lower limb spasticity was evaluated with the modified Ashworth scale (MAS) before and after treatment, and the three-dimensional gait parameters were compared between the two groups. At the same time, the simplified Fugl-Meyer assessment scale (FMA) was used to assess the patients′ lower extremity motor function, and the improved Barthel Index (MBI) was used to assess the patients′ daily activity ability. Results There were no significant differences in MAS scores, three-dimensional gait parameters, FMA scores or MBI scores between the two groups before treatment (P ＞ 0.05). After treatment, MAS scores of both groups were significantly lower than those before treatment, and those of the experimental group were significantly lower than those of the control group (P ＜ 0.05). Three-dimensional gait parameters (gait speed, stride frequency, stride length), FMA score and MBI score were all higher in the two groups than before treatment, and the experimental group was significantly higher than the control group (P < 0.05). Conclusion The application of local vibratory therapeutic apparatus in patients with hemiplegia has obvious effects in improving the degree of lower limb spasm, promoting the lower limb motor function and the ability of daily life activities, etc., and has certain clinical promotion and application advantages.
2020 Vol. 17 (29): 119-122 [Abstract] ( 151 ) HTML (1 KB)  PDF (528 KB)  ( 94 )
123 Mechanistic study of Scutellariae Barbatae Herba in the treatment of pancreatic cancer by using network pharmacology
XU Yachen1 XIE Yiqiang2 XIAO Man2 ZHANG Rui2 SUN Zaoxi1
Objective To study the mechanism of action of Scutellariae Barbatae Herba in treating pancreatic cancer by using network pharmacology. Methods Based on TCMSP, NPASS, HIT, TCMID, TCM-ID, CNKI, WANFANG DATA, CQVIP, Science Citation Index (SCI), PubMed databases. The active constituents of Scutellariae Barbatae Herba were searched from June 1971 to October 2019. The prediction platform was used to acquire and screen target genes. Venn analysis was used to screen interaction genes between component target genes and pancreatic cancer specific genes, then determined the key targets of the drug through drug-target-disease cross-linking. Then fully utilized gene ontology (GO) analysis and kyoto encyclopedia of genes and genomes (KEGG) signal pathway enrichment to analyze molecular mechanism of Scutellariae Barbatae Herba in treating the disease. Results A total of 24 kinds of drug-like compounds were obtained, 73 target genes were determined, five core components including baicalein, wogonin, baicalin, quercetin, stigmasterol, and ten key targets such as AKT1, HSP90A1, tumor necrosis factor, ESR1, epidermal growth factor receptor, post-transcriptional gene silencing 2, SRC, matrix metalloproteinase 9, matrix metalloproteinase 2 and AR were screened out. GO enriched in the regulation of apoptosis, inflammation and oxidative stress, and were involved in the specific binding of proteins, ATPases and DNA. KEGG enriched in cancer, pancreatic cancer, cancer proteoglycan, Ras, phosphatidylinositol-3-kinase-protein kinase B pathway. Conclusion Scutellariae Barbatae Herba may regulate multiple signaling pathways through multiple types of targets, affecting multiple function of cells, thus playing a role in the treatment of pancreatic cancer.
2020 Vol. 17 (29): 123-127,146 [Abstract] ( 190 ) HTML (1 KB)  PDF (1504 KB)  ( 217 )
128 Professor Chen Xianhai′s experience of differentiation and treatment of pulmonary diseases based on perpetual-motion thinking
MA Jialu1 CHEN Xianhai2
Professor Chen Xianhai, under the influence of medical classics such as Shanghan Lun, combined with his own clinical experience for many years, believes that, in Shanghan Lun, perpetual-motion thinking plays an important guiding role in the treatment of pulmonary diseases and runs through each stage of the disease, pulse, syndrome and treatment. Clinical thinking such as “the differentiating and treating hierarchically” “truncated therapy” and “strengthening body resistance” based on perpetual-motion thinking can often guide the clinical treatment. Perpetual-motion thinking has unique advantages in reducing symptoms, and the clinical results are quite good. This has brought new thinking to the prevention and cure of pulmonary diseases, and is worthy of learning and reference.
