健脾除湿化痰方治疗气虚痰湿型非小细胞肺癌脑转移的效果及对患者生活质量的影响

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Abstract Objective To explore the effect of Jianpi Chushi Huatan Decoction on brain metastasis of non-small cell lung cancer (NSCLC) patients with syndrome of qi deficiency and phlegm dampness and its influence on patients′ quality of life. Methods One hundred and twelve brain metastasis patients of NSCLC pationts with syndrome of qi deficiency and phlegm dampness admitted to the Central Hospital of Maanshan from February 2016 to February 2019 were selected and divided into control group and research group by using random number table method, 56 cases in each group. Control group was treated with whole brain radiotherapy plus pemetrexed combined with cisplatin (PP) chemotherapy, and research group was treated with Jianpi Chushi Huatan Decoction on the basis of control group, with 21 days as one cycle, all of which were treated for two cycles. Clinical efficacy, traditional Chinese medicine syndrome score, the incidence of side effects, the quality of life score and cellular immune function indexes were compared between two groups. Results Total effective rate of research group was higher than that of control group (P < 0.05). After treatment, CD3+, CD4+, CD4+/CD8+ in two groups were higher than those before treatment, and research group was higher than that in control group; CD8+ in two groups were lower than those before treatment, and research group was lower than that in control group (P < 0.05). After treatment, traditional Chinese medicine syndrome scores of two groups were lower than those before treatment, and research group was lower than that of control group; the quality of life scores of two groups were higher than those before treatment, and research group was higher than that of control group (P < 0.05). The incidence rate of nausea and vomiting, alopecia, leucopenia and thrombocytopenia in research group were lower than those in control group (P < 0.05). Conclusion Jianpi Chushi Huatan Decoction can effectively alleviate clinical symptoms of brain metastasis of NSCLC patients with syndrome of qi deficiency and phlegm dampness, improve the cellular immune function, improve the anti-tumor effect, and reduce the side effects of radiotherapy and chemotherapy, so as to improve the quality of life of patients.

Key words： Syndrome of qi deficiency and phlegm dampness Non-small cell lung cancer Brain metastasis Jianpi Chushi Huatan Decoction

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	YANG Song1
	2 XU Li1

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YANG Song1,2 XU Li1. Effect of Jianpi Chushi Huatan Decoction on brain metastasis of non-small cell lung cancer patients with syndrome of qi deficiency and phlegm dampness and its influence on patients′ quality of life[J]. 中国医药导报, 2020, 17(23): 138-141,166.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2020/V17/I23/138

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