柴胡平胃散在防治肿瘤化疗相关癌因性疲乏中的效果

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Abstract Objective To observe the clinical effect of Chaihu Pingwei Powder on the prevention and treatment of cancer-related fatigue (CRF) caused by chemotherapy. Methods A total of 60 hospitalized patients receiving chemotherapy admitted to the Department of Oncology, Hainan Hospital of Traditional Chinese Medicine from January 2017 to December 2018 were selected. According to the random number table method, they were divided into the Chaihu Pingwei Powder group and the conventional group, with 30 patients in each group. The conventional group received the best symptomatic and supportive treatment, while the Chaihu Pingwei Powder group was given oral administration of Chaihu Pingwei Powder on the first day after chemotherapy based on the symptomatic and supportive treatment of the conventional group, and was taken orally for seven days consecutively. The changes of fatigue, quality of life score, bone marrow suppression, gastrointestinal reaction, nutritional status and immune function were observed before and after treatment in the two groups. Results Before treatment, there was no significant difference in CRF scores between the two groups (P ＞ 0.05). After one week of treatment, CRF score of Chaihu Pingwei Powder group was not significantly different from that before treatment (P ＞ 0.05). The emotional and cognitive scores of the conventional group showed no statistically significant difference from those before treatment (P ＞ 0.05), behavioral and sensory scores of the conventional group increased compared with those before treatment, with statistically significant differences (all P ＜ 0.05). After one week of treatment, the behavioral and sensory scores of Chaihu Pingwei Powder group were lower than those of the conventional group, with statistically significant differences (all P ＜ 0.05), while the emotional and cognitive scores were not significantly different from those of the conventional group (P ＞ 0.05). Before treatment, there was no significant difference in Karnofsky functional status score (KPS score) between the two groups (P ＞ 0.05). After one week of treatment, KPS score of Chaihu Pingwei Powder group was not significantly different from that before treatment (P ＞ 0.05), while KPS score of the conventional group was lower than that before treatment, with highly statistically significant difference (P ＜ 0.01). After one week of treatment, KPS score of Chaihu Pingwei Powder group was higher than that of the conventional group, with statistically significant difference (P ＜ 0.05). The incidence of gastrointestinal reaction and bone marrow suppression in Chaihu Pingwei Powder group was significantly lower than that in the conventional group, and the difference was statistically significant (P ＜ 0.05). Before treatment, there was no statistically significant difference in CD4+/CD8+ between the two groups (P ＜ 0.05). After one week of treatment, CD4+/CD8+ of the Chaihu Pingwei Powder group was increased compared with that before treatment, and the difference was statistically significant (P ＜ 0.05), while CD4+/CD8+ of the conventional group was not significantly different from that before treatment (P ＞ 0.05). After one week of treatment, CD4+/CD8+ of Chaihu Pingwei Powder group was significantly higher than that of the conventional group, and the difference was highly statistically significant (P ＜ 0.01). Before treatment, there was no significant difference in the subjective overall nutritional status rating scale (PG-SGA) scores between the two groups (P ＞ 0.05). After one week of treatment, PG-SGA score of Chaihu Pingwei Powder group was not significantly different from that before treatment (P ＞ 0.05), while PG-SGA score of the conventional group was increased compared with that before treatment, with statistically significant difference (P ＞ 0.05). After one week of treatment, the PG-SGA score of Chaihu Pingwei Powder group was significantly lower than that of the conventional group, and the difference was highly statistically significant (P ＜ 0.01). Conclusion At the same time of chemotherapy, oral Chaihu Pingwei Powder can significantly reduce the degree of cancer fatigue fo some extent, improve the quality of life, reduce the incidence of gastrointestinal reaction and bone marrow suppression, and can enhance the immune function, has a certain effect on the prevention and treatment of CRF caused by chemotherapy.

Key words： Chaihu Pingwei Powder Cancer-related fatigue Chemotherapy

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	JIANG Jingwen1 ZHANG Hui1 ZHU Fengting1 LIN Lizhu2 CHEN Xuewu1

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JIANG Jingwen1 ZHANG Hui1 ZHU Fengting1 LIN Lizhu2 CHEN Xuewu1. Effect of Chaihu Pingwei Powder on the prevention and treatment of cancer-related fatigue caused by chemotherapy[J]. 中国医药导报, 2020, 17(23): 86-90.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2020/V17/I23/86

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