中国医药导报
      Home                                                                                    中文
中国医药导报
 
Forthcoming Articles
Current Issue
Archive
Advanced Search
Read Articles
Download Articles
Email Alert
 
Quick Search  
  Adv Search
2020 Vol. 17, No. 23
Published: 2020-08-15
 
 
4 Construction and expression of prokaryotic expression vector of vascular endothelial growth factor
PANG Lijun1 LIU Daojie2 LIN Minghua1 LIU Kai1 LIU Xiaoni1 CHEN Dexi1
Objective To construct a prokaryotic expression vector containing vascular endothelial growth factor (VEGF) and induce to express protein, it may lay a foundation for the follow-up study of VEGF. Methods Amplified The target fragment was amplified by reverse transcription polymerase chain reaction (RT-PCR) and the DNA fragment was cloned into pET-30a(+) vector with histidine tag. The recombinant plasmid was identified by polymerase chain reaction (PCR) and sequencing. The expression of recombinant plasmid was induced by isopropylthio-β-D-galactoside (IPTG) and identified by Western blot. Results The right size of the fragment was amplified from HepG2 cells. The recombinant plasmid pET-30a-VEGF was confirmed by PCR and DNA sequencing. Coomassie brilliant blue staining and Western blot results showed that the molecular weight of the fusion protein induced by IPTG was correct and the band was single. Conclusion The prokaryotic expression plasmid of pET-30a-VEGF is successfully constructed, in addition, it might lay the foundation for development of HCC diagnostic and treatment research.
2020 Vol. 17 (23): 4-7 [Abstract] ( 487 ) HTML (1 KB)  PDF (722 KB)  ( 158 )
8 Study on the relationship between obesity and single nucleotide polymorphism of obesity gene in children
ZHENG Yi1,2 HE Qi2,3 LI Yubo4 CHEN Jialiang1,2▲ LI Xiaodong2,5
Objective To study the mutation of obesity gene in children in Central China, and to explore the relationship between obesity and single nucleotide polymorphism (SNP) of obesity gene in children. Methods From May 2017 to May 2018, a total of 100 children aged five to ten were selected from the Department of Obesity and Internal Medicine of Hubei Hospital of Traditional Chinese Medicine. According to body mass index, they were divided into control group (24 cases), overweight group (42 cases) and obesity group (34 cases). Three SNP loci of obesity gene (rs9939609, rs1421085, rs8057044) were detected by the improved multiple high temperature ligase assay (iMLDR) and the mutations of SNP locus in three groups were detected by sequencing. Results There were no significant differences in genotype distribution of rs9939609 and rs1421085 loci among three groups (P > 0.05). Genotype distribution of RS8057044 locus were compared among three groups, and the differences were statistically significant (P < 0.05). There was no significant difference in allele frequency of rs8057044 locus between overweight group and obesity group (P > 0.05). Conclusion Among the children aged five to ten, rs8075044 locus can be used as a potential detection site for adult obesity.
2020 Vol. 17 (23): 8-11,19 [Abstract] ( 221 ) HTML (1 KB)  PDF (664 KB)  ( 68 )
12 Effect of Disulfiram on gene expression of cytokines secreted by tumor-associated macrophages
ZHANG Wenwen1 LIU Luyao1 CAO Juan1 LI Weibo1 DONG Chunling2 LI Bo1
Objective To study the effect of Disulfiram (DSF) on the genes expression of cytokine secreted by tumor-associated macrophages (TAMs) in oral squamous cell carcinoma (OSCC) tumor cell supernatant. Methods RAW264.7 cells were randomly divided into control group and research group. Two induction methods were used, the first inducement was that CAL27 tumor cell supernatant was used to induce RAW264.7 cells for 48 h in control group; and DSF and copper gluconate (DSF/Cu) 2 μmol/L were added to the CAL27 tumor cell supernatant to induce RAW264.7 cells for 48 h in research group. The second inducement was that RAW264.7 cells were induced with CAL27 tumor cell supernatant for 48 h, and then continued to be induced for 48 h in control group; in research group, after CAL27 tumor cell supernatant induced RAW264.7 cells for 48 h, DSF/Cu 2 μmol/L was used to intervene for 48 h. The gene expression levels of nitric oxide synthase (iNOS), interleukin-12 (IL-12), tumor necrosis factor-α (TNF-α), argininase 1 (Arg-1) and IL-10 were measured. Results DSF/Cu was added in the induction process, iNOS mRNA level of research group was higher than that of control group, Arg-1 mRNA level was lower than that of control group, and the differences were highly statistically significant (all P < 0.01). There were no significant differences in IL-12, TNF-α and IL-10 mRNA levels between two groups (P > 0.05). DSF/Cu was added 48 h after induction, iNOS mRNA, IL-12 mRNA, TNF-α mRNA, IL-10 mRNA levels in research group were higher than those in control group, and Arg-1 mRNA level was lower than that in control group, with statistically significant differences (P < 0.05 or P < 0.01). Conclusion DSF can regulate the gene expression of cytokines secreted by TAMs, which helps to further clarify the mechanism of disulfiram against OSCC. It may provide experimental basis and treatment strategies for the diagnosis and treatment of oral tumors in the future.
2020 Vol. 17 (23): 12-15 [Abstract] ( 227 ) HTML (1 KB)  PDF (646 KB)  ( 47 )
16 Expression and diagnostic efficacy of miR-135a and miR-146a in patients with Alzheimer′s disease
XUE Yufeng1 YE Lijun2 FU Pan1 LI Min1▲
Objective To investigate the expression and clinical significance of miR-135a and miR-146a in patients with Alzheimer′s disease (AD), and to provide evidence for the diagnosis of AD. Methods Sixty-five patients with AD who admitted to Department of Neurology, the First People′s Hospital of Taizhou of Zhejiang Province (“our hospital”for short) from June 2017 to May 2019 were enrolled in AD group. In addition, 30 healthy subjects who underwent physical examination in our hospital during the same period were selected as control group. The expression levels of miR-135a and miR-146a were detected by real-time fluorescent quantitative PCR and the diagnostic efficacy of miR-135a and miR-146a in AD were evaluated by receiver operating characteristic (ROC) curve. Results The expression of miR-135a in AD group was lower than that in control group, and the expression of miR-146a was higher than that in control group, with statistically significant differences (all P < 0.05). The cut-off value of miR-135a in the diagnosis of AD was 0.825, the sensitivity was 0.923, and the specificity was 0.700. The cut-off value of miR-146a in the diagnosis of AD was 2.065, the sensitivity was 0.877, and the specificity was 0.900. Conclusion The expression of miR-135a is down-regulated， the expression of miR-146a is up-regulated in AD patients, which have a higher diagnostic efficacy for AD.
2020 Vol. 17 (23): 16-19 [Abstract] ( 253 ) HTML (1 KB)  PDF (682 KB)  ( 140 )
20 Prognostic value of red blood cell volume distribution width in patients with acute decompensated heart failure with preserved ejection fraction
GUO Qinghong1 TANG Long2 FENG Qifan2 XI Xiaotu3
Objective To explore prognostic value of red blood cell distribution width (RDW) in patients with acute decompensated heart failure with preserved ejection fraction (HFpEF). Methods One hundred and twenty-nine patients with acute decompensated HFpEF admitted to People′s Hospital of Xuancheng City from January 2014 to December 2018 were selected. RDW level on admission was measured and followed up for 12 months. Patients were divided into good prognosis group and poor prognosis group according to the death and re-hospitalization of acute heart failure during the follow-up period. Clinical baseline of two groups was compared, and the value of RDW in predicting the prognosis of acute decompensated HFpEF patients was analyzed by receiver operating characteristic (ROC) curve. Results One hundred and twenty-one patients were followed up, 37 cases in poor prognosis and 84 cases in good prognosis. The age, the proportion of essential hypertension, the proportion of diabetes, atrial fibrillation, New York Heart Disease Association (NYHA) grade, creatinine, alanine aminotransferase, troponin I and RDW levels between two groups were compared, the differences were statistically significant (P < 0.05). Multiple logistic regression analysis showed that the history of atrial fibrillation (OR = 1.865, 95%CI: 1.325-12.592), NYHA grade (OR = 1.536, 95%CI: 1.205-10.628) and RDW (OR = 2.298, 95%CI: 1.406-16.274) were related to the poor prognosis of acute decompensated HFpEF (all P ＜ 0.01). ROC analysis results showed that RDW predicted acute decompensated HFpEF prognosis with the best cut-off value of 15%, the area under the curve was 0.724, the sensitivity was 72.97%, and the specificity was 66.67%. Conclusion The rise of RDW is closely related to the poor prognosis of acute decompensated HFpEF patients. RDW can be used as an auxiliary index to predict the prognosis of acute decompensated HFpEF patients.
2020 Vol. 17 (23): 20-23,27 [Abstract] ( 152 ) HTML (1 KB)  PDF (642 KB)  ( 80 )
24 Relationship between the expression of P16 and Ki-67 and the prognosis of patients with rectal cancer
CAI Lubing ZHAI Meijuan CHEN Xiaodan
Objective To investigate the relationship between the expression of multipletumor-suppressor gene1 P16 and proliferating cellnuclear antigen Ki-67 and the prognosis of rectal cancer patients. Methods From August 2016 to December 2018, postoperative tumors and adjacent normal tissues of 60 patients with rectal cancer were selected from the First People′s Hospital of Xiaoshan District of Hangzhou, Zhejiang Province. Immunohistochemical method was used to detect the expression of P16 and Ki-67. The positive rates of P16 and Ki-67 in different ages, pathological types, TNM stages, degree of differentiation and lymph node metastasis were observed. The survival of P16 and Ki-67 positive patients and negative patients one year after surgery was compared. Finally, the correlation between P16 and Ki-67 was analyzed by Spearman coefficient. Results The positive rates of P16 and Ki-67 in colorectal cancer tissues were significantly higher than that in paracancer normal tissues (P ＜ 0.05). TNM staging in patients with stage Ⅲ, high degree of differentiation P16 and Ki-67 were significantly higher than that of TNM stage Ⅱ, low-differentiation in patients (P ＜ 0.05); the Ki-67 positive rate of patients with lymph node metastasis was significantly higher than that of patients without lymph node metastasis, and the P16 positive rate of patients with lymph node metastasis was significantly higher than that of patients without lymph node metastasis(all P ＜ 0.05). The survival rate of P16 negative patients was significantly higher than that of positive patients (P ＜ 0.05). The one-year survival rate of Ki-67 positive patients was significantly lower than that of negative patients (P ＜ 0.05). There was no correlation between the expression of P16 and Ki-67 in rectal cancer tissues (r = 0.157, P = 0.461). Conclusion The expression levels of P16 and Ki-67 in rectal cancer tissues are closely related to the clinicopathological features of rectal cancer, which may provide reference for the clinical treatment and prognosis evaluation of rectal cancer.
