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2019 Vol. 16, No. 9
Published: 2019-03-25
 
 
9 The effect of chitosan oligosaccharide on the level of endoplasmic reticulum stress and inflammatory factors released in adipose tissue of obese mice induced by high-fat diet
YANG Shuo WANG Bin XIA Wenshui
Objective To investigate the effect of chitosan oligosaccharide on the level of endoplasmic reticulum stress and inflammatory factors released in adipose tissue of obese mice induced by high-fat diet. Methods Thirty C57BL/6J mice were divided into normal diet group (Control group), high-fat diet group (HF group) and high-fat diet+chitosan oligosaccharide group (HF+COS group) according to random number table method, with 10 mice in each group. After being fed for 16 weeks, glucose tolerance test and insulin tolerance test were carried out. Serum was collected to detect lipid profiles, mice body weights, perirenal and subcutaneous adipose tissue weights were estimated within groups. In addition, the protein and mRNA expression of endoplasmic reticulum stress markers glucose regulatory protein (GRP-78) and endoplasmic reticulum kinase (PERK) from adipose tissue were assessed. Meanwhile, the changes of nuclear factor-κB (NF-κB) inflammatory pathways in adipose tissue were also detected. Results Compared with the control group, the levels of glucose, lipid, the body weights and the size and weight of perirenal and subcutaneous adipocytes in HF group were significantly increased (P ＜ 0.05 or P < 0.01), the mRNA and protein expression of GRP-78 and PERK were increased significantly (P ＜ 0.05). And the activation states of NF-κB pathway was measured accordingly. Compared with HF group, except for total cholesterol, the mentioned indicators in HF+COS group were significantly decreased (P ＜ 0.05). Conclusion Chitosan oligosaccharide can lower blood lipids, reduce the excessive accumulation of adipose tissue and relieve endoplasmic reticulum stress in mice fed on high-fat diet. Chitosan oligosaccharide inhibits the activation of NF-κB, resulting in the reduced release of inflammatory factors which is likely to contribute to the insulin resistance alleviation.
2019 Vol. 16 (9): 9-14,33 [Abstract] ( 210 ) HTML (1 KB)  PDF (1662 KB)  ( 134 )
15 Expression and significance of IL-35 and IL-17 in intestinal mucosa of rats with ulcerative colitis
ZHAO Junya LI Wei LI Wei SUN Hongyu Li Xin GUAN Jie▲
Objective To investigate the expression level and significance of interleukin-17 (IL-17) and IL-35 in intestinal mucosa of Ulcerative colitis UC rats. Methods Six-five healthy SD male rats were divided into control group (n = 12) and experimental group (n = 53). The blank control group was not treated, and 12 SD rats were randomly selected from the experimental group for the preliminary experiment, the most appropriate dose of TNBS (2, 4, 6-trinitrobenzenesulfonic acid) modeling agent was selected to build UC animal model. Changes in body weight and general conditions (mental status, stool shape, color, etc.) were observed daily and scored according to disease activity level (DAI) since it has been formally modeled. The rest in the control group were sacrificed on day 3, day 7 and day 14, respectively. The remaining rats were formally modeled and divided into group A , group B and group C with 12 rats in each group according to the degree of ulcer (5 rats died accidently). Colonic mucosa damage index (CMDI) was used to score the colon and determine the degree of ulcer. The contents of IL-17 and IL-35 in the intestinal mucosa were detected by ELISA method, and the pathological changes of the colon were evaluated at the same time. The correlation between the levels of IL-17 and IL-35 and the degree of ulcer was obtained. Results Comparison between the experimental group and the blank group, DAI score and CMDI score were increased, and the pathological changes of colon tissue in the experimental group were significant under the microscope (P ＜ 0.05). The level of IL-17 in the intestinal mucosa of rats in each group increased significantly with the aggravation of the ulcer, and the level of IL-35 decreased significantly, with statistically significant differences (P ＜ 0.05). Conclusion During the development of ulcerative colitis, cytokines play an important role as mediators of inflammation. The content of IL-17 is positively correlated with the inflammatory response and may promote the occurrence of inflammatory response, while the content of IL-35 is negatively correlated with the degree of inflammation, and may be involved in inhibiting the occurrence and development of inflammatory response.
2019 Vol. 16 (9): 15-18 [Abstract] ( 234 ) HTML (1 KB)  PDF (571 KB)  ( 98 )
19 The effect of Genistein on the CREB gene expression in rat ovarian granulosa cells
WEN Haixia1 XIAO Xiaohui2 MENG Yi3 CHENG Danling4
Objective To investigate the effects of Genistein on the gene expression of cAMP response element binding protein (CREB) in the rats ovarian granulosa cells and the relationship with the estrogen receptor (ER). Methods The ovarian granulosa cells from female rat were isolated and collected, incubated and treated with Genistein (0.1, 1, 5, 10, 100 μmol/L) and ER blocker ICI182, 780 (1 μmol/L) for 24 h. Then the CREB mRNA expression level was assessed by RT-PCR. Results Compared with the control group, the expression of CREB mRNA of 1, 5 and 10 μmol/L Genistein group was higher (P ＜ 0.05 or P ＜ 0.01). After the cells pretreated with ER blocker ICI182, 780 for 30 min, 1, 10 mol/L Genistein added and pretreated 24 h group, the expression of CREB mRNA had no significant difference compared with the 1, 10 μmol/L Genistein group (P ＞ 0.05). Conclusion 1-10 μmol/L Genistein could up-regulate the expression of CREB gene in the rats ovarian granulosa cells. The molecular mechanism of Genistein effect on the CREB gene expression may not be mediated by ER.
2019 Vol. 16 (9): 19-21 [Abstract] ( 211 ) HTML (1 KB)  PDF (567 KB)  ( 149 )
22 Effect of Paclitaxel on autophagy of human nasopharyngeal carcinoma cells in vitro
SHI Xiaojing ZHENG Mingfen WAN Renqiang ZHANG Shenhua
Objective To investigate the effect of Paclitaxel on autophagy in human nasopharyngeal carcinoma cells in vitro. Methods Human nasopharyngeal carcinoma cell line CNE2 was cultured in vitro. The proliferation inhibition of Paclitaxel on human nasopharyngeal carcinoma cell line CEN2 was detected by MTT assay. The effect of Paclitaxel on CEN2 cell apoptosis was analyzed. The cell cycle changes and radiosensitization of Paclitaxel on CNE2 cell were observed and analyzed. Results After 12 h of treatment, the proportion of surviving cells was significantly lower than that of the control group (P < 0.05); after 48 h of treatment, the proportion of surviving cells was significantly lower than that of other groups (P < 0.05); after 24 h of treatment, the proportion of early apoptotic cells was the highest, significantly higher than that of other groups (P < 0.05); after 48 h of treatment, the proportion of cell necrosis and late apoptotic cells was the highest, significantly higher than that of other groups (P < 0.05). In the whole cell cycle, the proportion of G0/G1 cycle in blank control group was the highest, and significantly higher than that in other groups (P < 0.05); the proportion of G2/M cycle in paclitaxel group was the highest, and significantly higher than that in other groups (P < 0.05); there was no significant difference in the proportion of G0/G1, G2/M and S cycle in radiotherapy group (P > 0.05); and the proportion of G2/M cycle in paclitaxel + radiotherapy group was the highest (P <0.05). The apoptotic rate of paclitaxel + radiotherapy group was significantly higher than that of other groups (P < 0.05). Conclusion Paclitaxel has obvious toxic effects on human nasopharyngeal carcinoma CNE2 cells, which can inhibit the division of human nasopharyngeal carcinoma CNE2 cells, and can treat nasopharyngeal carcinoma to some extent. As the concentration of paclitaxel increases, its apoptosis effect on CNE2 cells is stronger. Paclitaxel combined with radiotherapy can further increase the apoptosis rate of CNE2 cells.
2019 Vol. 16 (9): 22-25 [Abstract] ( 206 ) HTML (1 KB)  PDF (589 KB)  ( 66 )
26 Research progress of long nong-coding RNA-LET in cancers
LIU Yuanshi XU Ximing CHEN Xin WU Long
Tumor low expression of lnRNA (lncRNA-LET) is located in 15q24.1 of 4 bands of 2 region of long arm of chromosome 15, which can inhibit the occurrence, development, metastasis and apoptosis of tumors. It has been proved that lncRNA-LET exists in various tumors and its expression is down-regulated. At present, it is believed that lncRNA-LET plays a role as a competing endogenous RNA (ceRNA) by competing with microRNAs （miRNAs）and acts as a "molecular sponge" of this group of miRNAs. LncRNA-LET is a hotspot of current research, which is expected to become a new marker for diagnosis and prognosis of tumors and a potential therapeutic target. This paper reviews the recent phase studies on the role of lncRNA-LET in tumors, with a view to providing reference for further research on ncRNA-LET and tumors.