2020 Vol. 17 (29): 128-130 [Abstract] ( 167 ) HTML (1 KB)  PDF (706 KB)  ( 23 )
131 Mechanism of kidney-reinforcing mass-disintegrating and removing blood stasis method in the treatment of IgA nephropathy
AN Mi1 TIAN Yun2
IgA nephropathy (IgAN) is an immune-mediated primary glomerular disease with a high incidence and no unified treatment plan. By discussing the theoretical basis of IgAN in traditional Chinese medicine and combining it with the microscopic pathological changes of the kidneys, it is clarified that the basic pathogenesis of IgAN is qi-deficiency and stasis of the collaterals in kidney and that the treatment of IgAN is kidney-reinforcing mass-disintegrating and removing blood stasis. With the studies of the pathogenesis of Western medicine of IgAN and the modern laboratory researches of kidney-reinforcing mass-disintegrating and removing blood stasis, it is found that this method can relieve the clinical symptoms of IgAN, prevent and cure the pathological changes of the kidney to delay the progression of the disease, which approves the efficacy of traditional Chinese medicine in the treatment of this disease and provides a reference for clinical treatment.
2020 Vol. 17 (29): 131-134 [Abstract] ( 157 ) HTML (1 KB)  PDF (719 KB)  ( 109 )
135 Effect of ulnar-tibial needle combined with body acupuncture on the local pain threshold, plasma 5-hydroxytryptamin and tumor necrosis factor-α in patients with cervical spondylosis and neck pain
ZHANG Li1 LIU Baoyu2 DONG Bo3
Objective To observe the clinical effects of ulnar-tibial needle combined with body acupuncture on local pain threshold, plasma 5-hydroxytryptamin (5-HT) and tumor necrosis factor-α (TNF-α) in patients with cervical spondylosis and neck pain. Methods A total of 74 patients with cervical spondylosis who met the inclusion criteria treated in the outpatient and inpatient Department of Orthopedics and Rehabilitation Medicine in the Affiliated Hospital of Shaanxi University of Chinese Medicine, who met the inclusion criteria, were divided into the observation group (treated with ulnar-tibia needle combined with body acupuncture) and the control group (treated with body acupuncture alone) according to random table method, with 37 cases in each group. The pain threshold, plasma 5-HT and TNF-α levels of patients in two groups were observed and analyzed before and after the treatment. Results The pain threshold of the two groups increased after treatment, and the observation group was higher than the control group (P ＜ 0.05). The levels of plasma 5-HT and TNF-α of the two groups were lower than those before treatment, and compared with the control group, the the observation group was lower than the control group (P ＜ 0.05). Conclusion The combination of ulnar-tibial needle and body acupuncture can significantly improve the pain threshold in patients with cervical spondylosis and neck pain. The mechanism of action may be related to the reduction of plasma 5-HT and TNF-α.
2020 Vol. 17 (29): 135-138 [Abstract] ( 228 ) HTML (1 KB)  PDF (755 KB)  ( 83 )
139 Director Wang Junling’s experience in the treatment of early threatened abortion combined with subchorionic hematoma with Jiaoai Decoction
LIU Yulei NING Yan TENG Hui YU Donghui WANG Junling
According to Director Wang Junling, the main pathogenesis of fetal leakage and threatened abortion is the loss of spleen and kidney, qi and blood, chong and conception channels, of which deficiency of kidney qi is the main cause. Subchorionic hematoma belongs to blood accumulation of menstrual separation and belongs to the category of “static blood”. The main pathogenesis of early threatened abortion combined with subchorionic hematoma is kidney deficiency and blood stasis, kidney deficiency is the foundation and blood stasis is the standard. The main treatment is to tonify kidney qi, and to activate blood circulation to stop bleeding. It is emphasized that blood stasis does not go away and blood does not return to meridians. Only proper blood circulation can achieve the purpose of hemostasis. In clinical practice, Jiaoai Decoction is commonly used to activate blood circulation and stop bleeding, Shoutai Pills to tonifying kidney for preventing miscarriage, and at the same time, attention should be paid to the observation of the condition of the disease and treat it according to the syndrome, so as to achieve the goal of “treating the disease and stabilizing the fetus simultaneously”.
