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2020 Vol. 17, No. 18 Published: 2020-06-25

	4	Study on the kidney-tonifying effect and mechanism of Shenbao Tablets
		SUN Jianhui1 ZHOU Qinggang2 SHEN Liqin2 HUO Hairu1 LI Xiaoqin1 LI Hongmei1
		Objective To study the kidney-tonifying effect of Shenbao Tablets and explore its mechanism. Methods The model of kidney-yang deficiency of Wistar rats induced by adenine was adopted. They were randomly divided into normal control group, model control group, Shenbao Tablets 1.14, 0.57 and 0.29 g/kg dose groups, Sildenafil Citrate Tablets group, with 13 rats in each group. Except the normal control group, the other rats were gavaged with adenosine 500 mg/kg for 10 d. On the second day of modeling, each group was administrated by gavage for 24 d. The body weight, the number of independent activities, the survival time of swimming at low temperature, the serum testosterone (T), blood urea nitrogen (BUN), creatinine (Cre), serum superoxide dismutase (SOD), malondialdehyde (MDA), cyclic guanosine phosphate (cGMP) and total nitric oxide synthase (NOS) were compared in each group. The castrated rat model was used, and 12 rats were randomly selected according to the body weight as the normal control group. The remaining rats were castrated. The castrated rats were randomly divided into model control group, Shenbao Tablets 2.28, 1.14 and 0.57 g/kg dose groups, and Sildenafil Citrate Tablets group, with 12 rats in each group. Each group was administrated by gavage once a day for 24 d, normal control group and model control group were gavaged the same volume of distilled water. The erectile latency，intracavernous pressure/blood pressure (ICP/BP), cGMP and total NOS levels and serum T levels were compared in each group. Results The body weight, the number of independent activities, the survival time of low temperature swimming, serum T levels and cGMP in penile sponge in model control group of kidney-yang deficiency were lower than those in normal control group, and serum BUN, Cre and MDA levels were higher than those in normal control group (P < 0.05). The survival time of low temperature swimming of Shenbao Tablets 1.14, 0.57 and 0.29 g/kg dose groups were longer than those of model control group, the BUN content was lower than that of model control group, the number of independent activities and cGMP levels in penile sponge of Shenbao Tablets 1.14 and 0.57 g/kg dose groups were higher than those of model control group, the serum T content and SOD activity of Shenbao Tablets 0.57 g/kg dose group were higher than those of model control group, and the Cre content was lower than that of model control group (all P < 0.05). There were no significant differences in the body weight, serum MDA content and total NOS levels in penile sponge in Shenbao Tablets 1.14, 0.57, 0.29 g/kg dose groups and model control group (P > 0.05). The erectile latency of castrated rats in model control group was higher than that in normal control group, and the serum T content, ICP value, ICP/BP ratio, cGMP level of penile sponge were lower than those in normal control group (P < 0.01). The erectile latency of Shenbao Tablets 2.28, 1.14 and 0.57 g/kg dose groups were lower than those of model control group, the serum T content, ICP value and ICP/BP ratio of penile sponge were higher than those of model control group, the cGMP levels of penile sponge in Shenbao Tablets 2.28 g/kg dose group were higher than those of model control group (all P < 0.05). There were no significant differences in BP value and total NOS of penile sponge in Shenbao Tablets 2.28, 1.14 and 0.57 g/kg dose groups and model control group (P > 0.05). Conclusion Shenbao Tablets has the effect of kidney-tonifying, and its mechanism is related to the increase of androgen content, the enhancement of NO/cGMP pathway activity and SOD activity.
		2020 Vol. 17 (18): 4-9 [Abstract] ( 97 ) HTML (1 KB) PDF (712 KB) ( 266 )

	10	Effect of Ckip-1 siRNA promotes osteogenic differentiation of bone marrow mesenchymal stem cells under extreme hypoxia
		LIU Xiangzhong1,2 NING Yu3 HU Jing4 YANG Aofei5 CAI Hantao6 LI Zhanghua2
		Objective To investigate the osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) by Ckip-1 siRNA under extreme hypoxia. Methods BMSCs were isolated and cultured in normal oxygen (20%) and extreme hypoxia (1%) for 72 h. The expression of osteogenic gene Runt-related transcription factor 2 (Runx2), Smad5 and bone morphogenetic protein 2 (BMP2) were detected by real-time quantitative PCR (qPCR) and Western blot. Alkaline phosphatase (ALP) activity in the supernatant was detected after 3, 5, 7 days of culture. BMSCs were cultured in 1% oxygen for 72 h to observe the effect of Ckip-1 siRNA on the expression of Runx2, Smad5, BMP2 and the activity of ALP. Results The osteogenic gene expression and ALP activity of BMSCs in 1% oxygen concentration were significantly lower than those in 20% oxygen concentration group, and the differences were statistically significant (P ＜ 0.05); the osteogenic gene expression and ALP activity of BMSCs after transfection with Ckip-1 siRNA were significantly higher than those without transfection, and the differences were statistically significant (P ＜ 0.05). Conclusion Hypoxia can inhibit the osteogenic differentiation of BMSCs, and Ckip-1 siRNA can promote the differentiation of BMSCs into osteoblasts.
		2020 Vol. 17 (18): 10-14,23 [Abstract] ( 133 ) HTML (1 KB) PDF (1008 KB) ( 96 )

	15	Clinical study of high expression of CD8+T lymphocytes surface inhibitory receptor NKG2A in lung adenocarcinoma tissue
		MA Mingyang1 YUAN Xiang1 LIU Yiwen1 SUN Jiangtao2
		Objective To analyze the correlation between expression of CD8+T cell surface inhibitory receptor NKG2A and clinicopathological characteristics and 5-year survival in patients with lung adenocarcinoma, and to explore its clinical significance and prognostic value. Methods From January 2014 to March 2015, 130 cases of lung adenocarcinoma with epidermal growth factor receptor (EGFR) (+) were resected in the First Affiliated Hospital of He′nan University of Science and Technology, and the paraffin-embedded samples of the carcinema tissues and adjacent lung tissues of patients with lung adenocarcinoma were selected as the research objects, immunohistochemistry was used to detect the expression of NKG2A protein on the surface of infiltrated CD8+T lymphocytes, and the correlation between NKG2A expression and clinicopathological characteristics and 5-year survival in patients with lung adenocarcinoma was analyzed. The influence of each factor on prognosis was analyzed by Cox regression method. The correlation between NKG2A protein expression and survival time was analyzed by Kaplan-Meier method. Results The expression of NKG2A protein was observed in the membrane of infiltrated CD8+T lymphocytes in lung adenocarcinoma and corresponding adjacent lung tissues, in lung adenocarcinoma tissues, the immunohistochemical score of NKG2A was higher than that of high differentiation and low differentiation than that of medium differentiation (P ＜ 0.05). High expression of NKG2A protein was associated with differentiation, lymph node metastasis, clinical stage and 5-year survival in patients with lung adenocarcinoma (P ＜ 0.05). The degree of differentiation, lymph node metastasis, clinical stage and high expression of NKG2A protein were independent risk factors for the prognosis of patients with lung adenocarcinoma. Moreover, the 5-year survival rate and median survival time of patients with high NKG2A protein expression were significantly lower than those with low expression, with statistically significant differences (P ＜ 0.05). Conclusion The high expression of the inhibitory receptor NKG2A on the surface of CD8+T lymphocytes may promote the development of lung adenocarcinoma by weakening its anti-tumor immunity. Inhibition of NKG2A expression may provide a new idea and an effective treatment for lung adenocarcinoma.
		2020 Vol. 17 (18): 15-18,27 [Abstract] ( 94 ) HTML (1 KB) PDF (734 KB) ( 86 )

	19	Effect of Acipimox combined with Clopidogrel on the improvement of serum lipids and carotid atherosclerosis in hyperlipidemia rats
		JIANG Aiwen1 DU Peishan2 WANG Shuzhen1 SHI Jinzheng1 LIU Yunning1 LI Fangjiang1
		Objective To investigate the effect of the improvement of serum lipids and carotid atherosclerosis in hyperlipidemia rats by Acipimox combined with Clopidogrel in a hyperlipidemia rat model. Methods Ten rats from 45 rats were given normal feed as the normal group. The remaining 35 rats were given high-fat feed to model for 4 consecutive weeks, and 5 of them were randomly selected to judge whether the model was successful or not with increased total cholesterol (TC) level and statistically significant difference compared with the normal group. After successful modeling, the remaining 30 rats were randomly divided into the model group, the Acipimox group (32 mg/kg), and the combined group (32 mg/kg Acipimox + 10 mg/kg Clopidogrel ), with 10 rats in each group. The body weight, blood lipid index, hemorheology relevant parameters and serum inflammatory factors of the rats were measured. The carotid artery intimal thickness (IMT) and carotid artery media thickness (MT) were measured by small animal ultrasound. Results The levels of triglyceride (TG), TC and low-density lipoprotein cholesterol (LDL-C) in blood lipid of the Acipimox group were lower than those of the model group, while the levels of high-density lipoprotein cholesterol (HDL-C) were higher than those of the model group, and the differences were statistically significant (all P ＜ 0.05). There was no significant difference in body weight between the two groups (P ＞ 0.05). The levels of TG, TC, and LDL-C in serum lipids in the combined group were significantly lower than those in the model group, while the levels of TC and LDL-C in the combined group were lower than those in the Acipimox group, with statistically significant differences (all P ＜ 0.05). The whole blood viscosity, plasma viscosity and erythrocyte aggregation index in Acipimox group were significantly lower than those in model group, and the differences were statistically significant (all P ＜ 0.05). The whole blood viscosity, plasma viscosity and erythrocyte aggregation index in the combined group were significantly lower than those in the model group, and the whole blood viscosity index (shear rate 5 and 1), plasma viscosity and erythrocyte aggregation index in the combined group were significantly lower than those in the Acipimox group, with statistically significant differences (all P ＜ 0.05). Serum levels of tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) in the Acipimox group were lower than those in the model group, while IL-10 were higher than those in the model group, and the differences were statistically significant (all P ＜ 0.05). The serum levels of TNF-α and IL-6 in the combined group were lower than those in the model group and the Acipimox group, and the level of IL-10 in the combined group was higher than that in the model group, and the differences were statistically significant (all P ＜ 0.05). IMT and MT in the model group, the Acipimox group and the combined group were all higher than those in the normal group, and the differences were statistically significant (P ＜ 0.05). IMT and MT in Acipimox group were lower than that in model group, and the differences were statistically significant (all P ＜ 0.05). MT in the combined group was significantly lower than that in the model group and the Acipimox group, and IMT was significantly lower than that in the model group, and the differences were statistically significant (all P ＜ 0.05). Conclusion Acipimox can effectively improve the hyperlipidemia and carotid atherosclerosis in rats induced by high-fat diet, and the protective effect is more significant when combined with Clopidogrel.
		2020 Vol. 17 (18): 19-23 [Abstract] ( 100 ) HTML (1 KB) PDF (645 KB) ( 73 )

