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| Research progress of miR-200c in thyroid cancer |
| ZHANG Yan WU Chenguang |
| Department of Endocrinology, People′s Hospital Affiliated to Jiangsu University, Jiangsu Province, Zhenjiang 212002, China |
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Abstract miRNA is a kind of endogenous, non-coding small molecule RNA, which is highly conserved and related to the occurrence and development of various human tumors including thyroid cancer. Compared with differentiated thyroid cancer, the prognosis of undifferentiated thyroid cancer is worse, which may be associated with a higher proportion of cancer stem cells. miR-200c, as a novel tumor suppressor, can inhibit the proliferation of thyroid cancer cells and promote their apoptosis. Moreover, miR-200c can modulate epithelial-mesenchymal transition through transforming growth factor-β (TGF-β) pathway and epidermal growth factor receptor (EGFR) pathway. Recent researches have found that epithelial-mesenchymal transition induces the formation of cancer stem cell. Hence, miR-200c may serve as a potential molecular target for biological treatment of refractory thyroid cancer. The research progress in the relationship between miR-200c and thyroid cancer is reviewed in this paper.
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