2019 Vol. 16 (9): 26-29,42 [Abstract] ( 236 ) HTML (1 KB)  PDF (691 KB)  ( 91 )
30 Progress in different types of osteonecrosis of microRNA
ZHAO Jun1 ZHANG Xiaofeng2 XU Xilin2 WANG Zhengchun1 JIAO Jianfei3 FANG Xiangchun1 HE Xuefeng1 JIA Xunyuan4
In recent years, microRNA (miRNA) has been deeply studied in the study of the mechanism of femoral head necrosis. Femoral head necrosis is a common orthopedic disease, and miRNA plays an important role in femoral head necrosis caused by different causes. This article reviews the research progress of different types of miRNAs related to femoral head necrosis, and summarizes and prospects its application.
2019 Vol. 16 (9): 30-33 [Abstract] ( 257 ) HTML (1 KB)  PDF (668 KB)  ( 145 )
34 Advances in nano-delivery systems targeting hepatic stellate cells for hepatic fibrosis
JIN Wenzhen1 TAN Xiaochuan1 WEN Jin2 SONG Hui1 ZHANG Yujia1 ZHENG Wensheng1
Hepatic fibrosis, a chronic disease, proposes a serious threat to human health. The low efficiency and occurrence of side effects are often contributed by the lack of liver specificity. In order to improve the therapeutic effect of liver fibrosis，research about the use of nanocarriers to achieve targeted delivery has become more and more extensive. This review summarizes the nano-delivery carriers targeting hepatic stellate cells that have been applied in the treatment of liver fibrosis in recent years from the type of carriers and target receptors，which offer a new idea to treat liver fibrosis and serve as the basis of designing safe and effective drug delivery systems for liber fibrosis.
2019 Vol. 16 (9): 34-37 [Abstract] ( 284 ) HTML (1 KB)  PDF (664 KB)  ( 126 )
38 Research progress about the relationship between microglial cells and ischemic-hypoxic brain injury
LIU Bo1 WANG Jialin1 CHEN Shilin2 SHI Jingwen1 LEI Bin1 WANG Yifan1 LI Hongpei1
Microglia cells is the main immune cells in the central nervous system, which induced inflammatory response plays an important role in ischemic-hypoxic brain injury. Ischemic stroke is a common type of cerebrovascular disease, and the existing treatment methods cannot achieve satisfactory clinical efficacy. Therefore, the study on the mechanism of action of microglia cells is of great significance for the treatment of ischemic stroke. In this paper, recent studies on microglia activation and its effect on ischemic and hypoxic brain injury and related drug therapy at home and abroad were reviewed, providing new ideas for the treatment of ischemic stroke.
2019 Vol. 16 (9): 38-42 [Abstract] ( 227 ) HTML (1 KB)  PDF (708 KB)  ( 125 )
43 Research progress on mechanism of Chinese and Western medicine and related drugs for myocardial ischemia reperfusion injury
JIANG Tongwei1 HAO Zhenzhu2 WANG Bingmei3 GUO Huiwen2 PIAO Xinghu2 CHENG Qi2
Myocardium may have metabolic dysfunction due to relative or absolute ischemia, which may lead to functional or structural damage in severe cases. Under certain conditions, restoring myocardial blood reperfusion is an effective treatment, but reperfusion can cause new myocardial injury, namely myocardial ischemia reperfusion injury (MIRI). How to treat and prevent MIRI has become a major issue in cardiovascular diseases. This article will summarize the previous literature, and elaborate the related mechanism of MIRI and the progress of drug treatment.
2019 Vol. 16 (9): 43-46,51 [Abstract] ( 308 ) HTML (1 KB)  PDF (724 KB)  ( 99 )
47 The understanding of aging in traditional Chinese medicine and its research progress
XIANG Minhong1 WEN Hang1 ZHAO Yanqing1 MIAO Wanhong2▲
Aging is a complex natural phenomenon. There are different opinions on its pathogenesis, the representative theories have free radical theory, mitochondrial DNA damage theory, telomere theory, signaling pathway theory and so on. The aging begins with the five viscera organs, which affect the six fu organs. Deficiency of the five viscera organs is the root of aging. Kidney deficiency, spleen deficiency, heart deficiency, liver deficiency and lung deficiency all lead to aging. As the population ages, anti-aging has become a hot topic in medical research. All kinds of single Chinese medicinal herbs can not only play alone, but also play a synergistic role in anti-aging effect. Based on the understanding of aging in modern theory and traditional Chinese medicine, this article discusses the research progress of traditional Chinese medicine in the prevention and treatment of aging, in order to guide clinical practice.
2019 Vol. 16 (9): 47-51 [Abstract] ( 190 ) HTML (1 KB)  PDF (673 KB)  ( 89 )
52 Research progress of the influence of synaptic plasticity on Alzheimer′s disease
TAN Xue1 GAO Li2 REN Jia2 MAO Lejing1 YAN Ming2
Synaptic plasticity, the process of forming memories through long-term changes in synaptic efficacy, is the basis for encoding and storing information in learning and memory. The most important difference between human brain and animals is that human brain can store a large amount of information, so it has good emotional cognition and learning and memory ability. One of the most important clinical manifestations of Alzheimer′s disease (AD) is affective cognitive dysfunction and learning and memory dysfunction. As a unique and basic existence in the nervous system, synapse is the structural basis for the nervous system to play its physiological function. A large number of studies have shown that synaptic dysfunction plays an important role in AD studies, and cognitive dysfunction is significantly related to the degree of synaptic density decline. In this paper, the effects of LTP, synaptic proteins and neurotransmitters on AD are briefly reviewed in order to provide a reference for the pathogenesis of AD.
2019 Vol. 16 (9): 52-55 [Abstract] ( 203 ) HTML (1 KB)  PDF (660 KB)  ( 102 )
56 Research progress of miR-200c in thyroid cancer
ZHANG Yan WU Chenguang
miRNA is a kind of endogenous, non-coding small molecule RNA, which is highly conserved and related to the occurrence and development of various human tumors including thyroid cancer. Compared with differentiated thyroid cancer, the prognosis of undifferentiated thyroid cancer is worse, which may be associated with a higher proportion of cancer stem cells. miR-200c, as a novel tumor suppressor, can inhibit the proliferation of thyroid cancer cells and promote their apoptosis. Moreover, miR-200c can modulate epithelial-mesenchymal transition through transforming growth factor-β (TGF-β) pathway and epidermal growth factor receptor (EGFR) pathway. Recent researches have found that epithelial-mesenchymal transition induces the formation of cancer stem cell. Hence, miR-200c may serve as a potential molecular target for biological treatment of refractory thyroid cancer. The research progress in the relationship between miR-200c and thyroid cancer is reviewed in this paper.
2019 Vol. 16 (9): 56-58,63 [Abstract] ( 197 ) HTML (1 KB)  PDF (683 KB)  ( 81 )
59 Phytochemical progress on a Mongolian folk medicine named Syringa pinnatifolia Hemsl
SUN Yuhui ZHANG Ye XUE Peifeng
Aloes of Mongolian medicine mountain belongs to Oleaceae, Syringa pinnatifolia Hemsl. which is used to treat angina， headache and dizziness， insomnia， dreaminess， palpitation and asthma, etc. Syringa pinnatifolia Hemsl chemical composition and biological activity have been the focus of domestic research in recent years. It is found that the main components of Syringa pinnatifolia Hemsl are volatile oil and lignin， which are difficult to isolate. Therefore， the chemical components of Syringa pinnatifolia Hemsl have not been studied deeply， and the pharmacodynamic substance basis of agarwood has not been fully explained. This review summarizes the phytochemical， extraction method and pharmacological research progress， and its future development trend is prospected.
2019 Vol. 16 (9): 59-63 [Abstract] ( 204 ) HTML (1 KB)  PDF (679 KB)  ( 86 )
64 Study of vitamin A and E nutrition of Chinese northern pregnant women in 2016
LI Hao NI Junjun ZHENG Chunmei▲
Objective To investigate the levels of vitamin A and E and evaluate the nutritional status of Chinese northern pregnant women, in order to provide the evidence of vitamin complement and diet for the pregnant women. Methods A survey of vitamin A and vitamin E of pregnant women was performed in maternity hospital (at or above municipal level) in six provinces, including Hebei, He′nan, Heilongjiang, Shanxi, Shaanxi and Tianjin from January to December 2016. The levels of serum vitamin A (21 932 cases) and E (20 243 cases) were measured by high performance liquid chromatography. Results ①In 2016, the average level of vitamin A in pregnant women in northern of China was (0.43±0.10) mg/L, with the deficiency and marginal deficiency as the main manifestations, and the detection rate was 7.3%. Tianjin had the highest proportion of deficiency and marginal deficiency (17.3%), followed by Heilongjiang (12.9%), Hebei (6.1%), He′nan (4.5%) and Shanxi (4.1%). Shaanxi had the lowest detection rate (3.1%). For the pregnant women older than 35 years, the detection rate of vitamin A deficiency and marginal deficiency (6.4%) was lower than pregnant women under 35 years of age (7.4%). ②The average level of vitamin E in pregnant women in northern China was (12.90±4.18) mg/L, with overdose as the main manifestation, the overdose detection rate was 6.2%. Among them, Tianjin has the highest detection rate (25.2%), followed by He′nan (5.3%), Shaanxi (4.3%), Shanxi (1.8%) and Heilongjiang (1.6%), and Hebei had the lowest detection rate (0.4%). The detection rate of vitamin E overdose in pregnant ≥35 years old (10.3%) was higher than that pregnant women ＜35 years old (5.7%). Vitamin E deficiency in pregnant women is rare. The differences in the detection rates of vitamin A and vitamin E in different regions and ages were statistically significant (P ＜ 0.05). Conclusion In 2016, the levels of vitamin A and vitamin E in the serum of pregnant women in northern China show significant differences between different provinces in northern China and between different ages. Vitamin A deficiency and vitamin E overdose are common in pregnant women.