	24	The relationship between sagittal facet joint angle and degenerative lumbar spondylolisthesis
		WANG Zongbo1 WANG Yuguang1 ZHU Yong2 ZHANG Zhiyong1
		Objective To investigate the relationship between sagittal facet joint angle (FJO) and degenerative lumbar spondylolisthesis (DLS). Methods A total of 100 inpatients with anteriorⅠ° spondylolisthesis of the lumbar 4 vertebral body from January 2017 to November 2019 in the Second Affiliated Hospital of Inner Mongolia Medical University were selected as the DLS group, while another 100 cases without lumbar spondylolisthesis were selected as control group. All patients underwent lumbar disc CT (including L3-S1 space) scanning. The scanning data was imported into postprocessing workstation for postprocessing, and the degree of spondylolisthesis was graded using the Meyerding method. The angle between the articular process joint of the transpedicular pedicle and the coronal plane of the vertebral body, the angle between the articular process joint and the spinous process were measured which were marked as α1 and α2, respectively, and the average value of the two is the intervertebral space FJO. Results The FJO of L3/4, L4/5, L5/S1 in DLS group were smaller than those in control group, and the differences were statistically significant (P ＜ 0.05). The difference value of FJO α1 and α2 on the left and right sides of L4/5 in the DLS group were greater than those of the control group, and the differences were statistically significant (P ＜ 0.05); compared with the control group, the difference value of FJO α1 and α2 on the left and right sides of L3/4, L5/S1 in the DLS group were not statistically significant (P ＞ 0.05). Conclusion Lumbar vertebrae FJO sagittal is closely related to lumbar spondylolisthesis, and the FJO of the adjacent vertebral body of the spondylolisthesis body has a sagittal tendency; the left and right FJO asymmetry of the spondylolisthesis body is obvious.
		2020 Vol. 17 (18): 24-27 [Abstract] ( 99 ) HTML (1 KB) PDF (757 KB) ( 138 )

	28	Visual analysis of motor imagery therapy based on CiteSpace in China
		WANG Min1 WAN Changxiu2▲ TIAN Linghua1 LIU Mengting1 CAI Xiaopeng1
		Objective To understand the research hotspots and trends of motor imagery therapy in Chinese medicine, analyze the development framework, provide reference for the further research and application of motor imagery therapy in China. Methods “Motor imagery therapy” or “imagery motor therapy” or “motor imagery training” as the main topic in CNKI, VIP and Wanfang were searched. The period was set up until May 2019. Bibliometric and visual analysis of the papers was taken by Note Express and CiteSpace. Results Four hundred and sixteen articles were included. The amount of published papers was on the rise. The most stable cooperation was Lu Qiongmei team. The amount of papers in Rehabilitation Center of the First Affiliated Hospital of He′nan College of Chinese Medicine came top. The interconnections of key words such as stroke and hemiplegia, rehabilitation were numerous and close. Nursing, quality of life, swallowing disorders had gradually become important parts in the field of motor imaging therapy medicine. Conclusion The unique advantages of motor imagery therapy make it more easily favored by patients in rehabilitation medicine, its core authors and institutions has not yet formed, which hinders the development of motor imaging therapy to some extent. The breadth and depth of therapy in clinical application deserves further exploration.
		2020 Vol. 17 (18): 28-32 [Abstract] ( 112 ) HTML (1 KB) PDF (1619 KB) ( 285 )

	33	Study on the effect of cell autophagy on diabetes mellitus and its chronic complications
		HE Shanshan LI Yanbo
		Many factors are involved in the pathogenesis of diabetes mellitus. Diabetes mellitus and its chronic complications can cause damage to multiple organs and systems of the whole body. Autophagy is a highly conservative catabolism process in eukaryotes. Its regulatory mechanism is very complex and involves the coordination of many pathways at different stages. It has been found that autophagy is closely related to the occurrence and development of diabetes mellitus and its chronic complications. In this paper, the latest research progress on the regulatory role of cell autophagy in diabetes and its chronic complications are reviewed.
		2020 Vol. 17 (18): 33-36 [Abstract] ( 114 ) HTML (1 KB) PDF (643 KB) ( 100 )

	37	Research progress on the etiology, pathogenesis and treatment of follicular maldevelopment in traditional Chinese medicine
		LI Kangmei1 DAI Mingming2 JIANG Yue2 CHEN Xiurong1 DUAN Guijiao2 LI Mingxing1 HE Guozhen1
		By combing and summarizing the literature on follicular maldevelopment in traditional Chinese medicine, this paper summarizes the etiology and pathogenesis of follicular maldevelopment in traditional Chinese medicine in recent years and elaborates the recent clinical treatment of follicular maldevelopment in traditional Chinese medicine. It is believed that the etiology and pathogenesis of follicular maldevelopment in traditional Chinese medicine are mainly caused by the three dirty dysfunction of kidney, liver, spleen, and see spittoon coagulation, blood stasis, etc.. Traditional Chinese medicine treatment mainly includes traditional Chinese medicine syndrome differentiation and treatment, traditional Chinese medicine cycle therapy, acupuncture and combination of acupuncture and medicine, traditional Chinese medicine retention enema, acupoint catgut embedding, traditional Chinese medicine combined with acupoint catgut embedding and other aspects. In this paper, through the elaboration of traditional Chinese medicine treatment methods and clinical efficacy, to understand the research status of traditional Chinese medicine treatment of this disease, for the follow-up further research to provide a certain reference.
		2020 Vol. 17 (18): 37-40 [Abstract] ( 126 ) HTML (1 KB) PDF (636 KB) ( 130 )

	41	Medicinal value of Scorzonera L.
		SHEN Dexin
		Scorzonera L. is a compositae plants, and it distributes in the region of Europe, Asia and northern Africa widely. The traditional application mostly has the effect of clearing away the heat-evil and expelling superficial evils while removing edema and nodule, antipyretic, detoxifying, reducing swelling and resolving mass. It mainly treats hard furuncle, carbuncle and other diseases, wound as well. Modern pharmacological studies have shown that Scorzonera L. have various biological activities, such as anti-tumor, anti-bacterial, anti-virus, anti-oxidation, anti-depression and liver protection, and so on. It shows a high medicinal value. At present, Scorzonera L. is also a natural inhibitor of bacterial “quorum sensing (QS)”, and has great potential in the development of a new generation of antibiotics targeted by QS. The morphological characteristics and medicinal value of Scorzonera L. are summarized in combination with domestic and foreign studies to provide reference for the development of innovative drugs and clinical in-depth use.
		2020 Vol. 17 (18): 41-44 [Abstract] ( 84 ) HTML (1 KB) PDF (695 KB) ( 108 )

	45	Progress in the pathogenesis of stroke-related sleep disorders
		WANG Li XU Bo YAN Bingchun
		Stroke is the leading cause of disability and death in the world. China is one of the countries with the largest burden of stroke, and the mortality rate is far higher than that in north America. Sleep disorders are one of the common complications after stroke, and the incidence are 76%-82%. Stroke and sleep are cause and effect since sleep disorders (including sleep-disordered breathing, dyskinesias, and sleep disorders) are closely related to co-morbid cerebrovascular diseases, which may seriously affect the recovery of neurological function and quality of life in patients after stroke, even induce or aggravate the risk factors of stroke leading to recurrence. The treatment of sleep disorders can not only improve sleep-related symptoms, but also promote the recovery of stroke, increase the connection between nerve cells, and reduce the risk of future relapses. Identifying and resolving sleep disorders should be part of primary and secondary stroke prevention. Therefore, investigating the pathogenesis of stroke-related sleep disorders can better develop corresponding prevention and treatment measures according their mechanisms. This article reviews the pathogenesis of stroke-related sleep disorders.
		2020 Vol. 17 (18): 45-48 [Abstract] ( 118 ) HTML (1 KB) PDF (681 KB) ( 96 )

	49	Research progress of exosomes and chemotherapeutic resistance in gastrointestinal tumors
		NI Xiufan1 ZHANG Youli2 XU Min2
		The digestive system tumor including esophageal cancer, gastric cancer, colorectal cancer, liver cancer, pancreatic cancer, which have high morbidity and mortality. At present, chemotherapy is one of the treatments for digestive system tumors, but long-term application of chemotherapy drugs often causes drug resistance in tumor cells, which is one of the important challenge in tumor treatment. Exosomes are small vesicles with a diameter of 30-100 nm, which are composed of bilayer membrane. The exosomes contain proteins, nucleic acids, lipids, etc. In recent years, it has been found that exosomes participate in a series of tumor development and development by mediating intercellular communication and regulating tumor microenvironment, especially having an important impact on tumor chemotherapy resistance. This paper mainly summarized the domestic and foreign studies on the involvement of exosomes in the chemotherapy resistance of digestive system tumors, aiming to intuitively expound the mechanism of exosomes mediating the chemotherapy resistance of digestive system tumors, and provide new ideas for the study of tumor resistance.
		2020 Vol. 17 (18): 49-52 [Abstract] ( 136 ) HTML (1 KB) PDF (639 KB) ( 78 )

