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Progress of metabolomics in the study of anti hepatic fibrosis of traditional Chinese medicine |
YANG Ni1* XU Jianliang1,2* SHENG Guoguang2 XIAO Mingzhong1,2 |
1.Clinical School of Chinese Medicine, Hubei University of Chinese Medicine, Hubei Province, Wuhan 430065, China;
2.Department of Hepatology, Hubei Provincial Hospital of Traditional Chinese Medicine, Hubei Province, Wuhan 430061, China |
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Abstract Metabolomics can reveal the nature of disease and look for disease markers through accurate qualitative and quantitative analysis of small molecular metabolites in the body, and analyze the relationship between metabolites and physiological and pathological changes. At present, no specific and effective Western medicine has been found in the treatment of liver fibrosis. The clinical use of traditional Chinese medicine and Chinese patent medicine has a significant effect on liver fibrosis. In recent years, metabolomics technology has developed rapidly, which provides a new technology platform for the research of traditional Chinese medicine treatment of liver fibrosis. This article mainly reviews the research progress of metabolomics in the treatment of liver fibrosis with traditional Chinese medicine in recent five years.
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[1] 阿基业,何骏,孙润彬.代谢组学数据处理——成分分析十个要点问题[J].药学学报,2018,53(6):929-937.
[2] Schuppan D,Ashfaq-Khan M,Yang AT,et al. Liver fibrosis:direct antifibrotic agents and targeted therapies [J]. Matrix Biol,2018,68-69:435-451.
[3] 刘成海,赵志敏,吕靖.中医对肝纤维化逆转的认识与治疗[J].临床肝胆病杂志,2019,35(4):728-733.
[4] 彭汝琴,王绍展,王媛媛,等.丹参素通过MEK/ERK信号通路抑制肝纤维化[J].中南药学,2017,15(5):580-586.
[5] 戈升荣,崔岚,王平全.汉防己甲素药理作用的研究进展[J].中草药,2000,31(8):附4-附6.
[6] 周永安,刘建民,师英霞.汉防己甲素治疗慢性肝炎肝纤维化50例疗效观察[J].山东医药,2007,47(23):86.
[7] 孔德松,张自力,张峰,等.姜黄素通过影响自噬调控肝细胞上皮间质转化及肝纤维化进程的作用与机制研究[J].中国药理学通报,2019,35(10):1388-1393.
[8] 金学琴,黎伟华,李志梅,等.苦参素对肝纤维化大鼠肝脏转化生长因子-β1的调节作用[J].畜牧与饲料科学,2018,39(12):19-22.
[9] 贺佩,胡君健,何永康,等.四种单味中药及其复方对小鼠血吸虫病肝纤维化Ⅰ、Ⅲ型胶原及TGF-β1表达的影响[J].热带病与寄生虫学,2016,14(1):29-32.
[10] 蒋华波,陆斌.鳖甲在抗肝纤维化和抗肝癌作用中的研究进展[J].基因组学与应用生物学,2017,36(4):1446-1450.
[11] 余华香,罗建屏,程静.鳖甲煎丸联合恩替卡韦治疗乙肝肝纤维化的效果[J].饮食保健,2019,6(31):55-56.
[12] 刘瑜,张静.安络化纤丸联合恩替卡韦治疗慢性乙型肝炎肝纤维化[J].牡丹江医学院学报,2019,40(4):54-55.
[13] 钟伟超,周楚莹,高磊,等.大黄蛰虫丸对小鼠酒精性肝纤维化损伤的保护作用[J].中成药,2017,39(12):2475-2480.
[14] 徐渴阳,苏晓倩,包剑锋.扶正化瘀胶囊对气虚血瘀型肝纤维化模型大鼠细胞自噬基因LC3Ⅱ和p62的干预作用[J].浙江中西医结合杂志,2019,29(4):281-284, 351.
[15] 尚立芝,季书,王琦,等.柴胡疏肝散的抗肝纤维化作用研究[J].中药药理与临床,2014,30(5):8-11.
[16] 夏雪皎,林庚庭,滕飞,等.疏肝健脾活血方对肝纤维化大鼠肝组织HIF-1α蛋白及VEGF mRNA表达的影响[J].中华中医药杂志,2018,33(4):1357-1360.
[17] 曹蓓,阿基业,王广基,等.代谢组学在临床研究中的应用及进展[J].生命科学,2010,22(8):761-771.