2019 Vol. 16 (9): 64-67,82 [Abstract] ( 205 ) HTML (1 KB)  PDF (720 KB)  ( 85 )
68 Status and trend of the desirable caring patterns for elderly of different generation in Chengdu City
PU Hongshan LI Siyuan
Objective To investigate the choice of old-age support of different age groups in Chengdu City and analyze the trend of choice of old-age support. Methods From November 2016 to April 2017, an on-the-spot questionnaire survey was conducted among 25-year-olds and above in 8 districts in Chengdu City. The questionnaire included general information, pension burden, family pension resources, the choice of old-age support, etc, which was used to know the choice of old-age support of different age groups and analyze the trend of choice of old-age support. Results Eight hundred and seventy-four people were surveyed, 441 males and 425 females; the subjects were divided into youth (25-44 years old), middle-aged (＞44-59 years old), and elderly (＞59 years old) by age. The choice of old-age support was, youth: 131 cases (51.8%) self care, 74 cases (29.2%) home care, 23 cases (9.1%) community care, 25 cases (9.9%) institutional care; middle-aged: 87 cases (34.9%) self care, 110 cases (44.2%) home care, 22 cases (8.8%) community care, 30 cases (12.0%) institutional care; elderly: 130 cases (36.6%) self care, 176 cases (49.6%) home care, 22 cases (6.2%) community care, 27 cases (7.6%) institutional care, there were statistically significant differences among different age groups' choice of old-age support (P ＜ 0.05). Conclusion Home care have gradually declined among the elderly, middle-aged and youth, while self care has risen and the proportion is not low. In different age groups, few people choose institutional care and community care. The awareness of old-age services is generally low.
2019 Vol. 16 (9): 68-71 [Abstract] ( 190 ) HTML (1 KB)  PDF (400 KB)  ( 89 )
72 Changes of serum indicators levels in patients with urinary obstructive sepsis and its significance
SHEN Longjiang ZUO Meiling CHEN Tao HUANG He PENG Hongliang QIAN Xiaohui
Objective To investigate the changes of white blood count (WBC), lactic acid (Lac), platelet count (PLT) and arterial oxygen pressure (PaO2) in patients with urinary obstructive sepsis and its significance. Methods From January 2017 to June 2018, 68 patients with urinary obstructive sepsis (observation group) in the Fourth Hospital of Changsha were selected as the observation group, and 70 cases of urinary tract infection were selected as control group, the levels of WBC, Lac, PLT and PaO2 were detected, the prognosis was evaluated by chronic health evaluation Ⅱ (APACH Ⅱ). Results The WBC, Lac in the observation group at 6 h in the onset of disease were significantly higher than those in the control group (P < 0.05), while PLT and PaO2 were significantly lower than those of the control group (P < 0.05); the WBC, Lac in the observation group at 24 h in the onset of disease were significantly higher than those in 6 h and 12 h (P < 0.05); the PLT, PaO2 in the observation group at 12 h in the onset of disease were significantly lower than that in 6 h and 24 h (P < 0.05). There were positive correlations between WBC and acute physiological and APACH Ⅱ in the onset of 6 h (r = 0.422, P < 0.05), and PLT, PaO2 were negatively correlated with APACH II (r = -0.341, -0.336, P < 0.05). Conclusion The levels of WBC, Lac in patients with urinary obstructive sepsis are elevated, while the levels of PLT and PaO2 are decreased, and the levels of WBC, PLT and PaO2 are related to the severity of the patients.
2019 Vol. 16 (9): 72-74 [Abstract] ( 187 ) HTML (1 KB)  PDF (341 KB)  ( 92 )
75 Clinical effect of combined internal fixation system with bridge in the treatment of nonunion of 1/4 fracture of humerus
ZHOU Jingyuan Suo nan ang xiu
Objective To analyze and discuss the clinical effect of the application of the bridge combined internal fixation system in the treatment of 1/4 fracture nonunion in the lower shaft of humerus. Methods Retrospective analysis was performed on the clinical data of 112 cases of fracture nonunion of the lower 1/4 of humerus from January 2009 to January 2015 in the Fourth Ward of Department of Orthopedics, Qinghai Provincial People′s Hospital. They were divided into control group and observation group with 56 cases in each group. A totol of 56 patients in the control group were treated with traditional single locking compression plate, and 56 patients in the observation group were treated with the bridge combined internal fixation system. The quality of life scores, elbow function scores (Constant-Murley) and recent complications of the two groups were compared before and after treatment. Results The observation group had significantly higher scores of daily life, social activities, depression, irritability, total quality of life and constant-murley after treatment than the control group (P ＜ 0.05). Infection and vascular and nerve injury were effectively controlled in the two groups at 1, 3 and 6 months after surgery, and the incidence of recent complications was not statistically significant (P ＞ 0.05). Conclusion The application of the bridge combined internal fixation system in the treatment of the nonunion of 1/4 fracture of the lower shaft of the humerus can effectively improve the quality of life of the patients, the joint function rehabilitation is good, the incidence of postoperative complications such as infection, vascular and nerve injury is low, and the clinical effect is significant.
2019 Vol. 16 (9): 75-78 [Abstract] ( 260 ) HTML (1 KB)  PDF (458 KB)  ( 62 )
79 Analysis of the influencing factors of proximal femoral anti-rotation intramedullary nail in the treatment of intertrochanteric fracture in senile patients with recessive blood loss
RAO Haijun ZHU Zhiqi LIN Xueyang
Objective To investigate and analyze the influencing factors of proximal femoral anti-rotation intramedullary nail (PFNA) in the treatment of senile intertrochanteric fracture (FIF). Methods Retrospective analysis was performed on 80 elderly FIF patients admitted to Shenzhen Longgang District People′s Hospital from August 2013 to February 2018, All patients were given PFNA operative treatment, and data of the patients were statistically recorded. The patients were followed up for 6 months to analyze the efficacy of the patients and the single and influential factors of PFNA in the treatment of FIF occult blood loss. Results After PFNA treatment, the total effective rate of 80 patients was 98.75%. Recessive blood loss was higher in patients aged≥70 years, with basic diseases and unstable fractures than in patients aged ＜70 years, without basic diseases and stable fractures, respectively (P ＜ 0.05). According to the Logistic regression analysis, the influencing factors of PFNA in the treatment of FIF occult blood loss include age≥70 years old, basic diseases, and unstable fractures (P < 0.01). Conclusion The therapeutic effect of PFNA on the treatment of elderly FIF patients is relatively good, and the main influencing factors for the occurrence of recessive blood loss are age≥70 years old, underlying diseases, and unstable fractures. Clinically, intervention measures can be taken for the above factors to help patients obtain a better prognosis.
2019 Vol. 16 (9): 79-82 [Abstract] ( 474 ) HTML (1 KB)  PDF (461 KB)  ( 92 )
83 Application effect of 3D printing technique in the treatment of distal humeral fractures in adults
MA Junchang CHEN Jin SONG Zhihui CHEN Si YUAN Jianbing
Objective To investigate the effect of 3D printing in the treatment of distal humeral fractures in adults. Methods Sixty cases of distal humeral fractures admitted to Dongguan Kanghua Hospital from March 2014 to March 2017 were selected. According to the random number table method, they were divided into experimental group (n = 30) and control group (n = 30). The control group received conventional surgical treatment, while the experimental group made fracture site models through 3D printing technology and received personalized surgical treatment. Patients in both groups were followed up for 3 months, and the levels of various surgical indicators, elbow function (Cassebaum) score and activity, and postoperative complications were compared between the two groups. Results The operative time and fracture healing time of the experimental group were shorter than those in the control group, and the intraoperative blood loss was less than that in the control group (all P ＜ 0.01). The excellent and good rate of Cassebaum score in the experimental group was higher than that in the control group (all P ＜ 0.01). The activities of postoperative elbow rotation, postrotation, flexion and dorsiflexion in the experimental group were higher than those in the control group (all P ＜ 0.05). In the experimental group, there were no complications such as bone nonunion, fracture malunion and internal fixation deformity, while in the control group, there was one case of postoperative deformity of internal fixation, resulting in fracture malunion. Conclusion The application of 3D printing technology in the treatment of adult distal humerus fracture has obvious effect, which is conducive to the early postoperative recovery of patients, and can significantly improve the elbow joint function and range of motion, and reduce the risk of postoperative complications. It is safe and worthy of clinical application.