	53	Research progress of transcranial ultrasound in the clinical diagnosis of Parkinson′s disease
		CAO Shuangshuang1 WANG Jianwei1 WANG Zhan2,3 MA Huizi2,3 FENG Tao2,3,4
		In the past two decades, transcranial ultrasound (TCS) examination has been used more and more in the diagnosis and differential diagnosis of movement disorders. Compared with other imaging inspection methods, such as computed tomography, as well as magnetic resonance imaging and positron emission tomography, TCS is worthy of promotion with the advantages of lower cost, more convenient and non-invasive operation. However, the results of TCS examination are affected by many factors, such as the patient′s temporal window display, the difference in the performance of the substantia nigra, the examiner′s experience and other factors, so the validity of the examination results is controversial. Due to the great clinical heterogeneity of Parkinson′s disease, the diagnosis of Parkinson′s disease requires a combination of clinical manifestations and multiple auxiliary examinations. Transcranial ultrasound can be used as an imaging marker to provide supporting evidence for the diagnosis of Parkinson′s disease. This paper describes the examination methods, determination criteria and possible mechanisms of transcranial substantia nigra in details. Furthermore, we have summarized and analyzed the value of TCS in the diagnosis, differential diagnosis and monitoring of high-risk populations in Parkinson′s disease, and pointed out its limitations with improving direction to help the better application in the further.
		2020 Vol. 17 (18): 53-56 [Abstract] ( 108 ) HTML (1 KB) PDF (681 KB) ( 120 )

	57	Research progress of intraspinal block in labor analgesia
		WU Huihong1 ZHAO Jun1 LI Yuru2
		Intraspinal delivery analgesia is the most safe and effective. Labor analgesia service is more and more used as comfortable way. With the development of anesthesiology and the development of new equipment, there are more and more ways of intraspinal analgesia. This paper reviews the related studies of intraspinal delivery analgesia native and foreign from the aspects of drug classification, analgesia methods, timing and the impact on mothers and infants.
		2020 Vol. 17 (18): 57-59,75 [Abstract] ( 99 ) HTML (1 KB) PDF (980 KB) ( 31 )

	60	Influence of job satisfaction, job stress and job burnout on turnover intention of health workers with senior professional titles in Xinjiang
		ZHAO Yang1 XU Chunyan2 LI Shan3 WENG Zhenqun1
		Objective To analyze the influence of job stress, job satisfaction and job burnout on turnover intention of health workers with senior professional titles by establishing structural equation model. Methods In this study, from January to June 2018, the two-dimensional code of the questionnaire was uniformly sent to the health and family planning personnel with senior professional titles meeting the inclusion criteria according to cluster sampling method. A total of 3226 health and family planning personnel with senior professional titles were surveyed in the three prefectures in southern Xinjiang, northern Xinjiang and Urumqi of Xinjiang by the job burnout scale, the questionnaire of job satisfaction, work stress, and turnover intention. Results Job stress, emotional exhaustion, cynicism, low sense of accomplishment, and satisfaction were related to turnover intention (P < 0.01). At the same time, job pressure, cynicism, and job satisfaction were also indirectly affected turnover intention of health workers with senior professional titles through the mediating effects of emotional exhaustion and low sense of accomplishment. Conclusion The hospital and management should take appropriate measures to reduce the problem of emotional exhaustion and low sense of achievement of medical staff, and reduce the turnover intention of medical staff with senior professional titles by decreasing their work pressure and improving their job satisfaction.
		2020 Vol. 17 (18): 60-63 [Abstract] ( 98 ) HTML (1 KB) PDF (593 KB) ( 131 )

	64	Analysis on whole blood donor complaints with unrelated blood donation adverse reactions
		GAO Bo GUO Chengcheng BI Qiyong LIN Jiao QIU Yan
		Objective To investigate the situation and causes of whole blood donor complaints with unrelated adverse blood donation reactions in Beijing. Methods This was a retrospective study. The original records and disposed of complaints during the period from 2012 to 2018 were collected and collated, while the original data for the complaints of whole blood donors with unrelated blood donation adverse reactions were entered in Excel 2007. The general and severity of complaints according to the effect of complaint processing were analyzed by direct counting method to summarize; the data of the ratio of first blood donation and sex ratio between the serious complaints were statistically analyzed; the reasons for complaints were classified and summarized, while the composition ratio was calculated. Results A total of 494 complaints from whole blood donors with unrelated blood donation adverse reactions were received, and the average annual complaint rate was 2.84/10 000. There were 215 serious complaint incidents, of which the first blood donor were 1.871 times that of repeated blood donors, and the male were 1.53 times as many as females (P ＜ 0.05). The service quality of the first complaint accounted for 50.7%. The blood donation rate of blood donors with serious complaints was 16.3% after return visit, and the blood donation rate of blood donor complaints with other reasons was 0% to 36%, and the difference was highly statistically significant (P ＜ 0.01). Conclusion The annual complaint rate of blood donors is on the rise. First-time blood donors are more prone to complaints, and men are more prone to dissatisfaction than women. Complaint reasons are diverse, and complaint reasons affect blood donors to donate blood again.
		2020 Vol. 17 (18): 64-67 [Abstract] ( 85 ) HTML (1 KB) PDF (518 KB) ( 84 )

	68	The present situation and related factors of sarcopenia in elderly hypertensive patients in community
		ZHANG Ke1 WANG Yuanxiao1 LI Qian1 CHE Yajie1 LU Yaoqin2 ZHANG Qinghua3 YAN Ping1
		Objective To investigate the detection rate of sarcopenia in elderly hypertensive patients in community and to explore the related factors of sarcopenia in elderly hypertensive patients. Methods From August to October 2019, a total of 555 hypertensive patients over 60 years old in three communities of Urumqi were selected for the study by convenient sampling method. The sarcopenia patients were screened by Ishii scale, and they were divided into sarcopenia group and non-sarcopenia group, while the age, exercise, grip strength, walking speed and other data were collected for statistical analysis. Results A total of 209 cases of sarcopenia were detected in 555 elderly hypertensive patients, and the detection rate was 37.66%. There were statistically significant differences in age, education level and weekly exercise frequency between the two groups (P ＜ 0.05). The sarcopenia group was older than the non-sclerosis group, while the grip strength, pace, waist circumference, hip circumference, calf circumference, upper arm circumference, and the body mass index (BMI) were lower than the non-sclerosis group, and the differences were statistically significant (P ＜ 0.05). Multivariate logistic regression analysis showed that age, education, grip strength, calf circumference and BMI were the influencing factors of sarcopenia in hypertensive patients (P ＜ 0.05). Conclusion The prevalence of sarcopenia is high in the elderly hypertensive patients in Urumqi, and the grip strength, calf circumference and BMI are the important related factors of sarcopenia in hypertensive patients in the community.
		2020 Vol. 17 (18): 68-71 [Abstract] ( 125 ) HTML (1 KB) PDF (518 KB) ( 52 )

	72	Study on the establishment of clinician retention scale based on occupational embedding
		HE Feiying1 LIAO Shengwu2
		Objective To explore the retention factors of clinicians, compile a scale of retention factors for clinicians, and to put forward strategies to stabilize the team of clinicians. Methods Through literature review and in-depth interviews, an open questionnaire survey was used to preliminarily prepare a quantitative table entry database. After consultation with experts, the preliminary draft of the clinical physician occupational embedding scale was determined. A convenient sampling method was used to investigate 1034 in-service clinicians in 37 hospitals in ten provinces and cities in China from March to September 2016. Through exploration and verification analysis, the final application measurement table was obtained. Results There were 14 measurement indicators for clinician retention factors, which were composed of three dimensions: matching, connection, and sacrifice; Cronbach′s α coefficient was 0.925, and the model fit value was good, χ2/df = 3.943, NFI=0.923, RFI=0.902, IFI= 0.941, RMSEA=0.069, TLI=0.925, CFI=0.941. Conclusions The factors of clinician retention can refer to the three-dimensional model and increase the implementation of embedded countermeasures and measures in the government, industry and hospital, so as to prevent the further loss of physician resources.
		2020 Vol. 17 (18): 72-75 [Abstract] ( 129 ) HTML (1 KB) PDF (550 KB) ( 87 )

	76	Correlation study between subcutaneous fat area and fasting C peptide level in patients with type 2 diabetes mellitus
		LIU Simo KE Jing AN Yaxin ZHAO Dong
		Objective To explore the characteristics and correlation between subcutaneous fat area and fasting C peptide level in patients with type 2 diabetes mellitus. Methods A total of 1461 patients with type 2 diabetes mellitus who admitted to the Center for Endocrine Metabolism and Immune Diseases, Beijing Luhe Hospital, Capital Medical University from October 2017 to November 2019 were included. They were divided into three groups according to subcutaneous fat area, namely T1 group < 173.5 cm2, 173.5 cm2 ≤T2 group < 223.5 cm2, and T3 group ≥ 223.5 cm2. There were 506 cases in T1 group, 482 cases in T2 group and 473 cases in T3 group. The clinical indicators of height, weight, waist circumference and fasting C peptide level and other related indices were compared among three groups. Correlation analysis was used to analyze the correlation between fasting C peptide level and body fat, metabolic index, and multiple regression model was used to analyze the independent influencing factors of fasting C peptide level. Results There were no statistically significant differences between three groups in the levels of gender, glycosylated hemoglobin, fasting blood glucose, total cholesterol, low density lipoprotein cholesterin and the indicator of estimated glomerular filtration rate (P ＞ 0.05). Compared with T2 group, the age of T3 group was younger, with statistically significant difference (P ＜ 0.05), while the age of T1 group and T2 group was not statistically significant difference (P ＞ 0.05). Compared with T1 group, the indicators of body mass index, waist circumference, visceral fat area, diastolic blood pressure and uric acid were increased in T2 group and T3 group, while T3 group was higher than T2 group, the differences were statistically significant (P ＜ 0.05 or P ＜ 0.01). Comparison of fasting C peptide levels between the three groups showed statistically significant differences (P ＜ 0.05). Correlation analysis showed that subcutaneous fat area were positively related with fasting C peptide level (r = 0.35, P ＜ 0.01)，and the two were still positively correlated after correction of age and diabetes course (r = 0.34, P ＜ 0.01). In multiple linear regression analysis, there was an independent positive correlation between subcutaneous fat area and fasting C-peptide level after correction for other confounding factors such as age, gender, visceral fat area, and glycosylated hemoglobin (B = 0.00, β = 0.16, P ＜ 0.01). Conclusion In patients with type 2 diabetes, fasting C peptide level increased with the increase of subcutaneous fat area, and the two show an independent positive correlation.
		2020 Vol. 17 (18): 76-80,86 [Abstract] ( 106 ) HTML (1 KB) PDF (675 KB) ( 63 )

