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| Correlation between growth differentiation factor 5 and congenital hip dislocation |
| AILI·Rehei1 CAO Li2▲ |
| 1.Department of First Pediatrics Surgical, the First Affiliated Hospital of Xinjiang Medical University, Xinjiang Uygur Autonomous Region, Urumchi 830054, China; 2.Department of Joint Surgical, the First Affiliated Hospital of Xinjiang Medical University, Xinjiang Uygur Autonomous Region, Urumchi 830054, China |
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Abstract Objective To explore and analyze the correlation between growth differentiation factor 5 (GDF5) and pediatric developmental dysplasia of the hip (DDH). Methods Forty-eight children with congenital hip dislocation treated in the First Affiliated Hospital of Xinjiang Medical University from October 2017 to October 2019 were selected as the observation group, and 42 healthy children checked the same period were selected as the control group. Single nucleotide gene polymorphism (SNP) site typing was investigated by TaqMan probe in both groups, the correlation between SNP and DDH. In addition, according to the severity of congenital dislocation of hip joint, they were grouped as congenital dysplasia group (n = 19), congenital hip subluxation group (n = 14), and complete hip dislocation group (n = 15), the correlation between congenital dislocation of hip joint and SNP site under different classifications was explored. Results There were statistically significant differences in genotype frequencies TT, TC and CC between the observation group and the control group (P ＜ 0.05). There was no significant difference in allele frequency T and C between the observation group and the control group (P ＞ 0.05). There were statistically significant differences in genotype frequencies of children in different categories in the observation group between TT, TC and CC(P ＜ 0.05). There were no significant differences in allele frequency T and C among children in different categories in the observation group (P ＞ 0.05). The frequency of T alleles in the complete hip dislocation group was 1.42 times that of the control group, the frequency of T alleles in the congenital hip subluxation group was 1.36 times of the control group, the complete hip dislocation group of the T allele frequency was 1.65 times of the congenital hip subluxation group (P ＜ 0.05). Conclusion GDF5 plays an important role in the occurrence and development of DDH, and it has obvious correlation.
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