卒中相关睡眠障碍发病机制研究进展

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Abstract Stroke is the leading cause of disability and death in the world. China is one of the countries with the largest burden of stroke, and the mortality rate is far higher than that in north America. Sleep disorders are one of the common complications after stroke, and the incidence are 76%-82%. Stroke and sleep are cause and effect since sleep disorders (including sleep-disordered breathing, dyskinesias, and sleep disorders) are closely related to co-morbid cerebrovascular diseases, which may seriously affect the recovery of neurological function and quality of life in patients after stroke, even induce or aggravate the risk factors of stroke leading to recurrence. The treatment of sleep disorders can not only improve sleep-related symptoms, but also promote the recovery of stroke, increase the connection between nerve cells, and reduce the risk of future relapses. Identifying and resolving sleep disorders should be part of primary and secondary stroke prevention. Therefore, investigating the pathogenesis of stroke-related sleep disorders can better develop corresponding prevention and treatment measures according their mechanisms. This article reviews the pathogenesis of stroke-related sleep disorders.

Key words： Stroke Sleep disorders Pathogenesis Progress Review

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	WANG Li XU Bo YAN Bingchun

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WANG Li XU Bo YAN Bingchun. Progress in the pathogenesis of stroke-related sleep disorders[J]. 中国医药导报, 2020, 17(18): 45-48.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2020/V17/I18/45