	81	Effects of Ginkgo Leaves Extract injection at Zúsānlǐ acupoint on arterial blood flow, hemorheology and angiogenesis index of lower extremity arteries in diabetic patients with peripheral vascular disease
		WANG Jing YU Yang ZHANG Haili HUI Xueying TENG Lin GUO Weiguang▲ SUN Shentian▲
		Objective To study the effect of Ginkgo Leaves Extract injection at Zúsānlǐ acupoint on angiogenesis index in patients with diabetic peripheral vascular disease (DPVD). Methods A total of 94 DPVD patients who admitted to the Second Affiliated Hospital of Heilongjiang University of Chinese Medicine from March 2017 to February 2019 were selected and simple randomization grouping was performed, with 47 patients in each group. The control group received integrated Western medicine treatment, and the observation group was added with Zúsānlǐ acupoint injection of Ginkgo Leaves Extract for a total of 2 weeks. The curative effect, arterial blood flow index of lower extremity (fluctuation index [PI], ankle brachial index [ABI], mean blood flow velocity [Vmean], resistance index [RI]), hemorheology index (plasma viscosity [PV], high cut in whole blood viscosity [H-WBV], mid cut whole blood viscosity [M-WBV], low cut whole blood viscosity [L-WBV]), angiogenesis indicators (number of peripheral blood endothelial progenitor cells [EPCs], basic fibroblast growth factor [bFGF], vascular endothelial growth factor [VEGF], platelet-derived endothelial cell growth factor [PD-ECGF]) levels and adverse reactions of the two groups after 2 weeks of treatment were compared. Results After 2 weeks of treatment, the total effective rate of the observation group was higher than that of the control group, with statistically significant difference (P ＜ 0.05). After 2 weeks of treatment, ABI and Vmean in the observation group were increased compared with those before treatment, and PI and RI were decreased compared with those before treatment, with statistically significant differences (all P ＜ 0.05). ABI was increased and RI was decreased in the control group after 2 weeks of treatment compared with those before treatment, and the differences were statistically significant (all P ＜ 0.05). Vmean and PI were not statistically significant compared with those before treatment (P ＞ 0.05). After 2 weeks of treatment, ABI and Vmean of the observation group were higher than those of the control group, and PI and RI were lower than those of the control group, with statistically significant differences (all P ＜ 0.05). After 2 weeks of treatment, PV, H-WBV, M-WBV and L-WBV of the two groups were all lower than those before treatment, and the observation group was lower than the control group, with statistically significant differences (all P ＜ 0.05). After 2 weeks of treatment, EPCs, bFGF, VEGF and PD-ECGF in the two groups were all higher than those before treatment, and the observation group was higher than the control group, with statistically significant differences (all P ＜ 0.05). There was no significant difference in the incidence of adverse reactions between the observation group and the control group (P ＞ 0.05). Conclusion The injection of Ginkgo Leaves Extract at Zúsānlǐ acupoint can improve the lower limb hemodynamics of DPVD patients, effectively relieve symptoms and signs of patients, improve the hypercoagulability state of patients, optimize microcirculation, and promote angiogenesis, which is safe and reliable.
		2020 Vol. 17 (18): 81-86 [Abstract] ( 103 ) HTML (1 KB) PDF (519 KB) ( 90 )

	87	Effect of invigorating the spleen and kidney and dredging channels method combined with Prednisone in the treatment of progressive IgA nephropathy
		XU Chao1，2 XIA Hong1 DENG Yueyi2
		Objective To study effect of invigorating the spleen and kidney and dredging channels method combined with Prednisone in the treatment of progressive IgA nephropathy (IgAN). Methods From January 2002 to March 2017, 69 patients with IgAN were selected from the Outpatient Department or Ward of Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine. Among them, 37 patients treated with the method of invigorating the spleen and kidney and dredging channels were taken as Chinese medicine group, 32 patients treated with invigorating the spleen and kidney and dredging channels method combined with Prednisone were taken as Chinese and Western medicine group. The indexes of fasting serum creatinine, blood urea nitrogen, serum albumin, glomerular filtration rate, serum uric acid and 24 h urine protein were compared between two groups before and after treatment, and the curative effect of two groups was observed. Results After treatment, the serum creatinine and 24-h urinary protein of two groups were lower than before treatment, the serum albumin and glomerular filtration rate were higher than before treatment, the differences were statistically significant (P < 0.05). After treatment, the glomerular filtration rate of Chinese and Western medicine group was higher than that of Chinese medicine group, and the 24-h urine protein of Chinese and Western medicine group was lower than that of Chinese medicine group, the differences were statistically significant (P < 0.05). Total effective rate of Chinese and Western medicine group was higher than that of Chinese medicine group, the difference was statistically significant (P < 0.05). Conclusion Invigorating the spleen and kidney and dredging channels method combined with Prednisone can further stabilize the renal function of IgAN patients and reduce proteinuria.
		2020 Vol. 17 (18): 87-90 [Abstract] ( 118 ) HTML (1 KB) PDF (388 KB) ( 106 )

	91	Correlation between growth differentiation factor 5 and congenital hip dislocation
		AILI·Rehei1 CAO Li2▲
		Objective To explore and analyze the correlation between growth differentiation factor 5 (GDF5) and pediatric developmental dysplasia of the hip (DDH). Methods Forty-eight children with congenital hip dislocation treated in the First Affiliated Hospital of Xinjiang Medical University from October 2017 to October 2019 were selected as the observation group, and 42 healthy children checked the same period were selected as the control group. Single nucleotide gene polymorphism (SNP) site typing was investigated by TaqMan probe in both groups, the correlation between SNP and DDH. In addition, according to the severity of congenital dislocation of hip joint, they were grouped as congenital dysplasia group (n = 19), congenital hip subluxation group (n = 14), and complete hip dislocation group (n = 15), the correlation between congenital dislocation of hip joint and SNP site under different classifications was explored. Results There were statistically significant differences in genotype frequencies TT, TC and CC between the observation group and the control group (P ＜ 0.05). There was no significant difference in allele frequency T and C between the observation group and the control group (P ＞ 0.05). There were statistically significant differences in genotype frequencies of children in different categories in the observation group between TT, TC and CC(P ＜ 0.05). There were no significant differences in allele frequency T and C among children in different categories in the observation group (P ＞ 0.05). The frequency of T alleles in the complete hip dislocation group was 1.42 times that of the control group, the frequency of T alleles in the congenital hip subluxation group was 1.36 times of the control group, the complete hip dislocation group of the T allele frequency was 1.65 times of the congenital hip subluxation group (P ＜ 0.05). Conclusion GDF5 plays an important role in the occurrence and development of DDH, and it has obvious correlation.
		2020 Vol. 17 (18): 91-94 [Abstract] ( 110 ) HTML (1 KB) PDF (537 KB) ( 41 )

	95	Effect of deep and shallow double channel wire encircling and Kirschner wire fixation on the treatment of the fracture of the inferior patella
		YUAN Wei CHEN Yangping ZHU Hengjie PENG Lei CHENG Shaowen
		Objective To study the effect of deep and shallow double bone channel wire encircling and Kirschner wire fixation on the fracture of the inferior patella. Methods From January 2015 to January 2019, 80 patients with infrapatellar fracture who were operated in the First Affiliated Hospital of Hainan Medical College were randomly divided into control group (Kirschner wire tension band fixation), observation group (based on the control group combined with deep and shallow double bone channel wire encircling fixation treatment), 40 cases in each group. The operation conditions, postoperative complication rate, operation effect, follow-up results and quality of life scores of the two groups were statistically analyzed. Results The operation time, intraoperative hemorrhage, incision length, the times of using C-arm X-ray machine, the total incidence of surgical complications, the time of starting to move to the ground, the time of complete fracture healing and the visual analogue score in the observation group were lower than those in the control group (all P ＜ 0.05). The excellent rate of operation and the scores of quality of life in the observation group were higher than those in the control group (all P ＜ 0.05). Conclusion The combination of deep and shallow double bone channel wire encircling and Kirschner wire fixation has a significant effect on the treatment of the fracture of the lower pole of patella, which can improve the surgical effect of the patients. The operation time is short, the trauma is small, the recovery is fast, the function of the knee joint is improved satisfactorily, and the quality of life of the patients after operation is improved.
		2020 Vol. 17 (18): 95-98 [Abstract] ( 141 ) HTML (1 KB) PDF (536 KB) ( 87 )

	99	Clinical effect of Buqi Huoxue Decoction combined with electroacupuncture on postoperative syndrome of lumbar disc herniation
		SHANG Rongan HU Di WANG Shaofei CHAO Jianhu LIU Dongqian
		Objeetive To observe the clinical effect of Buqi Huoxue Decoction combined with electroacupuncture on postoperative syndrome of lumbar disc herniation. Methods From August 2015 to April 2019, 50 patients with postoperative syndrome of lumbar disc herniation in the Department of Orthopedics, Baoji Traditional Chinese Medicine Hospital, Shaanxi Province were selected, and they were divided into control group (25 cases) and treatment group (25 cases) by random number table method. The treatment group was treated with Buqi Huoxue Decoction and electroacupuncture, while the control group received Mecobalamin Tablets. Both groups were treated for 4 weeks. The clinical efficacy between the two groups were compared, visual analogue scale (VAS) score, Japanese orthopaedic association evaluated treatment (JOA) score and adverse events were observed before and after treatment. Results The total effective rate of the treatment group was significantly higher than that of the control group (P ＜ 0.05). Compared with before treatment, VAS scores of both groups were significantly reduced, JOA scores were significantly increased, with statistically significant differences (P ＜ 0.05), VAS score of the treatment group was significantly lower than that of the control group, JOA score was higher than that of the control group, with statistically significant differences (all P ＜ 0.05). Conclusion Buqi Huoxue Decoction combined with electroacupuncture can improve the postoperative syndrome of lumbar disc herniation and promote the recovery of patients with remarkable effect.
		2020 Vol. 17 (18): 99-102 [Abstract] ( 176 ) HTML (1 KB) PDF (560 KB) ( 30 )

