首发精神分裂症血清神经调节蛋白 -1、脑电图γ活动及认知功能相关研究

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Abstract Objective To investigate the correlation among serum neuregulin-1 (NRG-1) level, EEG γ activity and cognitive function in patients with first-episode schizophrenia. Methods A total of 80 first-episode schizophrenic patients admitted to Qingdao Mental Health Center, Shandong Province (hereinafter referred to as “our hospital”) from January 2018 to August 2019 were randomly selected as the study group, and another 50 healthy people who underwent physical examination in our hospital during the same period were selected as the control group. The serum NRG-1 level and EEG γ activity of the two groups were detected. The condition of the study group was evaluated by the positive and negative symptom scale (PANSS), and the cognitive function of the two groups was evaluated by the MATRICS recognized cognitive battery test (MCCB). The correlation among NRG-1 level, EEG γ activity and cognitive function in the study group was analyzed. Results The NRG-1 level and the positive proportion of EEG γ activity in the study group were higher than those in the control group, while the processing speed, attention alertness, working memory, verbal memory, visual memory and reasoning resolution scores in the MCCB were all lower than those in the control group, and the differences were statistically significant (all P ＜ 0.05). Compared with patients with EEG γ activity in negative, the NRG-1 level and each MCCB factor scores (processing speed, attention alertness, working memory, verbal memory, visual memory and reasoning resolution) of patients with positive EEG γ activity were all decreased, and PANSS spirit of positive symptoms, negative symptoms, general psychopathology and total score were all increased, and the differences were statistically significant (all P ＜ 0.05). The level of NRG-1 in the study group was positively correlated with the score of verbal memory and reasoning resolution (r = 0.433, 0.554; P < 0.01), but negatively correlated with the total score of PANSS (r = -0.584, P ＜ 0.01). The EEG γ activity in the study group was negatively correlated with NRG-1 level, verbal memory and reasoning resolution score (r = -0.520, -0.610, -0.541; P < 0.01), but positively correlated with the total score of PANSS (r = 0.687; P ＜ 0.01). Conclusion In patients with first-onset schizophrenia, the level of serum NRG-1 is significantly decreased, and the EEG γ activity is significantly increased. Both of them are significantly related to the patients′ condition and cognitive function, patients can be given early personalized treatment clinically.

Key words： Schizophrenia Neuregulin-1 EEG &gamma activity Cognitive function Correlation

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	WANG Jindong1 ZHOU Tiantian1 CHEN Xiaoqin2 SUN Ping3 WANG Bailing1

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WANG Jindong1 ZHOU Tiantian1 CHEN Xiaoqin2 SUN Ping3 WANG Bailing1. Correlation study of serum neuromodulin-1, EEG γ activity and cognitive function in first-episode schizophrenia[J]. 中国医药导报, 2020, 17(23): 57-61.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2020/V17/I23/57

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