2020 Vol. 17 (23): 24-27 [Abstract] ( 266 ) HTML (1 KB)  PDF (641 KB)  ( 83 )
28 Research progress of acupucture treatment of depression
XU Xuejiao1 LI Tianying1 TIAN Jiahua1 LI Xin1 LIU Junlin1 WANG Jing1 ZOU Xiangni2
Depression has also been known as depression disorder, with the main clinical manifestations include decreased conscious activity and impaired cognitive function. With the increasing prevalence and disability rate, the treatment of depression has attracted much attention. Acupuncture treatment for depression mainly include acupuncture, moxibustion or a combination of the two method, and found that acupuncture as the main method of treatment has achieved good clinical efficacy and has been recognized by the majority of patients. Acupuncture treatment will not have the side effects and drug resistance of Western medicine. In combination with Western medicine, it improves the efficacy while reducing its side effects, providing an effective method for clinical treatment of depression. Acupuncture is expected to replace Western medicine and become the main treatment for depression. This paper summarizes the research progress of acupuncture in treating depression, and provides reference for clinical application and research.
2020 Vol. 17 (23): 28-30 [Abstract] ( 251 ) HTML (1 KB)  PDF (438 KB)  ( 283 )
31 Research progress on dynamic changes of care burden among informal caregivers for stroke patients
GUO Lizhen1 LU Gendi1 TIAN Jun2 MENG Yunjuan2 WU Wenwen1
Stroke has become a global public health problem due to its high incidence, disability and mortality rate. Stroke survivor may be left with different degrees of physical, mental or affective disorder after acute treatment. And most of them will make sustainable lifestyle and receive rehabilitation based on family, which require long-term support and help from their families. As a result, the caregiver endurance enormous physical, psychological and social pressure, which is not beneficial to the recovery of stroke survivor. This paper summarizes the characteristics of caring burden, the dynamic changes of caring burden with time flow and its related factors, the side effects of caring burden and the strategies on how to reduce the burden of caring. And eventually laying a theoretical suggestion on how to reduce care burden. Therefore, it lays the fundation for clinical improvement of emotional support of cavegivers.
2020 Vol. 17 (23): 31-33,40 [Abstract] ( 251 ) HTML (1 KB)  PDF (677 KB)  ( 59 )
34 Research advances of apigenin in the treatment of type 2 diabetes mellitus and its complications
ZHANG Chunping
Diabetes mellitus and its complications have become one of the major diseases threatening human health. Apigenin is a natural flavonoid widely distributed in a variety of vegetables and fruits. Apigenin has antioxidant, anti-inflammatory and neuroprotective effects, and confirmed its effectiveness in the treatment of diabetes mellitus and its complications. This paper summarizes the mechanism of apigenin in the treatment of diabetes mellitus and its complications, including apigenin can reduce antioxidant stress, protect the mitochondrial membrane of pancreatic beta cells, increase insulin sensitivity, and activate peroxisome proliferator-activated receptor-γ (PPAR-γ) to improve hemodynamics disorder after myocardial infarction and inhibits collagen Ⅳ and fibronectin to improve renal fibrosis. These results indicate that apigenin has therapeutic and prognostic advantages in patients with diabetes mellitus and complications based on multi-target, multi-pathway and multi-layer treatment, which provides a new idea and basis for the further development of apigenin.
2020 Vol. 17 (23): 34-36 [Abstract] ( 132 ) HTML (1 KB)  PDF (444 KB)  ( 87 )
37 Correlation study on perceived professional benefit of nurse and organizational commitment in department of emergency
ZHANG Jian1,2 YANG Xin1 JIANG Jinxia3 ZUO Dengxia1 DONG Hanqiong1 TIAN Meimei4
Objective To explore the correlation between the perceived professional benefit and organizational commitment of nurses in the department of emergency, a tertiary hospital in Shanghai. Methods From February to April 2019, a self-designed general information questionnaire, occupational benefit questionnaire of nurse and organizational commitment scale were used to survey 357 nurses in department of emergency of three tertiary hospitals in Shanghai. Results A total of 357 questionnaires were issued, and 357 valid questionnaires were returned, the effective response rate was 100%. The occupational benefit score of nurese in the department of emergency was (125.95±15.19) points, and the organizational commitment score was (83.24±17.12) points. The professional benefit of nurses was positively correlated with their organizational commitment (r ＞ 0, P ＜ 0.01). The professional benefit of nurses and its dimensions had an impact on all dimensions of organizational commitment (r ＞ 0, P ＜ 0.01). Conclusion The professional benefit of emergency nurses has a positive effect on organizational commitment. Nursing managers can implement effective interventions to improve the professional benefit of emergency nurses to further enhance their organizational commitment and promote the stable development of the nursing team.
2020 Vol. 17 (23): 37-40 [Abstract] ( 128 ) HTML (1 KB)  PDF (382 KB)  ( 77 )
41 Changes and clinical significance of miR-126 and sVCAM-1 levels in patients with coronary artery heart disease
YANG Nanran1 WANG Xiaoqun1 LIU Xiaohui1 FANG Bingxiong2
Objective To investigate the changes and clinical significance of plasma miR-126 and soluble vascular cell adhesion molecule-1 (sVCAM-1) levels in patients with coronary artery heart disease (CHD). Methods One hundred and three cases of CHD patients hospitalized in Puning People′s Hospital of Guangdong Province from February 2018 to December 2019 were selected. They were divided into acute coronary syndrome (ACS) of 58 cases and stable angina pectoris (SAP) of 45 cases according to the diagnostic criteria, and 55 non-CHD patients were selected as the control group. All patients underwent coronary angiography and the Gensini′s degree integral method was used to evaluate coronary artery stenosis. The plasma miR-126 and sVCAM-1 levels were measured, and Pearson correlation coefficient was used for correlation analysis. Results The levels of sVCAM-1 and Gensini′s degree integral score in ACS group were significantly higher than those of SAP group and control group, the levels of miR-126 were all lower than those of SAP group and control group (P ＜ 0.05). And the level of miR-126 in SAP group was lower than that of control group, the Gensini′s degree integral score was higher than that of control group (P ＜ 0.05). The levels of miR-126 in patients with multiple coronary artery lesions and moderate to severe disease were respectively lower than those in patients with single coronary artery lesion and mild disease (P ＜ 0.05). The levels of sVCAM-1 in patients with multiple coronary artery lesions and moderate to severe disease were respectively higher than those in patients with single coronary artery lesion and mild disease (P ＜ 0.05). Correlation analysis showed that miR-126 was negatively correlated with the number of coronary artery lesions (r = -0.536, P = 0.007) and Gensini′s degree integral score (r = -0.574, P = 0.015). sVCAM-1 was positively correlated with the number of coronary artery lesions (r = 0.619, P = 0.000) and Gensini′s degree integral score (r = 0.644, P = 0.000). miR-126 was negatively correlated with sVCAM-1 (r = -0.685, P = 0.000). Conclusion There are significant down-regulation of miR-126 expression and up-regulation of sVCAM-1 expression in CHD patients, and the indexes are closely related to the degree of coronary lesions, which may be used as reference indicators for the diagnosis and treatment of CHD.
2020 Vol. 17 (23): 41-44 [Abstract] ( 205 ) HTML (1 KB)  PDF (529 KB)  ( 101 )
45 Effect of Qili Qiangxin Capsules combined with Ivabradine in the treatment of ischemic cardiomyopathy
SHI Xinxia LU Lu LU Yanhong
Objective To explore the effect of Qili Qiangxin Capsules combined with Ivabradine in the treatment of ischemic cardiomyopathy (ICM). Methods Seventy ICM patients treated in Xintai Hospital of Traditional Chinese Medicine from June 2016 to June 2019 were selected and divided into control group and observation group according to random number table method, with 35 cases in each group. The two groups were given conventional treatment, on basis of which, the control group was given Qili Qiangxin Capsules and the observation group was given Qili Qiangxin Capsules combined with Ivabradine. The clinical effects of the two groups were compared and the changes of left heart function [peak ejection rate (PER), peak filling rate (PFR), left ventricular ejection fraction (LVEF) and left ventricular shortening fractional (LVSF)], autonomic nerve function [standard deviation of NN intervals (SDNN), standard deviation average of NN intervals (SDANN), root mean square of successive differences (rMSSD) of adjacent RR intervals, the proportion of successive RR intervals difference≥50 ms in percentage (pNN50), low-frequency/high-frequency (LF/HF)], related neuroendocrine factors [N-terminal pro-brain natriuretic peptide (NT-proBNP), cardiac troponin I (cTnI),] and myocardial enzymes [creatine kinase (CK), creatine kinase-MB (CK-MB)] were observed before and after treatment. Results The total effective rate in observation group was significantly higher than that in control group (P ＜ 0.05). After treatment, PER, PFR, LVEF and LVSF in both groups were higher than those before treatment (P ＜ 0.05). After treatment, LVEF and LVSF in observation group were higher than those in control group (P ＜ 0.05). After treatment, the levels of NT-proBNP, cTnI, CK and CK-MB in both groups were lower than those before treatment, and observation group were lower than those in control group (P ＜ 0.05). Compared with those before treatment, SDNN were increased in both groups, SDANN in observation group was significantly increased (P ＜ 0.05). After treatment, SDNN and SDANN in observation group were higher than those in control group (P ＜ 0.05). There was no significant difference in the incidence of adverse reactions between two groups (P ＞ 0.05). Conclusion Qili Qiangxin Capsules combined with Ivabradine is effective in the treatment of ICM, which can improve left heart function, regulate autonomic nerve function, adverse reaction is lower, and it is worthy of clinical promotion.
