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2019 Vol. 16, No. 12
Published: 2019-04-25
 
 
4 Effect of Tianma Shuxin Granules on the blood pressure and the mRNA and protein expression of ACE, ACE2 and Mas in the spontaneous hypertensive rats′ third-order branches of mesenteric arteries
LIU Kun XU Guicheng YIN Yijian PAN Limin WANG Yang
Objective To observe the effect of Tianma Shuxin Granules (TSG) to spontaneous hypertensive rats (SHRs) on the blood pressure (BP), as well as the mRNA and protein expression of angiotensin-converting enzyme (ACE), ACE2 and Mas in the third-order branches of mesenteric arteries, and investigate the possible mechanisms of SHRs′ resistance vascular eutrophic remodeling and the intervention of TSG. Methods Eighty male SPF SHRs were divided into five groups with 16 rats in each group according to the random number table method: high dosage traditional Chinese medicine group [11.592 g/(kg·d) TSG], medium dosage traditional Chinese medicine group [5.796 g/(kg·d) TSG] and low dosage traditional Chinese medicine group [2.898 g/(kg·d) TSG], Western medicine control group and model control group were treated with TSG, Losartan Potassium Suspension and distilled water respectively. Fifteen Wistar rats were taken as normal control group. The BP of rat tail artery was measured fortnightly. After 18 weeks, rats in each group were killed and the mesenteric arteries were separated. The protein and mRNA expression of ACE, ACE2 and Mas were measured by Western blot and RT-PCR respectively. Results After 2 weeks of administration, the BP of the Western medicine control group, the high dosage traditional Chinese medicine group and the middle dosage traditional Chinese medicine group were significantly lower than that of the model control group (P < 0.01). Compared with the normal control group, the mRNA and protein expression of ACE in the model control group were increased significantly (P < 0.05 or P < 0.01), and the content and the protein expression of mRNA of ACE2 and Mas were decreased significantly (P < 0.05 or P < 0.01). Compared with the model control group, the mRNA expression of ACE in the high dosage traditional Chinese medicine group was decreased (P < 0.05), the mRNA expression of Mas was increased (P < 0.05), the protein expression of ACE2 and Mas were increased (P < 0.01). The mRNA and protein expression of ACE were decreased (P < 0.05), the mRNA expression of ACE2 and the protein expression of Mas were increased in the medium dosage traditional Chinese medicine group (P < 0.05 or P < 0.01). The mRNA expression of ACE was decreased (P < 0.05), the mRNA and protein expression of Mas were increased in the low dosage traditional Chinese medicine group (P < 0.05 or P < 0.01). Conclusion TSG has markedly effect in lowering SHRs′ BP. Increased synthesis of ACE, and decreased synthesis of ACE2 and Mas may be one of the pathological mechanisms of vascular nutrition-rich remodeling in hypertension resistance. TSG can reverse the imbalance of ACE and ACE2, increase the expression of Mas, it can reverse the imbalance of RAS by means of interfering the ACE2 - Ang (1-7) - Mas pathways, it is beneficial to improve the vascular hypertension resistance eutrophic remodeling and reduce the target-organ damage.
2019 Vol. 16 (12): 4-8 [Abstract] ( 175 ) HTML (1 KB)  PDF (636 KB)  ( 131 )
9 The relationship between single nucleotide polymorphism of HIF-2α gene and susceptibility to gastric cancer of Qinghai area Tibetan, Han nationality
MA Jinhua1 MA Jinlan2 WANG Lijuan1 LI Jinzhang1 SHEN Cunfang1 MA Jinxiang3
Objective To explore relationship between single nucleotide polymorphism of HIF-2Αα gene and susceptibility to gastric cancer of Qinghai area Tibetan, Han nationality. Methods A total of 51 Tibetan and 60 Han nationality patients (long lived in Qinghai area) with gastric cancer were collected. DNA was extracted from peripheral blood. Polymerase chain reaction (PCR) was used to detect 3 sites of HIF-2α gene, namely rs6715787, 13419896 and 7598371, and correlation analysis was performed. Results The SNP genotypes of rs6715787 and rs7598371 were C/G, C/C and G/G, respectively, and the SNP genotypes of rs13419896 were A/G, G/G and A/A. The genotype frequencies of A/G, G/G and A/A in rs13419896 of Tibetan and Han nationality groups were 27.45%, 29.41%, 43.13% and 45.00%, 43.33%, 11.67%, respectively. The difference in genotype frequency distribution between the two groups was highly statistically significant (χ2 = 13.518, P ＜ 0.01), and the difference in allele was highly statistically significant (χ2 = 14.195, P ＜ 0.01). The allele difference was statistically significant (χ2 = 11.495, P ＜ 0.01). The frequency distribution of allele A in Tibetan gastric cancer group was higher than that in Han nationality gastric cancer group. The C/G, C/C, G/G genotype frequencies of rs7598371 in the Tibetan and Han nationality groups were 29.42%, 37.25%, 33.33% and 41.67%, 5.00%, 53.33%, respectively. The difference of genotype frequency distribution between the two groups was highly statistically significant (χ2 = 18.118, P ＜ 0.01), and the allele differences were highly statistically significant (χ2 = 16.002, P ＜ 0.01). The frequency distribution of allele C in Tibetan nationality gastric cancer group was higher than that in Han nationality gastric cancer group. The genotype distribution of the two groups was consistent with Hardy-Weinberg equilibrium law (P < 0.05). The C/G, C/C, G/G genotype frequencies of rs6715787 in the Tibetan and Han nationality group were 35.29%, 41.18%, 23.52% and 51.67%, 8.33%, 40.00%, respectively. The frequency distribution of allele C in Tibetan nationality gastric cancer group was highly significantly Higher nationality than that in han gastric cancer group (χ2 = 16.675, P ＜ 0.01). The expression of the gene loci was different in the Tibetan and Han nationality patients with gastric cancer, among which the high expression of HIF-2α gene of C/C type in the gastric cancer patients of Tibetan population in Qinghai province was found in rs6715787. The HIF-2α gene rs7598371 of C/C type was highly expressed in Tibetan gastric cancer patients. HIF-2α gene rs6715787 of C/G type is highly expressed in gastric cancer patients of Han nationality. The HIF-2α gene rs7598371 of G/G type was highly expressed in gastric cancer patients of Han nationality. Conclusion HIF-2α gene rs7598371, rs6715787, rs13419896 gastric cancer may be no correlation between the Han nationaltiy Chinese region of Qinghai Tibetan but region of Qinghai Tibetan, Han nationaltiy gastric cancer HIF-2α gene single nucleotide polymorphisms vary, gene loci to hide the control group, Tibetan and Han nationaltiy patients with gastric cancer express different, tip region of Qinghai Tibetan, Han nationaltiy gastric cancer patients with different genotypes, genetic basis may be different.
2019 Vol. 16 (12): 9-12,22 [Abstract] ( 184 ) HTML (1 KB)  PDF (676 KB)  ( 100 )
13 miR-145 promotes the pathological process of acute Kawasaki disease by downregulating the target gene ACVR1B
LYU Dianyi WU Fuxia CHEN Fengyi
Objective To investigate the effect of down-regulation of ACVR1B gene by miR-145 in promoting the pathological process of acute Kawasaki disease (KD). Methods A total of 108 children who were treated in Yichang First People′s Hospital from November 2015 to June 2018 were included in the retrospective analysis, according to the disease conditions, children were divided into acute KD group (n = 28), with a confirmed diagnosis of acute KD; KD recovery group (n = 24), who was admitted to the hospital during the same period and in the recovery stage after treatment; pyrexia control group (n = 30), who had pyrexia due to upper respiratory tract infection; and normal control group (n = 26), who underwent physical examination during the same period. Serum was taken from the patients to check the expression level of miR-145. Target gene database was searched, and chemical-activated luciferase gene expression, qRT-PCR, and Western blot were performed. Results The white blood cell count, C-reactive protein, and erythrocyte sedimentation rate of acute KD group were significantly higher than the normal control group (P < 0.05), the acute KD group had significantly higher expression of miR-145 in serum than the KD recovery group, the pyrexia control group, and the normal control group (P < 0.05). The expression level of ACVR1B mRNA in serum of the fever control group was significantly lower than that of the normal control group (P < 0.05). The expression level of ACVR1B mRNA in serum of the acute KD group was significantly lower than that of the normal control group, the fever control group and the KD rehabilitation group (P < 0.05). Conclusion miR-145 can bind the 3′-UTR of ACVR1B and inhibit the expression of ACVR1B, and the regulatory relationship between miR-145 and ACVR1B can promote the pathological development of acute KD.
