子宫卵巢超声结合Z-score方法对女性性早熟的诊断价值

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Abstract Objective To analyze the diagnostic value of uterine and ovarian ultrasound combined with Z-score method in female precocious puberty. Methods A total of 207 female with precocious puberty who aged three to eight years old from February 2017 to February 2020 in Dongguan Eighth People′s Hospital of Guangdong Province （hereinafter referred to as “our hospital”） were the experimental group. In addition, 112 healthy children aged three to eight years old who consulted height or physical examination in our hospital during the same period were selected as the control group. According to the location of precocious puberty, 50 cases were simple preature thelarhe (PT) and premature pubarche (PP) subgroup, 61 cases were peripheral precocious puberty (PPP) subgroup, and 96 cases were central precocious puberty (CPP) subgroup. Ultrasound examination of uterin and ovarin was performed in both groups to obtain uterine body and bilateral ovarian diameter lines, and the volume was calculated, the Z-score model was established and the Z value was calculated. Receiver operating characteristic (ROC) curve was used for the diagnosis of precocious puberty in female. Results Age had the greatest correlation with ovarian volume and uterine body length diameter (r = 0.82, 0.95, P < 0.05). The average Z value of uterine body length diameter with PPP children was 2.59±2.29 (-2.70, 6.00), the area under the curve was 0.909, the best diagnostic cut-off value was 1.05, the sensitivity was 97.99%, and the specificity was 81.90%. The average Z value of ovarian volume with CPP children was 7.49±7.49 (-0.48, 36.99), the area under the curve was 0.939, the best diagnostic cut-off value was 2.15, the sensitivity was 100.00%, and the specificity was 80.90% and the average Z value of ovarian volume with was 4.59±4.19 (-1.15, 22.79), the area under the curve was 0.839, the best diagnostic cut-off value was 1.13, the sensitivity was 90.80%, and the specificity was 85.10%. Conclusion Uterine and ovarian ultrasound combined with Z-score method can effectively diagnose PPP and CPP, which play a crucial role in the diagnosis of precocious puberty in children and adolescent females, worthy of clinical promotion.

Key words： Uterus Ovary Ultrasound Z-score method Female Precocious puberty

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	ZHONG Xianling1 ZHANG Guoqiang2▲ JIANG Shuanglan1 YI Quanying1 BU Qiuqiang1 YU Feng1

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ZHONG Xianling1 ZHANG Guoqiang2▲ JIANG Shuanglan1 YI Quanying1 BU Qiuqiang1 YU Feng1. Diagnostic value of uterine and ovarian ultrasound combined with Z-score method in female precocious puberty[J]. 中国医药导报, 2020, 17(23): 70-73,94.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2020/V17/I23/70

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