2019 Vol. 16 (9): 83-85,101 [Abstract] ( 404 ) HTML (1 KB)  PDF (808 KB)  ( 61 )
86 The expression and clinical significance of hypoxia-inducible factor-1α and glucose transporter-1 in cervical carcinoma tissues
ZHANG Jie1 JIN Hua1 Gulimire·Buranjiang1 LI Xiaowen1 YAO Liyan2
Objective To explore the expression and clinical significance of hypoxia-inducible factor-1α (HIF-1α) and glucose transporter-1 (Glut-1) in cervical carcinoma tissues. Methods From January 2015 to December 2017, the Third School of Clinical Medicine, Xinjiang Medical University, paraffin sections of cervical resection samples were randomly selected. The HIF-1α and Glut-1 expression of 87 cases of cervical carcinoma tissues (cervical carcinoma group), 75 cases of cervical intraepithelial neoplasia tissues (cervical intraepithelial neoplasia group) and 69 cases of cervical epithetium tissues (cervical epithetium group) was detected by immunohistochemical method, the relationship between the expression and the clinicopathological data was analyzed. Spearman test was used to analyze the correlation between the two proteins in cervical cancer tissues. Results The positive rate of HIF-1α in cervical carcinoma group (79.01%, 69/87) was significantly higher than that in cervical intraepithelial neoplasia group (13.33%, 10/75) and cervical epithetium group (5.80%, 4/69) (P < 0.01); the positive rate of Glut-1 in cervical carcinoma group (66.67%, 58/87) was significantly higher than that in cervical intraepithelial neoplasia group (24.00%, 18/75) (P < 0.01) and cervical epithetium group (20.29%, 14/69) (P < 0.01); the expression of HIF-1α was positively related with Glut-1 (r = 0.644, P < 0.05), and their expression was related with myometrial infiltration depth, lymph node metastasis and FIGO date (P < 0.05), but they were not related with age, cancer size, histological grades and tumor pathological types (P > 0.05). Conclusion The expression of HIF-1 and Glut-1 increased significantly in cervical carcinoma tissues, which is the potential biomarker of cervical cancer diagnosis and disease progression indication.
2019 Vol. 16 (9): 86-89 [Abstract] ( 245 ) HTML (1 KB)  PDF (529 KB)  ( 111 )
90 Effect of glutathione combined with adenosylmethionine butadiesulfonic acid in the treatment of intrahepatic cholestasis of pregnancy
PAN Juerong1 MENG Wenxia2 YE Yunfei1
Objective To study the effect of glutathione combined with adenosylmethionine butadiesulfonic acid (ABC) in the treatment of intrahepatic cholestasis of pregnancy (ICP). Methods From February 2016 to February 2018, in Liuzhou General Hospital, 80 patients with ICP were selected, they were divided into study group (40 cases) and control group (40 cases) according to the random number table method. The control group was treated with ursodeoxycholic acid, the study group was treated with glutathione combined with ABC. The clinical efficacy and the change of liver function index [aspartate aminotransferase (AST), bile acid (TBA), alanine transaminase (ALT)] and serum interleukin-18 (IL-18), tumor necrosis factor-α (TNF-α) were analyzed, and adverse pregnancy outcome of the two groups before and after treatment was recorded. Results The total effective rate of the study group was higher than the control group (P < 0.05). The levels of AST, TBA and ALT in the two groups were lower than before the treatment (P < 0.05), and the study group was lower than the control group (P < 0.05). The serum levels of IL-18 and TNF-α in the two groups were lower than those before treatment (P < 0.05), and the study group was lower than the control group (P < 0.05). The incidence of amniotic fluid contamination and fetal distress in the study group were lower than those in the control group (P < 0.05). Conclusion Glutathione combined with ABC in the treatment of ICP has a significant effect，it is helpful to reducing liver function damage, and reducing the incidence of adverse pregnancy outcome. It is worthy of clinical application.
2019 Vol. 16 (9): 90-93 [Abstract] ( 227 ) HTML (1 KB)  PDF (559 KB)  ( 68 )
94 Clinical effect of alveolar lavage with fiberoptic bronchoscope for severe neonatal pneumonia
DING Wujun1 YAO Xiaoyan2 YANG Rongwei1
Objective To investigate the clinical effect of bronchoalveolar lavage (BAL) in the treatment of neonatal severe pneumonia. Methods From November 2015 to January 2017, in Jiaxing Maternal and Child Health Hospital, 80 children with severe pneumonia neonates were selected, according to whether or not BAL treatment, they were divided into observation group (40 cases) and control group (40 cases). Both groups were given basic treatment measures such as anti-inflammation, oxygen inhalation, and immunity enhancement, the observation group was treated with BAL at the same time. The clinical symptom remission time, serum interleukin-2 (IL-2), interleukin-6 (IL-6), and interleukin-10 (IL-10),  arterial oxygen partial pressure (PaO2), arterial carbon dioxide partial pressure (PaCO2), blood lactate levels before and after treatment and clinical efficacy were compared between the two groups. Results The disappearance of cyanosis, dyspnea remission time, heart rate recovery time, disappearance of pulmonary rales and hospital stay in ICU in the observation group were significantly shorter than in the control group, the differences were statistically significant (P < 0.05). Before treatment, the levels of serum IL-2, IL-6 and IL-10 were compared, the differences were not statistically significant (P > 0.05); after treatment, the levels of serum IL-6 and IL-10 in the observation group were lower than the control group, the level of IL-2 was higher than the control group, the differences were statistically significant (P < 0.05). Before treatment, the levels of PaO2, PaCO2, and blood lactic acid in the two groups were compared, the differences were not statistically significant (P > 0.05); after treatment, the levels of PaCO2, lactic acid in the observation group were lower than the control group, and the level of PaO2 was higher than the control group, the differences were statistically significant (P < 0.05). After 7 days of treatment, the clinical efficacy of the observation group was better than the control group, the difference was statistically significant (P < 0.05). Conclusion BAL combined with basic treatment has a more significant therapeutic effect on neonatal severe pneumonia.
2019 Vol. 16 (9): 94-97 [Abstract] ( 278 ) HTML (1 KB)  PDF (528 KB)  ( 103 )
98 Effect of endometrial polyp on infertility patients
WANG Yu1 ZHANG Shaojing2 ZHANG Shaodi3 TAN Lixia1
Objective To investigate the effect of endometrial polyp on the pregnancy status of infertility patients. Methods From July 2016 to July 2018, in Shijiazhuang First Hospital, 340 infertility patients were selected, among them 140 failed to assist in pregnancy (group A) and 200 without assist pregnancy (group B). In group A, there were 69 cases with endometrial polyp, 71 cases without endometrial polyp; in group B, there were 98 cases with endometrial polyp, 102 cases without endometrial polyp. The incidence of endometrial polyp in different ages, different maternal history, and infertility years were observed, the clinical pregnancy rate of patients in two groups were further analyzed. Results There were significant differences in the incidence of endometrial polyp of patients in different ages, different maternal history and infertility (P < 0.05); in group A, the pregnancy success rate of endometrial polyp excision was significantly higher than that without endometrial polyp, the difference was statistically significant (P < 0.05); in group B, the pregnancy success rate of endometrial polypectomy was slightly higher than without endometrial polyp, but the difference was not statistically significant (P > 0.05). Conclusion Endometrial polyp is important factor leading to infertility in patients, it may affect the pregnancy and reduce the pregnancy rate. therefore, for patients with infertility, hysteroscopy should be performed in the early stage, once endometrial polyp is found, they should be timely removal to improve the patients′ clinical pregnancy success rate.
2019 Vol. 16 (9): 98-101 [Abstract] ( 192 ) HTML (1 KB)  PDF (526 KB)  ( 90 )
102 Meta analysis of compound trabeculectomy and traditional trabeculectomy in the treatment of primary angle-closure glaucoma
JIANG Pengfei1,2 LI Xiang1,2 PENG Qinghua1,2,3
Objective To evaluate the efficacy of compound trabeculectomy and traditional trabeculectomy in the treatment of primary angle-closure glaucoma by Meta analysis. Methods According to the method of Cochrane systematic review, the databases of Cochrane library, PubMed, Embase, CBM, CNKI, VIP, Wanfang were retrieved by computer. The retrieval time limit was from January 2013 to January 2017. The randomized controlled trials of compound trabeculectomy (experimental group) and traditional trabeculectomy (control group) in the treamtent of primary angle-closure glaucoma in recent years were included in this study. RevMan 5.0 software was used to take data extraction and Meta analysis. Results A total of 7 RCTs were included, all of which were Chinese. Follow-up was mentioned, ranging from six months to one year. The control effects of intraocular pressure after operation for two months and one year in the experimental group were all better than those of control group, the differences were statistically significant [MD = -2.79, 95%CI (-3.42, -2.16), P ＜ 0.000 01; MD = -3.85, 95%CI (-4.85, -2.85), P ＜ 0.000 01]. There was no significant difference in the filtration bleb after operation between the two groups [RR = 1.10, 95%CI (0.78, 1.55), P = 0.58]. The incidence of complications in the experimental group was lower than that of control group, the difference was statistically significant [RR = 0.45, 95%CI (0.24, 0.84), P = 0.01]. Conclusion The long-term control of intraocular pressure after compound trabeculectomy is superior to the traditional trabeculectomy and the incidence of complications is lower than the traditional trabeculectomy.