2019 Vol. 16 (12): 13-17 [Abstract] ( 187 ) HTML (1 KB)  PDF (934 KB)  ( 104 )
18 The effects of Alprostadil on myocardial ischemia and apoptosis in acute exhausted rats
JIN Lili1 QIE Tao2 ZHANG Tongle1 XU Bei3
Objective To observe the effects of Alprostadil on myocardial ischemia and apoptosis in acute exhausted rats. Methods Twenty-four male SD rats (SPF grade) were divided into control group (group C), exhausted exercise group (group E), low dose Alprostadil group (group L) and high dose Alprostadil group(group H) by random number table method. Group L and group H were respectively given intraperitoneal injection of 5 μg/(kg·d) and 10 μg/(kg·d) of Alprostadil for 7 days; and 0.9% NaCl 2 mL/(kg·d) was given intraperitoneal injection of group C and group E for 7 days. Ischemic modified albumin (IMA) was detected by enzyme-linked immunosorbent assay (ELISA). TUNEL detection of rat cardiomyocytes and the apoptosis index (AI) was calculated. The Bax and Bcl-2 in rat myocardium were detected by immunohistochemistry. The Fas, Caspase-3 and Caspase-9 in rat myocardium were detected by Western blot. Results ①The serum IMA levels of exhausted exercise rats were significantly increased. Compared with group E, the levels of IMA of group L and group H were decreased significantly (P ＜ 0.05). The levels of IMA of group H decreased more significantly than group L (P ＜ 0.05). ②Myocardial apoptosis was increased significantly after exhausted exercise. AI of group E and group L were significantly higher than group C (P ＜ 0.05). There was no significant difference between group H and group C in AI (P ＞ 0.05). Compared with group E and group L, AI of group H decreased significantly (P ＜ 0.05). ③The expression of Bax protein of group E and group L were significantly higher than that of group C (P ＜ 0.05). Bax of group H was significantly lower than group E and group L (P ＜ 0.05). Compared with group C, the expression of Bcl-2 protein of group E and group L significantly decreased (P ＜ 0.05). Compared with group E and group L, Bcl-2 of group H increased significantly (P ＜ 0.05). ④The Fas and Caspase-3 of group E, group L and group H were significantly higher than group C (P ＜ 0.05), while group H and group L were significantly lower than group E (P ＜ 0.05). The Caspase-9 of group E was higher than group C (P ＜ 0.05), compared with group E, the levels of Caspase-9 of group L and group H were significantly decreased (P ＜ 0.05), and the levels of Fas, Caspase-3 and Caspase-9 of group H were significantly lower than group L (P ＜ 0.05). Conclusion Alprostadil can improve myocardial ischemia, reduce cardiomyocytes apoptosis. And Alprostadil has a dose-dependent effect on myocardial ischemia and cardiomyocytes apoptosis.
2019 Vol. 16 (12): 18-22 [Abstract] ( 176 ) HTML (1 KB)  PDF (635 KB)  ( 70 )
23 Research progress of hnRNPA2/B1 in malignant tumor
LIU Yawen ZHANG Youli XU Min▲
Heterogeneous nuclear ribonucleoproteins (hnRNPs) are a group of RNA-binding proteins that play a key role in complex and various biological processes such as RNA splicing, mRNA processing, telomere synthesis, modulation of gene expression, translation of mRNAs. Heteregeneous nuclear ribonucleoprotein A2/B1 (hnRNPA2/B1) is a member of this proteins family. hnRNPA2/B1 abundantly and ubiquitously expresses in most human tissues and has various functions. Researches indicate that hnRNPA2/B1 is abnormally expressed in diverse malignant tumors, and it can modulate the expression of genes, promote the abilities of proliferation and migration, inhibit apoptosis and regulate tumor resistance in tumors. It also shows that hnRNPA2/B1 has important clinical value in the diagnosis, treatment and prognosis of malignant tumors. Therefore, this paper reviews the development of hnRNPA2/B1 in diverse cancers, such as lung cancer, breast cancer, pancreatic cancer, liver cancer and so on.
2019 Vol. 16 (12): 23-26 [Abstract] ( 165 ) HTML (1 KB)  PDF (641 KB)  ( 107 )
27 Diagnosis, treatment and prevention of splenic artery steal syndrome after liver transplantation
XU Yu DING Youming▲ ZHAO Kailiang
Splenic artery steal syndrome (SASS) is a syndrome characterized by ischemia and hypoxic injury of hepatocytes and cholangiocytes caused by competition between splenic artery and hepatic artery for celiac trunk blood flow in patients with portal hypertension and hypersplenism. It is also one of the causes of graft dysfunction and death of recipients after liver transplantation. This article reviews the principles, diagnosis, prevention and treatment of SASS after liver transplantation.
2019 Vol. 16 (12): 27-30 [Abstract] ( 201 ) HTML (1 KB)  PDF (642 KB)  ( 78 )
31 Current status of clinical research on the principle and function of moxibustion
YUAN Peiyu1 HAO Chongyao2 ZHANG Tiansheng2
In recent years, the use of moxibustion in the treatment of diseases has been paid more and more attention. The research on the principle and mechanism of moxibustion treatment has been deepened at home and abroad. This paper examines the principles and functions of moxibustion effects by consulting relevant literature in recent years. A detailed discussion was made and it was pointed out that the principle of moxibustion effect is not only a warming effect, but a combination of effects such as radiation, pharmacology, trauma and synthesis. With the advancement of medicine and the development of scientific research technology, the application of moxibustion effect has gradually become widespread, such as inhibiting the growth of early tumor cells, improving blood circulation, anti-inflammatory regulation of immune function, regulating body metabolism, and regulating endocrine. However, there are few studies on the efficacy of moxibustion and other heat source products. Therefore, on the basis of qualitative results of the moxibustion effect, it is necessary to quantitatively analyze the intensity of its action.
2019 Vol. 16 (12): 31-34 [Abstract] ( 192 ) HTML (1 KB)  PDF (638 KB)  ( 97 )
35 Modern progress of clear cell adenocarcinoma of the cervix
HU Xiaodi WU Yumei
Cervical clear cell carcinoma (CCAC) is a rare cervical malignancy. The treatment of CCAC is based on the clinical stages of the patients and their desire to have children. This article reviews the etiology, clinical manifestations, treatment and prognosis of CCAC.
2019 Vol. 16 (12): 35-37 [Abstract] ( 196 ) HTML (1 KB)  PDF (622 KB)  ( 81 )
38 Risk factors of postoperative nausea and vomiting and progress in prevention and treatment
WU Zhengyuan1 DU Jiaxi1 LIU Yao1 SHEN Wen2▲
Postoperative nausea and vomiting (PONV) are among the most frequent complications affecting the  recovery of patients during anesthesia period. It is of great significance to recognize the risk factors of PONV and take effective prevention and treatment measures in clinic. This review summarizes native and foreign thinking and researches of PONV currently, and formulates the influence factors of PONV, different scoring systems and prevention measures. Perioperative risk factors should be analysed, and the combined interventions should be considered during anesthesia. Adopting these practices should serve as the best strategy to minize the incidence of PONV and improve patients′ satisfaction.
2019 Vol. 16 (12): 38-41 [Abstract] ( 182 ) HTML (1 KB)  PDF (688 KB)  ( 131 )
42 Research status of human proprotease subtilis 9 inhibitor in hyperlipidemia and hypertension
CHEN Lu LI Jing▲
Cardiovascular and cerebrovascular disease (CVD) is a serious threat to human health. Among them, cholesterol, especially low-density lipoprotein cholesterol (LDL-C), is closely related to the pathogenesis. The current guidelines recommend statins as the first choice for LDL-C control, Howerer, some data showed that after taking can appear a variety of adverse reactions. In recent years, human proprotein invertase subtilis 9 (PCSK9) has been found to have a close correlation with LDL-C. At present, a large number of studies have proved that PCSK9 inhibitors can reduce the level of LDL-C in blood, and even have the opportunity to be applied in the antihypertensive therapy. In this paper, the research status of PCSK9 inhibitors in hyperlipidemia and hypertension was systematically reviewed.
2019 Vol. 16 (12): 42-45 [Abstract] ( 161 ) HTML (1 KB)  PDF (695 KB)  ( 64 )
46 The treatment progress of traditional Chinese medicine for diabetic nephropathy
XIE Qiufang LIANG Guiting DUAN Junhong WEI Xuan ZHANG Yitong
Diabetic nephropathy is a leading cause of mortality and morbidity in patients with diabetes, its complications reflect a complex pathophysiology, and various genetic and environmental factors determine the susceptibility of patients with diabetes and progress of end-stage renal disease. Western medicine has few methods of treatment, and most of them are accompanied by adverse reactions. Traditional Chinese medicine has achieved the curative effect and has certain advantages. This paper searches clinical research literatures about the treatment of diabetic nephropathy with traditional Chinese medicine in recent 5 years at home, and reviews the Chinese medicine treatment of diabetic nephropathy from single herb, treatment based on syndrome differentiation, classical prescription of Chinese medicine, Chinese patent medicine, Chinese medicine self-prescription, and so on.