	103	A randomized controlled study on the clinical effect of spinal manipulation and traditional massage in the treatment of lumbar spinal stenosis
		ZENG Haobin CHEN Maoshui▲ WU Yongsheng
		Objective To study the clinical effect of spinal manipulation and traditional massage in the treatment of lumbar spinal stenosis. Methods A total of 120 patients with lumbar spinal stenosis admitted to the Department of Spine Zhuhai Hospital, Guangdong Provincial Hospital of Traditional Chinese Medicine from March 2018 to March 2019 were collected. They were divided into the spinal manipulation treatment group (60 cases) and the control group (60 cases) by simple random method, and the clinical efficacy was evaluated by Japanese orthopaedic association (JOA) scores and visual analogue scale (VAS). The lumbar arch area and the sagittal anteroposterior diameter before and after treatment were measured. Results JOA, VAS scoring time, intergroup and interaction were compared before and after treatment, and the differences were statistically significant (P ＜ 0.05). JOA scores after treatment, 1 month of follow-up and 3 months of follow-up were higher than that before treatment, VAS scores were lower than that before treatment, and the differences were statistically significant (all P ＜ 0.05). Comparison between groups: JOA score of the treatment group was higher than that of the control group, and JOA score was lower than that of the control group after treatment, with statistically significant difference (P ＜ 0.05). There were no statistically significant differences between the two groups before treatment in the sagittal diameter of lumbar spinal canal and the area of lumbar curvature (P ＞ 0.05). In the treatment group, the sagittal diameter of lumbar spinal canal and the area of lumbar curvature were larger than those before treatment, and the differences were statistically significant (P ＜ 0.05). Conclusion Spinal manipulation is more effective than traditional massage in the treatment of lumbar spinal stenosis, it is worth popularizing in clinic.
		2020 Vol. 17 (18): 103-106 [Abstract] ( 97 ) HTML (1 KB) PDF (580 KB) ( 66 )

	107	Relationship between cervical high risk human papillomavirus infection and vaginal microecology and local cellular immunity
		TANG Qinghua1,2 LI Yanping3
		Objective To investigate the relationship between high risk human papillomavirus (HPV) infection and vaginal microecology and local cellular immunity. Methods From February 2017 to June 2019, 218 female patients with cervicitis who came to Kunming Maternal and Child Health Hospital were selected as the study subjects. All patients were tested for high risk HPV examination, according to the results, they were divided into observation group (n = 80, high risk HPV positive), control group (n = 138, high risk HPV negative). The vaginal microecology disorders and cervical local cell immunity were compared between two groups. Pearson correlation analysis was used to analyze the relationship between cervical high risk HPV infection and vaginal microecology and cervical local cellular immunity. Results Eighty cases were found to be high risk HPV infection, the positive rate was 36.70% (80/218), among which HPV16 was the highest (52.50%), followed by HPV52 (22.50%). The vaginal microecology disorder, mycoplasma, ureaplasma urealyticum, chlamydia, lactobacillus abnormal rate and bacterial vaginitis rate in observation group were higher than those in control group (P < 0.05). CD4+, CD4+/CD8+ in observation group were lower than those in control group (P < 0.05). High risk HPV infection was negatively correlated with CD4+, CD4+/CD8+ (r = -0.453,-0.421, P < 0.05), while positively correlated with bacterial vaginitis, chlamydia, lactobacillus and ureaplasma urealyticum (r = 0.432,0.525, 0.504,0.472, P < 0.05). Conclusion Cervical high risk HPV infection is closely related to vaginal microecology and cervical local cellular immunity, which can aggravate the disorder of vaginal microecology and reduce the local cellular immune function of patients.
		2020 Vol. 17 (18): 107-110 [Abstract] ( 139 ) HTML (1 KB) PDF (567 KB) ( 176 )

	111	Clinical study of Xiaoer Yanbian Granules combined with Oseltamivir Phosphate in the treatment of children′s influenza A with febrile convulsion
		SUN Junfeng1 WANG Yakun2 FAN Yanhui3 ZHANG Man2 TIAN Liyuan2 ZHANG Wenchao4 JIA Meixuan2
		Objective To explore the clinical efficacy of Xiaoer Yanbian Granules combined with Oseltamivir Phosphate in the treatment of children′s influenza A with febrile convulsion. Methods A total of 198 cases with influenza A and febrile convulsion children in Hebei Children′s Hospital from January 2016 to January 2019 were selected as subjects. They were divided into the control group (99 cases) and the observation group (99 cases) according to the random number table method. The control group was treated with Oseltamivir Phosphate, and the observation group was treated with Xiaoer Yanbian Granules on the basis of the control group. The clinical efficacy of the two groups were evaluated. The turnaround time of clinical symptoms and the recurrence rate of convulsion of the two groups were compared. The serum levels of neuronspecific enolase (NSE), brain-derived neurotrophic factor (BDNF), S-100β protein (S-100β), C-reactive protein (CRP), interleukin-8 (IL-8), interferon-γ (IFN-γ) of the two groups were compared. The adverse reactions of the two groups during the treatment were recorded and compared. Results Total effective rate of the observation group was higher than that of the control group (P < 0.05). The pharyngeal swelling pain turnaround time, cough congestion turnaround time, antifebrile time, convulsions disappear time of the observation group were significantly shorter than those of the control group and convulsions recurrence of the observation group was significantly lower than that of the control group (all P < 0.05). The serum levels of NSE, BDNF and S-100β of the two groups after treatment were significantly lower than those before treatment, and the observation group was lower than the control group (all P < 0.05). After treatment, the serum levels of CRP and IFN-γ were significantly lower than those before treatment, and the level of IL-8 was significantly higher than that before treatment and the serum levels of CRP and IFN-γ in the observation group were significantly lower than those in the control group, and the level of IL-8 was significantly higher than that in the control group (all P < 0.05). During the treatment, there was no significant difference in the incidence of adverse reactions between the two groups (P > 0.05). Conclusion The clinical effect of Xiaoer Yanbian Granules combined with Oseltamivir Phosphate in the treatment of children′s influenza A with febrile convulsion is significant, which can improve the clinical symptoms, reduce the inflammatory response and brain injury of children, and has good safety.
		2020 Vol. 17 (18): 111-114 [Abstract] ( 112 ) HTML (1 KB) PDF (531 KB) ( 78 )

	115	Clinical efficacy of Low molecular weight heparin combined with Oral Rehydration salts on critical amniotic fluid oligohydramnios
		CUI Dawei FAN Xufei LYU Ying JI Limei ZHENG Xiujuan HU Min
		Objective To study the clinical efficacy of low molecular weight heparin combined with Oral Rehydration Salts on critical amniotic fluid oligohydramnios. Methods From October 2018 to January 2019, 68 pregnant women with amniotic fluid index (AFI) between 5-8 cm were selected for color Doppler ultrasound examination in Jinhua Municipal Central Hospital of Zhejiang Province. According to the random number table method, they were divided into the observation group (36 cases) and the control group (32 cases). The observation group was treated with Low molecular weight heparin and Oral Rehydration Salt Ⅲ and the control group was given clinical observation without treatment. The changes of AFI and ratio of end systolic peak/end diastolic peak (S/D) in the two groups were observed after treatment for 7 d. Natural delivery rate, full-term birth rate, the incidence of neonatal asphyxia and postpartum hemorrhage in the two groups were counted. Results AFI values of the observation group after treatment were higher than those of the control group, S/D values were lower than those of the control group, and AFI values of the observation group were higher than those of the control group, S/D values were lower than those of the control group, and the differences were statistically significant (all P < 0.05). AFI and S/D values in the control group were not significantly different from those before treatment （P > 0.05）. The rates of spontaneous vaginal delivery and term delivery in the treatment group were higher than those in the control group, and the differences were statistically significant（P < 0.05）. There were no statistically significant differences in the incidence of neonatal asphyxia and postpartum hemorrhage between the two groups （P > 0.05）. Conclusion The Low molecular weight heparin combined with Oral Rehydration Salts has efficacy on critical amniotic fluid oligohydramnios.
		2020 Vol. 17 (18): 115-117,122 [Abstract] ( 102 ) HTML (1 KB) PDF (540 KB) ( 148 )

	118	Status and influencing factors of dietary behavior in pregnant women at high risk of gestational diabetes mellitus
		ZHANG Ping1 YANG huili1 JIANG qing2 JIN aiying1 WANG Xiaohua3 LIU Jinhuan4
		Objective To understand the status of dietary behaviors and its influencing factors in pregnant women at high risk of gestational diabetes mellitus (GDM) and analyze the correlation between dietary behaviors and GDM. Methods A convenient sampling method was used among 274 pregnant women with high risk of GDM in the First Affiliated Hospital of Soochow University from December 2018 to March 2019. Demographic data questionnaire and diet behavior scale were used to collect data. The incidence of GDM was observed in 160 pregnant women. Results The total scores of GDM diet was (34.70±8.60) points. Educational level, birth order and place of residence were the influencing factors of dietary behavior (P < 0.05); educational level, birth order and age were the influencing factors of dimension one (P < 0.05); educational level, birth order and family history of diabetes (first degree) were the influencing factors of dimension two (P < 0.05); personal monthly income, bad pregnancy history and pre-pregnancy body mass index were the influencing factors of dimension three (P < 0.05). The occurrence of GDM was positively correlated with the total score of eating behavior, score of dimension two and score of dimension three (rs = 0.201, 0.170, 0.180, P < 0.05). Conclusion Unhealthy dietary behaviors are one of the risk factors for the occurrence of GDM. Reasonable dietary behaviors during pregnancy can reduce the risk of GDM occurrence and early intervention should be carried out for the relevant population.
		2020 Vol. 17 (18): 118-122 [Abstract] ( 102 ) HTML (1 KB) PDF (576 KB) ( 180 )

