清宣止咳颗粒联合乙酰半胱氨酸泡腾片治疗慢性阻塞性肺疾病的临床效果

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Abstract Objective To investigate the effects of Qingxuan Zhike Granules combined with Acetylcysteine Effervescent Tablets on patients with chronic obstructive pulmonary disease (COPD). Methods One hundred and three patients with COPD admitted to the 904th Hospital of PLA Joint Logistics Support Force from January 2017 to June 2018 were selected and divided into control group (51 cases) and observation group (52 cases) according to the random number table method. The control group was given Acetylcysteine Effervescent Tablets, and the observation group was treated with Qingxuan Zhike Granules on the basis of the control group. The clinical effects of the two groups after treatment were observed, the inflammatory factors [interleukin-6 (IL-6), interleukin-8 (IL-8), tumor necrosis factor-α (TNF-α)], pulmonary function [forced vital capacity (FVC), forced expiratory volume in one second (FEV1), peak expiratory flow rate (PEF), the ratio of FEV1 to FVC], blood gas analysis [oxygen partial pressure (PO2), blood oxygen saturation (SaO2), partial pressure of carbon dioxide (PCO2)] were compared between the two groups before and after treatment, and the adverse reactions of the two groups were recorded during the treatment. Results After treatment, the total effective rate of the observation group was significantly higher than that of the control group (P ＜ 0.05). After treatment, the levels of IL-6, IL-8 and TNF-α in the two groups were lower than those before treatment, which in the observation group were lower than those in the control group (P ＜ 0.05). After treatment, FVC, FEV1, PEF, the FEV1 to FVC radio in both groups were higher than those before treatment, which of the observation group were higher than those of the control group (P ＜ 0.05). After treatment, PO2 and SaO2 in both groups were higher than those before treatment, which of the observation group were higher than those of the control group (P ＜ 0.05); PCO2 was lower than before treatment, which of the observation group was lower than that of the control group (P ＜ 0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P ＞ 0.05). Conclusion Qingxuan Zhike Granule combined with Acetylcysteine Effervescent Tablets is effective in the treatment of COPD, which can significantly improve the pulmonary function, arterial blood gas index, alleviate inflammatory reactions, and does not increase the incidence of adverse reactions.

Key words： Qingxuan Zhike Granules Acetylcysteine Effervescent Tablets Chronic obstructive pulmonary disease

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	JIANG Xinxin1 QIAN Xiaoling1 ZHANG Weiwei2 SHENG Xinyue1 WU Keren2

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JIANG Xinxin1 QIAN Xiaoling1 ZHANG Weiwei2 SHENG Xinyue1 WU Keren2. Clinical efficacy of Qingxuan Zhike Granules combined with Acetylcysteine Effervescent Tablets in treating chronic obstructive pulmonary disease[J]. 中国医药导报, 2019, 16(9): 123-126.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2019/V16/I9/123

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