2020 Vol. 17 (29): 139-142 [Abstract] ( 181 ) HTML (1 KB)  PDF (709 KB)  ( 63 )
143 Treatment of nodular goiter based on “dimple corresponding”
LI Xin′ai1 QI Shuo2 CHEN Xiaoheng2 LI Zhe2 LI Huilong2 DING zhiguo2 YANG Yapeng2
Nodular goiter in traditional Chinese medicine is called “gall”. It is traditionally believed that the pathogenesis of this disease is based on qi stagnation, syndrome of intermingled phlegm and blood stasis is main pathogenesis. For the disease syndrome differentiation, experts and scholars in different areas have different opinions. However, this disease has its own law of occurrence, development and evolution. On the basis of deficiency of vital qi and dysfunction of Zang Fu organs, qi stagnation, phlegm coagulation and blood stasis occur. Thyroid diseases often involve multiple systems in the whole body, that is, the disease is located in the thyroid gland, involving multiple systems, and the thyroid gland is integrated with the whole body, that is, “dimple corresponding”. This paper will start from the pathogenesis, clinical manifestations, treatment prescriptions, expounds the academic thought of “dimple corresponding” theory in the treatment of nodular goiter.
2020 Vol. 17 (29): 143-146 [Abstract] ( 192 ) HTML (1 KB)  PDF (721 KB)  ( 114 )
147 Study on the main indications and points combination rules of hégǔ point in Compendium of Acupuncture and Moxibustion
KUANG Xu1 FAN Wenjuan1 CHEN Xiaowei1 YI Wei2 XU Nenggui2▲
Objective To sum up the main indications and points combination rules of hégǔ point by studying the literatures in Compendium of Acupuncture and Moxibustion. Methods The search terms were “hégǔ” “hukou” “hankou” “hegu” “siguan”, and the qualified literatures were collected by the combination of electronic retrieval and manual retrieval. The main indications and points combination rules of hégǔ point were summed up through establishment of database and frequency analysis. Results In Compendium of Acupuncture and Moxibustion, there were 265 literatures related to hégǔ point and 246 literatures that met the inclusion criteria. The total frequency of hégǔ point in the treatment of diseases was 292. Main indications of hégǔ point involved traditional Chinese medicine of internal medicine, facial features, gynecology, surgery, pediatrics and orthopedics. The most common diseases treated by hégǔ point were internal medicine diseases and facial features diseases. The top three diseases in traditional Chinese medicine of internal medicine were brain diseases, body meridians diseases and lung diseases. The application frequency of traditional Chinese medicine of ophthalmic diseases in facial features was relatively high. The frequency of hégǔ point alone in the treatment of diseases was 21 and there were 179 matching acupoints of hégǔ point, and the total frequency of the matching acupoints was 838. The top 10 matching acupoints were qūchí, zúsānlǐ, sānyīnjiāo, bǎihuì, jiáchē, fēngchí, shuǐgōu, fùliū, xíngjiān, zhōngzhǔ. Conclusion Hégǔ point was widely used in the treatment of traditional Chinese medicine diseases, especially in internal medicine and facial features. The points combination rules of hégǔ point involved combination of affected channel, combination of points of namesake channels, superficies-interior points combination, superior-inferior points combination, yuan-source points and collateral-points combination.