	123	Relationship between deviation of nasal septum, chronic rhinosinusitis and anatomical variation of ostiomeatal complex
		REN Panpan YU Wenfa
		Objective To investigate the relationship between deviation of nasal septum, chronic rhinosinusitis (CRS) and anatomical variation of ostiomeatal complex (OMC). Methods Retrospective analysis was performed on 200 patients with deviation of nasal septum diagnosed in the First Affiliated Hospital of Xinxiang Medical University from December 2017 to July 2019. According to the absence of sinusitis, they were divided into CRS group (122 cases) and non-CRS group (78 cases). Combined with the CT imaging findings of the sinuses, the deviation of nasal septum, OMC anatomical variation and the incidence of sinusitis in the two groups were analyzed. Results The proportion of high deviation and severe deviation of nasal septum in CRS group was higher than that in non-CRS group, and the difference was statistically significant (P ＜ 0.05). The CT score distribution of Lund-Mackay sinus in the narrow nasal cavity of the maxillary sinus, anterior ethmoid sinus, posterior ethmoid sinus and frontal sinus in the CRS group was different from that of the broad nasal cavity (P ＜ 0.05). The CT score distribution of Lund-Mackay sinus in the narrow nasal cavity of the sphenoid sinus was no statistically significant different from that of the broad nasal cavity (P ＞ 0.05). Anterior ethmoid sinusitis and frontal sinusitis in the CRS group had statistically significant differences in the high and low deviation of the nasal septum (P ＜ 0.05). Differences in the variation rates of middle turbinate hypertrophy, ethmoid hypertrophy, uncinate hypertrophy, middle turbinate reverse tension, vesicular middle turbinate and middle turbinate compression under compression on both sides of nasal cavity in non-CRS group were statistically significant (P ＜ 0.05 or P ＜ 0.01). There were no significant differences between Haller, Onodi and Agger air chamber in bilateral nasal cavity (P ＞ 0.05). The variation rates of middle turbinate hypertrophy, ethmoid hypertrophy, middle turbinate antitension, vesicular middle turbinate and Agger gas chamber in the non-CRS group were higher than those in the low turbinate, and the differences were statistically significant (all P ＜ 0.05). However, in the non-CRS group, there were no statistically significant differences in the variation rates of uncinate hypertrophy, middle turbinate compression, Haller and Onodi air chamber when the nasal septum was high and low deviated (P ＞ 0.05). Conclusion The constituent ratio of CRS is higher when the nasal septum is high deviated and severe deviated, and the severity of sinusitis is different on the broad and narrow side. The incidence of OMC variation in different nasal cavity and different deviated position is different, which may be caused by compensatory development abnormality of OMC structure after nasal cavity broadening, which may cause obstructive changes of ipsilateral sinuses.
		2020 Vol. 17 (18): 123-126 [Abstract] ( 74 ) HTML (1 KB) PDF (434 KB) ( 72 )

	127	Effects of Butylphthalide combined with carotid artery stenting in the treatment of ocular ischemia syndrome
		WANG Hui ZHANG Qiang SHEN Xianghui WANG Haibo MENG Yanzhi HOU Xiaoying
		Objective To observe the therapeutic effect of Butylphthalide combined with carotid artery stenting in the treatment of ocular ischemia syndrome (OIS). Methods A total of 106 OIS patients who admitted to Handan Central Hospital, Hebei Province from November 2017 to January 2018 were included in the study. They were divided into the conventional group (53 cases) and the Butylphthalide group (53 cases) according to random number table method. Patients in both groups were treated with carotid artery stenting, the conventional group received perioperative conventional treatment, and the Butylphthalide group was treated with Butylphthalide on the basis of the conventional group treatment. Postoperative 20 d, the changes of visual acuity level, hemodynamic indexs of central retinal artery (CRA) (systolic peak velocity [SPV], end diastolic peak velocity [EDV], resistance index [RI]), cervical lesions arterial blood flow mechanics index (SPV, EDV) and the US national institutes of health stroke scale (NIHSS) in the two groups were observed. Results Before treatment, there was no statistically significant difference in the visual acuity between the two groups (P ＞ 0.05). After treatment, the visual acuity level of both groups was improved compared with that before treatment, and the Butylphthalide group was superior to the conventional group, with statistically significant differences (all P ＜ 0.05). After treatment, SPV and EDV of ocular CRA in both groups were increased compared with those before treatment, while RI was decreased. SPV and EDV in the Butylphthalide group were higher than those in the conventional group, while RI was lower than that in the conventional group, and the differences were statistically significant (all P ＜ 0.05). After treatment, SPV, EDV and NIHSS of patients in the two groups were all lower than those before treatment, and Butylphthalide group was lower than the conventional group, with statistically significant differences (all P ＜ 0.05). Conclusion The application of Butylphthalide in carotid artery stenting can effectively improve postoperative visual acuity level of patients and improve the hemodynamic indexs of central retinal artery and cervical artery of patients.
		2020 Vol. 17 (18): 127-130 [Abstract] ( 59 ) HTML (1 KB) PDF (454 KB) ( 55 )

	131	Effect of Mufangji Decoction combined with Methotrexate on oxygen free metabolism, bone metabolism and blood stasis in patients with acute rheumatoid arthritis
		DING Wencong1 CHEN Taofu2 MIAO Huiyu3
		Objective To explore clinical effect of Mufangji Decoction combined with Methotrexate (MTX) in the treatment of acute attack of rheumatoid arthritis (RA). Methods A total of 122 patients with acute episode RA admitted to the Third Affiliated Hospital of Guangzhou University of Chinese Medicine from January 2014 to May 2018 were selected and they were divided into the observation group (61 cases) and the control group (61 cases). The control group was orally treated with MTX + Folic Acid Tablets, and the observation group was treated with Mufangjitang on the basis of the control group. All patients were treated for 8 weeks. The clinical effects, indicators of free oxygen metabolism [total antioxidant capacity (T-AOC), superoxide dismutase (SOD), reactive oxygen species (ROS)], bone metabolism indicators [osteocalcin (BGP), type Ⅰ collagen carboxy terminal peptide β special sequence (β-CTX), propeptide of typeⅠprocollagen (PINP)], blood stasis status indicators [erythrocyte sedimentation rate (ESR), D-dimer (D-D), Fibrinogen (Fbg)] level changes, and adverse reactions of the two groups were compared before and after treatment. Results After treatment, the total effective rate in the observation group was significantly higher than that in the control group (P ＜ 0.05). After treatment, serum T-AOC, SOD, BGP, and PINP levels in the two groups were higher than those before treatment, and those of the observation group were higher than the control group (P ＜ 0.05). The concentrations of serum ROS, β-CTX, the ESR value and plasma D-D, Fbg levels in the two groups were lower than those before treatment, and those of the observation group were lower than the control group (P ＜ 0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P ＞ 0.05). Conclusion Mufangji Decoction combined with Methotrexate helps patients with acute rheumatoid arthritis relieve symptoms, corrects the imbalance of oxygen free radical metabolism in body, maintains the balance of bone metabolism and improves blood stasis state with practical curative effect and high safety.
		2020 Vol. 17 (18): 131-134,142 [Abstract] ( 126 ) HTML (1 KB) PDF (518 KB) ( 101 )

	135	Effect of Nao′an Granules combined with Clopidogrel in the treatment of acute cerebral infarction
		ANG Wei1 HUANG Zhixiong2 LIN Xufang1 ZHU Youling3 QIN Kan1
		Objective To explore the clinical effect of Nao′an Granule combined with Clopidogrel in the treatment of acute cerebral infarction. Methods A total of 102 patients with acute cerebral infarction who were admitted to Hefei First People′s Hospital from January 2017 to June 2019 were selected, they were divided into the control group (Clopidogrel treatment) and the study group (Na′oan Granules+Clopidogrel treatment) by the random number table method, with 51 cases in each group. The hemorheology index, clinical effect, serum inflammatory factor index, daily activity ability, nerve function defect and adverse reactions were compared between the two groups. Results The total clinical effective rate of the study group was higher than the control group, the difference was statistically significant (P ＜ 0.05). After treatment, the levels of fibrinogen, whole blood viscosity high cut, hematocrit and whole blood viscosity low cut in the study group were lower than those in the control group, the levels of interleukin-6, hypersensitive C-reactive protein and tumor necrosis factor-α in the study group were lower than those in the control group, the Barthel index score of the study group was higher than that of the control group (P ＜ 0.05), while the NIH stroke scale score was lower than that of the control group, the differences were statistically significant (P ＜ 0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P ＞ 0.05). Conclusion Patients with acute cerebral infarction using Nao′an Granules combined with Clopidogrel therapy has good clinical curative effect, security is higher.
		2020 Vol. 17 (18): 135-138 [Abstract] ( 91 ) HTML (1 KB) PDF (499 KB) ( 76 )