2019 Vol. 16 (9): 102-105,113 [Abstract] ( 284 ) HTML (1 KB)  PDF (1073 KB)  ( 97 )
106 Study on the relationship between HMW-ADP, TNF-α, VEGF and diabetic retinopathy
YAN Pei1 ZHANG Xiaohong1▲ ZHANG Li1 LI Jin2
Objective To observe the relationship between high molecular weight adiponectin (HMW-ADP), tumor necrosis factor (TNF) -α, vascular endothelial growth factor (VEGF) and diabetic retinopathy (DR). Methods Data of 150 patients with type 2 diabetes who visited the Outpatient Department of Hebei Geriatric Hospital from January 2013 to January 2016 were selected, they were divided into simple diabetes mellitus group (NDR group, 50 cases), proliferative retinopathy group (PDR group, 50 cases) and non-proliferative retinopathy group (NPDR group, 50 cases) according to the condition. Meanwhile, 50 healthy subjects were selected as the control group. One-way variance and multivariate Logistic regression were used to analyze the influence of HMW-ADP, VEGF, TNF-α and related factors on PDR and NPDR, and Pearson correlation method was used to analyze the relationship between the three factors and DR. Results Logistic regression analysis showed that duration, age, VEGF and TNF-α were risk factors for PDR patients, and the differences were statistically significant (P ＜ 0.05); HMW-ADP and high-density lipoprotein cholesterol were protective factors for PDR patients (P ＜ 0.05). HMW-ADP in DR patients was negatively correlated with VEGF and TNF-α levels (r = -0.813, -0.325，all P ＜ 0.05). Conclusion The levels of VEGF and TNF-α in DR patients are relatively high, while HMW-ADP is low and negatively correlated with VEGF and TNF-α. The three factors have a great impact on the occurrence and development of DR.
2019 Vol. 16 (9): 106-109 [Abstract] ( 260 ) HTML (1 KB)  PDF (569 KB)  ( 74 )
110 Clinical effect of Minocycline Hydrochloride in the treatment of periodontitis
WANG Bin1 LYU Jin1▲ KONG Min1 TANG Xiaolin2
Objective To explore the clinical effect of Minocycline Hydrochloride in the treatment of periodontitis. Methods Eighty-eight patients with periodontitis admitted to Department of Stomatology, Chengdu First People′s Hospital from January 2016 to January 2018 were selected, they were divided into study group(47 teeth) and control group(51 teeth) by using hidden digit randomized method, with 44 cases in each group. The two groups were treated with basic treatment, the study group received Minocycline Hydrochloride treatment, the control group received Iodine Glycerol treatment, the therapeutic effects, probing depth (PD), plaque index (PLI), periodontal attachment level (AL), gingival sulcus bleeding index (SBI) and adverse reactions of the two groups were compared. Results Before treatment, there was no significant difference in the levels of PD, PLI, AL and SBI between the two groups (P ＞ 0.05), 2 or 4 weeks after treatment, the levels of PD, PLI, AL and SBI in the study group were lower than those in the control group, the differences were statistically significant (P ＜ 0.05); there were statistically significant differences in the levels of PD, PLI, AL and SBI between the two groups before and after 2, 4 weeks of treatment (P ＜ 0.05). The excellent and good rate in the study group was higher than that in the control group, the incidence of adverse reactions of the study group was lower than that of the control group, the differences were statistically significant (P ＜ 0.05). Conclusion Minocycline Hydrochloride is effective in treating periodontitis, with high security. It is worthy of clinical recommendation.
2019 Vol. 16 (9): 110-113 [Abstract] ( 220 ) HTML (1 KB)  PDF (494 KB)  ( 117 )
114 Identification method for the source of frankincense in Huoxue Zhitong Capsules
NIE Lixing SUN Lei DAI Zhong MA Shuangcheng
Objective To establish the identification method for the source of frankincense in Huoxue Zhitong Capsules from Jiangxi Baishen Pharmaceutical Co., Ltd., Nanjing Zhongshan Pharmaceutical Co., Ltd., and Nanjing Zhongshan Pharmaceutical Co., Ltd.. Methods Microscopy and gas chromatography (GC) were used to investigate Huoxue Zhitong Capsules from 3 manufactures and their processed frankincense. Samples were ultrasonicated with ethanol and analyzed on an HP-INNOWAX capillary column. The column temperature was set at 50℃ for 3 min and then programmed at 15℃/min to 160℃. Results According to microscopic identification, India frankincense was excluded first. Then based on the results of GC identification, octyl acetate instead of α-pinene was found in all samples, which indicated that the manufactures used Ethiopic frankincense rather than Somali frankincense as raw material. Conclusion The method established in this study is accurate, simple and rapid, and can provide reference for the quality control of Chinese patent medicines containing frankincense.
2019 Vol. 16 (9): 114-116,122 [Abstract] ( 495 ) HTML (1 KB)  PDF (648 KB)  ( 354 )
117 Establishment of HPLC fingerprint of Jiangzhi Shuxin Mixture and detection of influencing factors of preparation safety project
LIU Min FAN Lei CHEN Guiyun YU Le FENG Meiling
Objective To improve the quality control standard of Jiangzhi Shuxin Mixture. Methods Waters XB C18 (4.6 mm × 250 mm, 5 μm) was used as the mobile phase, and methanol was used as mobile phase A. The mixed aqueous solution (containing 0.6% phosphoric acid and 0.2% tetrahydrofuran) was used as mobile phase B. Gradient elution: 0-15 min, 2% A; 15-55 min, 2%-25% A; 55-90 min, 25%-40% A; 90-110 min, 40%-50% A. The detection wavelength was 280 nm, the column temperature was 30℃, the flow rate was 1.0 mL/mim, the analysis time was 120 min, and the injection volume was 10 μL. The above method was used to establish a fingerprint for Jiangzhi Shuxin Mixture. The content of the preservative in the preparation was determined by high performance liquid chromatography. Inductively coupled plasma mass spectrometry is used to detect heavy metals and harmful elements that may be contained. Results The similarity of 10 batches of samples met the requirements. The contents of benzoic acid were less than 0.3%. The contents of lead, cadmium, chromium, arsenic, nickel, copper and mercury in the samples all conform to the new general rule <232> of the American Pharmacopoeia. Conclusion The fingerprint established in this study is simple, reproducible and provides a scientific basis for the comprehensive quality evaluation of Jiangzhi Shuxin Mixture. It is suggested that more items affecting the safety of the preparation should be added in order to strictly control the quality of the preparation.
2019 Vol. 16 (9): 117-122 [Abstract] ( 183 ) HTML (1 KB)  PDF (944 KB)  ( 94 )
123 Clinical efficacy of Qingxuan Zhike Granules combined with Acetylcysteine Effervescent Tablets in treating chronic obstructive pulmonary disease
JIANG Xinxin1 QIAN Xiaoling1 ZHANG Weiwei2 SHENG Xinyue1 WU Keren2
Objective To investigate the effects of Qingxuan Zhike Granules combined with Acetylcysteine Effervescent Tablets on patients with chronic obstructive pulmonary disease (COPD). Methods One hundred and three patients with COPD admitted to the 904th Hospital of PLA Joint Logistics Support Force from January 2017 to June 2018 were selected and divided into control group (51 cases) and observation group (52 cases) according to the random number table method. The control group was given Acetylcysteine Effervescent Tablets, and the observation group was treated with Qingxuan Zhike Granules on the basis of the control group. The clinical effects of the two groups after treatment were observed, the inflammatory factors [interleukin-6 (IL-6), interleukin-8 (IL-8), tumor necrosis factor-α (TNF-α)], pulmonary function [forced vital capacity (FVC), forced expiratory volume in one second (FEV1), peak expiratory flow rate (PEF), the ratio of FEV1 to FVC], blood gas analysis [oxygen partial pressure (PO2), blood oxygen saturation (SaO2), partial pressure of carbon dioxide (PCO2)] were compared between the two groups before and after treatment, and the adverse reactions of the two groups were recorded during the treatment. Results After treatment, the total effective rate of the observation group was significantly higher than that of the control group (P ＜ 0.05). After treatment, the levels of IL-6, IL-8 and TNF-α in the two groups were lower than those before treatment, which in the observation group were lower than those in the control group (P ＜ 0.05). After treatment, FVC, FEV1, PEF, the FEV1 to FVC radio in both groups were higher than those before treatment, which of the observation group were higher than those of the control group (P ＜ 0.05). After treatment, PO2 and SaO2 in both groups were higher than those before treatment, which of the observation group were higher than those of the control group (P ＜ 0.05); PCO2 was lower than before treatment, which of the observation group was lower than that of the control group (P ＜ 0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P ＞ 0.05). Conclusion Qingxuan Zhike Granule combined with Acetylcysteine Effervescent Tablets is effective in the treatment of COPD, which can significantly improve the pulmonary function, arterial blood gas index, alleviate inflammatory reactions, and does not increase the incidence of adverse reactions.