[1] 北京神经内科学会睡眠障碍专业委员会.卒中相关睡眠障碍评估与管理中国专家共识[J].中华内科杂志，2019， 58（1）：17-26.
[2] Li LJ，Yang Y，Guan BY，et al. Insomnia is associated with increased mortality in patients with first-ever stroke：a 6-year follow-up in a Chinese cohort study [J]. Stroke Vasc Neurol，2018，3（4）：197-202.
[3] Hepburn M，Bollu PC，French B，et al. Sleep Medicine：Stroke and Sleep [J]. Mo Med，2018，115（6）：527-532.
[4] Zhang W，Li F，Zhang T. Relationship of nocturnal concentrations of melatonin，gamma-aminobutyric acid and total antioxidants in peripheral blood with insomnia after stroke：study protocol for a prospective non-randomized controlled trial [J]. Neural Regen Res，2017，12（8）：1299-1307.
[5] 田娜颖，吴硕琳，王春雪，等.脑卒中后失眠患者的临床特点及危险因素分析[J].中国医刊，2018，53（9）：979-982.
[6] Harris AL，Elder J，Schiff ND，et al. Post-stroke apathy and hypersomnia lead to worse outcomes from acute rehabilitation [J]. Transl Stroke Res，2014，5（2）：292-300.
[7] Sacchetti ML，Di Mascio MT，Tinelli E，et al. Resting state functional thalamic connectivity abnormalities in patients with post-stroke sleep apnoea：a pilot case-control study [J]. Eur Rev Med Pharmacol Sci，2017，21（11）：2676-2689.
[8] Turin TC，Kita Y，Rumana N，et al. Is there any circadian variation consequence on acute case fatality of stroke? Takashima Stroke Registry, Japan（1990-2003）[J]. Acta Neurol Scand，2012，125（3）：206-212.
[9] Li Q，Zhao X，Gong DH，et al. Sleep disorders of acute thalamic stroke and its influence on plasma IL-17 [J]. J Biol Regul Homeost Agents，2017，31（3）：745-751.
[10] Tuo H，Tian Z，Ma X，et al. Clinical and radiological characteristics of restless legs syndrome following acute lacunar infarction [J]. Sleep Med，2019，53：81-87.
[11] Lee SJ，Kim JS，Song IU，et al. Poststroke restless legs syndrome and lesion location：anatomical considerations [J]. Mov Disord，2009，24（1）：77-84.
[12] Shiina T，Suzuki K，Okamura M，et al. Restless legs syndrome and its variants in acute ischemic stroke [J]. Acta Neurol Scand，2019，139（3）：260-268.
[13] Ruppert E，Bataillard M，Namer IJ，et al. Hyperdopaminergism in lenticulostriate stroke-related restless legs syndrome：an imaging study [J]. Sleep Med，2017，30：136-138.
[14] Han SH，Park KY，Kim JM，et al. Restless legs syndrome is associated with arterial stiffness and clinical outcome in stroke patients [J]. Sleep Med，2019，60：219-223.
[15] 张力三，孙毅，王甜甜，等.缺血性脑卒中患者合并不宁腿综合征的特点和临床意义[J].浙江大学学报：医学版，2019，48（3）：275-281.
[16] Kim KT，Moon HJ，Yang JG，et al. The prevalence and clinical significance of sleep disorders in acute ischemic stroke patients-a questionnaire study [J]. Sleep Breath，2017，21（3）：759-765.
[17] Culebras A，Anwar S. Sleep Apnea Is a Risk Factor for Stroke and Vascular Dementia [J]. Curr Neurol Neurosci Rep，2018，18（8）：53.
[18] Lee MC，Klassen AC，Heaney LM，et al. Respiratory rate and pattern disturbances in acute brain stem infarction [J]. Stroke，1976，7（4）：382-385.
[19] Faludi B，Toth M，Pusch G，et al. Dynamic changes in sleep-related breathing abnormalities in bilateral paramedian mesencephalon and thalamus stroke：a follow-up case study [J]. Sleep Breath，2016，20（1）：237-242.
[20] Aviv JE，Martin JH，Sacco RL，et al. Supraglottic and pharyngeal sensory abnormalities in stroke patients with dysphagia [J]. Ann Otol Rhinol Laryngol，1996，105（2）：92-97.
[21] Michou E，Mistry S，Jefferson S，et al. Targeting unlesioned pharyngeal motor cortex improves swallowing in healthy individuals and after dysphagic stroke [J]. Gastroenterology，2012，142（1）：29-38.
[22] Turkington PM，Bamford J，Wanklyn P，et al. Prevalence and predictors of upper airway obstruction in the first 24 hours after acute stroke [J]. Stroke，2002，33（8）：2037-2042.
[23] Brown DL，Bapuraj JR，Mukherji SK，et al. MRI of the pharynx in ischemic stroke patients with and without obstructive sleep apnea [J]. Sleep Med，2010，11（6）：540-544.
[24] Martinez-Garcia MA，Galiano-Blancart R，Soler-Cataluna JJ，et al. Improvement in nocturnal disordered breathing after first-ever ischemic stroke：role of dysphagia [J]. Chest，2006，129（2）：238-245.
[25] Ahn SH，Kim JH，Kim DU，et al. Interaction between Sleep-Disordered Breathing and Acute Ischemic Stroke [J]. J Clin Neurol，2013，9（1）：9-13.
[26] Brown DL，McDermott M，Mowla A，et al. Brainstem infarction and sleep-disordered breathing in the BASIC sleep apnea study [J]. Sleep Med，2014，15（8）：887-891.
[27] Siccoli MM，Valko PO，Hermann DM，et al. Central periodic breathing during sleep in 74 patients with acute ischemic stroke-neurogenic and cardiogenic factors [J]. J Neurol，2008，255（11）：1687-1692.
[28] Blissitt PA. Sleep-Disordered Breathing After Stroke：Nursing Implications [J]. Stroke，2017，48（3）：81-84.
[29] Menon D，Sukumaran S，Varma R，et al. Impact of obstructive sleep apnea on neurological recovery after ischemic stroke：A prospective study [J]. Acta Neurol Scand，2017，136（5）：419-426.
[30] Hedayatpour A，Shiasi M，Famitafreshi H，et al. Co-Administration of Progesterone and Melatonin Attenuates Ischemia-Induced Hippocampal Damage in Rats [J]. J Mol Neurosci，2018，66（2）：251-260.
[31] Adamczak-Ratajczak A，Kupsz J，Owecki M，et al. Circadian rhythms of melatonin and cortisol in manifest Huntington′s disease and in acute cortical ischemic stroke [J]. J Physiol Pharmacol，2017，68（4）：539-546.
[32] Kroll ME，Green J，Beral V，et al. Adiposity and ischemic and hemorrhagic stroke：Prospective study in women and meta-analysis [J]. Neurology，2016，87（14）：1473-1481.
[33] Ma C，Pavlova M，Liu Y，et al. Probable REM sleep behavior disorder and risk of stroke：A prospective study [J]. Neurology，2017，88（19）：1849-1855.
[34] Tang WK，Hermann DM，Chen YK，et al. Brainstem infarcts predict REM sleep behavior disorder in acute ischemic stroke [J]. BMC Neurol，2014，14：88.