小胶质细胞在脑白质损伤发生发展中的作用

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Abstract Microglia is widely distributed in the central nervous system and is the inherent immune cells. The nerve inflammation mediated by microglia is an important factor that cause white matter damage. More and more evidences show that the activation pathways of microglia in different white matter damage diseases are different, which is the basis of their complex role in the central nervous system. The typical manifestation of white matter damage is demyelination, which is a common pathological stage in multiple diseases including multiple sclerosis, Alzheimer′s disease, vascular cognitive impairment and dementia. In this article, the medical mechanism for microglia playing biological role through different activation pathways under various disease types and different brain regions is discussed. In addition, microglia can play a biphasic role in brain white matter damage, such as proinflammatory and immunomodulatory effects, therefore further research on these microglial subtypes may lead to new treatments that promote the repair of white matter damage.

Key words： Microglia Nerve inflammation White matter damage Demyelination

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	XU Manman CHAO Bin CUI Hanming PAN Juhua ZHANG Qiuyan HUANG Shijing

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XU Manman CHAO Bin CUI Hanming PAN Juhua ZHANG Qiuyan HUANG Shijing. The role of microglia in the development of white matter damage[J]. 中国医药导报, 2020, 17(29): 37-39,44.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2020/V17/I29/37

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