2019 Vol. 16 (9): 123-126 [Abstract] ( 217 ) HTML (1 KB)  PDF (406 KB)  ( 82 )
127 Treatment experience of elderly sepsis shock with integrated Chinese and Western medicine
FU Yuefeng KONG Lingbo GUO Nan JIANG Shangshang MIAO Qing LI Xinyuan
Septic shock is an important clinical problem for intensive medicine. As the population aging, the incidence of cancer rises, and the number of invasive medical measures increases, as well as the incidence of sepsis, and the sepsis shock mortality rate can be as high as 50% above. This article analyzes the treatment of senile sepsis by integrated traditional Chinese and Western medicine. The case was acute onset, with the diagnosis of fever, and the disease progressed rapidly, white blood cell, C-reactive protein, procalcitonin, D-Dimer increased significantly, the indicators of various organs rapidly deteriorated. Through comprehensive treatment with traditional Chinese and Western medicine, the patient's infection index decreased, and the indicators of various organs returned to normal. Although sepsis is fierce and the progress is rapid, as long as the treatment is timely, the patient can turn crisis into safety. The early participation of Chinese medicine in the early stage of treatment is of great significance to improve the overall condition of the patient and it can improve the prognosis.
2019 Vol. 16 (9): 127-130 [Abstract] ( 242 ) HTML (1 KB)  PDF (384 KB)  ( 146 )
131 Experience summary of professor Lin Hongsheng in the treatment of lung cancer
XU Weiru1 LIN Hongsheng2
Primary bronchogenic carcinoma is a malignant disease that seriously threatens people's life and health. In recent years, the incidence and mortality of lung cancer rank first among malignant tumors. Professor Lin Hongsheng has accumulated rich experience in the treatment of this disease and achieved better therapeutic effect. This article introduces the experience of professor Lin Hongsheng in the treatment of lung cancer. “Qi deficiency is the pathogenic basis of lung cancer” “phlegm and blood stasis is the main manifestation of lung cancer” “qi yin deficiency and blood stasis is the main syndrome of lung cancer after radiotherapy” and other academic ideas are presented. The role of “cancer toxin” in the pathogenesis of cancer is summed up. “The integration of Western medicine and Chinese medicine and treatment by stage” and other experience are proposed.
2019 Vol. 16 (9): 131-133 [Abstract] ( 256 ) HTML (1 KB)  PDF (713 KB)  ( 159 )
134 Longjiang Medical School′s famous physician Bai Junfu′s experience in processing traditional chinese medicine for treating skin diseases
WANG Yuanhong1 ZHAO Weihao2 LI Xiaoling1 JIANG Deyou2 WANG Shaoying3 GAO Jie1
Processing of traditional Chinese medicine can purify medicinal materials and ensure their quality; can correct odor and taste, and be easy to take; can reduce or eliminate toxicity; cut into pieces to facilitate preparation; change the performance of drugs; guide medicine to meridian, etc. Mr. Bai Junfu attaches great importance to the processing methods of traditional Chinese medicine, including fire method, water method, water and fire method, oil method, frost method, fermentation method, juice extraction and other processing methods. Each traditional Chinese medicine has its inherent nature, taste and meridian attribution. However, in clinical medication, different processing methods should be selected according to the different purposes of the prescription, so as to achieve the best therapeutic effect.
2019 Vol. 16 (9): 134-136,153 [Abstract] ( 197 ) HTML (1 KB)  PDF (764 KB)  ( 115 )
137 Clinical effect of Buzhong Yiqi Decoction combined with post-auricular injection for sudden hearing loss
WANG Xiang TAN Yenong XIE Liu WU Xiaoqin
Objective To investigate the clinical effect of Buzhong Yiqi Decoction combined with post-auricular injection of Methylprednisolone Sodium Succinate and Lidocaine Hydrochloride in the treatment of sudden hearing loss. Methods A total of 140 sudden hearing loss patients admitted to Hainan Provincial Hospital of Traditional Chinese Medicine from November 2015 to November 2017 were selected as resarch subjects. They were divided into observation group (n = 70) and control group (n = 70) according to random number table method. The control group was treated with post-auricular injection of Methylprednisolone Sodium Succinate and 2% Lidocaine Hydrochloride, while the observation group was treated with Buzhong Yiqi Decoction on the basis of the control group. The clinical effects of the two groups were observed and compared. The pure tone threshold audiometry (PTA), hemorheology parameters and plasma homocysteine (Hcy) levels were measured before and after treatment. The incidence of adverse reactions in the two groups during treatment were recorded. Results The total effective rate of the observation group was significantly higher than that of the control group (P < 0.05). After treatment, the PTA of the two groups were significantly lower, and the observation group was lower than that of the control group, the differences were highly statistically significant (P < 0.01). After treatment, the blood rheology indexes [plasma viscosity, platelet aggregation rate, hematocrit] of the two groups were lower than those before treatment, and those in the observation group were lower than the control group, the differences were highly statistically significant (P < 0.01); after treatment, the levels of Hcy in the two groups were lower than before treatment, the observation group was lower than that in the control group, the differences were highly statistically significant (P < 0.01). There was no significant difference in adverse reactions between the two groups (P > 0.05). Conclusion Buzhong Yiqi Decoction combined with post-auricular injection of Methylprednisolone Sodium Succinate and Lidocaine Hydrochloride for the treatment of sudden hearing loss has significant clinical effects, which can improve plasma Hcy and hemorheology, and its safety is good. It is worthy of clinical application.
2019 Vol. 16 (9): 137-140 [Abstract] ( 201 ) HTML (1 KB)  PDF (755 KB)  ( 67 )
141 Professor Wang Shizhen′s experience in treating sudden deafness introduction
LIAO Xiaojun1 HE Weiping2
Professor Wang Shizhen is a famous expert in otolaryngology of traditional Chinese medicine, an academic tutor of national old Chinese medicine experts, and he has rich experience in the diagnosis and treatment of diseases of otolaryngology by integrating traditional Chinese and Western medicine. Sudden deafness refers to unexplained sudden hearing loss and the treatment has been irregularity at present. Professor Wang treat sudden deafness according to the characteristics of the patients, paying attention to both body and mind, with the help of modern medical technology in diagnosis and treatment, paying attention to the combination of disease differentiation and dialectical, concentrating on regulating liver and spleen function, good at combining internal treatment with external treatment, and treating comprehensively with a view to returning to hearing. Well clinical effect has been obtained. In addition, patients with hearing impairment can be guided to use hearing aids to improve their living quality. The author has the honor to follow the teacher in clinic, and summarize Professor Wang experience in the treatment of sudden deafness as following, for reference to the others.
2019 Vol. 16 (9): 141-144 [Abstract] ( 204 ) HTML (1 KB)  PDF (727 KB)  ( 207 )
145 Effects of transcutaneous acupoint electrical stimulation assisted with general anesthesia on postoperative immune function and cognitive function in elderly patients undergoing cardiac surgery
WU Xiaohui CHEN Wenting▲
Objective To explore the effects of transcutaneous acupoint electrical stimulation (TEAS) assisted with general anesthesia on postoperative immune function and cognitive function in elderly patients undergoing cardiac surgery. Methods A total of 84 elderly patients undergoing open heart surgery in Shuguang Hospital, Shanghai University of Traditional Chinese Medicine from April 2016 to March 2018 were selected as study subjects and they were divided into control group and observation group according to the random number table method, with 42 cases in each group. The control group was given general anesthesia and routine analgesia to complete the operation, and the observation group was given TEAS intervention on the basis of control group. The pain visual analogue scale (VAS) at 8, 12 h and 24 h after operation and occurrence of postoperative analgesia-related adverse reactions were recorded and compared between the two groups, and the stress response [cortisol (COR), β-endorphin (β-EP)], immune function [T lymphocyte subsets (CD4+, CD8+), CD4+/CD8+] and cognitive function [mini-mental state examination (MMSE)] were compared before operation and at 3 d after operation between the two groups. Results There was no significant difference in VAS score at 8 h and 12 h after operation within the groups (P ＞ 0.05). However, the VAS score at 24 h after operation was significantly higher than that at 8 h and 12 h after operation (P ＜ 0.05). The VAS score at different time points after operation and the total incidence rate of postoperative analgesia-related adverse reactions in the observation group were lower than those in the control group (P ＜ 0.05). At 3 d after operation, the COR, β-EP levels were higher than those before operation (P ＜ 0.05) while CD4+, CD8+, CD4+/CD8+ and MMSE score were lower than those before operation (P ＜ 0.05), and the changes in the control group were larger than those in the observation group (P ＜ 0.05). Conclusion TEAS assisted with general anesthesia has significant improvement effects on postoperative immune function and cognitive function in elderly patients undergoing cardiac surgery, and it can effectively relieve analgesia and alleviate analgesic-related adverse reactions and surgical stress response, and it is beneficial for postoperative recovery.
