慢性精神分裂症患者血清SOD、BDNF、PANSS量表评分及临床意义

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Abstract Objective To study the clinical significance of serum superoxide dismutase (SOD), brain-derived nutrition factor (BDNF) and scores of positive and negative symptom scale (PANSS) scale in patients with chronic schizophrenia, and to provide guidance for patients′ condition and prognosis evaluation. Methods From March 2018 to March 2020, 80 patients with chronic schizophrenia admitted to the Department of Psychiatric of the Fourth People′s Hospital of Wuhu City, Anhui (hereinafter referred to as “our hospital”) were selected as the observation group, and 80 healthy normal people served who received physical examination in our hospital during the same period were selected as the control group. Enzyme-linked immunosorbent assay was used to detect serum SOD and BDNF levels in the two groups, and PANSS score was used to assess psychopathological symptoms. The correlation between serum SOD and BDNF levels and PANSS score were analyzed. Results The serum SOD level of the observation group was higher than that of the control group, while BDNF level was lower than that in the control group, and the differences were statistically significant (P < 0.05). The general pathology, negative symptoms, positive symptoms scores and total scores of the observation group were higher than those of the control group, and the differences were statistically significant (P < 0.05). Serum SOD level was positively correlated with negative symptoms, positive symptom scores and total scores (r ＞ 0, P ＜ 0.05); serum BDNF level was positively correlated with general pathological scores (r ＞ 0, P ＜ 0.05), while negatively correlated with PANSS negative symptoms and positive symptoms (r ＜ 0, P ＜ 0.05). Conclusion The serum SOD level and PANSS score of patients with chronic schizophrenia are significantly increased, and the BDNF level is significantly decreased, which is related to the severity of the disease. The detection of the above indicators helps to judge the condition and assess the prognosis.

Key words： Schizophrenia Superoxide dismutase Negative symptoms Brain-derived nutrition factor Psychopathological symptoms

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	ZHU Ming SONG Chuanfu

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ZHU Ming SONG Chuanfu. Clinical significance of serum SOD, BDNF and scores of PANSS scale in patients with chronic schizophrenia[J]. 中国医药导报, 2020, 17(23): 118-121.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2020/V17/I23/118

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