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| Routine coagulation test and platelet parameter level of ischemic stroke and their clinical significance |
| CHEN Li1 TANG Xiaolei2▲ |
1.Department of Clinical Laboratory, the Second People′s Hospital of Wuhu City, Anhui Province, Wuhu 241000, China;
2.Basic Laboratory, the Second Affiliated Hospital of Anhui Wannan Medical College, Anhui Province, Wuhu 241000, China |
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Abstract Objective To study the routine coagulation test and platelet parameter level of ischemic stroke and their clinical significance, so as to provide guidance for the clinical diagnosis of patients. Methods A total of 95 patients with ischemic stroke admitted to the Second People′s Hospital of Wuhu City, Anhui Province (hereinafter referred to as “our hospital”) from October 2017 to November 2019 were selected as the observation group, and 45 patients without cardiovascular and cerebrovascular diseases who underwent physical examination in our hospital during the same period were selected as the control group. The levels of prothrombin time (PT), activated partial thromboplastin time (APTT), fibrinogen (FIB), thrombin time (TT), D-dimer (DDR), fibrin and FIB degradation products (FDP) and antithrombin Ⅲ (AT-Ⅲ) were compared between the two groups. The mean platelet volume (MPV) and platelet (PLT) were compared between the two groups. The levels of total cholesterol, low density lipoprotein cholesterol, high density lipoprotein cholesterol, triglyceride and fasting glucose were compared between the two groups. Results The APTT and PT in the observation group were shorter than those in the control group, the levels of FIB, DDR, FDP and MPV were higher than those in the control group, TT was longer than that in the control group and the levels of AT-Ⅲ, PLT were lower than those in the control group, with statistically significant differences (all P ＜ 0.05). The levels of low density lipoprotein cholesterol and fasting glucose in the observation group were higher than those in the control group, and the level of high density lipoprotein cholesterol was lower than that in the control group, with statistically significant differences (all P ＜ 0.05). There was no significant difference in triglyceride and total cholesterol levels between the observation group and the control group (P ＞ 0.05). Conclusion Routine coagulation test and platelet parameter level detection in patients with ischemic stroke have important clinical significance for the treatment intervention and prevention of disease progression of patients, which is worthy of clinical application.
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