2020 Vol. 17 (23): 45-48 [Abstract] ( 171 ) HTML (1 KB)  PDF (535 KB)  ( 50 )
49 Correlation between preoperative PCI dynamic electrocardiogram characteristics and prognosis in patients with coronary artery heart disease and heart failure
YE Dabin SONG Wenxin▲ SUN Feng TAN Yan CHEN Zhengyin CHEN Ye
Objective To observe the characteristics of preoperative percutaneous coronary intervention (PCI) dynamic electrocardiogram characteristics in patients with coronary artery heart disease and heart failure with different prognosis and to analyze the relationship between preoperative PCI dynamic electrocardiogram and prognosis. Methods The clinical data of 80 patients with coronary artery heart disease and heart failure who were treated in Dazu Hospital Affiliated to Chongqing Medical University from January 2018 to January 2019, completed PCI treatment and one year follow-up after treatment, was retrospectively analyzed. All patients received dynamic electocardiogram detection before PCI, according to whether the patients had adverse cardiovascular events during the one year follow-up period, they were divided into good prognosis group (69 cases) and poor prognosis group (11 cases). The baseline data and preoperative dynamic electrocardiogram characteristics of patients with coronary artery heart disease and heart failure with different prognostic outcomes were compared, then the receiver operating characteristic (ROC) curve was drew to analyze the value of preoperative dynamic electrocardiogram characteristics in predicting the poor prognosis of patients with coronary artery heart disease and heart failure after PCI. Results The incidence of adverse cardiovascular events in patients with coronary artery heart disease and heart failure was 13.75% (11/80); the standard deviation of NN intervals (SDNN), standard deviation average of NN intervals (SDANN), standard deviation of normal RR intervals index (SDNNI), root mean square of successive differences (rMSSD) in the poor prognosis group were lower than those in the good prognosis group, the differences were statistically significant (P ＜ 0.05). The ROC curve was drew to obtain SDNN, SDANN, SDNNI and rMSSD to predict the poor prognosis of patients with coronary artery heart disease and heart failure after PCI, the area under the curve (AUC) were 0.865, 0.920, 0.848 and 0.918 separately, and the predictive value was ideal. The prediction values of SDANN and rMSSD were better. Conclusion Patients with coronary artery heart disease and heart failure can predict the prognosis by SDNN, SDANN, SDNNI, rMSSD and other heart rate variability time domain indicators before PCI, to give reasonable intervention as soon as possible to improve the prognosis.
2020 Vol. 17 (23): 49-52 [Abstract] ( 140 ) HTML (1 KB)  PDF (598 KB)  ( 59 )
53 Routine coagulation test and platelet parameter level of ischemic stroke and their clinical significance
CHEN Li1 TANG Xiaolei2▲
Objective To study the routine coagulation test and platelet parameter level of ischemic stroke and their clinical significance, so as to provide guidance for the clinical diagnosis of patients. Methods A total of 95 patients with ischemic stroke admitted to the Second People′s Hospital of Wuhu City, Anhui Province (hereinafter referred to as “our hospital”) from October 2017 to November 2019 were selected as the observation group, and 45 patients without cardiovascular and cerebrovascular diseases who underwent physical examination in our hospital during the same period were selected as the control group. The levels of prothrombin time (PT), activated partial thromboplastin time (APTT), fibrinogen (FIB), thrombin time (TT), D-dimer (DDR), fibrin and FIB degradation products (FDP) and antithrombin Ⅲ (AT-Ⅲ) were compared between the two groups. The mean platelet volume (MPV) and platelet (PLT) were compared between the two groups. The levels of total cholesterol, low density lipoprotein cholesterol, high density lipoprotein cholesterol, triglyceride and fasting glucose were compared between the two groups. Results The APTT and PT in the observation group were shorter than those in the control group, the levels of FIB, DDR, FDP and MPV were higher than those in the control group, TT was longer than that in the control group and the levels of AT-Ⅲ, PLT were lower than those in the control group, with statistically significant differences (all P ＜ 0.05). The levels of low density lipoprotein cholesterol and fasting glucose in the observation group were higher than those in the control group, and the level of high density lipoprotein cholesterol was lower than that in the control group, with statistically significant differences (all P ＜ 0.05). There was no significant difference in triglyceride and total cholesterol levels between the observation group and the control group (P ＞ 0.05). Conclusion Routine coagulation test and platelet parameter level detection in patients with ischemic stroke have important clinical significance for the treatment intervention and prevention of disease progression of patients, which is worthy of clinical application.
2020 Vol. 17 (23): 53-56 [Abstract] ( 254 ) HTML (1 KB)  PDF (515 KB)  ( 130 )
57 Correlation study of serum neuromodulin-1, EEG γ activity and cognitive function in first-episode schizophrenia
WANG Jindong1 ZHOU Tiantian1 CHEN Xiaoqin2 SUN Ping3 WANG Bailing1
Objective To investigate the correlation among serum neuregulin-1 (NRG-1) level, EEG γ activity and cognitive function in patients with first-episode schizophrenia. Methods A total of 80 first-episode schizophrenic patients admitted to Qingdao Mental Health Center, Shandong Province (hereinafter referred to as “our hospital”) from January 2018 to August 2019 were randomly selected as the study group, and another 50 healthy people who underwent physical examination in our hospital during the same period were selected as the control group. The serum NRG-1 level and EEG γ activity of the two groups were detected. The condition of the study group was evaluated by the positive and negative symptom scale (PANSS), and the cognitive function of the two groups was evaluated by the MATRICS recognized cognitive battery test (MCCB). The correlation among NRG-1 level, EEG γ activity and cognitive function in the study group was analyzed. Results The NRG-1 level and the positive proportion of EEG γ activity in the study group were higher than those in the control group, while the processing speed, attention alertness, working memory, verbal memory, visual memory and reasoning resolution scores in the MCCB were all lower than those in the control group, and the differences were statistically significant (all P ＜ 0.05). Compared with patients with EEG γ activity in negative, the NRG-1 level and each MCCB factor scores (processing speed, attention alertness, working memory, verbal memory, visual memory and reasoning resolution) of patients with positive EEG γ activity were all decreased, and PANSS spirit of positive symptoms, negative symptoms, general psychopathology and total score were all increased, and the differences were statistically significant (all P ＜ 0.05). The level of NRG-1 in the study group was positively correlated with the score of verbal memory and reasoning resolution (r = 0.433, 0.554; P < 0.01), but negatively correlated with the total score of PANSS (r = -0.584, P ＜ 0.01). The EEG γ activity in the study group was negatively correlated with NRG-1 level, verbal memory and reasoning resolution score (r = -0.520, -0.610, -0.541; P < 0.01), but positively correlated with the total score of PANSS (r = 0.687; P ＜ 0.01). Conclusion In patients with first-onset schizophrenia, the level of serum NRG-1 is significantly decreased, and the EEG γ activity is significantly increased. Both of them are significantly related to the patients′ condition and cognitive function, patients can be given early personalized treatment clinically.
2020 Vol. 17 (23): 57-61 [Abstract] ( 211 ) HTML (1 KB)  PDF (676 KB)  ( 71 )
62 Effect of Rivastigmine Hydrogen Tartrat Capsules combined with Selegiline in the treatment of Parkinson′s disease
LEI Yuanbiao1 LEI Yu2 OU Fuyong1 YI Jiping1
Objective To investigate the effect of Rivastigmine Hydrogen Tartrat Capsules combined with Selegiline in the treatment of Parkinson′s disease. Methods A total of 100 patients with Parkinson′s disease admitted to Chenzhou NO.1 People′s Hospital, Hu′nan Province from November 2016 to October 2019 were selected and divided into the study group and the control group by random number table method, with 50 patients in each group. The control group was treated with Selegiline, and the study group was treated with Rivastigmine Hydrogen Tartrat Capsules on the basis of the control group. Both groups were treated for 8 weeks. The curative effect, the scores of WHO quality of life (WHOQOL-BREF), Parkinson′s disease rating scale (UPDRS) and autonomic nerve symptom scale (SCOPT-AUT), montreal cognitive assessment scale (MoCA), the levels of  insulin-like growth factor (IGF-1), β-amyloid protein 1-42 (Aβ1-42) and dopamine transporter (DAT) activity activity in the affected side and healthy side were compared between the two groups. The adverse reactions during the treatment in both groups were recorded. Results After 8 weeks of treatment, the total clinical effective rate of the study group was higher than that of the control group, with statistically significant difference (P ＜ 0.05). After 8 weeks of treatment, WHOQOL-BREF and MOCA scores, the levels of Aβ1-42 and IGF-1 were all higher in both groups than those before treatment, and the study group was higher than the control group; UPDRS and SCOPT-AUT scores were both lower than those before treatment, and the study group was lower than the control group, with statistically significant differences (P ＜ 0.05). After 8 weeks of treatment, the DAT activity in the affected side of both groups and the healthy side of the control group decreased compared with that before treatment, and the differences were statistically significant (all P ＜ 0.05). The DAT activity in the healthy side of the study group after 8 weeks of treatment was not significantly different from that before treatment (P ＞ 0.05). After 8 weeks of treatment, the DAT activity of both the affected side and the healthy side of the study group was higher than that of the control group, with statistically significant differences (all P ＜ 0.05). There was no statistically significant difference in the incidence of adverse reactions between the two groups (P ＞ 0.05). Conclusion Treatment of Parkinson′s disease with Rivastigmine Hydrogen Tartrat Capsules combined with Selegiline can rapidly improve the clinical symptoms of patients, improve serum Aβ1-42 and IGF-1 levels, delay the rate of DAT inactivation, and do not increase the incidence of adverse reactions, the effect is significant.
2020 Vol. 17 (23): 62-65,69 [Abstract] ( 227 ) HTML (1 KB)  PDF (543 KB)  ( 54 )
66 Effect of current perception threshold measurement on sensory quantitative evaluation of trigeminal neuralgia patients
PAN Jie1 WEI Yujing2 XIONG Yingqiong1 WU Lingfeng1 QU Xinhui1
Objective To evaluate the effect of current perception threshold (CPT) measurement on sensory quantification in patients with trigeminal neuralgia. Methods From January 2017 to October 2018, 26 patients with primary trigeminal neuralgia involving the mandibular branches were selected from the Inpatient Department of Neurology or Outpatient Department of Jiangxi Provincial People′s Hospital. All patients were routinely treated with nutritive nerve drugs. The CPT and the simplified McGill pain questionnaire (SF-MPQ) were measured before, 7 and 14 days after treatment, and the CPT and SF-MPQ pain score were compared to evaluate the application value of CPT in the sensory function of patients with trigeminal neuralgia before and after treatment. Results Before treatment, when stimulated by 5 and 250 Hz, CPT on the affected side was higher than that on the healthy side, with statistically significant differences (all P ＜ 0.05); while when stimulated by 2000 Hz, CPT on both sides showed no statistically significant difference (P ＞ 0.05). CPT at 7 and 14 days after treatment on the affected side decreased under 5 and 250 Hz stimulation compared with before treatment, and the differences were statistically significant (all P < 0.05), while CPT on the affected side at 7 and 14 days after treatment under 2000 Hz stimulation was not statistically significant compared with that before treatment (P ＞ 0.05). The pain score of SF-MPQ at 7 and 14 days after treatment was lower than that before treatment, and the differences were statistically significant (all P ＜ 0.05). Pearson correlation analysis showed that SF-MPQ pain score at 7 and 14 days after treatment was positively correlated with CPT under 5 Hz stimulation of the affected mandibular branches (r = 0.656, 0.418, 0.697, P ＜ 0.05). Conclusion CPT can quantitatively detect the sensory function of patients with trigeminal neuralgia before and after treatment, and objectively evaluate the severity of the condition before and after treatment and the therapeutic effect.