2019 Vol. 16 (12): 46-49 [Abstract] ( 155 ) HTML (1 KB)  PDF (635 KB)  ( 282 )
50 Progress in diagnosis and treatment of AL-type myocardial amyloidosis
Zhu Jialiang1,2 Li Guohua2
The mechanism of myocardial amyloidosis is the deposition of insoluble amyloid in myocardial tissue，a disease that causes cardiac dysfunction such as impaired myocardial electrical activity, cardiac hypertrophy, increased myocardial stiffness, and decreased diastolic function. Primary amyloidosis and amyloidosis associated with plasma cell disease are all immunoglobulin light chains, so they are collectively referred to as AL-type amyloidosis. Early symptoms of myocardial amyloidosis are not obvious, but as the disease progresses, symptoms of myocardial diastolic function may appear, which often indicates poor prognosis. Among them, AL-type myocardial amyloidosis is more common than other types, so this article focuses on the early clinical manifestations, staging and prognosis ,treatment of AL-type myocardial amyloidosis.
2019 Vol. 16 (12): 50-53,57 [Abstract] ( 184 ) HTML (1 KB)  PDF (914 KB)  ( 145 )
54 Fatigue of systemic lupus erythematosus patients and its influencing factors
FENG Chenchen ZHAO Shuzhen WU Yan LI Ruiyue LIU Yan HE Xiaoli
Objective To investigate the fatigue status and the influencing factors of fatigue in systemic lupus erythematosus patients. Methods Two hundred and one patients enrolled from Rheumatic Immunology Department of West China Hospital of Sichuan University from May to July 2017 were investigated with self-designed questionnaire, fatigue severity scale, self-rating anxiety scale, self-rating depression scale, NRS pain scoring and Pittsburgh sleep quality index. Results Ninety-nine patients (49.3%) showed fatigue. Average family monthly income, depression and pain were the influencing factors. The rate of fatigue in patients with average family monthly income between 2000 to 5000 RMB was lower than patients with income less than 2000 RMB (P ＜ 0.05). The higher the degree of depression, the higher the rate of fatigue (P ＜ 0.01). Fatigue rate was higher in patients with moderate or above pain (P ＜ 0.01). Conclusion Fatigue problem of low-income people should be paid more attention. To reduce fatigue, psychological methods should be adopted to relieve depression, and measures should be taken to alleviate pain.
2019 Vol. 16 (12): 54-57 [Abstract] ( 192 ) HTML (1 KB)  PDF (384 KB)  ( 123 )
58 Effects of early and adequate use of hormone combined with mortethaphenolate on the efficacy and prognosis of patients with proliferative lupus nephritis
XIAO Liyan1 CHEN Yong1▲ WANG Aiguo2
Objective To analyze the effect of early and sufficient application of hormone combined with mortethaphenolate on the efficacy and prognosis of patients with proliferative lupus nephritis. Methods From April 2016 to October 2017, 92 patients with proliferative lupus nephritis admitted and treated in the Department of Internal Medicine of  the People′s Hospital of Kaizhou District Chongqing were selected and divided into two groups according to the random number table method, 46 patients in each group. The control group was treated with adequate Hormone and Cyclophosphamide at the early stage, and the observation group was treated with adequate Hormone combined with Motimecophenolate at the early stage, and the clinical effects of the two groups were compared. Results Compared with the control group, the total effective rate was significantly increased in the observation group (P ＜ 0.05), and the results of urea nitrogen, serum creatinine level and 24 h urine protein quantification after treatment were lower than the control group, with statistically significant differences (P ＜ 0.05). The total incidence of adverse reactions in the observation group was significantly lower than that in the control group (P ＜ 0.05). After 1 year follow-up, the recurrence rate of renal disease in the observation group was significantly lower than that in the control group (P ＜ 0.05). Conclusion Early and sufficient application of Hormone combined with Morteofloxacin has a significant effect on proliferative lupus nephritis, which can improve the renal function of patients, reduce the risk of renal recurrence, and the drug safety is relatively high.
2019 Vol. 16 (12): 58-61 [Abstract] ( 190 ) HTML (1 KB)  PDF (363 KB)  ( 61 )
62 Comparison of the effect of bilateral decompression through unilateral approach and bilateral decompression through bilateral paracinar small incision in lumbar spinal stenosis patients with internal fixation
SONG Yuguang LI Jie CAI Jianping CHEN Ji
Objective To compare the clinical effect of bilateral decompression through unilateral approach and bilateral decompression through bilateral paracentric small incision in lumbar spinal stenosis patients. Methods From January 2015 to January 2017, the Second People′s Hospital of Yibin City were analyzed during the period of 113 patients with lumbar spinal stenosis disease as the research objects, and they were divided into observation group (n = 60) and control group (n = 53) according to the different surgical procedure, the observation group uses the unilateral approach bilateral decompression treatment, control group adopts double side beside the spine bilateral decompression treatment through small incision. The operative status, complication rate, pain degree and lumbar function of the two groups were evaluated and compared. Results The operation time, intraoperative blood loss, postoperative drainage volume, hospitalization time and other indicators in the observation group were all lower than those in the control group (P ＜ 0.05). There was no significant difference in the incidence of postoperative complications between the observation group and the control group (P ＞ 0.05). The visual simulation score (VAS) and Oswestry dysfunction index (ODI) at 12 months after surgery were lower in the two groups than those before surgery, and the VAS and ODI at 12 months after surgery in the observation group were lower than those in the control group, with statistically significant differences (P ＜ 0.05). Conclusion Bilateral decompression through unilateral approach and bilateral decompression through bilateral paracentric small incision can both treat lumbar spinal stenosis, but bilateral decompression through unilateral approach has less trauma and faster postoperative recovery, and is better for postoperative pain and improvement of lumbar function, which is worthy of further promotion and application.
2019 Vol. 16 (12): 62-65 [Abstract] ( 168 ) HTML (1 KB)  PDF (576 KB)  ( 90 )
66 Comparison of the effect of gastrocnemius tendon flap turnover reinforcement and modified Kessler suture in the treatment of acute closed Achilles tendon rupture
ZHOU Jingyuan SUO NAN Ang xiu
Objective To analyze the clinical effect of gastrocnemius tendon flap turnover and reinforcement in the treatment of acute closed achilles tendon rupture, and to compare its effect with modified Kessler suture. Methods From April 2010 to April 2014, 50 patients with acute closed achilles tendon rupture who were treated in the Fourth Ward Department of Orthopedics, Qinghai Provincial People′s Hospital were selected as the research objects. Patients were divided into experimental group and control group according to different treatment methods, with 25 cases in each group. In the experimental group, the gastrocnemius tendon flap was used for treatment. The control group was treated with modified Kessler suture. The clinical symptoms of the two groups after treatment were observed and the clinical effects of the two groups was compared after treatment. Results After treatment, the total effective rate of the control group was 68.00%, which was significantly lower than that of the experimental group (92.00%), the difference was statistically significant (P < 0.05). The scores of achilles tendon activity in the two groups after 1, 5 and 10 months of treatment were higher than that before treatment, and the difference were statistically significant (P ＜ 0.05). In addition, the scores of achilles tendon activity in the experimental group after 1, 5 and 10 months of treatment were higher than those in the control group, and the differences were statistically significant (P ＜ 0.05). Conclusion The application of gastrocnemius tendon flap turnover reinforcement has a better clinical effect in the adjuvant treatment of this disease, with less intraoperative blood loss and better recovery after surgery. This treatment method is safer than the modified Kessler suture.
2019 Vol. 16 (12): 66-68,84 [Abstract] ( 176 ) HTML (1 KB)  PDF (593 KB)  ( 68 )
69 Analysis of risk factors and prevention of secondary fracture of distal radius fracture in elderly women
LI Yan CHANG Junying MU Weilu JIA Dongzhao WANG Yanzhi XING Zhaoguo GAO Yang
Objective To analyze the risk factors of secondary fracture of distal radius fractures in elderly women and to make recommendations. Methods Clinical data of 160 elderly patients with distal radius fractures received by the First Department of Traumatology, the Third Hospital of Shijiazhuang City from April 2015 to April 2017 were respectively analyzed. According to the occurrence of re-fracture, they were divided into occurrence group (45 cases) and non-generation group (115 cases). The risk factors for the secondary fracture of distal radius fractures in elderly women were determined by single factor and multivariate Logistic linear regression analysis. Results There were no differences in the rates of hypertension, coronary heart disease, diabetes, type of fracture, combined distal radioulnar joint dislocation, ulna styloid process fracture, treatment, external fixation time, residual articular surface unevenness, serum phosphorus (P), calcium (Ca), calcitonin (CT ) and type Ⅰ collagen amino terminal propeptide (PINP) levels of the patients between the two groups (P > 0.05). The rates of age > 80, bone cement leakage, osteoporosis, no anti-osteoporosis treatment, 25-OH-D < 8.0 ng/mL of the occurrence group were significantly higher than those of the non-occurrence group (P < 0.05), which were the independent risk factors for secondary fracture of distal radius fractures (P < 0.05). Conclusion There are many risk factors for secondary fracture of distal radius fractures in elderly women, clinical needs to attach great importance to and strengthen preventive measures.