2020 Vol. 17 (29): 147-150 [Abstract] ( 132 ) HTML (1 KB)  PDF (756 KB)  ( 30 )
151 Analysis of 125 adverse drug reaction cases caused by anti-tuberculosis drugs
LI Hui ZHANG Hongliang YANG Tianyan HUANG Zhenguang LIU Taotao WEI Fang
Objective To analyze the adverse drug reactions (ADR) caused by the anti-tuberculosis drugs, and to provide the reference for the rational use of the tuberculosis. Methods A retrospective study was conducted to collect 125 ADR cases of anti-tuberculosis drugs reported by the First Affiliated Hospital of Guangxi Medical University from 2012 to 2018. The gender, age, occurrence time of ADR, types of suspected drugs, route of administration, ADR related systems and clinical manifestations in the reports were statistically analyzed. Results ADR reports were mainly male patients, accounting for 64.80%; most ADRs occurred within 30 days after administration, accounting for 96.80%; the suspicious drugs causing ADR were Isoniazid Tablets, Isoniazid Injection, Isoniazid Aminosalicylate Tablets, Rifampicin Tablets, Rifapentine Capsules, Pyrazinamide Tablets, Ethambutol Tablets, Streptomycin Sulfate for injection, Levofloxacin Capsules; the ADR caused by oral preparation was more, accounting for 96.80%; the main ADR caused by various antituberculosis drugs was urinary system damage, the main clinical manifestation was hyperuricemia, accounting for 45.60%, followed by hepatobiliary system damage, accounting for 21.60%; there were nine cases of severe ADR, accounting for 7.20%; 81 cases of ADR patients had good prognosis, accounting for 64.80%. Conclusion Clinical medical workers should pay attention to the monitoring and treatment of ADR from anti-tuberculosis drug, adjust the medication plan when necessary, and promote rational use of drug.
2020 Vol. 17 (29): 151-154 [Abstract] ( 261 ) HTML (1 KB)  PDF (354 KB)  ( 50 )
155 Effects of Peplau′s interpersonal relationship theory on positive and negative emotions, mental resilience and social function in patients with chemotherapy for liver cancer
LIU Guoyan SONG Ruipeng▲
Objective To explore and analyze the influence of Peplau′s interpersonal relationship theory on positive and negative emotions, mental resilience and social function in patients with liver cancer chemotherapy. Methods From October 2017 to October 2019, 89 cases of liver cancer patients undergoing chemotherapy treated in the First Affiliated Hospital of Harbin Medical University were selected, the patients were divided into control group (n = 45) and observation group (n = 44) by random number table method, the control group was only given conventional chemotherapy intervention, the observation group was implemented the Peplau′s interpersonal relationship theory based on the control group. The proportion of patients with anxiety and depression before and after the intervention were compared, mindfulness attention awareness scale (MAAS), the 10-item conner-davidon resilence scale (CD-RISC10), the positive and negative affect scales (PANAS), and the scale of social function psychosis inpatients (SSPI) score were compared. Results The proportion of patients with anxiety and depression after intervention in the two groups was lower than that before intervention, and the proportion of patients in the observation group after intervention was lower than that in the control group, and the difference was statistically significant (P ＜ 0.05). The scores of MAAS, CD-RISC10, and PANAS after intervention were significantly higher in the two groups than before the intervention, and the observation group was higher than the control group, and the difference was statistically significant (P ＜ 0.05). The two groups after intervention factors Ⅰ, Ⅱ, Ⅲ score and total score were significantly higher than that of before intervention, and observation group was higher than group, and the differences were statistically significant (P ＜ 0.05). Conclusion The application of Peplau′s interpersonal relationship theory in patients with liver cancer chemotherapy can effectively improve the negative emotions of patients, help establish confidence in the treatment of disease, improve mental resilience, improve social function, and promote prognosis.
2020 Vol. 17 (29): 155-158 [Abstract] ( 169 ) HTML (1 KB)  PDF (590 KB)  ( 104 )
159 Effect of alternating bed head elevation on complications in patients with neurosurgical mechanical ventilation
YANG Guiping GU Yudan QIN Shu FEI Yaya SHI Wei
Objective To explore the effect of alternating bed head elevation on the complications of neurosurgical mechanical ventilation patients. Methods Ninety patients with mechanical ventilation admitted to the Department of Neurosurgery, Affiliated Hospital of Nantong University from November 2018 to November 2019 were selected and divided into control group and observation group by random number table method, with 45 cases in each group. The control group was given conventional bed head elevation, and the observation group was given alternating bed head elevation. the improvement of lung function, compliance with altcrnating bed head elevation and incidence of complications in the two groups were compared. Results After intervention, the arterial partial pressure of oxygen (PaO2) and oxygenation index (OI) of both groups were higher than those before intervention, and the inhaled oxygen concentration (FiO2) was lower than that before intervention. Moreover, the PaO2 and OI of the observation group were higher than those of the control group, and FiO2 was lower than that of the control group, with statistically significant differences (P ＜ 0.05); after seven days of intervention in the observation group, the compliance of alternating bed head elevation was higher than that of the control group, and the difference was statistical significance (P ＜ 0.05); the total incidence of complications after 7 days of intervention in the observation group was lower than that in the control group, and the difference was statistically significant (P ＜ 0.05). Conclusion Alternating bed head elevation is used in patients with neurosurgical mechanical ventilation, which can improve lung function, improve bedside elevation compliance, and effectively reduce the incidence of complications. It is worth promoting.
