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| Clinical study of Xiaoer Yanbian Granules combined with Oseltamivir Phosphate in the treatment of children′s influenza A with febrile convulsion |
| SUN Junfeng1 WANG Yakun2 FAN Yanhui3 ZHANG Man2 TIAN Liyuan2 ZHANG Wenchao4 JIA Meixuan2 |
1.The Second Department of Intensive Care, Hebei Children′s Hospital, Hebei Province, Shijiazhuang 050031, China;
2.Department of Respiratory, Hebei Children′s Hospital, Hebei Province, Shijiazhuang 050031, China;
3.Department of Medical Imaging, Hebei Children′s Hospital, Hebei Province, Shijiazhuang 050031, China;
4.Department of Laboratory, Hebei Children′s Hospital, Hebei Province, Shijiazhuang 050031, China |
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Abstract Objective To explore the clinical efficacy of Xiaoer Yanbian Granules combined with Oseltamivir Phosphate in the treatment of children′s influenza A with febrile convulsion. Methods A total of 198 cases with influenza A and febrile convulsion children in Hebei Children′s Hospital from January 2016 to January 2019 were selected as subjects. They were divided into the control group (99 cases) and the observation group (99 cases) according to the random number table method. The control group was treated with Oseltamivir Phosphate, and the observation group was treated with Xiaoer Yanbian Granules on the basis of the control group. The clinical efficacy of the two groups were evaluated. The turnaround time of clinical symptoms and the recurrence rate of convulsion of the two groups were compared. The serum levels of neuronspecific enolase (NSE), brain-derived neurotrophic factor (BDNF), S-100β protein (S-100β), C-reactive protein (CRP), interleukin-8 (IL-8), interferon-γ (IFN-γ) of the two groups were compared. The adverse reactions of the two groups during the treatment were recorded and compared. Results Total effective rate of the observation group was higher than that of the control group (P < 0.05). The pharyngeal swelling pain turnaround time, cough congestion turnaround time, antifebrile time, convulsions disappear time of the observation group were significantly shorter than those of the control group and convulsions recurrence of the observation group was significantly lower than that of the control group (all P < 0.05). The serum levels of NSE, BDNF and S-100β of the two groups after treatment were significantly lower than those before treatment, and the observation group was lower than the control group (all P < 0.05). After treatment, the serum levels of CRP and IFN-γ were significantly lower than those before treatment, and the level of IL-8 was significantly higher than that before treatment and the serum levels of CRP and IFN-γ in the observation group were significantly lower than those in the control group, and the level of IL-8 was significantly higher than that in the control group (all P < 0.05). During the treatment, there was no significant difference in the incidence of adverse reactions between the two groups (P > 0.05). Conclusion The clinical effect of Xiaoer Yanbian Granules combined with Oseltamivir Phosphate in the treatment of children′s influenza A with febrile convulsion is significant, which can improve the clinical symptoms, reduce the inflammatory response and brain injury of children, and has good safety.
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[1] 孙波.流行性感冒危害及接种流行性感冒疫苗的研究[J].中国卫生产业，2016，13（4）：76-78.
[2] 付惠玲，韩长青，焦书真，等.2017年冬季本院甲乙型流感患儿的临床特点[J].临床医学研究与实践，2019，4（8）：82-85.
[3] 张雪.小儿热性惊厥易感因素的临床研究[J].中国医药指南，2019，17（11）：136-137.
[4] 潘伟韶，庞国象，曹巧玲，等.物理降温+吸氧辅助药物方案在小儿热性惊厥治疗中的应用效果[J].北方药学，2019， 16（7）：24-25.
[5] 钟敏，焦健，金毅，等.磷酸奥司他韦治疗流行性感冒的效果研究[J].中国处方药，2016，14（8）：64-65.
[6] 李锁，张晓瑞，尤献民，等.小儿咽扁颗粒中野鸢尾黄素和白射干素含量测定方法研究[J].辽宁中医杂志，2015， 42（9）：1733-1735.
[7] 卫生部流行性感冒诊断与治疗指南编撰专家组.流行性感冒诊断与治疗指南（2011年版）[J].中华结核和呼吸杂志，2011，34（10）：725-734.
[8] 国家中医药管理局.中医病症诊断疗效标准[M].北京：中国医药科技出版社，2012：11.
[9] 宋彩丽.感染致小儿热性惊厥的临床研究[J].临床医药实践，2018，27（12）：897-900.
[10] 谭丽芬，王明义，郭小芳.小儿热性惊厥的临床特征和脑电图变化分析[J].当代医学，2018，24（13）：4-6.
[11] 孙常华，侯智慧.磷酸奥司他韦治疗流行性感冒的临床疗效观察[J].临床研究，2016，24（5）：20-21.
[12] 王亚昆.病毒合剂联合磷酸奥司他韦治疗儿童甲型流行性感冒的临床观察[J].天津中医药，2019，36（8）：763-766.
[13] 陈强，叶文斌，苏小芳.利巴韦林气雾剂联合小儿咽扁颗粒治疗急性口咽喉炎疗效观察[J].吉林医学，2018， 39（7）：1328-1329.
[14] 吴琼，陈凤仪，杨翠.小儿咽扁颗粒治疗上呼吸道感染伴热性惊厥的临床效果[J].中国医药导报，2019，16（11）：73-76.
[15] 李冉.小儿牛黄清心散对热性惊厥后脑损伤保护作用的临床研究[J].湖南中医药大学学报，2017，37（2）：216-219.
[16] 王和生.左乙拉西坦治疗小儿热性惊厥临床疗效及对患儿脑神经相关因子和免疫功能的影响[J].空军医学杂志，2018，34（3）：170-173.
[17] 黄捷，张小利，王学翠，等.病毒清口服液联合奥司他韦治疗儿童热毒袭肺型流行性感冒的临床效果[J].中国医药导报，2019，16（10）：132-136.
[18] 翟艳玲.奥司他韦治疗小儿流行性感冒对血清CRP、IFN-γ水平的影响[J].河南预防医学杂志，2018，29（4）：262-263，295.
[19] 张可可，陈建新，张芬，等.小儿咽扁颗粒抗急性咽炎药理作用研究[J].世界中医药，2019，14（5）：1158-1162.
[20] 陆睿，邹璐檐，吉学元，等.小儿牛黄清心散治疗上呼吸道感染合并热性惊厥 36 例疗效观察[J].中国中西医结合儿科学，2013，5（6）：547-548. |
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