2019 Vol. 16 (12): 69-72 [Abstract] ( 178 ) HTML (1 KB)  PDF (614 KB)  ( 84 )
73 Effect of additional lateral plate combined with autologous bone transplantation in the treatment of postoperative nonunion of femoral shaft fractures with intramedullary nail fixation
XIONG Kai ZHANG Bo RAN Fenghua LI Jin
Objective To evaluate the clinical effect of additional lateral plate combined with autologous bone transplantation in the treatment of postoperative nonunion of femoral shaft fractures with intramedullary nail fixation. Methods A retrospective study was conducted on the data of 13 cases of bone nonunion after intramedullary nail internal fixation of femoral shaft fractures admitted to the Traumatic Hand Surgery Department of the Nanning Second People′s Hospital from March 2016 to January 2018, to observe the clinical effect of treating patients with additional lateral plates combined with autologous bone transplantation. Results All the 13 patients were followed up for 6 to 26 months, and all femoral shaft fracture ends had bone healing with an average healing time of (5.70±3.52) months. According to the Tohner-Wrnch evaluation criteria, 11 cases were excellent and 2 cases were good. Conclusion Bone nonunion after intramedullary nailing for femoral shaft fractures with additional lateral plate fixation combined with autologous bone transplantation has a good clinical effect.
2019 Vol. 16 (12): 73-76 [Abstract] ( 193 ) HTML (1 KB)  PDF (713 KB)  ( 92 )
77 Expression and significance of mechanically sensitive ion channel protein Piezo1 in nucleus pulposus cells of the intervertebral disc
YIN Tao1 SHAO Jin2 ZHANG Yan2 YANG Tieyi2
Objective To study the expression of Piezo1, a mechanically sensitive ion channel protein in human intervertebral disc nucleus cells, and to explore its role in human intervertebral disc degeneration. Methods A total of 26 specimens (15 males and 11 females) of intervertebral disc tissue surgically removed due to lumbar degenerative diseases were collected in the Shanghai Pudong New Area Gongli Hospital From January 2017 to January 2018. There were 3 cases of Pfirrmann Ⅱ, 8 cases of Pfirrmann Ⅲ, and 15 cases of Pfirrmann Ⅳ. According to the degree of degeneration, Pfirrmann Ⅱ tissue specimens were used as the control group, and Pfirrmann Ⅲ and Ⅳ were used as the degeneration group. HE staining was used to observe the histological changes of intervertebral discs with different degrees of degeneration. Immunohistochemistry staining was used to detect the localization and expression level of mechanically sensitive ion channel protein Piezo1 in tissues with different degrees of degeneration. Results The results of HE staining showed that with the increase of intervertebral disc degeneration, the extracellular matrix content of nucleus pulposus decreased, and the number of nucleus pulposus cells decreased, showing different degrees of degeneration or necrosis. The results of immunohistochemistry showed that Piezo1 was expressed in the nucleus pulposus cells of both the control group and the degenerative group, and the expression was mainly in the nucleus and cytoplasm; the positive expression rates of the control group and the degenerative group were (45.43±13.14)% and (68.75±19.67)%, there was a difference in the positive expression rate between the two groups (P ＜ 0.05). Conclusion Piezo1 expression was observed in nucleus pulposus cells of intervertebral disc with different degrees of degeneration, and the expression level of Piezo1 in the degenerative group was higher than that in the normal group, suggesting that Piezo1, a mechanically-sensitive ion channel protein, may be involved in the degenerative process of nucleus pulposus cells in intervertebral disc.
2019 Vol. 16 (12): 77-80 [Abstract] ( 204 ) HTML (1 KB)  PDF (672 KB)  ( 143 )
81 Clinical effect of anterior approach surgery in the treatment of fracture and dislocation of lower cervical spine combined with spinal cord injury
SHAO Chuanqiang LIU Yong
Objective To explore the clinical effect of anterior approach in the treatment of fracture and dislocation of lower cervical spine combined spinal cord injury. Methods A total of 30 patients with fracture and dislocation of lower cervical spine combined spinal cord injury admitted to Baoji Central Hospital from January 2010 to March 2017 were selected. All the patients were treated with anterior cervical decompression and reduction, bone graft fusion, and internal fixation. The postoperative cervical curvature, bone graft fusion degree and recovery of nerve function were evaluated. Results All patients were followed up for 12 to 24 months, with an average of (13.5±1.5） months. Bone graft fusion was achieved in all patients within 6 months postoperatively. The cervical intervertebral height and the physiological curvature maintained satisfactory. No looseness or breakage was detected in the internal fixation. The Cobb angle after operation for 6 months was significantly better than that before operation, the difference was highly statistically significant (P = 0.000）. According to the Frankel classification, degree B to D patients had improvement in the posfoperative nerve function while degree A and D patients had no obvious changes. The JOA scores of all the patients increased after operation compared with that before operation, with highly statistically significant difference (P = 0.000）. Conclusion Anterior cervical decompression combined with bone graft fusion and internal fixation approach in treating lower cervical fracture-dislocation with spinal cord injury could reconstruct the stability of cervical spine, restore the normal cervical curve and height, effectively relieve spinal cord compression, and promote the recovery of spinal cord nerve function.
2019 Vol. 16 (12): 81-84 [Abstract] ( 184 ) HTML (1 KB)  PDF (777 KB)  ( 124 )
85 Clinical and biochemical characteristics of different glucose metabolic states of obese women with polycystic ovary syndrome
MENG Xiaoyu HOU Lihui ZHANG Chunlan XU Fang SUN Miao
Objective To discuss the metabolism characteristics of different glucose metabolic states of obese women with polycystic ovary syndrome. Methods From October 2014 to October 2016, 378 obese patients with PCOS were selected, the age, waist circumference, hip circumference and other indicators of hormones and glucolipid metabolism of patients were collected. These patients were all treated in the First Affiliated Hospital of the Heilongjiang University of Chinese Medicine. Patients were divided into three groups of normal glucose tolerance (NGT group, n = 246), impaired glucose tolerance (IGT group, n = 96), and type 2 diabetes mellitus (T2DM group, n = 36) according to oral glucose tolerance test results. The patients′ hormone levels and glucolipid metabolism were compared in the study. Results ①The incidence of obese PCOS patients with IGT was 25.4%, with T2DM was 9.5%; ②the age, WHR and systolic pressure of IGT group were significantly higher than the NGT group; the BMI, systolic pressure and diastolic pressure of T2DM group were significantly higher than the other groups; the age, WHR and waistline of T2DM group were significantly higher than NGT group, the differences were statistically significant (P < 0.05); ③the LH of T2DM group was significantly lower than the other groups, the differences were statistically significant (P < 0.05); ④the levels of OGTT at five time points and Aucg in T2DM group were significantly higher than IGT group, and in IGT group were significantly higher than NGT group; the levels of TC, TG and LDL in NGT group were significantly lower than the other groups, the differences were statistically significant (P < 0.05); ⑤the levels of INS at five time points, HOMA-IR, ln(ISI) and AIR in T2DM group were significantly higher than IGT group, and IGT group were significantly higher than NGT group; the level of HOMA-β in T2DM group was significantly lower than the other groups; the level of IGI in NGT group was significantly higher than the other groups, the differences were statistically significant (P < 0.05). Conclusion The obese patients of PCOS with abnormal glucose metabolism are mainly impaired glucose tolerance and then developed into type 2 diabetes gradually. The internal insulin-β-cell function of these patients was damaged as the deterioration of sugar metabolic abnormalities.