2020 Vol. 17 (23): 66-69 [Abstract] ( 121 ) HTML (1 KB)  PDF (519 KB)  ( 89 )
70 Diagnostic value of uterine and ovarian ultrasound combined with Z-score method in female precocious puberty
ZHONG Xianling1 ZHANG Guoqiang2▲ JIANG Shuanglan1 YI Quanying1 BU Qiuqiang1 YU Feng1
Objective To analyze the diagnostic value of uterine and ovarian ultrasound combined with Z-score method in female precocious puberty. Methods A total of 207 female with precocious puberty who aged three to eight years old from February 2017 to February 2020 in Dongguan Eighth People′s Hospital of Guangdong Province （hereinafter referred to as “our hospital”） were the experimental group. In addition, 112 healthy children aged three to eight years old who consulted height or physical examination in our hospital during the same period were selected as the control group. According to the location of precocious puberty, 50 cases were simple preature thelarhe (PT) and premature pubarche (PP) subgroup, 61 cases were peripheral precocious puberty (PPP) subgroup, and 96 cases were central precocious puberty (CPP) subgroup. Ultrasound examination of uterin and ovarin was performed in both groups to obtain uterine body and bilateral ovarian diameter lines, and the volume was calculated, the Z-score model was established and the Z value was calculated. Receiver operating characteristic (ROC) curve was used for the diagnosis of precocious puberty in female. Results Age had the greatest correlation with ovarian volume and uterine body length diameter (r = 0.82, 0.95, P < 0.05). The average Z value of uterine body length diameter with PPP children was 2.59±2.29 (-2.70, 6.00), the area under the curve was 0.909, the best diagnostic cut-off value was 1.05, the sensitivity was 97.99%, and the specificity was 81.90%. The average Z value of ovarian volume with CPP children was 7.49±7.49 (-0.48, 36.99), the area under the curve was 0.939, the best diagnostic cut-off value was 2.15, the sensitivity was 100.00%, and the specificity was 80.90% and the average Z value of ovarian volume with was 4.59±4.19 (-1.15, 22.79), the area under the curve was 0.839, the best diagnostic cut-off value was 1.13, the sensitivity was 90.80%, and the specificity was 85.10%. Conclusion Uterine and ovarian ultrasound combined with Z-score method can effectively diagnose PPP and CPP, which play a crucial role in the diagnosis of precocious puberty in children and adolescent females, worthy of clinical promotion.
2020 Vol. 17 (23): 70-73,94 [Abstract] ( 160 ) HTML (1 KB)  PDF (931 KB)  ( 131 )
74 Prognostic value of SOFA, SIRS, qSOFA score and lactate level in pediatric sepsis
WU Yunduo1,2 LIN Xiaofei2 GU Xiaohai2 ZHANG Jun2 LYU Yanguan2 WANG Jun1
Objective To investigate the prognostic value of sequential organ failure assessment (SOFA), systemic inflammatory response syndrome (SIRS) score, quick sequential organ failure assessment (qSOFA) score and lactate level in pediatric sepsis. Methods A total of 259 pediatric patients with Sepsis-3 diagnosis in general and intensive care units of Huai′an Maternal and Child Health Hospital of Jiangsu Province from January 2016 to December 2018 were retrospectively analyzed. They were divided into survival group (241 cases) and death group (18 cases) according to the prognosis. Receiver operating characteristic curve (ROC) was used to assessed the predictive value of lactate level, SOFA within 24 h and SIRS and qSOFA for prognosis of patients. Results Lactate level, SIRS, SOFA and qSOFA scores in death group were higher than those in survival group, and the differences were all highly statistically significant (all P < 0.01). The cut-off value for the death of sepsis by SOFA score was 7.5 points, the sensitivity was 68.8%, and the specificity was 80.0% respectively. The cut-off value for the death of sepsis by qSOFA score was 1.5 points, the sensitivity was 68.8%, and the specificity was 80.0%. The cut-off value for the death of sepsis by lactate value was 1.75 mmol/L, the sensitivity was 93.8%, and the specificity was 40.0%. Conclusion Compared with SIRS score, SOFA and qSOFA scores have better prognostic accuracy in predicting the prognosis of children with sepsis. Although lactate level has good sensitivity and is a reliable indicator for the prognosis of children with sepsis, but its specificity is low.
2020 Vol. 17 (23): 74-77 [Abstract] ( 313 ) HTML (1 KB)  PDF (506 KB)  ( 183 )
78 Risk factors of group B streptococcus infection during pregnancy and the influence of pregnancy outcome
HE Wei1 DENG Yao2 LU Yu1
Objective To explore the risk factors of group B streptococcus (GBS) infection during pregnancy and analyze the effect of GBS infection on pregnancy outcome. Methods From January 2018 to December 2019, 15 200 pregnant women who received treatment in Department of Obstetrics, Chengdu Women′s and Children′s Central Hospital were selected as the study objects. According to the antigen test results, they were devided into GBS antigen test positive 920 cases (infection group) and GBS antigen test negative 14 280 cases (control group). Clinical data of patients was collected, the risk factors of GBS infection in pregnancy were analyzed by multiple logistic regression. Pregnancy outcome and maternal and child clinical outcome were tracked. Results The proportion of patients with age ≥ 35 years old, history of abortion, vaginitis, gestational diabetes and vaginal microecology score (Nugent score) ≥ 4 points in infection group were higher than those in control group (all P ＜ 0.05）, and the proportion of undergraduates and above, living cities and participating in perinatal health care were lower than those in control group (all P < 0.05). Multiple logistic regression analysis showed that age ≥ 35 years old, history of abortion, vaginitis, gestational diabetes and Nugent score ≥ 4 points were the high risk factors of GBS infection in pregnancy (OR = 1.865, 2.073, 15.656, 14.129, 14.089, all P < 0.05). The incidence of cesarean section, preterm delivery, low birth weight, GBS infection in newborn in infection group were higher than those in control group (P < 0.05). Conclusion The infection rate of GBS in pregnancy is high. The high risk group of GBS infection is the elderly parturient, history of abortion, vaginitis, gestational diabetes and high Nugent score, who have high risk of adverse pregnancy outcome.
2020 Vol. 17 (23): 78-81 [Abstract] ( 264 ) HTML (1 KB)  PDF (490 KB)  ( 166 )
82 Study on the prognostic value of peripheral blood lymphocyte-to-monocyte ratio in multiple myeloma treated by new agents
LIAO Zhongting1 LI Juan1 LAN Xia1 HU Qiongying2
Objective To explore the prognostic value of the peripheral blood lymphocyte-to-monocyte ratio (LMR) on multiple myeloma (MM). Methods The overall survival of 100 MM patients who received new proteasome inhibitors and/or immunomodulatory drugs from January 2013 to January 2019 in the People′s Hospital of Ziyang, Sichuan Province was systematically reviewed, and the effect of LMR on prognosis was evaluated by the receiver operating characteristic curve (ROC) and other indicators. Results The area under the ROC curve was 0.612 and the corresponding optimal diagnostic threshold was 4.0, that was, the total survival time of MM patients with LMR≤4.0 was shorter than that of patients with LMR＞4.0. Conclusion LMR is a simple and economic indicator calculated by blood routine test results and provides a method to predict clinical outcomes in patients with MM who were treated with new agents.
2020 Vol. 17 (23): 82-85 [Abstract] ( 217 ) HTML (1 KB)  PDF (633 KB)  ( 85 )
86 Effect of Chaihu Pingwei Powder on the prevention and treatment of cancer-related fatigue caused by chemotherapy
JIANG Jingwen1 ZHANG Hui1 ZHU Fengting1 LIN Lizhu2 CHEN Xuewu1
Objective To observe the clinical effect of Chaihu Pingwei Powder on the prevention and treatment of cancer-related fatigue (CRF) caused by chemotherapy. Methods A total of 60 hospitalized patients receiving chemotherapy admitted to the Department of Oncology, Hainan Hospital of Traditional Chinese Medicine from January 2017 to December 2018 were selected. According to the random number table method, they were divided into the Chaihu Pingwei Powder group and the conventional group, with 30 patients in each group. The conventional group received the best symptomatic and supportive treatment, while the Chaihu Pingwei Powder group was given oral administration of Chaihu Pingwei Powder on the first day after chemotherapy based on the symptomatic and supportive treatment of the conventional group, and was taken orally for seven days consecutively. The changes of fatigue, quality of life score, bone marrow suppression, gastrointestinal reaction, nutritional status and immune function were observed before and after treatment in the two groups. Results Before treatment, there was no significant difference in CRF scores between the two groups (P ＞ 0.05). After one week of treatment, CRF score of Chaihu Pingwei Powder group was not significantly different from that before treatment (P ＞ 0.05). The emotional and cognitive scores of the conventional group showed no statistically significant difference from those before treatment (P ＞ 0.05), behavioral and sensory scores of the conventional group increased compared with those before treatment, with statistically significant differences (all P ＜ 0.05). After one week of treatment, the behavioral and sensory scores of Chaihu Pingwei Powder group were lower than those of the conventional group, with statistically significant differences (all P ＜ 0.05), while the emotional and cognitive scores were not significantly different from those of the conventional group (P ＞ 0.05). Before treatment, there was no significant difference in Karnofsky functional status score (KPS score) between the two groups (P ＞ 0.05). After one week of treatment, KPS score of Chaihu Pingwei Powder group was not significantly different from that before treatment (P ＞ 0.05), while KPS score of the conventional group was lower than that before treatment, with highly statistically significant difference (P ＜ 0.01). After one week of treatment, KPS score of Chaihu Pingwei Powder group was higher than that of the conventional group, with statistically significant difference (P ＜ 0.05). The incidence of gastrointestinal reaction and bone marrow suppression in Chaihu Pingwei Powder group was significantly lower than that in the conventional group, and the difference was statistically significant (P ＜ 0.05). Before treatment, there was no statistically significant difference in CD4+/CD8+ between the two groups (P ＜ 0.05). After one week of treatment, CD4+/CD8+ of the Chaihu Pingwei Powder group was increased compared with that before treatment, and the difference was statistically significant (P ＜ 0.05), while CD4+/CD8+ of the conventional group was not significantly different from that before treatment (P ＞ 0.05). After one week of treatment, CD4+/CD8+ of Chaihu Pingwei Powder group was significantly higher than that of the conventional group, and the difference was highly statistically significant (P ＜ 0.01). Before treatment, there was no significant difference in the subjective overall nutritional status rating scale (PG-SGA) scores between the two groups (P ＞ 0.05). After one week of treatment, PG-SGA score of Chaihu Pingwei Powder group was not significantly different from that before treatment (P ＞ 0.05), while PG-SGA score of the conventional group was increased compared with that before treatment, with statistically significant difference (P ＞ 0.05). After one week of treatment, the PG-SGA score of Chaihu Pingwei Powder group was significantly lower than that of the conventional group, and the difference was highly statistically significant (P ＜ 0.01). Conclusion At the same time of chemotherapy, oral Chaihu Pingwei Powder can significantly reduce the degree of cancer fatigue fo some extent, improve the quality of life, reduce the incidence of gastrointestinal reaction and bone marrow suppression, and can enhance the immune function, has a certain effect on the prevention and treatment of CRF caused by chemotherapy.