	139	Effect of Carvedilol combined with Nicotil on elderly patients with coronary heart disease and angina pectoris and its effect on sICAM-1 and MPO levels
		WU Wei1 ZHANG Ting2 MENG Yibing3 ZHANG Xue1
		Objective To explore the effect of Carvedilol combined with Nicorandil in the treatment of elderly patients with coronary heart disease and angina pectoris and its effect on soluble intercellular adhesion molecule-1(sICAM-1) and myeloperoxidase (MPO) levels. Methods A total of 166 elderly patients with coronary heart disease and angina pectoris admitted to Beijing Huimin Hospital from January 2016 to January 2019 were selected as the subjects. According to the treatment regimen, the patients were divided into control group and study group, with 83 patients in each group. The control group was treated with Carvedilol, and the study group was treated with Nicordil based on the control group. sICAM-1, MPO, soluble P-selectin levels, heart rate and blood pressure in both groups were observed and recorded. Results After treatment, the effective rate of the study group was higher than that of the control group, and the difference was statistically significant (P ＜ 0.05). There were no statistically significant differences in the sICAM 1, MPO, soluble P-select element level between the two groups before treatment (P ＞ 0.05), after treatment sICAM-1, MPO, soluble P-level in the two groups were lower than those before treatment, those of the study group were lower than the control group, the differences were all statistically significant (all P ＜ 0.05). There were no statistically significant differences in heart rate and blood pressure between the two groups before treatment (P ＞ 0.05), after treatment, the heart rate and blood pressure of the two groups were lower than those before treatment, and those of the study group were lower than those of the control group, with statistically significant differences (all P ＜ 0.05). Conclusion Carvedilol combined with Nicorandil is effective in the treatment of angina pectoris in elderly patients with coronary heart disease, and it can also improve patients′ ventricular function, heart rate, blood pressure and other conditions.
		2020 Vol. 17 (18): 139-142 [Abstract] ( 92 ) HTML (1 KB) PDF (493 KB) ( 87 )

	143	Study on the prescription of Chinese Medical Code in the treatment of ulcerative colitis based on data mining
		LI Pengfan1 LUO Yue2 ZHANG Yuli1 WANG Xueying1 CHEN Kanjun1 GU Sizhen1 DOU Danbo1
		Objective To explore the characteristics and regularity of prescriptions for the treatment of ulcerative colitis in Chinese Medical Code. Methods Based on the traditional Chinese medicine inheritance support system, the drug frequency, drug properties and taste menstruation, association rules, prescription rules, core drug combinations in the treatment of “dysentery”, “intestinal dysentery”, “stagnation” and “diarrhea” in Chinese Medical Code were analyzed. Results Among the 341 prescriptions, 200 Chinese herbs were involved, including Radix Angelicae Sinensis, Rhizoma Coptidis, Radix Glycyrrhizae, Radix Aucklandiae, Radix Paeoniae Alba, and Poria. The drugs with neutral temperature, bitter taste and pungent taste were the most frequently used, followed by those with cold nature and sweet taste, those attributed to the spleen meridian were the highest, and those attributed to the stomach meridian were the second. The drug combinations with support ≥34 were 49 groups, the core drug combinations were 10 groups, and 5 new prescriptions were produced. Conclusion Through the traditional Chinese medicine inheritance support system, the prescription medication law of ulcerative colitis in Chinese Medical Code can be revealed to a certain extent, which is helpful to improve the curative effect of traditional Chinese medicine in the treatment of ulcerative colitis.
		2020 Vol. 17 (18): 143-146 [Abstract] ( 108 ) HTML (1 KB) PDF (821 KB) ( 51 )

	147	Professor Cui Shusheng′s experience in the treatment of dislocation of temporomandibular joint
		CHEN Junwei1 CUI Shusheng2 DING Honglei2 SUN Jingqing3
		Dislocation of temporomandibular joint is a kind of joint dislocation with high incidence. The common cause is excessive mouth opening, such as yawning, long time oral treatment or intubation, or trauma caused by a collision or accident. In the early stage of disease, manual reduction is the most effective treatment method, but at present, simple manual reduction often causes secondary injury to patients. According to the theory of meridians and collaterals of traditional Chinese medicine, combined with the characteristics of massage and clinical experience, professor Cui Shusheng, a national famous traditional Chinese medicine doctor, treated dislocation of temporomandibular joint by point and intraoral reduction. This paper expounds the above experience and gives an example.
		2020 Vol. 17 (18): 147-150 [Abstract] ( 98 ) HTML (1 KB) PDF (700 KB) ( 337 )

	151	Clinical effect of Funai Jiangxiao Ointment combined with Chinese medicine diet in the treatment of impaired glucose tolerance
		WANG Feifei
		Objective To explore the effect of Funai Jiangxiao Ointment combined with Chinese medicine diet in the treatment of impaired glucose tolerance. Methods Ninety-eight patients with impaired glucose tolerance treated in Liaocheng Traditional Chinese Medicine Hospital from June 2017 to June 2018 were selected and divided into control group and observation group by random number table method. There were 49 cases in each group. Two groups were given routine health. Control group was treated with traditional Chinese medicine diet, and observation group was treated with Funai Jiangxiao Ointment on the basis of control group. Clinical efficacy, traditional Chinese medicine syndrome score, blood glucose and blood lipid indexes (FPG, 2hPBG, HbA1c, TC, TG), inflammatory factors (IL-6, TNF-α, hs-CRP) were compared between two groups. Results Total clinical effective rate of observation group was higher than that of control group, the difference was statistically significant (P < 0.05). After treatment, traditional Chinese medicine syndrome scores of two groups were lower than those before treatment, observation group was lower than control group, the differences were statistically significant (P < 0.05). After treatment, the levels of FPG, 2hPBG, HbA1c, TC and TG in two groups were lower than those before treatment, observation group was lower than control group, the differences were statistically significant (P < 0.05). After treatment, the levels of IL-6, TNF-α and hs-CRP in two groups were lower than those before treatment, observation group was lower than control group, the differences were statistically significant (P < 0.05). Conclusion Clinical effect of Funai Jiangxiao Ointment combined with Chinese medicine diet in the treatment of impaired glucose tolerance is significant. It can significantly improve the level of blood glucose and blood lipid, regulate the inflammatory reaction, and there is no obvious adverse reaction during the treatment period, with high safety.
		2020 Vol. 17 (18): 151-154 [Abstract] ( 111 ) HTML (1 KB) PDF (744 KB) ( 66 )

	155	Clinical effect of Jinghua Weikang Capsules combined with quadruple therapy in the treatment of Helicobacter pylori positive senile chronic gastritis
		JIANG Xin LIU Dan▲ HAN Lin CHENG Li
		Objective To explore clinical efficacy of Jinghua Weikang Capsules combined with quadruple therapy in the treatment of Helicobacter pylori (Hp) positive elderly chronic gastritis. Methods One hundred and twelve Hp positive elderly patients with chronic gastritis admitted to Dandong Central Hospital from March 2015 to September 2018 were selected and divided into control group and study group according to the random number table method, with 56 cases in each group. Control group was given quadruple therapy, and study group was treated with Jinghua Weikang Capsules on the basis of control group. Clinical efficacy, traditional Chinese medicine symptom score, inflammatory factors, Hp eradication rate and adverse reactions of two groups were compared. Results Total effective rate of study group was significantly higher than that of control group (P < 0.05). The eradication rate of Hp in study group was significantly higher than that in control group (P < 0.05). The scores of stomachache fullness, belching and acid regurgitation, stomachache, stomachache and xerostomia in two groups after 90 days of treatment were lower than those before treatment, and the scores in study group were lower than those in control group (P < 0.05). The levels of serum hs-CRP, IL-6 and TNF-α in two groups after 90 days treatment were lower than those before treatment, and the level in study group was lower than that in control group (P < 0.05). There was no significant difference in incidence of adverse reaction between two groups (P > 0.05). Conclusion Jinghua Weikang Capsules combined with quadruple therapy in the treatment of Hp positive elderly patients with chronic gastritis can rapidly improve clinical symptoms, reduce the level of inflammatory factors, and the medication is safe and effective, which has a certain clinical application value.
		2020 Vol. 17 (18): 155-158 [Abstract] ( 126 ) HTML (1 KB) PDF (712 KB) ( 114 )

	159	Selection of traditional Chinese medicine for treatment of postherpetic neuralgia by the viewpoint of collaterals
		ZHANG Fengchuan1 WANG Jingjun2 SUN Zhanxue1 LI Yuanwen1
		Postherpetic neuralgia is the most common sequela of herpes zoster. The pathogenic factors of herpes zoster are missed toxic pathogenic attack, and the deficiency of qi, blood, yin and yang is its pathogenic basis. The damage of main and collateral channels are the key to the pathogenesis of post-herpes zoster neuralgia; the proper choice of traditional Chinese medicine is the premise of repairing collateral damage. In view of collateral damage, collateral stasis, collateral deficiency and collateral obstruction which form post-herpes zoster neuralgia, the prescription of Qingre Jiedu Huluo Formula, Huoxue Huayu Tongluo Formula, Yiqi Yangxue Xiuluo Formula, insect drug selection, etc.. At the same time, prescriptions should be added and subtracted, or the best combination of prescriptions should be selected according to the syndrome. In addition, Tongluo Zhitong Decoction is used for local lesion by means of hydropathic compress. To repair collateral damage, restore collateral function and eliminate post-herpes zoster neuralgia would be our objective. At the same time, a case is attached for reference.
		2020 Vol. 17 (18): 159-162 [Abstract] ( 95 ) HTML (1 KB) PDF (702 KB) ( 74 )

	163	Clinical effect of zúsānlǐ point by raising one′s feet combined with cìliáo point by milli fire needle in the treatment of primary dysmenorrhea
		ZHANG Jin1 LIU Haiyong1 ZHOU Zhimin1 LI Yanqin2 DUAN Xiaoxia1 LI Chunxia1
		Objective To observe clinical effect of zúsānlǐ point by raising one′s feet combined with cìliáo point by milli fire needle in the treatment of primary dysmenorrhea. Methods Eighty patients with dysmenorrhea treated in Sanhe Hospital of Hebei Province from December 2018 to October 2019 were selected as the research objects. They were divided into two groups by random number table method, with 40 cases in each group. Zúsānlǐ point combined with cìliáo point needling of milli fire needle were used in treatment group, control group was treated with Ibuprofen Sustained-Release Capsules during dysmenorrhea attack. Once a day from the beginning of menstrual period to the end of menstrual period was a course of treatment, and the curative effect was evaluated after three courses of treatment. Results After treatment, VAS in two groups was lower than that before treatment, and VAS in treatment group was lower than that in control group (P < 0.05). After treatment, the scores of severity and duration of dysmenorrhea in two groups were lower than those before treatment, and treatment group was lower than control group (P < 0.05). Total effective rate of treatment group was higher than that of control group, the difference was statistically significant (P < 0.05). Conclusion Zúsānlǐ point combined with cìliáo point needling of milli fire needle in the treatment of primary dysmenorrhea is effective, it has less adverse reactions, and the curative effect is better than that of oral analgesics.
		2020 Vol. 17 (18): 163-166 [Abstract] ( 166 ) HTML (1 KB) PDF (753 KB) ( 77 )