2020 Vol. 17 (29): 159-162 [Abstract] ( 200 ) HTML (1 KB)  PDF (582 KB)  ( 99 )
163 Nursing effect of tampon combined with wound repairing antibacterial dressing in intensive care unit patients with fecal incontinence associated dermatitis
LIU Huali1 LI Yulong1 WANG Junying2
Objective To investigate the effect of tampon combined with wound repairing antibacterial dressing on the care of patients with incontinence-associated dermatitis in ICU. Methods From October 2017 to December 2018, 180 patients who met the criteria for fecal incontinence were selected from department of ICU in Jianyang Municipal People′s Hospital. The randomized number table method was used to divide the patients into three groups, the control group (group A, B) and the experimental group (group C), with 60 patients in each group. The group A was treated with tampon perforator anal therapy, the group B was treated with wound repairing antibacterial dressing, and the group C was given two treatments in the same period. The incidence, severity, nursing expenses, healing time, and nursing satisfaction of incontinent-associated dermatitis (IAD) were compared among the three groups after one month of continuous nursing care. Results After nursing, IAD incidence, severity, healing time and nursing expenses in group C were significantly lower than those in group A and B (P ＜ 0.05), and the expenses of patients without IAD in group C were significantly lower than those in group A and B (P ＜ 0.05). The total satisfaction degree in group C was significantly higher than that in group A and B (P ＜ 0.05). Conclusion The tampon combined with wound repairing antibacterial dressing has a significant nursing effect on ICU patients with fecal incontinence related dermatitis which can significantly reduce the nursing cost of patients and improve the satisfaction of patients. It is worthy of clinical application.
2020 Vol. 17 (29): 163-166 [Abstract] ( 124 ) HTML (1 KB)  PDF (545 KB)  ( 221 )
167 The influence of intervention nursing based on chronic disease trajectory model on the psychological status and quality of life of lung cancer patients
GU Zhaoqin LIU Kouying▲
Objective To explore the effect of intervention nursing based on chronic disease trajectory model on psychological status and quality of life of lung cancer patients. Methods Eighty patients with lung cancer who underwent targeted therapy in Jiangsu Provincial People′s Hospital from March 2018 to March 2020 were selected as the research subjects. According to the random number table method, the patients were divided into control group and observation group, with 40 cases in each group. The control group was given routine nursing, and the observation group was given nursing based on trajectory model on psychological status. After one month of nursing, the scores of self rating anxiety scale (SAS) and self rating depression scale (SDS) were compared between the two groups before and after the intervention, and the quality of life questionnaire (QLQ-C30) scores of the two groups were compared after nursing, and the incidence of adverse reactions was compared. Results After nursing, the SDS and SAS scores of the two groups were significantly reduced, and the observation group were lower than the control group, the difference is statistically significant (P ＜ 0.05); the QLQ-C30 scores of the observation group after nursing, the cognitive function, role function, emotional function, social function, physical function and total score were significantly higher than those of the control group, the differences were statistically significant (P ＜ 0.05); the incidence of adverse reactions in the observation group was significantly lower than that in the control group, the difference is statistically significant (P ＜ 0.05). Conclusion Based on the chronic disease trajectory model can significantly improve the psychological status and quality of life of patients with lung cancer targeted therapy, high safety, worthy of clinical application.