2019 Vol. 16 (9): 145-148,157 [Abstract] ( 208 ) HTML (1 KB)  PDF (754 KB)  ( 100 )
149 Clinical efficacy of thunder fire moxibustion on insomnia with liver qi stagnation and yin deficiency syndrome
WU Shaoxia LIU Zhenzhen LI Siyi
Objective To observe the clinical efficacy of thunder fire moxibustion in the treatment of insomnia patients with liver qi stagnation and yin deficiency syndrome. Methods A total of 80 patients diagnosed as insomnia with liver qi stagnation and yin deficiency syndrome in Sleep Clinic Outpaitient, Guangdong Provincial Hospital of Chinese Medicine, were recruited and they were divided into thunder fire moxibustion group and medicine group by random number table method, with 40 cases in each group. The thunder fire moxibustion group received thunder fire moxibustion treatment. The medicine group was given 1mg Estazolam half an hour before bedtime per night. The two groups were treated once a day and after 1 month′s continous treatment, the efficacy of treating insomnia were observed in the two groups. Pittsburgh sleep quality index (PSQI) score, self-rating anxiety scale (SAS) score, average weekly insomnia days and Epworth sleepiness scale (ESS) score as well as adverse reactions were recorded. Results After one month′s treatment, the thunder fire moxibustion group had better clinical efficacy and less adverse reactions compared to the medicine group (P ＜ 0.05 or P ＜ 0.01). Compared with before treatment, PSQI and SAS scores were lower after treatment in the thunder fire moxibustion group (P ＜ 0.05), while PSQI and SAS scores in the medicine group had no statistically significant difference before and after treatment (P ＞ 0.05). After treatment, PSQI and SAS scores in the thunder fire moxibustion group were lower than the medicine group, the difference was statistically significant (P ＜ 0.05). After treatment, the average weekly insomnia days of thunder fire moxibustion group and medicine group were less than that before treatment, and the difference were statistically significant (P ＜ 0.05). Compared with the medicine group, the average weekly insomnia days of thunder fire moxibustion group were less in the thunder fire moxibustion group, and the difference was statistically siginificant (P ＜ 0.05). After treatment, the ESS scores of the two groups were less than those before treatment, the difference was statistically significant (P ＜ 0.05). And after treatment, the ESS scores of the thunder fire moxibustion group was less than that of the medicine group, the difference was statistically significant (P ＜ 0.05). Adverse reaction rate in the thunder fire moxibustion group was lower than that in the medicine group, and the difference was highly statistically significant (P ＜ 0.01）. Conclusion Thunder fire moxibustion can effectively improve the symptoms of insomnia patients with liver qi stagnation and yin deficiency syndrome with less adverse reactions, which is worthy of clinical promotion.
2019 Vol. 16 (9): 149-153 [Abstract] ( 184 ) HTML (1 KB)  PDF (736 KB)  ( 105 )
154 Clinical effect of filiform-fire needling on lumbar muscle with cold and dampness syndrome strain under the guidance of meridian-muscle region theory
WANG Cheng1 LYU Ya′nan1 CHEN Yuzhao2 DENG Xiangqiang1 HUANG Woning1 LIANG Shufen3
Objective To investigate the clinical effect of filiform-fire needling on lumbar muscle strain cold and dampness syndrome under meridian-muscle region theory. Methods A total of 70 cases of lumbar muscle strain with cold and dampness syndrome from October 2014 to September 2016 in Department of Massage, Guangxi Zhuang Autonomous Region People′s Hospital and they were divided into treatment group and control group by random number table method, with 35 cases in each group. The treatment group was guided by the theory of meridian-muscle region filiform-fire needling, while the control group was treated with warm acupuncture therapy. Both groups were treated twice a day and 10 times totally. The visual analogue scale (VAS) and clinical efficacy of the two groups were compared before and after treatment. Results After treatment, The VAS score of the two groups after treatment was lower than that before treatment, and the difference was highly statistically significant (P ＜ 0.01). The VAS score of the treatment group after treatment was lower than that of the control group, and the difference was statistically significant (P ＜ 0.05). The clinical efficacy of the treatment group was better than that of the control group, and the difference was highly statistically significant (P ＜ 0.01). Conclusion The theory of meridian-muscle region filiform-fire needling has better clinical effect on lumbar muscle strain with cold and dampness syndrome.
2019 Vol. 16 (9): 154-157 [Abstract] ( 404 ) HTML (1 KB)  PDF (756 KB)  ( 81 )
158 Effect of Fengshiqing Mixture combined with Methotrexate on the treatment of active rheumatoid arthritis
TAN Jinhui LI Bo HUANG Hai SHE Ruonan WU Ximei
Objective To analyze the effect of Fengshiqing Mixture combined with Methotrexate on the treatment of active rheumatoid arthritis (ARA). Methods From January 2015 to June 2018, 60 ARA patients admitted to the Department of Rheumatology in Shenzhen Longhua District People′s Hospital of Cuangdong Province were selected. According to the random number table method, the patients were divided into control group (n = 30) and observation group (n = 30). The control group was treated with Methotrexate, while the observation group was treated with Fengshiqing Mixture combined with Methotrexate. After 3 months, the efficacy of main symptoms, pain visual analogue scale (VAS) score, bone mineral density, interleukin-17 (IL-17), tumor necrosis factor-α(TNF-α) and adverse reaction rate were compared between the two groups. Results The time of morning stiffness, number of joint tenderness, number of joint swelling and VAS pain score in the observation group were not significantly different from those in the control group (P ＞ 0.05). The time of morning stiffness, number of joint tenderness, number of joint swelling and VAS pain score in the observation group after treatment were significantly less than those in the control group, with statistically significant differences (P ＜ 0.05). There was no significant difference in bone mineral density, IL-17, TNF-α between the observation group and the control group before treatment (P ＞ 0.05), after treatment, bone mineral density in the observation group was higher than that in the control group, and IL-17 and TNF-α were lower than those in the control group, with statistically significant differences (P ＜ 0.05). The adverse reaction rate in the observation group was lower than that in the control group, and the difference was statistically significant (P ＜ 0.05). Conclusion Compared with single Methotrexate treatment, Fengshiqing Mixture combined with Methotrexate treatment has a more significant effect, which can effectively improve the clinical symptoms of patients, improve bone density, reduce the level of inflammatory factors, and have a low adverse reaction rate.
2019 Vol. 16 (9): 158-161 [Abstract] ( 214 ) HTML (1 KB)  PDF (727 KB)  ( 93 )
162 Clinical effect of needle-knife in the treatment of knee osteoarthritis
HONG Hanqing1 ZHANG Cairong2 CHEN Dechun3 HUA Zhijuan3 WANG Pei1 RUAN Zhizhong2
Objective To observe the clinical effect of needle-knife therapy for patients with knee osteoarthritis, and to evaluate the effectiveness and safety of needle-knife in the treatment of knee osteoarthritis. Methods From October 2017 to April 2018, 61 patients with knee osteoarthritis admitted to Nanjing Hospital of Traditional Chinese Medicine Affiliated to Nanjing University of Chinese Medicine and Daishan Community Health Service Center of Yuhuatai District in Nanjing City were randomly divided into the needle-knife group (31 cases) and the acupuncture group (30 cases) by random number table method. In the needle-knife group, the positive reaction points around the knee joint were selected for needle-knife treatment, once a week, totally for 3 times; in the acupuncture group, routine acupoints were selected for acupuncture treatment, once a day, 5 times each week, totally for 3 weeks. The Western Ontario and McMaster University Osteoarthritis Survey Scale (WOMAC) questionnaire, visual analogue scale (VAS), the levels of nitric oxide (NO), interleukin 1β (IL-1β), transforming growth factor (TGF-β1) in joint fluid were measured at the time of enrollment and the end of treatment. Results In the two groups, 30 patients completed the course of treatment, one patient in the needle-knife group fell off. In terms of WOMAC score, the needle-knife group and the acupuncture group were both significantly decreased at the first week, the 3rd week, and one month after treatment (P ＜ 0.05 or P < 0.01). The needle-knife group was better than the acupuncture group at the 3rd week and one month after treatment (P ＜ 0.05). In terms of VAS score, the needle-knife group was significantly decreased at the first week, the 3rd week, and one month after treatment (P ＜ 0.01), the acupuncture group was significantly decreased at the 3rd week of treatment and one month after treatment (P ＜ 0.05). The needle-knife group was superior to the acupuncture group at the first week and the 3rd week of treatment (P ＜ 0.05 or P < 0.01). At the 3rd week of treatment, the levels of NO and IL-1β in joint fluid of both groups increased (P ＜ 0.05), the level of TGF-β1 decreased (P ＜ 0.05), and the needle-knife group was superior to the acupuncture group (P ＜ 0.05). In terms of total efficiency, the needle-knife group was superior to the acupuncture group (P ＜ 0.05). Conclusion Needle-knife therapy has a good curative effect on the knee osteoarthritis, and the mechanism may be related to its regulation of the levels of NO, IL-1β and TGF-β1 in the joint fluid.