2019 Vol. 16 (12): 85-88 [Abstract] ( 222 ) HTML (1 KB)  PDF (443 KB)  ( 102 )
89 Expression of CRP, IL-8 and VEGF in serum and peritoneal fluid of patients with endometriosis and its significance
WEI Shunying WANG Liehong QI Qingling WANG Qianyin WANG Yonghua JIA Jia
Objective To explore the expression of C-reactive protein (CRP), interleukin-8 (IL-8) and vascular endothelial growth factor (VEGF) in serum and peritoneal fluid of patients with endometriosis and its clinical significance. Methods A total of 93 patients with endometriosis (endometriosis group) admitted to Qinghai Red Cross Hospital from August 2015 to August 2017 were divided into stage Ⅰ (n = 19), stage Ⅱ (n = 25), stage Ⅲ (n = 28) and stage Ⅳ (n = 21) according to the American Fertility Society (r-AFS). At the same time, 60 patients with uterine leiomyoma (uterine leiomyoma group) and 60 healthy volunteers as control group were randomly selected. The levels of CRP, IL-8 and VEGF in serum and peritoneal fluid was detected by enzyme-linked immunosorbent assay. Results The levels of serum CRP, IL-8 and VEGF in endometriosis group were higher than those in uterine leiomyoma group and control group (P < 0.05). The levels of CRP, IL-8 and VEGF in peritoneal fluid were higher than those in patients with uterine leiomyoma group (P < 0.05). With the increase of disease stages, the levels of CRP, IL-8 and VEGF in serum and peritoneal fluid in patients with endometriosis increased gradually (P < 0.05). Pearson moment correlation analysis showed that serum CRP, IL-8, VEGF was positively associated with r-AFS score (r = 0.639, 0.712, 0.655; P < 0.05), and which in peritoneal fluid was positively associated with r-AFS score (r = 0.682, 0.764, 0.670; P < 0.05). The area under ROC curve (AUC) of CRP was 0.784, the best cut-off value was 12.23 mg/L, the sensitivity and specificity was 0.77 and 0.72, respectively, and the accuracy was 0.71. The AUC of IL-8 was 0.884, the best cut-off value was 20.97 mg/L, the sensitivity and specificity was 0.82 and 0.76, respectively, and the accuracy was 0.78. The AUC of VEGF was 0.889, the best cut-off value was 175.34 pg/mL, the sensitivity and specificity were 0.82 and 0.78, respectively, and the accuracy was 0.80. The AUC of CRP, IL-8 and VEGF was 0.931, the sensitivity and specificity was 0.92 and 0.85, respectively, and the accuracy was 0.89. Conclusion The levels of CRP, IL-8 and VEGF in serum and peritoneal fluid of patients with endometriosis are significantly elevated and positively associated with the progression of the disease. Early detection of CRP, IL-8 and VEGF is helpful to differential diagnosis of endometriosis and to evaluate the severity of the disease.
2019 Vol. 16 (12): 89-92,104 [Abstract] ( 180 ) HTML (1 KB)  PDF (795 KB)  ( 101 )
93 Effect of endoscopic low temperature plasma radiofrequency ablation in the treatment of snoring with allergic rhinitis in children
LONG Songliang ZHAO Sijun HUANG Min LI Yun LUO Xinyou
Objective To study the effect of low temperature plasma radiofrequency ablation (ELTPRA) under nasal endoscope in the treatment of snoring with allergic rhinitis (AR) in children. Methods A total of 115 children with snoring and AR who were treated in Hu′nan Children′s Hospital from June 2017 to June 2018 were enrolled. The children were divided into observation group (n = 58) and control group (n = 57) according to the random number table method. The control group was treated with tonsillectomy combined with adenoidectomy, while the observation group was treated with ELTPRA. After 3 months follow-up, the curative effect, clinical indicators, inflammatory factors and complications before and after treatment were compared between the two groups. Results The total effective rate of the observation group was 98.28%, which was significantly higher than that of the control group (89.47%), and the difference was statistically significant (P < 0.05). The operation time, intraoperative bleeding volume and hospitalization time of the observation group were significantly less than those of the control group, and the differences were statistically significant (P < 0.01). After treatment, the levels of interleukin-4 (IL-4), IL-8 and tumor necrosis factor-alpha (TNF-α) were significantly decreased in both groups (P < 0.05), and the levels of IL-4, IL-8, TNF-α in the observation group were significantly lower than those in the control group, and the differences were statistically significant (P < 0.01). The incidence of pain and complications in the observation group were lower than those in the control group, and the differences were statistically significant (P < 0.05). Conclusion ELTPRA is effective in the treatment of children with snoring and AR, and has fewer complications. It can also effectively promote postoperative recovery and reduce the level of inflammatory factors in children, which is effective and worthy of promotion.
2019 Vol. 16 (12): 93-97 [Abstract] ( 185 ) HTML (1 KB)  PDF (463 KB)  ( 164 )
97 Effect of contact lens on repair of corneal injury in patients with pterygium
ZHANG Moli CHEN Yunzhen DU Shubo
Objective To investigate the effect of contact lens on the repair of corneal injury in patients with pterygium. Methods A total of 54 eyes of 52 patients with recurrent pterygium who were treated in the Outpatient Department of People′s Hospital of Beijing Daxing District from March 2016 to March 2018 were randomly divided into group A (28 eyes) and group B (26 eyes). The pterygium resection was performed in both groups, and the conjunctival flap with some limbal stem cells was taken and sutured on the sclera surface of the operation area. Group A was treated with contact lens for 5 days, and group B was routinely covered. The postoperative corneal irritation, corneal wound healing and dry eye syndrome were observed. Results On the first day after operation, the scores of corneal irritation symptoms in the two groups included eye pain, foreign body sensation, photophobia and tears, with significant difference (P < 0.05); on the third and fifth day after operation, there was no significant difference in the scores of corneal irritation symptoms between the two groups (P > 0.05). The scores of corneal irritation symptoms such as eye pain, foreign body sensation, photophobia and tear in both groups decreased with the prolongation of postoperative time. On the first day after operation, the corneal epithelial healing rate of the two groups had significant difference (P < 0.05), and the corneal epithelial healing rate of group A was significantly higher than that of group B (P < 0.05); the corneal epithelial healing rate of the two groups on the third and fifth day had no significant difference (P > 0.05); the corneal epithelial healing rate of the two groups on the first, third and fifth day after operation had significant difference (P < 0.05). There was no significant difference in subjective symptom score, corneal fluorescence staining (FL), tear break-up time (BUT) and Schirmer I test (SIt) between the two groups (P > 0.05). There were significant differences in subjective symptom score, FL and BUT between the two groups (P < 0.05), and group B were higher or longer than group A. Compared with pre-operation, there were significant differences in subjective symptom score, FL, BUT and SIt between the two groups (P < 0.05), and postoperative were higher or longer than preoperative. Conclusion Contact lens can significantly improve the corneal irritation sympotoms after operation in patients with pterygium, promote the repair of corneal injury and reduce postoperative discomfort.
2019 Vol. 16 (12): 97-100 [Abstract] ( 253 ) HTML (1 KB)  PDF (439 KB)  ( 97 )
101 Determination of 7 nucleosides in red yeast rice by HPLC
LI Yongsheng1 ZHANG Chunling1 YANG Yuanyuan2 CHEN Zhiyon1,3
Objective To establish a high performance liquid chromatography method for the simultaneous determination of seven nucleosides of uracil, cytidine, hypoxanthine, adenine, inosine, thymidine and adenosine in red yeast rice. Methods Shiseido C18 (4.6 mm×250 mm，5 μm) was adopted to separate the sample at the column temperature of 25°C. Acetonitrile (A)-0.05 mol/L KH2PO4 (B) was used as the mobile phase. Gradient elution method: 0-9 min, 0% A; 9-40 min, 0%-8% A. The injection volume was 20 μL, and flow rate was 1 mL/min. The detection wavelength was 254 nm. Results Uracil, cytidine, hypoxanthine, adenine, inosine, thymidine and adenosine showed a good linear relationship with the peak area (r < 0.9995) in the range of 1.00-5.00 μg, 3.08-15.35 μg, 2.78-13.95 μg, 9.37-46.87 μg, 4.58-22.86 μg, 1.06-5.29 μg, 4.41-22.28 μg, respectively. The average recovery rates were 99.34%, 99.56%, 100.18%, 97.95%, 98.02%, 99.28%, RSD < 2.00%.  Conclusion The method is reproducible and accurate, and can be used for the determination and quality evaluation of nucleotide in red yeast rice.
