hnRNPA2/B1在恶性肿瘤中的研究进展

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Abstract Heterogeneous nuclear ribonucleoproteins (hnRNPs) are a group of RNA-binding proteins that play a key role in complex and various biological processes such as RNA splicing, mRNA processing, telomere synthesis, modulation of gene expression, translation of mRNAs. Heteregeneous nuclear ribonucleoprotein A2/B1 (hnRNPA2/B1) is a member of this proteins family. hnRNPA2/B1 abundantly and ubiquitously expresses in most human tissues and has various functions. Researches indicate that hnRNPA2/B1 is abnormally expressed in diverse malignant tumors, and it can modulate the expression of genes, promote the abilities of proliferation and migration, inhibit apoptosis and regulate tumor resistance in tumors. It also shows that hnRNPA2/B1 has important clinical value in the diagnosis, treatment and prognosis of malignant tumors. Therefore, this paper reviews the development of hnRNPA2/B1 in diverse cancers, such as lung cancer, breast cancer, pancreatic cancer, liver cancer and so on.

Key words： Heterogeneous nuclear ribonucleoproteins hnRNPA2/B1 Malignant tumor

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	LIU Yawen ZHANG Youli XU Min▲

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LIU Yawen ZHANG Youli XU Min▲. Research progress of hnRNPA2/B1 in malignant tumor[J]. 中国医药导报, 2019, 16(12): 23-26.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2019/V16/I12/23

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