冠心病患者miR-126、sVCAM-1水平变化及临床意义

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Abstract Objective To investigate the changes and clinical significance of plasma miR-126 and soluble vascular cell adhesion molecule-1 (sVCAM-1) levels in patients with coronary artery heart disease (CHD). Methods One hundred and three cases of CHD patients hospitalized in Puning People′s Hospital of Guangdong Province from February 2018 to December 2019 were selected. They were divided into acute coronary syndrome (ACS) of 58 cases and stable angina pectoris (SAP) of 45 cases according to the diagnostic criteria, and 55 non-CHD patients were selected as the control group. All patients underwent coronary angiography and the Gensini′s degree integral method was used to evaluate coronary artery stenosis. The plasma miR-126 and sVCAM-1 levels were measured, and Pearson correlation coefficient was used for correlation analysis. Results The levels of sVCAM-1 and Gensini′s degree integral score in ACS group were significantly higher than those of SAP group and control group, the levels of miR-126 were all lower than those of SAP group and control group (P ＜ 0.05). And the level of miR-126 in SAP group was lower than that of control group, the Gensini′s degree integral score was higher than that of control group (P ＜ 0.05). The levels of miR-126 in patients with multiple coronary artery lesions and moderate to severe disease were respectively lower than those in patients with single coronary artery lesion and mild disease (P ＜ 0.05). The levels of sVCAM-1 in patients with multiple coronary artery lesions and moderate to severe disease were respectively higher than those in patients with single coronary artery lesion and mild disease (P ＜ 0.05). Correlation analysis showed that miR-126 was negatively correlated with the number of coronary artery lesions (r = -0.536, P = 0.007) and Gensini′s degree integral score (r = -0.574, P = 0.015). sVCAM-1 was positively correlated with the number of coronary artery lesions (r = 0.619, P = 0.000) and Gensini′s degree integral score (r = 0.644, P = 0.000). miR-126 was negatively correlated with sVCAM-1 (r = -0.685, P = 0.000). Conclusion There are significant down-regulation of miR-126 expression and up-regulation of sVCAM-1 expression in CHD patients, and the indexes are closely related to the degree of coronary lesions, which may be used as reference indicators for the diagnosis and treatment of CHD.

Key words： Coronary artery heart disease miR-126 Vascular cell adhesion molecule-1

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	YANG Nanran1 WANG Xiaoqun1 LIU Xiaohui1 FANG Bingxiong2

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YANG Nanran1 WANG Xiaoqun1 LIU Xiaohui1 FANG Bingxiong2. Changes and clinical significance of miR-126 and sVCAM-1 levels in patients with coronary artery heart disease[J]. 中国医药导报, 2020, 17(23): 41-44.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2020/V17/I23/41

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