2020 Vol. 17 (23): 86-90 [Abstract] ( 139 ) HTML (1 KB)  PDF (590 KB)  ( 70 )
91 Relationship between the levels of serum IL-17, Hcy and clinicopathological features in patients with gastric cancer and its diagnostic value
LIU Zheng1 GONG Xiangliang2 XU Ai′fang1
Objective To explore the relationship between serum interleukin (IL)-17, homocysteine (Hcy) levels and pathological features in patients with gastric cancer and its clinical diagnostic value. Methods A total of 80 patients with gastric cancer admitted to Tangshan People′s Hospital from March 2015 to March 2017 were selected as gastric cancer group, another 80 patients with benign gastric lesions were selected as the benign lesion group, and 60 volunteers with health examination during the same period were selected as the normal control group. The serum IL-17 and Hcy levels in each group were compared, and the relationship between serum IL-17 and Hcy and pathological features in gastric cancer patients was analyzed. ROC curve was drawn to evaluate the predictive value of combined IL-17 and Hcy detection for gastric cancer. Results The serum IL-17 and Hcy levels in gastric cancer group were higher than those in the benign lesion group and the normal control group, and serum IL-17 and Hcy levels in the benign lesion group were higher than those in the normal control group (P ＜ 0.05). The serum IL-17 and Hcy levels in the gastric cancer patients were related to infiltration depth, lymph node metastasis and TNM stage (P ＜ 0.05). The area under the curve, sensitivity, specificity and Youden index of IL-17 combined with Hcy detection were all higher than those of IL-17 detection and Hcy detection separately (P ＜ 0.05). Conclusion IL-17 and Hcy are highly expressed in the serum of patients with gastric cancer, which are related to the depth of invasion, lymph node metastasis and TNM stage of gastric cancer. Combined detection of IL-17 and Hcy can improve the diagnosis effect of early gastric cancer.
2020 Vol. 17 (23): 91-94 [Abstract] ( 194 ) HTML (1 KB)  PDF (614 KB)  ( 120 )
95 Clinical effect of Docetaxel combined with Apatinib in the second-line treatment of advanced non-small cell lung cancer
XU Qin1 BAO Yu2 KANG Xiaobin1
Objective To investigate the clinical effect of Docetaxel combined with Apatinib in the second-line treatment of advanced non-small cell lung cancer (NSCLC). Methods A total of 80 NSCLC patients admitted to Chizhou People′s Hospital from January 2017 to October 2019 were selected and they were divided into control group (40 cases) and study group (40 cases) by random number table method. The control group was treated with Docetaxel chemotherapy, while the study group was treated with Apatinib and Docetaxel chemotherapy, both groups were treated for four courses. The clinical efficacy, serum tumor markers and quality of life of the two groups were compared. The adverse reactions in the two groups were statisticsed. Results The total clinical effective rate of the study group was higher than that of the control group (P ＜ 0.05). After treatment, carcinoembryonic antigen, squamous cell carcinoma antigen and glycoprotein antigen 125 in both groups were decreased compared with before treatment, and the study group was lower than the control group (P ＜ 0.05). After treatment, the quality of life scores of both groups increased, and the study group was higher than the control group (P ＜ 0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P ＞ 0.05). Conclusion Docetaxel combined with Apatinib as the second-line treatment of advanced NSCLC has significant curative effect, it can effectively improve the quality of life of patients, and prevent disease progression, and has good safety.
2020 Vol. 17 (23): 95-98 [Abstract] ( 220 ) HTML (1 KB)  PDF (537 KB)  ( 155 )
99 Effect and safety of systemic lymph node dissection and sampling for early lung cancer
QIN Dalei1 CHEN Liang2 GENG Yuliu1 LI An1
To analyze the effect and complications of systemic lymphadenectomy for early lung cancer. Methods The data of 80 patients with early stage non-small cell lung cancer who were treated in the Department of Cardiothoracic Surgery, General Hospital of Wanbei Coal and Power Group from August 2016 to October 2019 were selected, they were divided into research group (systemic lymph node cleaning and sampling) and control group (normal operation) according to whether the systematic lymph node cleaning and sampling was, with 40 cases in each group. The clinical data of the patients were analyzed retrospectively, and the perioperative indexes and safety indexes of the two groups were compared. Results The operation time and hospitalization time of the research group were longer than those of the control group, and the differences were statistically significant (P ＜ 0.05). There was no significant differences in incision length, intraoperative bleeding and drainage tube removal time between the two groups (P ＞ 0.05). There was no statistically significant difference in the incidence of postoperative complications between the two groups (P ＞ 0.05). Conclusion Systematic lymph node dissection and sampling will not increase the incidence of postoperative complications, and it is beneficial to improve the prognosis of patients, which is worthy of clinical application and promotion.
2020 Vol. 17 (23): 99-101,106 [Abstract] ( 142 ) HTML (1 KB)  PDF (898 KB)  ( 37 )
102 “Three antibodies” intervention treatment and follow-up for hepatitis B liver failure survivors
MO Shizao1 WANG Zhenchang2 LYU Yanhang3 WU Shanshan3 WEI Qinying2 PENG Li′na1
Objective To observe the curative effect of anti-virus, anti-inflammation and anti-fibrosis (“three antibodies”) on the survivors of hepatitis B liver failure. Methods From January 2016 to January 2018, 240 cases of hepatitis B liver failure survivors were confirmed in the Department of Spleen and Stomach Liver disease of Guangxi International Zhuang Medical Hospital, liver Disease Center of the First Affiliated Hospital of Guangxi University of Chinese Medicine, and the Teng County Hospital of Traditional Chinese Medicine, Wuzhou City, Accordance with 1:1:2 principle, they were divided into group A (simple antivirus, n = 60), group B (antivirus combined with compound Yiganling Capsules, n = 60), and group C (“ three anti-virus ”combined treatment, namely antivirus combined with compound Yiganling Capsules and Liangan Chemical fiber granule, n = 120) by random number table method. The biochemical responses, hepatic fibrosis indexes, HBeAg, HBeAb, HBeAg/Ab conversion rates and liver tissue score of the three groups before and after treatment were analyzed. Results After 12 and 24 months of treatment, the biochemical response index cereal third transaminase (ALT), total bilirubin (TBil) and albumin in the three groups were all lower than those when entering the group, while albumin (ALB), cholinesterase (CHE) and prothrombin (PTA) were all higher than those when entering the three groups, and the biochemical response indexes were compared among the three groups, the differences were statistically significant (all P ＜ 0.05). In addition, ALT and TBil of group C were lower than those of group A and B, while ALB, CHE and PTA were higher than those of group A and B (P ＜ 0.05). After 12 and 24 months of treatment hyaluronic acid (HA), layer mucins (LN), collagen type Ⅳ (ⅣC), collagen type Ⅲ (PCⅢ) of three groups were lower than those when entering the group, and the hepatic fibrosis indexes were compared among the three groups, the differences were statistically significant (P ＜ 0.05), and HA, LN, Ⅳ C, PC Ⅲ of group C were lower than those of group A and B (P ＜ 0.05), after treatment HBeAg/Ab conversion in each group was lower than that before treatment (P ＜ 0.05), and group C was lower than group A and B (P ＜ 0.05). Among the 56 patients who passed the risk period, there was no statistically significant difference in liver histological score between group C and group A, group B before treatment (P ＞ 0.05). The total SSS score of inflammation and liver fibrosis after treatment was lower than that before treatment, and the total SSS score of group C was lower than that of group A and B (P ＜ 0.05). Conclusion The combined treatment of “three antibodies” can significantly improve liver function, liver inflammation, liver fibrosis and inhibition of viral replication, and improve the overall treatment efficiency and quality of life.
2020 Vol. 17 (23): 102-106 [Abstract] ( 171 ) HTML (1 KB)  PDF (622 KB)  ( 87 )
107 Effect of Haikunshenxi Capsules combined with Leflunomide in the treatment of chronic glomerulonephritis and its effect on endothelial cell function and immune function
LUO Boxun1 ZHANG Weiping2 WANG Jun3
Objective To investigate the effect of Haikunshenxi Capsules combined with Leflunomide on chronic glomerulonephritis (CGN) and its effect on endothelial cell function and immune function. Methods From June 2016 to June 2019, 89 CGN patients admitted in Huizhou Central People′s Hospital and Southern Hospital of Southern Medical University were selected. According to the method of random number table, the patients were randomly divided into control group (44 cases) and observation group (45 cases). The control group was treated with Leflunomide, the observation group was treated with Haikunshenxi Capsules and Leflunomide, both groups were treated for 3 months. The clinical effect of the two groups was evaluated and compared, the levels of serum creatinine (Scr), urea nitrogen (BUN), nitric oxide (NO), endothelin-1 (ET-1) and peripheral blood CD4+, CD8+, CD4+/CD8+ were compared before and after treatment, and the adverse reactions were recorded in the two groups. Results After treatment, the total clinical effective rate of the observation group was higher than the control group (P ＜ 0.05). The serum Scr, BUN and ET-1 levels of the two groups were significantly lower than those before treatment, and the observation group was lower than the control group (P ＜ 0.05), the NO level was significantly higher than that before treatment, and the observation group was higher than the control group (P ＜ 0.05). The level of CD4+ and CD4+/CD8+ in peripheral blood of the two groups after treatment were significantly higher than those before treatment, and the observation group was higher than the control group (P ＜ 0.05), the CD8+ level was significantly lower than that before treatment, and the observation group was lower than the control group (P ＜ 0.05). During the treatment, there was no significant difference in the incidence of adverse reactions between the two groups (P ＞ 0.05). Conclusion Haikunshenxi Capsules combined with Leflunomide has a significant clinical effect in the treatment of CGN, which is helpful to improve the function of endothelial cells, improve the immune function of the body, and has a good safety.