2020 Vol. 17 (29): 167-170 [Abstract] ( 167 ) HTML (1 KB)  PDF (545 KB)  ( 29 )
171 Effect of rehabilitation training nursing based on muscle energy technology on functional rehabilitation after meniscus injury
YE Zhiyu LI Simin▲
Objective To investigate the intervention effect of rehabilitation training nursing based on muscle energy technique in patients with meniscus injury. Methods Retrospectively analysis, collected the clinical data of 82 meniscus injury patients who completed surgical treatment, postoperative rehabilitation and follow-up from March 2018 to October 2019 in West China Hospital, Sichuan University, and they were divided into control groups (conventional rehabilitation training nursing, 38 cases) and observation group (conventional rehabilitation training nursing + rehabilitation training nursing based on muscle energy technology, 44 cases) according to different rehabilitation training nursing interventions, they were treated with 4 weeks of intervention. Before intervention, at 3 d and at 7 d of intervention, visual analogue scale (VAS) was used to assess the pain level in both groups; Lysholm knee scale was used to assess the recovery of knee function in both groups; protractor was used to measure the knee joint mobility of the two groups, the isokinetic strength test and training system were used to assess the degree of quadriceps atrophy in both groups. Results The VAS scores of patients at different times and groups were different, and there was an interaction between time and group (P ＜ 0.05). Further comparison between the two groups, comparison within the group: the VAS scores of the two groups at 3 d and 7 d were lower than before the intervention; comparison between the groups: the VAS scores of the observation group at 3d and 7d were lower than the control group (P ＜ 0.05); Before intervention, there was no significant difference in knee joint function (LKSS) score between the two groups (P ＞ 0.05); after intervention, the LKSS scores of the two groups were higher than before intervention, and the observation group was higher than the control group (P ＜ 0.05); before intervention, there was no statistically significant difference in knee joint mobility and quadriceps atrophy between the two groups (P ＞ 0.05); after intervention, the knee joint mobility of the two groups was higher than before intervention, and the degree of atrophy of the quadriceps muscle was lower than before the intervention, and the knee joint mobility of the observation group was higher than that of the control group, and the degree of atrophy of the quadriceps muscle was lower than that of the control group (P ＜ 0.05). Conclusion The application of rehabilitation training nursing based on muscle energy technology in patients with meniscus injury has a significant effect, which can effectively reduce the pain of patients, promote the rehabilitation of knee joint function, and is more conducive to the recovery of postoperative function of patients.
2020 Vol. 17 (29): 171-174 [Abstract] ( 154 ) HTML (1 KB)  PDF (580 KB)  ( 84 )
175 Professor Cai Bingqin′s experience of using traditional Chinese medicine to treat thyroid cancer during perioperative period
JIANG Sijing1 WANG Jianchun2 CHEN Ling2 ZHOU Yuteng2 CAI Bingqin2
With the development of social economy and the popularization of thyroid ultrasound during the national health checkup, thyroid malignant tumors have become the fastest growing malignant tumors in the world. The diagnosis and treatment of thyroid malignant tumors are also receiving more and more attention. Generally speaking, surgical operations treatment is the clinically recognized preferred treatment method. The treatment feature of removing cancerous lesions directly is also one of the traditional Chinese medicine “eliminate evils” methods, which can clearly help patients with thyroid malignant tumors to provide a higher survival rate. The principle of dialectical treatment of traditional Chinese medicine believes that each patient with thyroid malignant tumor should be provided with a more comprehensive and individualized treatment plan. Professor Cai Bingqin adheres to the theory of traditional Chinese medicine treatment, combining “eliminating pathogen and strengthening vital qi” “strengthening vital qi to eliminate pathogenic factor” “conditioning qi movement” “medicine channel tropism” “balance of Yin and Yang” and other classic Chinese medicine principles in the perioperative period of thyroid cancer has achieved good clinical efficacy in the treatment of traditional Chinese medicine.
2020 Vol. 17 (29): 175-178 [Abstract] ( 167 ) HTML (1 KB)  PDF (596 KB)  ( 186 )
179 Feasibility analysis of prevention and treatment of community breast tumor by integrating Chinese and Western medicine based on PEST model
WANG Lei LU Juanyi MA Qiayi CHEN Ge ZHU Ji
Breast cancer is the cancer with the highest incidence of urban women, but the “urban community breast cancer prevention and treatment process” that has been developed in the past has encountered resistance in the real world. The first is the economic compensation for the technical output of the supplier, and the second is the local cultural adaptation of the demand-side health education. The newly promulgated primary care development policy has provided a new background for the advancement of this prevention and treatment process. This study analyzes the feasibility and implementation countermeasures of establishing, perfecting and implementing the integrated Chinese and Western treatment process for breast tumors in urban communities by integrating the policy advantages of the family doctor system and the technical advantages of traditional Chinese medicine treatment under this new background. It is hoped that while implementing breast cancer prevention and treatment, the construction of the family doctor system and the development of community health services will be accelerated.