2019 Vol. 16 (12): 101-104 [Abstract] ( 214 ) HTML (1 KB)  PDF (517 KB)  ( 202 )
105 Simultaneous determination of puerarin, daidzein, aurantio-obtusin and chrysophanol in Liuwei Gelan Jiangzhi Tablets by HPLC
XIAO Ming1 ZHOU Yaqi2 LI Fangchan3 JIANG Lin3 WEI Bowei2
Objective To establish a high performance liquid chromatography method for the simultaneous determination of puerarin, daidzein, aurantio-obtusin and chrysophanol in Liuwei Gelan Jiangzhi Tablets. Methods High performance liquid chromatography method was used. Phenomenex Gemini C18 (250 nm × 4.6 mm, 5 um) was used as the chromatographic column. The mobile phase was acetonitrile-0.1% phosphoric acid aqueous solution. The gradient elution method was used. The detection wavelength was 285 nm, the column temperature was 30℃, and the flow rate was 1.0 mL/min. Results The injection quantities of puerarin, daidzein, aurantio-obtusin and chrysophanol showed good linear relationship with peak area in the range of 0.014 58-0.065 62 mg/mL, 0.1074-0.2417 mg/mL, 0.014 58-0.065 62 mg/mL, 0.012 01-0.054 04 mg/mL (r = 0.995 94, 0.999 95, 0.999 97, 0.991 57), respectively, and the average recovery rates were 99.0%, 102.9%, 104.1%, 104.1%, and RSD were 0.390%, 0.910%, 0.050%, 0.057% (n = 6), respectively. Conclusion The method is simple, accurate, stable and reproducible. It can be used for the quality control of Liuwei Gelan Jiangzhi Tablets.
2019 Vol. 16 (12): 105-108,112 [Abstract] ( 180 ) HTML (1 KB)  PDF (758 KB)  ( 77 )
109 Determination of kanamycin sulfate in hospital preparation Compound Diphenhydramine Nasal Drops
LIU Min LIU Junli TIAN Jiayi ZENG Weixin
Objective To establish a method for the determination of kanamycin sulfate in Compound Diphenhydramine Nasal Drops by ultraviolet-visible spectrophotometry so as to better control the quality of the drug and ensure its safety of medication. Methods The content of kanamycin sulfate was determined by ultraviolet-visible spectrophotometry at 568 nm. Results The linear relationship between the concentration of kanamycin sulfate and UV absorbance in the range of 0.1-0.5 mg/mL was good (r = 0.9999), the average recovery was 100.35%, and the RSD was 0.66% (n = 9). Conclusion The method is simple, accurate and reproducible. It can be used for the determination of kanamycin sulfate in hospital preparation Compound Diphenhydramine Nasal Drops.
2019 Vol. 16 (12): 109-112 [Abstract] ( 244 ) HTML (1 KB)  PDF (577 KB)  ( 132 )
113 Meta analysis of Compound Danshen Dripping Pills combined with Amiodarone in the treatment of arrhythmia
WANG Dandan1,2 HU Yuanhui2▲ SHI Shuai2 WEI Namin1,2
Objective To systematically evaluate the clinical efficacy and safety of Compound Danshen Dropping Pills combined with Amiodarone in the treatment of arrhythmia. Methods Cochrane Library, CBM, Clinicaltrials.gov, PubMed, Embase, Medline, CNKI, Wanfang database, VIP full-text electronic journals (VIP) were searched by computer, and randomized controlled trials of Compound Danshen Dropping Pills combined with Amiodarone in the treatment of arrhythmia were collected from the database to September 2018. Randomized controlled trials of arrhythmias were performed by two researchers independently according to inclusion and exclusion criteria. Meta analysis was performed by RevMan 5.3 software. Results Finally, 13 studies were included, involving 1178 subjects including 590 patients of Compound Danshen Dripping Pills combined with Amiodarone trenatment and 588 patients of Amiodarone treatment. Compared with Amiodarone alone, Compound Danshen Dripping Pills combined with Amiodarone has better clinical efficacy [RR = 1.21，95%CI（1.16，1.27），P ＜ 0.00 001] and ventricular premature beats [MD = -178.09，95%CI（-201.94，-154.25），P ＜ 0.00 001], atrial premature beats [MD = -119.14，95%CI（-134.21，-104.06），P ＜ 0.00 001], borderline. Sexual premature beats [MD = -54.88， 95%CI（-68.61，-41.59），P ＜ 0.00 001] frequency were reduced, the incidence of adverse reactions was lower [RR = 0.28，95%CI（0.13，0.60），P ＜ 0.00 001], the difference was statistically significant (P ＜ 0.05). Conclusion Compared with Amiodarone alone, Compound Danshen Dropping Pills combined with Amiodarone has more significant clinical effect and higher safety in the treatment of arrhythmia. However, due to the low quality of the included literature, the above conclusions still need to be supported by more high quality randomized controlled trials.
2019 Vol. 16 (12): 113-118 [Abstract] ( 252 ) HTML (1 KB)  PDF (1414 KB)  ( 113 )
119 Clinical study of Erythromycin and Budenide combined with recombinant human interferon α1b in the treatment of children with bronchiolitis obliteratus
DING Shuyu1 LI Yawei1 YANG Xinli1 YAN Haiyan1 YANG Huiwei2 SHANG Geng3 PAN Xiao1 ZHANG Qing1
Objective To investigate the clinical effect and safety of Erythromycin and Budesonide combined with recombinant human interferon α1b in the treatment of pediatric bronchiolitis obliteratus (BO). Methods From January 2012 to June 2016, 82 children with BO in the Second Center Hospital of Baoding were selected, and they were divided into the control group (n = 41) and observation group (n = 41) according to the random number table method. The control group were given low dose of Erythromycin combined with Budesonide, and the observation group was treated with low dose of Erythromycin combined with Budesonide and recombinant human interferon α1b, the two groups were treated for 7 days. The clinical efficacy, wheezing and holding disappeared time, cough disappeared time, shortness of breath disappeared time, lung rale disappeared time, respiratory rate (RR), tidal volume (VT), respiratory time ratio (Ti/Te), serum gamma interferon (IFN-γ), interleukin-4 (IL-4) levels and adverse reactions were observed and compared between the two groups. Results The total clinical effective rate of the observation group was significantly higher than that of the control group, and the difference was statistically significant (P ＜ 0.05). The disappearance times of wheezing and holding, cough, shortness of breath and lung rale in the observation group were significantly shorter than that in the control group (P ＜ 0.05). After treatment, the RR, Ti/Te and serum IFN-γ levels in the two groups were lower than that before treatment, and the VT and serum IL-4 levels were higher than that before treatment. The RR, VT, Ti/Te and serum IFN-γ and IL-4 levels in the observation group were significantly improved than those in the control group (P ＜ 0.05). No serious adverse reactions occurred during the treatment in both groups. Conclusion Erythromycin, Budesonide combined with recombinant human interferon α1b in the treatment of pediatric BO has a significant clinical effect, can significantly improve the clinical symptoms, improve pulmonary function and inflammatory response, and better safety.
2019 Vol. 16 (12): 119-122 [Abstract] ( 203 ) HTML (1 KB)  PDF (450 KB)  ( 93 )
123 Exploration of three ways to cure purpura in Haizangbanluncuiying
GAO Ya XU Shijie▲
This article presents and explores three ways to cure purpura from the perspective of Haizangbanluncuiying, proposing purpura symptoms should be classified as three kinds: not coming out, coming out and coming out on blocking. When purpura doesn′t come out viscera syndrome as cold and warmth alternately, it should be distinguished to treat. When purpura appears, it is better to keep stool unobstructed and detoxicate, then expel the etiology. While purpura diffuses on blocking, it should be treated from the three Yang channels to expel the etiology of the Yang channels. From the three ways to cure purpura symptom, the drug use on the meridian, focus on protecting the spleen and stomach, choosing the proper treating method, prevention and care are presented abundantly. The internal and external simultaneously treating method on purpura extend the treatment thoughts about taking oral medicine as principle, which deeply influences on later generations.
2019 Vol. 16 (12): 123-125 [Abstract] ( 198 ) HTML (1 KB)  PDF (751 KB)  ( 63 )
126 Thingking on the development of traditional Chinese medicine in the future based on the idea of new concept of development
LIU Xiaoxia ZHANG Honglei
New development concept is a significant part of the thought of Xijinping socialism with Chinese characteristics for a new era, and also the theoretical direction and action guide for the development of traditional Chinese medicine. To be guided by the new vision of development is economic and social development, and is the inevitable choice of the fast development of traditional Chinese medicine. Innovation is the soul of TCM development. Green is a prerequisite for the development of traditional Chinese medicine. Coordination is the inherent demand of the development of traditional Chinese medicine. Open is the inevitable path of  the development of traditional Chinese medicine. Sharing is the eventual goal of the development of traditional Chinese medicine.