2020 Vol. 17 (23): 107-110 [Abstract] ( 114 ) HTML (1 KB)  PDF (600 KB)  ( 103 )
111 Clinical effect of laparoscopic cholecystectomy in early treatment of cholecystolithiasis complicated with acute biliary pancreatitis
HUANG Peng WEI Yi LI Mingwu
Objective To investigate the clinical effect of laparoscopic cholecystectomy (LC) in the early treatment of cholecystolithiasis complicated with acute biliary pancreatitis. Methods Sixty patients with acute biliary pancreatitis caused by cholecystolithiasis admitted to Suzhou Hospital Affiliated to Anhui Medical University from January 2016 to January 2018 were selected as the study objects, and 30 patients receiving LC treatment within one week of onset were selected as the experimental group; after 10-14 days of conservative treatment, 30 patients who improved and received delayed LC treatment 12 weeks later were treated as the control group. The length of hospital stay, cost of hospital stay, postoperative complications, recurrence of pancreatitis (follow-up for 12 months), alanine aminotransferase + glutamic oxalacetic transaminase (ALT+AST), average alkaline phosphatase (AKP) and C-reactive protein (CRP) values on the first, third and seventh days after surgery were compared between the two groups. Results The length and cost of hospital stay in the experimental group were significantly lower than those in the control group, and the differences were statistically significant (all P ＜ 0.05). One case of bile leakage occurred in both groups after surgery, but were all cured by unobvious drainage. No recurrence of pancreatitis was observed in both group. AST+ALT and average AKP values of the two groups on the third day after surgery were significantly higher than those of the first and seventh days after surgery, and the differences were statistically significant (all P ＜ 0.05). There was no significant difference in AST+ALT and average AKP values between the two groups on the first, third and seventh days after surgery (P ＞ 0.05). CRP value on the first, third and seventh days after surgery in the experimental group was significantly lower than that before surgery, and the differences were statistically significant (all P ＜ 0.05). Conclusion The application of laparoscopic cholecystectomy in the early treatment of cholecystolithiasis complicated with acute biliary pancreatitis is safe and effective, and significantly reduces the length and cost of hospital stay.
2020 Vol. 17 (23): 111-114 [Abstract] ( 209 ) HTML (1 KB)  PDF (560 KB)  ( 64 )
115 Value of ESAT-6 combined with MMP-14 in the evaluation of HIV patients with tuberculosis
LU Nihong1 XIA Jiawei2 LIU Honglu1 LIU Jun3▲
Objective To explore the value of early secretion of targeted antigen (ESAT-6) and matrix metalloproteinase 14 (MMP-14) in the evaluation of the severity of human immunodeficiency virus (HIV) patients with tuberculosis. Methods A retrospective analysis was made on 42 cases of HIV complicated with tuberculosis infection(group A), 50 cases of tuberculosis infection (group B) and 21 people of health examination (group C) in outpatient clinic from July 2018 to July 2019 in Kunming Third People′s Hospital. Fasting venous blood was taken to detect ESAT-6, MMP-14 and immune function. Results The expression of ESAT-6 in the three groups were compared, and the difference were statistically significant (P ＜ 0.05), while there was no expression in group C. Comparison of the levels of MMP-14, CD4+T, CD8+T and CD3+T cells in the three groups showed statistically significant differences (P ＜ 0.05). Among them, the MMP-14 of patients in group A and B were higher than those in group C, while group A was higher than that in group B, and the differences were statistically significant (P ＜ 0.05); the levels of CD4+T, CD8+T and CD3+T cells in group A and B were lower than those in group C, while group A was lower than that in group B, and the differences were statistically significant (P ＜ 0.05). ESAT-6 was negatively correlated with the expression of CD4+ T and CD8+ T (r = -0.34, -0.48, P ＜ 0.05). The expression of MMP-14 was negatively correlated with the expression of CD4+ T, CD8+ T, and CD3+ T (r = -0.32, -0.33, -0.54, P ＜ 0.05). MMP-14 was positively correlated with the severity of the disease (r = 0.78, P = 0.00). Conclusion The expression of ESAT-6 and MMP-14 are increased in severely ill patients with HIV and tuberculosis, and MMP-14 is significantly increased in severely ill patients. Both are closely related to disease progression, and the prognosis of these patients can be further evaluated.
2020 Vol. 17 (23): 115-118 [Abstract] ( 312 ) HTML (1 KB)  PDF (624 KB)  ( 29 )
118 Clinical significance of serum SOD, BDNF and scores of PANSS scale in patients with chronic schizophrenia
ZHU Ming SONG Chuanfu
Objective To study the clinical significance of serum superoxide dismutase (SOD), brain-derived nutrition factor (BDNF) and scores of positive and negative symptom scale (PANSS) scale in patients with chronic schizophrenia, and to provide guidance for patients′ condition and prognosis evaluation. Methods From March 2018 to March 2020, 80 patients with chronic schizophrenia admitted to the Department of Psychiatric of the Fourth People′s Hospital of Wuhu City, Anhui (hereinafter referred to as “our hospital”) were selected as the observation group, and 80 healthy normal people served who received physical examination in our hospital during the same period were selected as the control group. Enzyme-linked immunosorbent assay was used to detect serum SOD and BDNF levels in the two groups, and PANSS score was used to assess psychopathological symptoms. The correlation between serum SOD and BDNF levels and PANSS score were analyzed. Results The serum SOD level of the observation group was higher than that of the control group, while BDNF level was lower than that in the control group, and the differences were statistically significant (P < 0.05). The general pathology, negative symptoms, positive symptoms scores and total scores of the observation group were higher than those of the control group, and the differences were statistically significant (P < 0.05). Serum SOD level was positively correlated with negative symptoms, positive symptom scores and total scores (r ＞ 0, P ＜ 0.05); serum BDNF level was positively correlated with general pathological scores (r ＞ 0, P ＜ 0.05), while negatively correlated with PANSS negative symptoms and positive symptoms (r ＜ 0, P ＜ 0.05). Conclusion The serum SOD level and PANSS score of patients with chronic schizophrenia are significantly increased, and the BDNF level is significantly decreased, which is related to the severity of the disease. The detection of the above indicators helps to judge the condition and assess the prognosis.
2020 Vol. 17 (23): 118-121 [Abstract] ( 201 ) HTML (1 KB)  PDF (563 KB)  ( 77 )
122 Systematic review and meta-analysis of Tripterygium wilfordii multiglucoside in the treatment of adult IgA nephropathy
WANG Hongyun1 YUAN Jun2，3，4 WANG Xiaoqin1，3，4 ZOU Xinrong1，3，4
Objective To evaluate clinical efficacy and safety of Tripterygium wilfordii multiglucoside (TWM) in the treatment of IgA nephropathy (IgAN). Methods EMbase, The Cochrane Library, PubMed, CNKI, CBM, Wanfang and VIP databases were searched for all published randomized controlled trials on the treatment of IgAN with TWM from the establishment of the databases to October 2019. After the two researchers screened the literature, extracted the data and assessed the risk of bias independently, the RevMan 5.3 software was used for meta-analysis. Results A total of 20 studies were included, including 729 cases in experimental group and 685 cases in control group. The results of meta-analysis showed that the experimental group was better than control group in decreasing 24 h urinary protein (MD = -0.57, 95%CI: -0.71 to -0.42, P < 0.000 01), serum creatinine (MD = -9.26, 95%CI:-13.09 to -5.44, P < 0.000 01), urinary transforming growth factor-β1 (MD = -1.67, 95%CI: -1.92 to -1.41, P < 0.000 01) and increasing clinical total effective rate (RR = 1.35, 95%CI: 1.26 to 1.45, P < 0.000 01), serum albumin (MD = 3.03, 95%CI: 1.67 to 4.38, P < 0.0001). There was no significant difference in the incidence of adverse reactions between two groups (RR = 1.14, 95%CI: 0.84 to 1.53, P = 0.40). Conclusion TWM for the treatment of IgAN can improve clinical efficacy and the safety is relatively good. Due to limited quantity of the included studies, more high quality studies are required to verify the conclusion mentioned above.
2020 Vol. 17 (23): 122-129 [Abstract] ( 304 ) HTML (1 KB)  PDF (3252 KB)  ( 88 )
130 Effect of Modified Danggui Niantong Decoction in the treatment of diabetic peripheral neuropathy
SONG Jun TONG Xiaolin▲
Objective To observe clinical efficacy of Modified Danggui Niantong Decoction in the treatment of diabetic peripheral neuropathy. Methods Sixty patients with diabetic peripheral neuropathy in Department of Endocrine, Guang′anmen Hospital from January 2017 to December 2018 were selected and divided into control group and treatment group according to random number table method, 30 cases in each group. In addition to basic treatment, control group was treated with Mecobalamin, and treatment group was treated with Modified Danggui Niantong Decoction for 30 days. The curative effect of two groups was compared. FPG, 2hPBG, HbA1c, TG/HDL-C, MNCV and SNCV of median nerve and common peroneal nerve of two groups were observed before and after treatment. Results Total effective rate of treatment group was higher than that of control group (P ＜ 0.05). FPG and TG/HDL-C in treatment group after treatment were lower than those in control group (P ＜ 0.05). FPG, 2hPBG, HbA1c and TG/HDL-C in treatment group after treatment were lower than those before treatment (P ＜ 0.05). The 2hPBG of control group after treatment was lower than that before treatment (P ＜ 0.05). After treatment, the median nerve MNCV, median nerve SNCV, common peroneal nerve MNCV and common peroneal nerve SNCV of two groups were faster than those before treatment (P ＜ 0.05). Conclusion Modified Danggui Niantong Decoction can improve the nerve conduction velocity of patients with diabetic peripheral neuropathy, improve the clinical symptoms of patients, and reduce TG/HDL-C, the curative effect is significant.
2020 Vol. 17 (23): 130-133 [Abstract] ( 192 ) HTML (1 KB)  PDF (659 KB)  ( 81 )
134 Professor Liu Hongfang′s clinical experience in the treatment of gout nephropathy
LIANG Liyun1 AN Zhichao1 XU Zhenmin2 LIU Hongfang1
Gouty nephropathy is a disorder of purine metabolism which leads to hyperuricemia, and urate deposits in the kidneys cause kidney damage. After many years of clinical practice, professor Liu Hongfang believes that the heat, turbid and stasis are the pathological basis of gout nephropathy, and the yang deficiency of spleen and kidney is the basic cause of this disease. She emphasizes that the treatment must obey treating both manifestation and root cause of disease, reinforcing deficiency and reducing excess. The method is to warm up spleen and kidney, and to clear the heat, the dredge collaterals, and the transform damp turbidity. According to Zhang Jingyue′s yin and yang essence theory, professor Liu is good at using large doses of prepared rehmannia root to nourish kidney essence. It is curative for the proteinuria, hematuria, elevated serum creatinine. Besides, this paper will provide one case to support it.