2019 Vol. 16 (9): 162-165,169 [Abstract] ( 250 ) HTML (1 KB)  PDF (550 KB)  ( 97 )
166 Effects of suboccipital triangle release with acupotomy on symptom and functional score and vertebral artery blood flow of vertebral artery type of cervical spondylosis
LIU Xifang1,2 YANG Minyi1 HUI Guodong1 LI Hanxiao2 JI Xiaoyan2
Objective To observe the effects of suboccipital triangle release with acupotomy on symptom and functional score and vertebral artery blood flow of vertebral artery type of cervical spondylosis. Methods Fifty-seven patients with cervical vertigo admitted to Neurospinal Ward of Chinese Medicine Orthopaedic Department of Honghui Hospital Affiliated to Medical School of Xi'an Jiaotong University from March 2017 to March 2018 were selected, and they were divided into observation group and control group by random number table method. 29 cases in observation group were treated with needle-knife to loosen the suboccipital triangle. 28 cases in control group were treated with acupuncture and interference electrical therapy. Both groups were given neck function rehabilitation exercise at the end of treatment. The changes of symptom and functional score and peak values of vertebral artery blood flow in the cerebral hemodynamics of vertebral artery type of cervical spondylosis were respectively observed after the first treatment and after treatment for 2 weeks and 3 months. The clinical efficacy of the two groups was evaluated. Results At the end of treatment, the symptom and functional score and peak values of vertebral artery blood flow in the two groups were all higher than those before treatment, the differences were statistically significant (P ＜ 0.05). After the first treatment and 2 weeks after treatment, the symptom and functional score and peak values of vertebral artery blood flow in the treatment group were significantly higher than those in the control group, the differences were statistically significant (P ＜ 0.05). After treatment for 3 months, the symptom and functional score and peak values of vertebral artery blood flow in the two groups were all higher than those before treatment (P < 0.05), but there were no significant differences between the two groups (P ＞ 0.05). Conclusion The soft tissue of suboccipital triangle released by acupotomy can rapidly and effectively improve the symptom, cervical function and vertebral artery blood flow of vertebral artery type of cervical spondylosis. The short-term effect is better than acupuncture and physiotherapy. The long-term efficacy is similar. Needle-knife treatment has quick returns, and it is simple, cheap and worthy of promotion and application.
2019 Vol. 16 (9): 166-169 [Abstract] ( 338 ) HTML (1 KB)  PDF (490 KB)  ( 87 )
170 Study on clinical anatomy of a new surgical method of needle-knife in the treatment of carpal tunnel syndrome
ZHOU Qiaoyin1,2 SHEN Yifeng1,2 JIA Yan1,2 QIU Zuyun1,2 SUN Xiaojie1,2 WANG Jianwei3 ZHANG Weiguang3 LI Shiliang1
Objective To explore the safety and accuracy of the new surgical method of needle-knife in the treamtent of carpal tunnel syndrome, and provide anatomical basis for clinical treatment. Methods Twenty-six adult specimens (15 males and 11 females) of 10% formalin-preserved fixed specimens, aged 60-90 years, with an average of (69.30±15.33) years old, total 52 sides (two of them could not be tested). The specimen was collected from the Donation Center of Peking University School of Basic Medicine. The research period was from November 2017 to May 2018. The operation of acupotomology to release the transverse wrist ligament was simulated in human specimens, and the safety and accuracy values of the two needle points were measured and calculated. Results Safety: The shortest lateral distances L1 and L2 of the released marks by needle-knife from the median nerve were (3.26±0.82) mm (2.13-5.85 mm) and (3.19±0.73) mm (2.04-5.45 mm), respectively. No obvious median nerve injury was found. The shortest distances L3 and L4 of the the released marks by needle-knife from ulnar artery were (3.89±1.17) mm (1.95-7.11 mm) and (3.95±1.14) mm (2.01-6.86 mm), respectively. No ulnar artery injury was observed. The release depth H1 and H2 of needle-knife of the needle insertion point 1 and point 2 was (10.20±1.22) mm (6.56-12.79 mm) and (8.96±1.31) mm (5.73-12.01 mm), respectively, and shadow scratch was found on the surface of the tendon of 6 cases, the tendon injury rate was 12.00%. Accuracy: 39 cases were successful and 11 cases were failed. The length of the release trace was (3.52±0.78) mm (2.04-4.89 mm). The total success rate of release was 78.00%. Conclusion The operational safety of new surgical method of needle-knife in the treatment of carpal tunnel syndrome by releasing transverse carpal ligament is higher, but its accuracy remains to be improved because of its blind vision operation.
2019 Vol. 16 (9): 170-173 [Abstract] ( 265 ) HTML (1 KB)  PDF (731 KB)  ( 95 )
174 One case of prostate cancer with unilateral testicular metastasis and literature review
DU Quan1 QIAO Ximin1▲ XU Xiaofeng1 LI Nan1 ZHANG Shaojie1 XIAO Xiang1 SHI Xiaozhi2
This article retrospectively analyzed a patient with advanced prostate cancer with unilateral testicular metastasis. This patient was admitted to hospital with a lack of sleep and anorexia. He was diagnosed with prostate cancer. The prostate biopsy was graded 8 points by Gleason and transferred to urology on January 4, 2018. Both sides of the orchiectomy were performed. Prostate cancer testicular metastasis is a rare case and lacks diagnostic features, so it is suggested that for patients with advanced prostate cancer, attention should be paid to prostate cancer testicular metastasis.
2019 Vol. 16 (9): 174-175,180 [Abstract] ( 197 ) HTML (1 KB)  PDF (626 KB)  ( 127 )
176 Development status of China′s innovative pharmaceutical industry cluster
TAN Wei WANG Shuo GUO Dongmei
This paper systematically combs the relevant policy documents of innovative industrial clusters issued by the website of Torch High-tech Industrial Development Center of the Ministry of Science and Technology and the relevant data of innovative industrial clusters in China Torch Statistical Yearbook (2015-2017), analyzes the total quantity, field distribution, economic situation and innovation resource agglomeration of the pilot pharmaceutical innovative industrial clusters. The study finds that since the implementation of the innovative industrial cluster construction project, the pilot pharmaceutical industrial cluster has expanded in scale, the agglomeration effect is obvious, the proportion of high-tech industries continues to increase, and the overall innovation capability has been enhanced. At the same time, there is also a situation that the scale of individual industrial clusters is reduced, the profitability is reduced, and the concentration of innovation resources is weakened.
2019 Vol. 16 (9): 176-180 [Abstract] ( 171 ) HTML (1 KB)  PDF (552 KB)  ( 98 )
181 Characteristics and experience of Qingdao′s medical care and pension system
TIAN Yuan1 XU Guanghao2 YANG Guangjie1
In order to cope with the increasing aging of the population and establish a perfect medical care and pension system for the elderly, this paper introduces the experience and Enlightenment of Qingdao, which is in the forefront of the whole country in the exploration of the mode of the elderly through field investigation and literature retrieval. Therefore, the corresponding suggestions and strategies are put forward to provide a reference for the formulation of China′s pension service policy and the planning of the construction of pension institutions.
2019 Vol. 16 (9): 181-184 [Abstract] ( 317 ) HTML (1 KB)  PDF (504 KB)  ( 108 )
185 Study on general practitioners′ knowledge and attitudes toward dementia care at community level in Beijing
LI Jing1,2 WANG Meirong1 SHAO Shuang1 LIU Yingjie1 XU Xiaojingyuan1 DU Juan1
Objective To investigate general practitioners′ knowledge and attitudes toward dementia care at community level in Beijing, so as to provide reference for future practice in dementia care at community level. Methods From December 2017 to January 2018, a total of 20 general practitioners were selected from 14 community health service centers across 8 districts and counties in Beijing. Data was collected through focus group interviews and was analyzed by using content analysis, which further summarized the themes of the interviews. Results ①General practitioners lacked professional training of dementia; ②general practitioners were fully aware of their lack of professional knowledge of dementia care; ③general practitioners were willing to provide medical care for patients with dementia and support for caregivers in the community; ④services would be confined to the limited time general practitioners could spare, a team-based management model was hence recommended. Conclusion It is necessary to strengthen the professional training of community medical staffs in terms of dementia and the allocation of human resources for community health care, explore the establishment of a community-based dementia team management model for dementia care, which is led by general practitioners and is in cooperation with specialists, community health service centers and community committees.
2019 Vol. 16 (9): 185-188 [Abstract] ( 236 ) HTML (1 KB)  PDF (548 KB)  ( 113 )
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