2019 Vol. 16 (12): 126-129,149 [Abstract] ( 187 ) HTML (1 KB)  PDF (769 KB)  ( 96 )
130 The experience summary of Professor Yu Chenghui in treating renal anemia
LIU Qiong1,2 WANG Xufang1,2 JIANG Yan1,2 CHEN Jihong1,2
Renal anemia is a common complication of end-stage chronic kidney disease. Professor Yu Chenghui considers that deficiency and excess are all throughout this disease. Its basic pathogenesis is deficiency of spleen and kidney, endogenous phlegm, dampness, turbidity and toxicity, bloodstream obstruction, dystrophy of qi and blood. Its location is mainly in the spleen and stomach, which is related to the heart, liver, lung and other viscera. The treatment mainly consists of invigorating kidney, strengthening spleen and nourishing blood, combined with the methods of eliminating dampness and turbidity, promoting blood circulation and removing blood stasis. In the treatment of blood-nourishing, emphasis is laid on promoting blood circulation and cooling blood and nourishing blood. Blood-nourishing and compatible with qi-promoting drugs make the tonic not stagnant. Aiming at the treatment of tonifying blood, it is necessary to give priority to gentle tonic, and Chinese medicine should choose more drugs such as tonifying blood and activating blood circulation, and uses sentient flesh and blood of the goods with caution, so as to avoid excessive nourishment, even if used, the dosage should be small.
2019 Vol. 16 (12): 130-133 [Abstract] ( 152 ) HTML (1 KB)  PDF (792 KB)  ( 135 )
134 Application status of acupuncture and moxibustion in clinical diseases
LI Ruiling1 LI Yijing2 TONG Qiuyu2 LU Xinling1
As a traditional clinical diagnosis and treatment method in China, acupuncture and moxibustion has been increasing and expanding in modern clinical application and mechanism research. A lot of research results have already attracted worldwide attention. This paper will review from the following aspects: the application status of functional magnetic resonance imaging in the study of acupuncture central mechanism, the treatment progress of acupuncture and moxibustion in stroke, uroclepsia, infertility and glaucoma, and the acupuncture anesthesia, hoping that acupuncture and moxibustion can be used more scientifically and rationally.
2019 Vol. 16 (12): 134-137 [Abstract] ( 211 ) HTML (1 KB)  PDF (742 KB)  ( 88 )
138 Application of combining three identification methods in the treatment of liver cancer
XIE Xianglan WU Yu GUO Zhongning▲ SONG Jinjie
Primary hepatocellular carcinoma ("liver cancer" for short) has a high incidence and mortality in China, and is one of the clinical refractory diseases. Although the treatment methods of Western medicine for liver cancer are various, it has not achieved satisfactory results based on the pathological characteristics of liver cancer. In the aspect of traditional Chinese medicine treatment, there are many deficiencies in the treatment of liver cancer with single syndrome differentiation, but in the long-term clinical practice, it has established the clinical thinking mode of disease differentiation - pathogenesis differentiation - syndrome differentiation to explore the traditional Chinese medicine treatment of liver cancer, established the basic pathogenesis and treatment principles of liver cancer, and cited one clinical case to provide more clinical diagnosis and treatment ideas for the treatment of liver cancer, and for the general liver cancer brings good news.
2019 Vol. 16 (12): 138-140 [Abstract] ( 185 ) HTML (1 KB)  PDF (730 KB)  ( 57 )
141 The clinical effects of massage by coordinating Chong and Conception Channels in the treatment of hyperplasia of mammary glands patients with syndrome of stagnation of liver qi and coagulated phlegm
LI Dandan RUAN Di WANG Cheng▲
Objective To evaluate the effects of massage by coordinating Chong and Conception Channels on the symptoms, hormone levels and quality of life in hyperplasia of mammary glands patients with syndrome of stagnation of liver qi and coagulated phlegm. Methods Total 84 hyperplasia of mammary glands patients with syndrome of stagnation of liver qi and coagulated phlegm treated in Traditional Chinese Medicine Hospital of Xinjiang Uygur Autonomous Region from January 2017 to January 2018 were selected and randomly divided into control group (42 cases) and observation group (42 cases) by random number table method. The control group was treated with Rupixiao Capsules. The observation group was treated with Rupixiao Capsules combined with massage by coordinating Chong and Conception Channels, both were treated for 2 courses. The clinical efficacy, visual analogue scale (VAS), TCM syndrome score, hormone level and quality of life were compared between the two groups. Results The total effective rate of the observation group was significantly higher than that of the control group (P ＜ 0.05). After treatment, the TCM syndrome scores, VAS and estradiol (E2) levels of the two groups were significantly lower than those before treatment (P ＜ 0.05), the progesterone levels, the scores of European Organization for Reasearch and Treatment of Cancer (EORTC) quality of life questionnaire (QLQ-C30) of the two groups were significantly lower than those before treatment (P ＜ 0.05). The improvement of the indices above in the observation group was better than that in the control group (P ＜ 0.05). Conclusion The curative effect of massage by coordinating Chong and Conception Channels in the treatment of hyperplasia of mammary glands patients with syndrome of stagnation of liver qi and coagulated phlegm is good, which can significantly increase the symptom scores and hormone levels, relieve pain and improve the quality of life.
2019 Vol. 16 (12): 141-144 [Abstract] ( 149 ) HTML (1 KB)  PDF (791 KB)  ( 115 )
145 Treatment of myasthenia gravis based on the theory of "hidden pathogen"
RAN Weizheng1 YUE Xifeng2 GAO Fang3 LI Nannan3 LIU Jialin4 ZHANG Xinning1 WANG Yao1 CHEN Zhigang3
Myasthenia gravis (MG) is a kind of acquired autoimmune disease with neuromuscular junction transmission disorder, which is always characterized by insidious onset. It is progressive or develops alternately with remission and recurrence, and can be induced or aggravated by infection, fatigue and other factors. Combined with the discussion of related symptoms of MG in the ancient literature and the modern researches, it is believed that hidden pathogen plays an important role in the pathogenesis of MG. Therefore, in the treatment of MG, on the basis of supplementing deficiency, attention should be paid to the differentiation and treatment of hidden pathogen. In the acute stage, reinforcing deficiency shouled be paid equal attention with eliminating pathogenic factors. In the remission stage, gradually reduce eliminating pathogenic factors while increase efforts to reinforcing deficiency. Reinforcing deficiency mainly benefits spleen and kidney, while eliminating pathogens is given different treatment methods according different factors: pathogenic toxin, heat, dampness, phlegm and blood stasis.
2019 Vol. 16 (12): 145-149 [Abstract] ( 189 ) HTML (1 KB)  PDF (799 KB)  ( 85 )
150 Effect and safety of Jiawei Liujunzi Decoction in treating hyperuricemia due to spleen deficiency and dampness obstruction
ZHANG Kaixian WEI Shufeng DONG Xia XU Lei
Objective To investigate the effect of Jiawei Liujunzi Decoction on reducing blood uric acid (UA) level and safety in patients with hyperuricemia. Methods Sixty-four patients with hyperuricemia diagnosed as hyperlipidemia of spleen deficiencyand dampness obstruction syndrome were selected from December 2016 to December 2017 in Beijing Fangshan District Hospital. They were randomly divided into treatment group and control group, with 32 cases in each group. The control group was treated with routine living and dietary guidance. The treatment group was treated with Jiawei Liujunzi Decoction on the basis of the control group. The improvement of traditional Chinese medicine symptoms, UA, alanine aminotransferase (ALT), aspartate aminotransferase (AST), urea nitrogen (BUN) and creatinine (CREA) levels, clinical efficacy and adverse reactions were compared between the two groups before and after treatment. Results After treatment, both groups′ traditional Chinese medicine syndromes scores decreased (P < 0.01), the total score of traditional Chinese medicine syndromes of the treatment group was significantly less than the control group, and the difference was highly statistically significant (P ＜ 0.01); UA level in the treatment group was significantly lower than that before treatment, the difference was highly statistically significant (P ＜ 0.01), and the treatment group was significantly lower than that in the control group, the difference was highly statistically significant (P < 0.01); there was no significant change in ALT, AST, BUN, CREA levels before and after treatment in the two groups (P > 0.05).  The total effective rate of the treatment group was highly significantly higher than that of the control group, and the difference was highly statistically significant (P < 0.01). The incidence of adverse reactions was low in the two groups, and the difference was not statistically significant (P > 0.05). Conclusion The treatment of hyperuricemia with Jiawei Liujunzi Decoction can reduce the UA level, and it is safe. It is worthy of clinical application.
2019 Vol. 16 (12): 150-153 [Abstract] ( 149 ) HTML (1 KB)  PDF (794 KB)  ( 66 )
154 A case report and literature review on misdiagnosis of meningeal carcinomatosis
LI Shuang
Meningeal carcinomatosis is a kind of cancer meningitis caused by invasion of meninges by lung cancer, gastric cancer, breast cancer, colon cancer, prostate cancer, cervical cancer and melanoma, etc. The clinical manifestations are not specific, and there are no abnormal findings in early cranial CT or MRI examinations. The misdiagnosis rate is high. This article reports a case of cerebrospinal fluid cytology (CSF) finding abnormal cells in a patient who was admitted to hospital with dizziness and misdiagnosed as "peripheral vertigo", to enhance clinicians′ vigilance against the disease.
