SOFA、SIRS、qSOFA评分和乳酸对儿童脓毒症预后的判断价值

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Abstract Objective To investigate the prognostic value of sequential organ failure assessment (SOFA), systemic inflammatory response syndrome (SIRS) score, quick sequential organ failure assessment (qSOFA) score and lactate level in pediatric sepsis. Methods A total of 259 pediatric patients with Sepsis-3 diagnosis in general and intensive care units of Huai′an Maternal and Child Health Hospital of Jiangsu Province from January 2016 to December 2018 were retrospectively analyzed. They were divided into survival group (241 cases) and death group (18 cases) according to the prognosis. Receiver operating characteristic curve (ROC) was used to assessed the predictive value of lactate level, SOFA within 24 h and SIRS and qSOFA for prognosis of patients. Results Lactate level, SIRS, SOFA and qSOFA scores in death group were higher than those in survival group, and the differences were all highly statistically significant (all P < 0.01). The cut-off value for the death of sepsis by SOFA score was 7.5 points, the sensitivity was 68.8%, and the specificity was 80.0% respectively. The cut-off value for the death of sepsis by qSOFA score was 1.5 points, the sensitivity was 68.8%, and the specificity was 80.0%. The cut-off value for the death of sepsis by lactate value was 1.75 mmol/L, the sensitivity was 93.8%, and the specificity was 40.0%. Conclusion Compared with SIRS score, SOFA and qSOFA scores have better prognostic accuracy in predicting the prognosis of children with sepsis. Although lactate level has good sensitivity and is a reliable indicator for the prognosis of children with sepsis, but its specificity is low.

Key words： Pediatric sepsis Sequential organ failure assessment Quick sequential organ failure assessment Systemic inflammatory response syndrome score Lactate

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	WU Yunduo1
	2 LIN Xiaofei2 GU Xiaohai2 ZHANG Jun2 LYU Yanguan2 WANG Jun1

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WU Yunduo1,2 LIN Xiaofei2 GU Xiaohai2 ZHANG Jun2 LYU Yanguan2 WANG Jun1. Prognostic value of SOFA, SIRS, qSOFA score and lactate level in pediatric sepsis[J]. 中国医药导报, 2020, 17(23): 74-77.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2020/V17/I23/74

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