	167	Comparative analysis of Chinese and foreign medical sociology research based on bibliometrics
		LIU Hui
		Objective To compare and analyze the research status and trend of international and domestic medical sociology to provide support for relevant research. Methods The research literature of medical sociology published from January 1945 to March 2020 in PubMed and SinoMed database were measured by using the subject headings clustering method. Results In the recent 10 years of international medical sociology research, 9 topics, such as health status disparities, were the most popular, and 18 topics, such as the accessibility of health services, rank significantly ahead of the whole time (form January 1945 to March 2020). Conclusion It is suggested that the concept and scope of medical sociology research in China should be further clarified, the research field of vision should be extended to the whole field of hygiene and health, and the sociological perspective and multidisciplinary method tools should be fully used to provide academic reference for the formulation of health policy in China.
		2020 Vol. 17 (18): 167-171 [Abstract] ( 110 ) HTML (1 KB) PDF (1293 KB) ( 19 )

	172	Network meta-analysis of needle knife and needle knife combined with other therapies in the treatment of lumbar disc herniation
		WANG Dexiang1 WANG Shixuan2
		Objective To systematically evaluate the effect of needle knife and needle knife combined with other therapies in the treatment of lumbar disc herniation (LDH) by network meta-analysis. Methods The following databases were searched online: PubMed, Cochrane Library, CNKI, Wanfang database, VIP and China biomedical literature database (CBMdisc). The search was conducted using a combination of subject words and free words. The search keywords included needle knife, sharp needle and lumbar disc herniation. The search time limit was from January 2009 to July 2019. Two investigators independently screened the literature, extracted the data and evaluated the risk of bias in the included studies. Data was analyzed using Stata 15.0, ADDIS v1.16.8 and Review Manager 5.3 software. Results A total of 41 studies with 3962 patients were included, involving 17 interventions. The results of network meta-analysis showed that the 10 ten intervention measures in the order of total clinical effective rate were as followed: needle knife plus internal administration of traditional Chinese medicine, needle knife plus manipulation, needle knife plus epidural injection, needle knife plus external use of traditional Chinese medicine, needle knife plus acupuncture, traditional Chinese medicine internal administration, electroacupuncture, needle knife, manipulation, needle knife plus functional exercise. Conclusion The effect of needle knife combined with other therapies is better than that of needle knife alone. Needle knife therapy combined with manipulation for LDH is well developed. The therapeutic effect of needle knife combined with traditional Chinese medicine on LDH deserves further study.
		2020 Vol. 17 (18): 172-176,184 [Abstract] ( 194 ) HTML (1 KB) PDF (1314 KB) ( 135 )

	177	Clinical effect of needle knife lysis for popliteus combined with saphenous nerve block in the treatment of knee osteoarthritis with limited flexion and extension function
		ZHANG Xin1 LI Kaiping2
		Objective To investigate clinical effect of needle knife lysis for popliteus combined with saphenous nerve block in the treatment of knee osteoarthritis (KOA) with limited flexion and extension function. Methods Sixty-eight KOA patients with limited flexion and extension in Department of Acupuncture, Massage and Pain, Shuyang Hospital of Traditional Chinese Medicine Affiliated to Nanjing University of Chinese Medicine from September 2017 to September 2019 were selected and divided into two groups according to the random number table method, with 34 cases in each group. Control group was treated with saphenous nerve block, observation group was treated with needle knife lysis for popliteus and saphenous nerve block. Clinical effect of two groups was compared. The improvement of pain was recorded by NRS before and after treatment. The mean power frequency (MPF) and root mean square (RMS) of quadriceps femoris and biceps femoris were measured by Noraxon telemyo 2400 surface electromyography. Results Total effective rate of observation group was significantly higher than that of control group (P < 0.05). NRS of two groups after treatment was significantly lower than that before treatment, which of observation group was lower than that of control group (P < 0.05). MPF of biceps femoris, rectus femoris, lateral femoris and medial femoris in two groups were significantly higher than those before treatment, and MPF of observation group was higher than that of control group (P < 0.05). RMS of biceps femoris, rectus femoris, lateral femoris and medial femoris in two groups were significantly higher than those before treatment, and RMS of observation group was higher than that of control group (P < 0.05). Conclusion The effect of needle knife lysis for popliteus combined with saphenous nerve block in the treatment of KOA is satisfactory. It can reduce the degree of pain, enhance the contractile force and endurance to fatigue of biceps femoris and quadriceps femoris, so as to effectively improve the movement function of knee joint.
		2020 Vol. 17 (18): 177-180 [Abstract] ( 138 ) HTML (1 KB) PDF (503 KB) ( 92 )

	181	Analysis of one case misdiagnosed of moderately differentiated adenocarcinoma in the left inferior lobe of the Lung
		GUO Yang1 JIA Huijun2 YAO Jie1 DONG Bo3 YANG Feng1 LIU Fang1 LI Xiaowei1 LIU Deyu3
		Lung cancer is a malignant tumor with the highest incidence and mortality in the world. Its onset is insidious, early signs and symptoms are subtle, clinical misdiagnosis and missed diagnosis often occur, delaying the best time for treatment. In this paper, a case with the first symptom of left shoulder joint pain was misdiagnosed as ischemic necrosis of left humerus head. Combined with relevant literatures at home and abroad, this disease was introduced in terms of its pathogenesis, imaging characteristics, pathological tissue characteristics and the differentiation of similar diseases. The patient was admitted to Affiliated Hospital of Shaanxi University of Chinese Medicine on May 30, 2019 due to “left shoulder pain with limited movement for one week”. The patient was considered as tumor lesions, peripheral lung cancer with possibility of multiple metastasis in the lungs. The postoperative pathology examination showed differentiatiated carcinoma in the left lower lobe. The first onset symptoms of the patient do not match the symptoms of lung cancer. The doctor diagnozed and treated the patient with a fixed thinking mode while failing to diverge thinking, effectively differentiate the symptoms. The related imaging signs are not typical, leading to misdiagnosis. The purpose of this paper is to analyzed and summarized the case and provide reference for improving the diagnosis and treatment of lung cancer in the future.
		2020 Vol. 17 (18): 181-184 [Abstract] ( 100 ) HTML (1 KB) PDF (680 KB) ( 146 )

	185	Reflection on traditional medicine′s culture exchange and inheritance protection in Greater Mekong Sub-region
		ZUO Yuanyuan ZHAO Shaoqin LI Zizhi WU Fei QI Yuanhong
		Greater Mekong Sub-region is well known for its vast territory, abundant resources and multi nationalities, due to its geographical, national as well as historical factors that forms regional traditional medicine′s unique culture and technology coexist in the way of harmony in diversity, therefore, traditional medicine culture exchange and communications in Greater Mekong Sub-region has a long and profound history. The paper sorts out the exchange history and current development on traditional medicine from the perspective of ecological crisis and intergenerational transition to analyze the problems and shortcoming of traditional medicine culture development in Greater Mekong Sub-region countries, and puts forward suggestions such as cultivate traditional medicine personnel jointly, introduce new discipline in research and international cooperative development based on cross-border and cross nations. With the aim of promoting exchange level and scale on traditional medicine as well as strengthen inheritance and protection in Greater Mekong Sub-region countries.
		2020 Vol. 17 (18): 185-188 [Abstract] ( 67 ) HTML (1 KB) PDF (578 KB) ( 112 )

	189	Study on the interrogative mood characteristics in doctor-patient interaction from the perspective of interpersonal pragmatics
		LIU Qi XUE Yingli XUE Ting
		Interrogative mood is an important component in language use. Interrogative tone is widely used as a language art in interpersonal communication. In the process of doctor-patient interaction, there is also the use of a number of questions about the statement, through to the interpersonal environment question tone of pragmatics choice characteristics are analyzed, and the research question tone features, both doctors and patients can make stand on equal status for communication, fundamentally solve the contradiction in the language of communication between doctors and patients. This paper expounds the concept of interrogative mood, the present situation of interpersonal pragmatics research at home and abroad, and puts forward the pragmatic function of interrogative mood selection in doctor-patient interaction. This paper collects a large number of effective corpus between doctors and patients and conducts text analysis, so as to obtain the corpus conducive to the construction of harmonious relations between doctors and patients, solves the contradiction between doctors and patients from the perspective of language communication, alleviates the relationship between doctors and patients, and makes the relationship between doctors and patients more harmonious.
		2020 Vol. 17 (18): 189-192 [Abstract] ( 77 ) HTML (1 KB) PDF (575 KB) ( 134 )

	193	Problems countermeasures in improving the construction quality of Party branch in public hospitals by using the “Party Branch Work Low”
		XU Baoyi
		Since the 18th National Congress of the Communist Party of China, especially with the promulgation of “the Regulations on the Work of the Party Branches of the Communist Party of China (trial)”, great progress has been made in the construction of grass-roots Party branches of the public hospitals in Beijing. However, there are still some problems in the standardization about the construction of the Party branches. Based on the practice of the “working method of the Party branch” in 16 Beijing public hospitals, this paper analyzes the deficiencies and puts forward some feasible suggestions in order to provide a reference for the grass-roots Party branch of the public hospitals. It will be significant in improving the quality of the Party branch construction by using “the working method of the Party branch”.
		2020 Vol. 17 (18): 193-196 [Abstract] ( 112 ) HTML (1 KB) PDF (579 KB) ( 182 )

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