[18] Jenkins H,Hardy N,Beckmann M,et al. A proposed framework for the description of plant metabolomics experiments and their results [J]. Nat Biotechnol,2004,22(12):1601-1606.
[19] Szymanska E,Markuszewski MJ,Capron X,et al. Increasing conclusiveness of metabonomic studies bychem-informatic preprocessing of capillary electrophoreticdata on urinary nucleoside profiles [J]. J Pharm Biomed Anal,2007,43(2):413-420.
[20] Adamko DJ,Sykes BD,Rowe BH. The metabolomics of asthma:novel diagnostic potential [J]. Chest,2012,141(5):1295-1302.
[21] Nybo SE,Lamberts JT. Integrated use of LC/MS/MS and LC/Q-TOF/MS targeted metabolomics with automated label-free microscopy for quantification of purine metabolites in cultured mammalian cells [J]. Purinergic Signal,2019,15(1):17-25.
[22] Ahamad SR,Alhaider AQ,Raish M,et al. Metabolomicand elemental analysis of camel and bovine urine by GC-MS and ICP-MS [J]. Saudi J Biol Sci,2017,24(1):23-29.
[23] 张艳,李卉,满成云,等.基于气相色谱质谱联用技术的平菇多糖治疗大鼠急性肝损伤的代谢组学研究[J].食品工业科技,2018,39(20):309-313.
[24] 文佳.不同摄碘人群甲状腺乳头状癌的血清代谢组学研究[D].福州:福建医科大学,2019.
[25] Tokushige K,Hashimoto E,Kodama K,et al. Serum meta-bolomic profile and potential biomarkers for severity of fibrosis in nonalcoholic fatty liver disease [J]. J Gastroenterol,2013,48(12):1392-1400.
[26] Embade N,Marino Z,Diercks T,et al. Metabolic characterization of advanced liver fibrosis in HCV patients as studied by serum 1H-NMR spectroscopy [J]. PLoS One,2016,11(5):e0155094.
[27] 周永峰,牛明,房吉祥,等.基于UPLC-Q-TOF-MS的五味子保肝作用代谢组学研究[J].中国中药杂志,2018, 43(18):3756-3763.
[28] 涂灿,何琴,周元园,等.基于代谢组学的大黄对正常和肝纤维化大鼠双向作用对比研究[J].药学学报,2018, 53(7):1-5.
[29] 常虹,孟洪宇,王宇,等.基于尿液代谢组学的黄芩抗肝纤维化作用研究[J].中国中药杂志,2018,43(10):2140-2146.
[30] Liu XW,Tang CL,Zheng H,et al. Investigation of the hepatoprotective effect of Corydalis saxicola Bunting on carbon tetrachloride-induced liver fibrosis in rats by 1H-NMR-based metabonomics and network pharmacology approaches [J]. J Pharmaceut Biomed Anal,2018, 159:252-261.
[31] 滕杨,罗时旋,郭英雪,等.代谢组学法考察金银花醇提物对DMN诱导大鼠肝损伤的保护作用[J].食品研究与开发,2016,37(4):40-45.
[32] Gao GY,Zheng XY,Peng Y,et al. Effect of Fuzheng Huayu capsule on serum metabolomics in rats with liver fibrosis induced by dimethylnitrosamine [J]. Zhongguo Zhong Yao Za Zhi,2016,41(9):1725-1731.
[33] Zhang H,Wang X,Hu P,et al. Serum metabolomic characterization of liver fibrosis in rats and anti-fibrotic effects of Yin-Chen-Hao-Tang [J]. Molecules,2016,21(1):E126.
[34] 高家荣,陈金锋,姜辉,等.疏肝健脾方对四氯化碳诱导的肝纤维化大鼠肝脏代谢组学的影响[J].中医杂志,2015,56(11):961-966.
[35] 姜辉,吴芙蓉,高家荣,等.疏肝健脾方对四氯化碳诱导肝纤维化大鼠血清代谢组学的影响[J].中华肝脏病杂志,2015,23(2):139-141.
[36] 姜辉,吴芙蓉,高家荣,等.疏肝健脾方对CCl4诱导的肝纤维化大鼠尿液代谢组学的影响[J].中成药,2014, 36(12):2457-2462.
[37] 仰贤莉,李光伟,康璐,等.扶正化瘀方抗大鼠肝纤维化疗效的代谢组学研究[J].中成药,2016,38(11):2342-2346. |
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