2020 Vol. 17 (23): 134-137 [Abstract] ( 194 ) HTML (1 KB)  PDF (659 KB)  ( 44 )
138 Effect of Jianpi Chushi Huatan Decoction on brain metastasis of non-small cell lung cancer patients with syndrome of qi deficiency and phlegm dampness and its influence on patients′ quality of life
YANG Song1，2 XU Li1
Objective To explore the effect of Jianpi Chushi Huatan Decoction on brain metastasis of non-small cell lung cancer (NSCLC) patients with syndrome of qi deficiency and phlegm dampness and its influence on patients′ quality of life. Methods One hundred and twelve brain metastasis patients of NSCLC pationts with syndrome of qi deficiency and phlegm dampness admitted to the Central Hospital of Maanshan from February 2016 to February 2019 were selected and divided into control group and research group by using random number table method, 56 cases in each group. Control group was treated with whole brain radiotherapy plus pemetrexed combined with cisplatin (PP) chemotherapy, and research group was treated with Jianpi Chushi Huatan Decoction on the basis of control group, with 21 days as one cycle, all of which were treated for two cycles. Clinical efficacy, traditional Chinese medicine syndrome score, the incidence of side effects, the quality of life score and cellular immune function indexes were compared between two groups. Results Total effective rate of research group was higher than that of control group (P < 0.05). After treatment, CD3+, CD4+, CD4+/CD8+ in two groups were higher than those before treatment, and research group was higher than that in control group; CD8+ in two groups were lower than those before treatment, and research group was lower than that in control group (P < 0.05). After treatment, traditional Chinese medicine syndrome scores of two groups were lower than those before treatment, and research group was lower than that of control group; the quality of life scores of two groups were higher than those before treatment, and research group was higher than that of control group (P < 0.05). The incidence rate of nausea and vomiting, alopecia, leucopenia and thrombocytopenia in research group were lower than those in control group (P < 0.05). Conclusion Jianpi Chushi Huatan Decoction can effectively alleviate clinical symptoms of brain metastasis of NSCLC patients with syndrome of qi deficiency and phlegm dampness, improve the cellular immune function, improve the anti-tumor effect, and reduce the side effects of radiotherapy and chemotherapy, so as to improve the quality of life of patients.
2020 Vol. 17 (23): 138-141,166 [Abstract] ( 98 ) HTML (1 KB)  PDF (1104 KB)  ( 16 )
142 Liu Hui′s experience in the treatment of adenomyosis based on collateral disease theory
YANG Baoyu1 LIU Hui2
With the gradual deepening of traditional Chinese medicine′s research on the theory of collaterals, the theory of collaterals has gradually matured, and this theory has been applied to various diseases related to collaterals. Adenomyosis is one of the common clinical diseases in gynecology. The typical symptoms are menstrual disorders and dysmenorrhea. As one of the most common symptoms in gynecology, dysmenorrhea has a great impact on patients′ lives and work. This article starts from the theory of collateral disease, mainly based on the physical factors of patients with adenomyosis, combined with the female′s menstrual period and the special internal environment before and after menstruation, to explore the etiology, pathogenesis and onset characteristics of this disease, and summarize and arrange Liu Hui′s medication characteristics and treatment methods in the treatment of patients with adenomyosis, and attach a case to the test. The purpose is to improve the physical condition of such patients and improve their quality of life.
2020 Vol. 17 (23): 142-145 [Abstract] ( 234 ) HTML (1 KB)  PDF (657 KB)  ( 80 )
146 Effect of Modified Tianma Gouteng Decoction combined with otopoint pellet-pressing in the treatment of insomnia
LIU Meihua1 LI Shuang2
Objective To observe the effect of Modified Tianma Gouteng Decoction combined with otopoint pellet-pressing in the treatment of insomnia with the syndrome of hyperactivity of fire due to yin deficiency. Methods Sixty-four patients with insomnia of syndrome of hyperactivity of fire due to yin deficiency at outpatient in Huguosi Hospital of Chinese Medicine Affiliated to Beijing University of Chinese Medicine from August 2016 to December 2018 were selected and divided into observation group and control group according to random number table method, 32 cases in each group. Observation group was treated with Modified Tianma Gouteng Decoction combined with otopoint pellet-pressing, while control group was treated with Estazolam orally for four weeks. Before and after treatment, Pittsburgh sleep quality index (PSQI) was used to evaluate sleep quality, and self-rating scale of traditional Chinese medicine was used to evaluate the efficacy. Adverse reactions of the two groups were observed. Results Total effective rate of observation group was higher than that of control group (P ＜ 0.05). PSQI and self-rating scale of traditional Chinese medicine scores of two groups after treatment were lower than those before treatment (P ＜ 0.05), and PSQI and self-rating scale of traditional Chinese medicine scores of observation group after treatment were lower than those of control group (P ＜ 0.05). The incidence of adverse reaction in observation group was lower than that in control group (P ＜ 0.05). Conclusion The effect of Modified Tianma Gouteng Decoction combined with otopoint pellet-pressing in the treatment of insomnia with syndrome of hyperactivity of fire due to yin deficiency is better than Estazolam.
2020 Vol. 17 (23): 146-149 [Abstract] ( 126 ) HTML (1 KB)  PDF (702 KB)  ( 95 )
154 Systematic review of effectiveness of smartphone-based self-management interventions in patients with type 2 diabetes
HUANG Houqiang1 GUO Shengmin2 CHEN Peiyun3 ZHENG Silin1▲
Objective To systematic evaluate the effect of using smart phones on the management of patients with type 2 diabetes. Methods PubMed, Cochrane, CINAL, JBI, Embase, CBM, CNKI, Wanfang database, VIP database for randomized controlled studies were searched on the effect of smartphones on blood glucose in patients with type 2 diabetes, and the search time limit was from the construction of the database to November 15, 2019. Through literature screening and literature quality evaluation, RevMan 5.3 software was used for data integration. Results A total of 19 articles and 2376 patients were included. Glycated hemoglobin in the test group was significantly lower than that in the control group (MD[95%CI]：-0.54[-0.68，-0.40]), while the patient′s quality of life was significantly higher than the control group(MD[95%CI]：0.26[0.06，0.47]), and the differences were statistically significant (P ＜ 0.05). The results of the subgroups showed that the after three months of intervention, and the difference between the two groups of glycosylated hemoglobin was not statistically significant (P ＞ 0.05); the glycosylated hemoglobin of experimental group after intervention for six months (MD[95%CI]：-0.42[-0.63，-0.22]) and 10 to 12 months (MD[95%CI]：-0.63[-0.85，-0.41]) were lower than those of the control group, and the differences were statistically significant (P ＜ 0.05). Conclusion The smartphone-based management for patients with type 2 diabetes can improve the management effect of glycosylated hemoglobin and the quality of life.
2020 Vol. 17 (23): 154-159,172 [Abstract] ( 135 ) HTML (1 KB)  PDF (1926 KB)  ( 53 )
160 Application of trans SBAR model of condition reporting in improving critical thinking of nursing students
WENG Yehong CHEN Hongyun▲ ZHANG Yongmei JIANG Jihao CHEN Yequn WU Qian
Objective To explore the clinical application effect of the trans situation-background-assessment recommendation model (SBAR) condition report in improving the critical thinking of nursing students. Methods A total of 102 rotation nursing students from the Department of Orthopedics, Guangdong Provincial Hospital of Traditional Chinese Medicine were selected from January 2018 to November 2019. They were divided into experimental and control groups according to the random number table method, with 51 people in each group. The control group used traditional teaching; while the experimental group added the method of trans-SBAR disease reporting and intensive training on this basis. The critical thinking ability scale was used to compare the total scores of critical thinking ability and the differences in scores of various dimensions of nursing students between the two groups before and after teaching were compared. Results After teaching, the scores of finding the truth in the control group were higher than those before teaching, while the scores of finding the truth, analytical ability, systematic ability, and self-confidence in the experimental group were higher than those before education, and the differences were statistically significant (P ＜ 0.05). The analytical ability, systematic ability, and self-confidence scores in the experimental group after teaching were higher than those in the control group, and the differences were statistically significant (P ＜ 0.05). The total score and the degree of improvement of the experimental group after teaching were higher than those of before teaching and the control group, and the differences were statistically significant (P ＜ 0.05). Conclusion Integrating the trans-SBAR disease reporting model into clinical teaching can improve the critical thinking ability of nursing students and help strengthen the core competence of nursing students.
2020 Vol. 17 (23): 160-162 [Abstract] ( 158 ) HTML (1 KB)  PDF (700 KB)  ( 20 )
163 Effect of continuous nursing based on information-motivation-behavioral skills model on cognitive impairment of stroke patients
WANG Ping1 MA Yu2 YANG Yue1 ZHAO Ruiwen1 QI Yuxia1 Burebiguli·Aini1 CHANG Haixia3
Objective To explore the impact of implementing continual nursing based on the information-motivation-behavioral skills (IMB) model on the cognitive dysfunction of patients with ischemic stroke. Methods From June 2018 to May 2019, 76 patients with cognitive dysfunction after ischemic stroke who were hospitalized in the Department of Neurology, the Fifth Affiliated Hospital of Xinjiang Medical University were divided into control group (38 cases) and IMB group (38 cases) by random number table method. Finally, 70 cases were followed up, including 36 cases in the IBM group and 34 cases in the control group. The control group was given conventional treatment and nursing care, while the IMB group was given a continuation nursing plan based on the IMB model on the basis of the control group. Before nursing intervention and three months after nursing intervention, the Montreal cognitive assessment scale (MoCA) and the Barthel index (BI) were used to evaluate the changes in the cognitive function of stroke patients. Results After three months of intervention, the MoCA and BI scores in the IMB group were higher than those before the intervention and higher than those in the control group, and the differences were statistically significant (P ＜ 0.05). Conclusion Continuous care based on the IMB skills model can improve the cognitive function of patients with cognitive dysfunction in stroke and improve the quality of life of patients.