2019 Vol. 16 (12): 154-156 [Abstract] ( 208 ) HTML (1 KB)  PDF (373 KB)  ( 64 )
157 Optimized design of China public health emergency response system
WEI Jingjing1 FANG Xian1 HE Guixiang1 MA Guofang1 WANG Li1 Gulibadan·Kehan1 WANG Yanjie1 WANG Xin1,2
Public health emergency has received more and more attention of the whole society. Due to some defects still existing in our current emergency system, facing the new public health emergencies brings tremendous challenges to our country, the current emergency system is in urgent need of reform and improvement. Thus, this article presents optimizes design of emergency system, mainly including： improving the real-time monitoring system, establishing a unified command center; strengthening personnel training and team system construction; perfection of the material and funds storage; improving information system; deepening the awareness of the crisis of the public and strengthening emergency ability. It aims at providing reference and suggestion for China public health emergency management system, to further improve China public health emergency management system.
2019 Vol. 16 (12): 157-159,168 [Abstract] ( 272 ) HTML (1 KB)  PDF (739 KB)  ( 85 )
160 Empirical study on TCM acceptance behavior based on social cognition theory
HUANG Meiyin GUO Ying TAN Wei
Objective To explore the relationship among science popularization environment,  literacy level, and residents′ use behavior of TCM. Methods The moderation effect of environment on people′s behavior and their literacy level was tested using method put forward by Ping in 1995, and the regional path difference was tested through structural weight of multi-group structural equation models. Results The standardized path coefficients of environmental factors to residents′ behavior and literacy were 0.274 and 0.254, respectively, and the standardized path coefficient of literacy influence on behavior was 0.175 (P < 0.05). Ping test showed that environmental factors have a regulatory effect (P < 0.05). Conclusion Environmental factors should be considered to promote residents′ health management and healthy behavior adoption of TCM.
2019 Vol. 16 (12): 160-164 [Abstract] ( 162 ) HTML (1 KB)  PDF (943 KB)  ( 235 )
165 Screening best combination of features based on adaptive vector machine for detecting sleep apnea syndrome
WANG Xinkang1 LIU Lei2 WANG Lianghong2 FAN Minghui2
There are so much characteristic parameters can be extracted based on adaptive vector machine for detecting sleep apnea syndrome. It has important significance which is selected the characteristic parameters to reduce the amounts of calculation applied in sleep apnea syndrome. This study adopted the electrocardiogram signals from limb guided lead-Ⅱ and then denoised the signal interference and detected the R-wave to get the heart rate variability data and ECG-derived respiratory data. Analysis these two data that we can obtain the twenty-two features in time domain and frequency domain, moreover, using support vector machines algorithm to classify the sleep apnea syndrome feature parameters. Compared the twenty-two features with optimal fifteen feature parameters we proposed, the amounts of calculation are decrease obviously without decay the classification accuracy. It can be used as an extension of clinical long time electrocardiogram detection because it can reduce the dependence on health care professional. Therefore, it has good economy and popularity.
2019 Vol. 16 (12): 165-168 [Abstract] ( 181 ) HTML (1 KB)  PDF (786 KB)  ( 179 )
169 Promoting cultural connotation construction of university clean government innovated by traditional Chinese medicine culture
FU Wendi1 YIN Zhanjun2
The culture of traditional Chinese medicine and the culture of clean government both belong to the category of Chinese traditional culture, which are the representative and important part of Chinese excellent culture. It is necessary to highlight the characteristics of traditional Chinese medicine to innovate cultural connotation construction of clean government in higher institutions of Chinese medicine that is started from carrying forward and inheriting traditional Chinese medicine culture. It makes use of the characteristics of the consistency of the goals of TCM culture and clean government culture, the convergence of principles, the communication of concepts and the correspondence of methods. The theories of "integration of nature and man" "preventive treatment of disease" "virtual of great physician" and "life-paramountcy" and diagnostic treatment techniques such as "three causes and measures" "treatment based on syndrome differentiation" "governing exterior to infer interior", etc are used for reference. We should enrich and develop the methods of work and operation modes of building a clean and honest culture in TCM colleges in the new era, create a clean and honest education environment, and cultivate qualified talents for the party and the country.
2019 Vol. 16 (12): 169-172,封三 [Abstract] ( 186 ) HTML (1 KB)  PDF (806 KB)  ( 126 )
173 Effect of WeChat appointment of venous blood collection in outpatients
CHEN Jing1 MENG Yanming1 WU Yongkang2 CHEN Tao1
Objective To study the application of WeChat appointment venous blood collection service mode in department of laboratory medicine, and evaluate its value. Methods From August 2017 to July 2018, in People′s Hospital of Xindu District, 75 107 patients took venous blood collection were selected, 66 718 cases uesd the way of taking a queue number (950 cases were selected randomliy as control group), 8389 cases used the way of WeChat appointment (950 cases were selected randomliy as experiment group). The cases of venous blood collection and WeChat appointment in each month were counted, proportion of WeChat appointment in different age composition (18-30, >30-40, >40-50, and >50 years old) was analyzed. The blood collection waiting time and medical satisfaction of the two groups were compared. Results The proportion of WeChat appointment for venous blood collection ranged from 1.71% in August 2017 rose to 16.76% in July 2018, and proportion of WeChat appointment in >30-40 years old was yhe highest (25.49%), proportion in >50 years old was the lowest. The patients′ waiting time for blood collection [(4.9±1.8) min] in experiment group was significantly lower than control group [(33.7±17.3) min], the satisfaction rate in experiment group (99.58%) was significantly higher than control group (71.30%), the differences were statistically significant (P < 0.05). Conclusion WeChat appointment blood collection is simple and quick to operate, and it can significantly shorten the waiting time, improve the satisfaction of medical treatment, reduce the occurrence of medical disputes, and effectively save the labor of outpatient nursing staff, improve work efficiency, it is worthy of promotion and application.
2019 Vol. 16 (12): 173-175 [Abstract] ( 160 ) HTML (1 KB)  PDF (711 KB)  ( 67 )
175 Qualitative study on effective teaching behavior of the clinical instructors for postgraduate students of clinical medicine professional degree
SUN Shenghua WANG Xinjun ZHU Yan
Objectiv To make the qualitative research on effective teaching behavior of the clinical instructors for postgraduate students of clinical medicine professional degree. Methods A total of 100 rotating postgraduate students with clinical medicine science (including the various majors of 2015~2018 internal medicine) underwent the standardized training from January 2017 to March 2018 in Department of Endocrinology, the First Affiliated Hospital of Hainan Medical University were selected. They were divided into two groups according to their student number, namely control group （n = 50）and experimental group （n = 50）. The control group was taught by traditional clinical rotation method, while the experimental group was taught by clinical pathway (CP) method for 2 months. The application effect of the two methods was evaluated. Results The comprehensive scores of theoretical examination and skill operation in the test group were significantly higher than control group (P ＜ 0.05); the student′s satisfaction on the teacher′s trust relationship, knowledge instruction, assistance behaviors as failed, professional ethics teaching, experiencing opportunity, academic exploration, professional skills, smooth exchanges, thoughtful medical behaviors and favorable working attitudes in the test group were significantly higher than control group (P ＜ 0.05). Conclusion The CP teaching method for postgraduates of clinical medicine professional degree by clinical instructors can improve the students′ concept of standardized treatment of diseases, and enhance the systematicness and scientificity of teaching.
2019 Vol. 16 (12): 175-178 [Abstract] ( 177 ) HTML (1 KB)  PDF (669 KB)  ( 96 )
179 Clinical analysis of eysenck personality test on patients with mastodynia
LEI Yeyan LI Dongmei BAI Shuang LUO Yingying
Objective To explore the psychological characteristics and states of patients with Mastodynia. Methods The eysenck personality test questionaire (EPQ, adult version) was used to investigate 117 patients with Mastodynia from March 2016 to June 2017 in Zhuhai Hospital, Guangdong Hospital of Traditional Chinese Medicine including the patients′ breast pain time and breast pain level. 58 patients with breast pain grade 3 and above were applied to the test group, and 59 patients with breast pain grade 2 and below were applied to the control group. The difference of pain time, and Eysenck scale (E, N, P, L) in two groups were compared. Results The pain time of the test group was longer than that of the control group (P < 0.05); the score of E in the test group was lower than that of the contorl group (P < 0.01); the score of N in the test group was higher than that of the contorl group (P < 0.05); the score of P and L in these two group were closed (P > 0.05). Conclusion The patients with Mastodynia have the personality characteristics of ivtroversion and instability. The patients with this type of personality characteristics may be related to difficult to alleviate and recurrent breast pain.
2019 Vol. 16 (12): 179-封三 [Abstract] ( 229 ) HTML (1 KB)  PDF (786 KB)  ( 59 )
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