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| Research progress of circular RNA in nervous system diseases |
| GAO Yongchao WANG Shuang WANG Jing TAI Xiantao |
| Acupuncture and Massage Rehabilitation Institute, Yunnan University of Traditional Chinese Medicine, Yunnan Province, Kunming 650000, China |
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Abstract Circular RNA (circRNA) is a long-chain non-coding RNA molecule, which is widely found in eukaryotic cells. It is highly conserved in expression and has the functions of sponge adsorption, protein binding and protein translation. CircRNA can be involved in the regulation of a variety of diseases, such as tumors, cardiovascular diseases and nervous system diseases. Recent studies have found that circRNA is highly expressed in the nervous system and has tissue specificity, especially in the brain tissue. It is involved in the development and signal transmission of the nervous system and regulates the complex functions and various neural activities of the brain. CircRNA is closely associated with the development of nervous system diseases, and it has been found to be involved in cerebral palsy, alzheimer′s disease, and stroke. CircRNA is stable in structure, has a long half-life in exosomes, and is not easily degraded. Therefore, circRNA is considered as an ideal biomarker for monitoring a variety of nervous system diseases. This paper reviews the biological functions of circRNA and its application in nervous system diseases.
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