|
|
Mechanism of kidney-reinforcing mass-disintegrating and removing blood stasis method in the treatment of IgA nephropathy |
AN Mi1 TIAN Yun2 |
1.The First Clinical Medical College, Shaanxi University of Chinese Medicine, Shaanx Province, Xianyang 712046, China;
2.The First Department of Nephrology, Shaanxi Traditional Chinese Medicine Hospital, Shaanx Province, Xi′an 710000, China |
|
|
Abstract IgA nephropathy (IgAN) is an immune-mediated primary glomerular disease with a high incidence and no unified treatment plan. By discussing the theoretical basis of IgAN in traditional Chinese medicine and combining it with the microscopic pathological changes of the kidneys, it is clarified that the basic pathogenesis of IgAN is qi-deficiency and stasis of the collaterals in kidney and that the treatment of IgAN is kidney-reinforcing mass-disintegrating and removing blood stasis. With the studies of the pathogenesis of Western medicine of IgAN and the modern laboratory researches of kidney-reinforcing mass-disintegrating and removing blood stasis, it is found that this method can relieve the clinical symptoms of IgAN, prevent and cure the pathological changes of the kidney to delay the progression of the disease, which approves the efficacy of traditional Chinese medicine in the treatment of this disease and provides a reference for clinical treatment.
|
|
|
|
|
[1] Donadio JV,Grande JP. IgA nephropathy [J]. N Engl J Med,2002,347(10):738-748.
[2] 刘刚,马序竹,邹万忠,等.肾活检患者肾脏病构成十年对比分析[J].临床内科杂志,2004(12):834-838.
[3] Shimizu C,Matsumoto K,Fujita T,et al. Imbalance of interleukin-18 and interleukin-18 binding protein in patients with IgA nephropathy implicating renal vasculopathy [J]. Clin Lab,2015,61(1/2):23-30.
[4] 陈香美.临床诊疗指南.肾脏病学分册[M].北京:人民卫生出版社,2011:6.
[5] 兰小梅.IgA肾病血管病变与预后不良因素的相关性分析[D].银川:宁夏医科大学,2014.
[6] 吴杰,陈香美,师锁柱,等.血管病变在1005例IgA肾病中的意义及其影响因素[J].中华医学杂志,2003,83(4):289-293.
[7] Radford MG Jr,Donadio JV Jr,Bergstralh EJ,et al. Predicting renal outcome in IgA nephropathy [J]. J Am Soc Nephrol,1997,8(2):199-207.
[8] 陈香美,陈以平,李平,等.1016例IgA肾病患者中医证候的多中心流行病学调查及相关因素分析[J].中国中西医结合杂志,2006,26(3):197-201.
[9] 巴元明,林晓媛.邵朝弟治疗IgA肾病的经验[J].时珍国医国药,2015,26(3):707-708.
[10] 杨雨竹,管鑫,高建东.IgA肾病中医药治疗进展[J].中国中西医结合肾病杂志,2017,18(10):932-933.
[11] 孙建实.IgA肾病中医病因病机新探[J].中医药学报,2006(2):1-2.
[12] 屈凯,延佩,张楠,等.肾复康Ⅱ号胶囊治疗慢性肾小球肾炎的疗效观察[J].湖北中医药大学学报,2015,17(5):30-32.
[13] 程小红,于小勇,毛加荣.IgA肾病的病理改变与中医微观辨证[J].中国中西医结合肾病杂志,2014,15(2):185-186.
[14] 张宏.IgA肾病发病机制研究进展[C]//中国中西医结合学会肾脏疾病专业委员会.2008年全国中西医结合肾脏病南京论坛论文汇编,2008:2.
[15] 陈琴,王蔚,王莉.IgA肾病发病机制的研究进展[J].实用医院临床杂志,2019,16(2):242-245.
[16] Canetta PA,Kiryluk K,Appel GB. Glomerular diseases:emerging tests and therapies for Ig A nephropathy [J]. Clin J Am Soc Nephrol,2014,9(3):617-625.
