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| Advances in nano-delivery systems targeting hepatic stellate cells for hepatic fibrosis |
| JIN Wenzhen1 TAN Xiaochuan1 WEN Jin2 SONG Hui1 ZHANG Yujia1 ZHENG Wensheng1 |
1.Institute of Materia Medica Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing City Key Laboratory of Drug Delivery Technology and Novel Formulation, Beijing 100050, China;
2.Chinese Pharmaceutical Association, Beijing 100022, China |
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Abstract Hepatic fibrosis, a chronic disease, proposes a serious threat to human health. The low efficiency and occurrence of side effects are often contributed by the lack of liver specificity. In order to improve the therapeutic effect of liver fibrosis，research about the use of nanocarriers to achieve targeted delivery has become more and more extensive. This review summarizes the nano-delivery carriers targeting hepatic stellate cells that have been applied in the treatment of liver fibrosis in recent years from the type of carriers and target receptors，which offer a new idea to treat liver fibrosis and serve as the basis of designing safe and effective drug delivery systems for liber fibrosis.
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