2020 Vol. 17 (29): 179-182 [Abstract] ( 223 ) HTML (1 KB)  PDF (566 KB)  ( 23 )
184 Application of PDCA cycle in the process of fund declaration of National Natural Science Foundation of China in Peking University of Aerospace Clinical Medicine School
GAO Yuan SHI Han JIAO Jingxuan WANG Hongquan
The number of projects funded by the National Natural Science Foundation of China (NSFC) and the amount of funding provided by NSFC are important indicators of the influence of hospital in terms of science and technology. To its application for NSFC and the management of the application, Peking University of Aerospace Clinical Medicine School applied the theory of PDCA cycle. First, the hospital analyze the influential factors in the process of application and created a project management plan. Then it take various measures according to the plan, including revising the reward policy on scientific research, attaching great importance to scientific research, managing the process of application in detail, improving human resources management, supporting the development of distinctive disciplines in the hospital, and improving the training system. Based on the feedback on the application from NSFC, a summary is made. The process of application shows that the PDCA cycle management method is able to improve the quality and quantity of the projects applied for and funded by NSFC, also achieving continuous advancement of project management.
2020 Vol. 17 (29): 184-188 [Abstract] ( 178 ) HTML (1 KB)  PDF (599 KB)  ( 81 )
189 Development status of overseas Chinese material medica and thinking of industrial chain control
ZHU Dewei1 SONG Xinyang2 SHEN Yunhui1
The development of good quality Chinese material medica is the prerequisite for the modernization and internationalization of Chinese material medica. The whole industrial chain control ensures the quality for seeds, crude herbs, pieces, preparations and finished products of Chinese material medica. In recent years, a large number of imported Chinese medicinal materials imported from overseas have flooded into the domestic market, but there are often some problems such as unknown origin, mixed authenticity and so on, leading to the unstable efficacy of Chinese material medica, and the problems of introduction difficulty and higher import cost make things worse to the development of Chinese material medica. The following methods of controlling the overseas Chinese material medica industry chain， the construction of standardized base of Chinese material medica, carrying out the localization research of Chinese material medica and traditional Chinese medicine talent output will be of great benefit, which will promote “The Belt and Road” comprehensive health industry of traditional Chinese medicine.
2020 Vol. 17 (29): 189-192,196 [Abstract] ( 256 ) HTML (1 KB)  PDF (490 KB)  ( 250 )
193 Application of high-resolution satellite remote sensing technology in the field of poverty alleviation of  Chinese herbal medicines industry
CAI Miaoting HE Xiaoqun CHEN Chao WANG Xiaoqing
Chinese herbal medicines are the material basis for the inheritance and development of Chinese traditional medicine, and are strategic resources related to the national economy and the people′s livelihood. Chinese herbal medicines are widely planted in poverty-stricken areas in China, and the cultivation of Chinese herbal medicines is one of the important sources of income for the poor rural population in China. This paper analyzes the characteristics and application status of high-resolution satellite remote sensing technology, discusses the ideas and methods of applying remote sensing technology to the poverty alleviation of Chinese herbal medicines industry. The sources of dried tangerine peel of Jiangxi Province in Nanfeng County and the estimation of the planting area of Citrus reticulata Blanco′ Kinokuni′ are taken as cases to reflect the advantages of remote sensing technology in accurately obtaining the distribution information of Chinese herbal medicines and estimating the planting area, which provides a prerequisite for the digital monitoring of poverty alleviation of Chinese herbal medicines industry in the future and provides a reference for the intelligentization of rational distribution of Chinese herbal medicines.
2020 Vol. 17 (29): 193-196 [Abstract] ( 101 ) HTML (1 KB)  PDF (589 KB)  ( 95 )
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