[17] 吴嵩.黄葵胶囊联合RAS系统阻滞剂治疗IgA肾病Meta分析[D].武汉:湖北中医药大学,2019.
[18] Zhong Z,Feng S,Shi D,et al. Association of FCRL3 Gene Polymorphisms with IgA Nephropathy in a Chinese Han Population [J]. DNA Cell Biol,2019,38(10):1155-1165.
[19] 石咏琪,王墨.肾间质纤维化发生机制研究进展[J].现代医药卫生,2019,35(19):3002-3006.
[20] Han SY,Kim CH,Jee YH,et al. Spionlactone prevents diabetic nephropathy through an anti-inflammatory mechanism in type 2 diabetic rats [J]. J Am Soc Nephrol,2006, 17(5):1362-1372.
[21] Ruiz-Ortega M,Ruperez M,Esteban V. Molecular mechanisms of angiotensin Ⅱ-induced vascular injury [J]. Curr Hypertens Rep,2003,5(1):73-79.
[22] 张浩.转化生长因子β1ROS依赖的ERK-NF-κB通路对血管平滑肌细胞生MMP-9的影响[D].武汉:武汉大学,2013.
[23] 华军谊,何煜舟,蒋旭宏,等.川芎嗪抑制血管平滑肌细胞增殖及胶原合成的作用机制研究[J].中国中西医结合杂志,2013,33(9):1226-1231.
[24] 陈天怡,谌贻璞,董鸿瑞,等.IgA肾病患者肾内小动脉病变的临床及病理意义[J].中国实用内科杂志,2014, 34(4):391-394.
[25] 赵唯含,顾焕,廖江铨,等.IgA肾病与动脉硬化指数的相关性研究[J].中华中医药杂志,2014,29(7):2201-2203.
[26] 查汗·索林格.IgA肾病间质纤维化程度与临床指标及病理相关性分析[D].乌鲁木齐:新疆医科大学,2018.
[27] Sato M,Muragaki Y,Saika S,et al. Targeted disruption of TGF-β1/Smad3 signaling protects against renal tubulointerstitial fibrosis induced by unilateral ureteral obstruction [J]. JCI,2003,112(10):1486-1494.
[28] 李锋.肾间质纤维化发生机制的研究进展[J].中国医药指南,2011,9(35):287-289.
[29] Zhang G,Kernan K A,Collins S J,et al. Plasmin(ogen)Promotes Renal Interstitial Fibrosis by Promoting Epithelial-to-Mesenchymal Transition:Role of Plasmin-Activated Signals [J]. J Am Soc Nephrol,2007,18(3):846-859.
[30] 王建中,陈香美,师锁柱,等.Ⅰ型纤溶酶原激活物抑制物在IgA肾病肾小管间质损伤中的作用研究[J].中华肾脏病杂志,2000,16(1):11-15.
[31] 张晓凤,田耘,程小红等.肾复康Ⅱ号对MSCs旁分泌作用的实验研究[J].西部中医药,2018,31(10):4-7.
[32] 程小红,邢斌,刘建红,等.益肾散结法对大鼠肾脏间质纤维化组织TGF-β1和PAI-1表达的影响[J].陕西中医,2018,39(2):143-145,153.
[33] 史健,刘建红,程小红,等.肾复康Ⅱ号对大鼠肾间质纤维化及转化生长因子-β1的影响[J].中药药理与临床,2012,28(3):99-101.
[34] 史健,杨洪涛,胡锐,等.肾复康Ⅱ号抗肾间质纤维化及对人肾上皮小管细胞转分化的作用[J].陕西中医,2014, 35(1):103-105.
[35] 陈香美.凝血纤溶系统与细胞外基质调控系统在肾脏疾病中的作用[J].中华肾脏病杂志,2001(5):348-349.
[36] 田耘,程小红,于小勇,等.肾血安对IgA肾病大鼠凝血纤溶系统的影响[J].陕西中医,2013,34(12):1674-1676.
[37] 白玉华,黄芳.丁樱教授治疗IgA肾病经验[J].中医研究,2009,22(3):57-59. |
|
|
|