2020 Vol. 17 (23): 163-166 [Abstract] ( 286 ) HTML (1 KB)  PDF (722 KB)  ( 81 )
167 A concept analysis of self-disclosure in cancer
LIU Linglong ZHANG Xiaoqian LIU Changying CHEN Mingxia
Objective To define the concept of cancer self-disclosure from the perspective of nursing. Methods The concept analysis method of Rodgers′ evolutionary was used to systematically search in China National Knowledge Internet, China Biology Medicine disc, Wanfang, VIP, PubMed, CINHAL, the Cochrane Library, Web of Science, Embase and PsycINFO. The search period was between the construction date of database and October 2019. The original studies, systematic reviews, case reports and others about cancer self-disclosure were included in this study. Results Cancer self-disclosure has five core characteristics: healthy personality and psychological characteristics, interpersonal relationship regulation variables, core of social relations, dynamic interaction process, and self-definition related to cancer development trajectory. Finally, it is defined as a kind of getting along and communication mode between cancer patients and their caregivers or listeners. On the one hand, express your cognition, emotion, consciousness, experience or confusion to others during the illness. On the other hand, express my attitude and feedback to the external situation or others. The purpose was to deal with the physical and psychological troubles related to cancer, prevent cancer from affecting the normal life trajectory, provide opportunities for them to find the meaning of life and personal growth, create a good mental and physical health outcome, and promote mutual understanding and interpersonal communication with other caregivers. Conclusion The clarification and interpretation of the important concept of cancer self-disclosure through strict methodology will make its application in nursing practice effective and reliable.
2020 Vol. 17 (23): 167-172 [Abstract] ( 130 ) HTML (1 KB)  PDF (1008 KB)  ( 35 )
173 Effect of characteristic nursing intervention based on time medicine of traditional Chinese medicine on the improvement of syndromes and prognosis of patients with chest arthralgia and heartache
WANG Yan1 LI Jun2 LYU Rongde3 ZHANG Lili4 ZHOU Li Mei5▲
Objective To analyze the influence of characteristic nursing intervention based on time medicine of traditional Chinese medicine on the improvement of syndromes and prognosis of patients with chest arthralgia and heartache, so as to provide basis for clinical treatment. Methods From February 2019 to February 2020, 100 cases patients with chest arthralgia and heartache from the 901th Hospital of the Joint Service Support Force were studied. According to the method of random number table, they were divided into control group (50 cases) and observation group (50 cases). The control group was given routine nursing intervention, and the observation group was given characteristic nursing intervention based on time medicine of traditional Chinese medicine on the basis of the control group. Before and after treatment, traditional Chinese medicine syndrome score, quality of life score, nursing satisfaction and treatment effect were observed. Results The total effective rate of the observation group was significantly higher than that of the control group (P ＜ 0.05). After nursing, the traditional Chinese medicine syndrome scores of the two groups were significantly reduced, and the traditional Chinese medicine syndrome scores of the observation group were significantly lower than that of the control group, the differences were statistically significant (P ＜ 0.05). After nursing, the quality of life scores of patients in both groups were significantly increased, and the scores of physiological function, health status, physical disease, mental health and social function in the observation group were significantly higher than those in the control group (P ＜ 0.05); the nursing satisfaction of the observation group was significantly higher than that of the control group (P ＜ 0.05). Conclusion The characteristic nursing intervention based on time medicine of traditional Chinese medicine has a significant effect on the patients with chest arthralgia and heartache, which can obviously improve the syndrome and quality of life of traditional Chinese medicine and improve the satisfaction of nursing and is worth popularizing and applying in clinic.
2020 Vol. 17 (23): 173-176,184 [Abstract] ( 172 ) HTML (1 KB)  PDF (730 KB)  ( 66 )
177 Effects of a new triad home care model on blood glucose, body mass index, lipid level and eating behavior in patients with type 2 diabetes mellitus
WANG Ruihuan1 SUN Xiaojian2 WANG Yonghai1
Objective To explore the effects of the new triad home care model on blood glucose, body mass and lipid levels and dietary behaviors in patients with type 2 diabetes mellitus (T2DM). Methods From January 2018 to December 2019, 100 patients with T2DM admitted to Qingdao Hospital Affiliated to Shandong First Medical University were selected and divided into control group and observation group, with 50 cases in each group, according to the random number table method. The control group adopted the conventional nursing mode, and the observation group implemented the new triad home care model on the basis of the control group, and the blood glucose, body mass, lipid level and dietary behavior of the two groups were compared. Results Fasting plasma glucose (FPG), postpranational blood glucose (2 hPBG), HbAlc and body mass index (BMI) of the two groups were all lower after intervention, and FPG, 2 hPBG, HbAlc and BMI of the observation group were all lower than those of the control group, with statistically significant differences (all P ＜ 0.05). After intervention, total cholesterol (TC), triglyceride (TG) and high-density lipoprotein cholesterol (HDL-C) in the two groups were all lower than those before intervention, while low-density lipoprotein cholesterol (LDL-C) was higher than that before intervention. Moreover, TC, TG and HDL-C in the observation group were lower than that in the control group, and LDL-C was higher than that in the control group, with statistically significant differences (all P ＜ 0.05). The dietary compliance rate of the observation group was higher than that of the control group, and the difference was statistically significant (P ＜ 0.05). Conclusion The application of the new home care model of the trinity can reduce the blood sugar of patients, regulate the blood lipid of the body, and improve the daily eating behavior.
2020 Vol. 17 (23): 177-180 [Abstract] ( 175 ) HTML (1 KB)  PDF (661 KB)  ( 125 )
180 Effects of systematic first aid nursing intervention on resuscitation, survival rate and parental satisfaction of children with neonatal asphyxia
YANG Ni1 CHENG Gongmei2 ZHU Xiaoyu3▲
Objective To explore the effects of systematic first aid nursing intervention on the resuscitation, survival rate and parental satisfaction of children with neonatal asphyxia. Methods From January 2017 to December 2019, 90 neonatal asphyxia children admitted to the Neonatal Department of Xijing Hospital, Air Force Medical University were selected as the research object, and they were divided into control group of 42 cases and observation group of 48 cases according to the random number table method. The control group adopted routine rescue nursing intervention, and the observation group implemented systematic emergency nursing intervention. Rescue time, 5 min Apgar score, hospital stay and other treatment indicators, resuscitation rate and mortality rate, and parental nursing satisfaction were compared between the two groups. Results The rescue time and hospital stay of the observation group were lower than those of the control group, and the 5 min Apgar score was higher than that of the control group, with statistically significant differences (P ＜ 0.05). The resuscitation rate of the observation group was higher than that of the control group within 5 minutes, with statistically significant difference (P ＜ 0.05). The comparison of resuscitation rate and mortality rate within 10 minutes between the two groups showed no statistically significant difference (P ＞ 0.05). Parents′ nursing satisfaction in the observation group was higher than that in the control group, and the difference was statistically significant (P ＜ 0.05). Conclusion The application of systematic first aid nursing intervention in newborn asphyxia children has a good effect on the efficiency of rescue, the survival rate of children and the satisfaction of parents′ nursing, which is worthy of popularization and application.
2020 Vol. 17 (23): 180-184 [Abstract] ( 160 ) HTML (1 KB)  PDF  (0 KB)  ( 20 )
185 Aneurysmal bone cyst of left calcaneal bone：a case report
WANG Tong1 JIA Huijun2 DONG Bo3 YANG Feng1 YUAN Puwei1 KANG Wulin3 LI Xiaowei1 LIU Deyu3
Aneurysmal bone cyst is a kind of swelling, bleeding and multilocular cyst. It is a benign single bone tumor with local invasion. Early clinical manifestations are not specific, patients often see the doctor for pain. The author reviews the literature and find that there were rare reports of aneurysmal bone cysts in the calcaneus in the past 10 years. Recently, one case of left calcaneal aneurysmal bone cyst patients are treated with curettage of calcaneus disease plus iliac bone grafting. Through this case, the following conclusions are drawn: the incidence of calcaneal aneurysmal bone cyst is low and easy to be misdiagnosed clinically. Pathological examination is the main basis for its diagnosis, and imaging examination can provide a higher diagnostic basis before its diagnosis. Curettage with or without bone grafting is the main treatment at present, depending on the patient′s condition. This disease is easy to relapse after surgery, so regular follow-up after surgery is extremely important, which has great significance for the successful treatment of this disease.
2020 Vol. 17 (23): 185-187 [Abstract] ( 213 ) HTML (1 KB)  PDF (451 KB)  ( 90 )
188 Research on application of “internet +” technology in traditional Chinese medicine
LI Jing1,2 LI Liang1,2 WU Huaying1,2 DENG Wenxiang1,2 ZHU Jianping1,2 ZHONG Senjie1,2 HUANG Huiyong1,2
The innovation and development of traditional Chinese medicine (TCM) is the theme of the present era, and the development of “internet +” technology has brought new opportunities and challenges to the field of traditional Chinese medicine. This article summarizes the relevant literature of the application of “internet +” technology in the field of TCM, summarizes its application, and analyzes the “internet +” technology in the field of TCM from the aspects of cultural heritage of TCM, TCM medical system, and TCM health management advantages and prospects. In terms of TCM culture inheritance, “internet +” technology helps to promote the effective spread of TCM culture and promote the TCM culture to the world. In terms of TCM medical system, “internet +” technology helps to optimize the TCM medical system and improve the convenience of clinical diagnosis and treatment. In terms of TCM health management, the “internet +” technology helps to raise awareness of national health and the level of disease prevention and control. Therefore, the field of TCM should focus on the deep integration with “internet +” technology, with a view to further promoting the innovative development of TCM.
2020 Vol. 17 (23): 188-190,196 [Abstract] ( 173 ) HTML (1 KB)  PDF (455 KB)  ( 104 )
191 Discussion on the working paths of cultivating and practicing core socialist values with cultural edification in public hospitals
WU Zheng DING Xiaowei XIANG Chunmei LIU Yong YU Yi′an LU Xi
Objective To investigate the degree of attention and recognition of the different forms of cultural construction of public hospitals in Beijing, and to explore the working paths of cultivating and practicing core socialist values with cultural edification in public hospitals. Methods The study was carried out through questionnaires and interviews. From March to April in 2019, 2200 employees in 22 municipal public hospitals in Beijing were taken as the research objects, 2523 pieces of questionnaires provided and 2200 valid redemptory, then heads of the party affairs departments of 10 hospitals with different professional characteristics were interviewed to study related issues. Results The respondents′ overall attention to different forms of cultural construction was 86.45% to 96.05%, and the recognition was 81.82% to 94.00%. Conclusion Public hospitals should carry out various forms of education; and through exploring and learning the progressive and advanced typical story, to form a working path by dramatizing as high-quality public performances or works; incorporating the values and ethics of traditional Chinese culture into patriotism education; integrating the construction of scientific research culture into the construction of hospital culture, and exploring the establishment of a model of cultural construction that is appropriate to the type of discipline and post characteristics; further improving the communication mechanism, and innovating the forms and carriers of communication.
2020 Vol. 17 (23): 191-196 [Abstract] ( 207 ) HTML (1 KB)  PDF (488 KB)  ( 66 )
Copyright © Editorial Board of 中国医药导报
Supported by:Beijing Magtech