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| Study of vitamin A and E nutrition of Chinese northern pregnant women in 2016 |
| LI Hao NI Junjun ZHENG Chunmei▲ |
| Beijing Harmony Health Medical Diagnostics Co., Ltd., Beijing 101111, China |
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Abstract Objective To investigate the levels of vitamin A and E and evaluate the nutritional status of Chinese northern pregnant women, in order to provide the evidence of vitamin complement and diet for the pregnant women. Methods A survey of vitamin A and vitamin E of pregnant women was performed in maternity hospital (at or above municipal level) in six provinces, including Hebei, He′nan, Heilongjiang, Shanxi, Shaanxi and Tianjin from January to December 2016. The levels of serum vitamin A (21 932 cases) and E (20 243 cases) were measured by high performance liquid chromatography. Results ①In 2016, the average level of vitamin A in pregnant women in northern of China was (0.43±0.10) mg/L, with the deficiency and marginal deficiency as the main manifestations, and the detection rate was 7.3%. Tianjin had the highest proportion of deficiency and marginal deficiency (17.3%), followed by Heilongjiang (12.9%), Hebei (6.1%), He′nan (4.5%) and Shanxi (4.1%). Shaanxi had the lowest detection rate (3.1%). For the pregnant women older than 35 years, the detection rate of vitamin A deficiency and marginal deficiency (6.4%) was lower than pregnant women under 35 years of age (7.4%). ②The average level of vitamin E in pregnant women in northern China was (12.90±4.18) mg/L, with overdose as the main manifestation, the overdose detection rate was 6.2%. Among them, Tianjin has the highest detection rate (25.2%), followed by He′nan (5.3%), Shaanxi (4.3%), Shanxi (1.8%) and Heilongjiang (1.6%), and Hebei had the lowest detection rate (0.4%). The detection rate of vitamin E overdose in pregnant ≥35 years old (10.3%) was higher than that pregnant women ＜35 years old (5.7%). Vitamin E deficiency in pregnant women is rare. The differences in the detection rates of vitamin A and vitamin E in different regions and ages were statistically significant (P ＜ 0.05). Conclusion In 2016, the levels of vitamin A and vitamin E in the serum of pregnant women in northern China show significant differences between different provinces in northern China and between different ages. Vitamin A deficiency and vitamin E overdose are common in pregnant women.
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[1] Pannia E，Cho CE，Kubant R，et al. Role of maternal vitamins in programming health and chronic disease [J]. Nutr Rev，2016，74（3）：166-180.
[2] 张琰，冯小静，王晓彩.孕妇维生素Ａ水平与胎儿先天性心脏病的相关研究[J].中国医药指南，2017，15（16）：45-46.
[3] Greaves RF，Woollard GA，Hoad KE，et al. Laboratory Med-icine Best Practice Guideline：Vitamins A，E and the Car-otenoids in Blood [J]. Clin Biochem Rev，2014，35（2）：81-113.
[4] 申南，陆娣，郑春梅，等.常规保健下不同年龄段孕妇妊娠早期血清维生素A、E水平分析[J].中国妇产科临床杂志，2018，19（4）：356-358.
[5] van de Pavert SA，Ferreira M，Domingues RG，et al. Maternal retinoids control type 3 innate lymphoid cells and set the offspring immunity [J]. Nature，2014，508（7494）：123-127.
[6] 江载芳，申昆玲，沈颖，等.诸福棠实用儿科学[M].8版.北京：人民卫生出版社，2015：556.
[7] 荫士安，汪之顼，译.现代营养学[M].8版.北京：化学工业出版社，2004：195.
[8] Cohen JM，Beddaoui M，Kramer MS，et al. Maternal Antioxidant Levels in Pregnancy and Risk of Preeclampsia and Small for Gestational Age Birth：A Systematic Review and Meta-Analysis [J]. PLoS One，2015，10（8）：1-27.
[9] Godfrey KM，Cutfield W，Chan SY，et al. Nutritional Intervention Preconception and During Pregnancy to Maintain Healthy Glucose Metabolism and Offspring Health（“NiPPeR”）：study protocol for a randomised controlled trial [J]. Trials，2017，18（1）：131.
[10] 胡玉红，吴阿莉，候世慧，等.妊娠中晚期正常孕妇及子痫前期患者血清维生素A的水平及其意义[J].黑龙江医药科学，2017，40（1）：9-10.
[11] Cruz S，Matos A，da Cruz SP，et al. Relationship between the Nutritional Status of Vitamin A per Trimester of Pregnancy with Maternal Anthropometry and Anemia after Roux-en-Y Gastric Bypass [J]. Nutrients，2017，9（9）：1-10.
[12] Al-Mekhlafi HM，Al-Zabedi EM，Al-Maktari MT，et al. Effects of Vitamin A Supplementation on Iron Status Indices and Iron Deficiency Anaemia：A Randomized Controlled Trial [J]. Nutrients，2013，6（1）：190-206.
[13] Ca?觡ete A，Cano E，Mu?觡oz-Chápuli R，et al. Role of Vitamin A/Retinoic Acid in Regulation of Embryonic and Adult Hematopoiesis [J]. Nutrients，2017，9（2）：1-18.
[14] Raederstorff D，Wyss A，Calder PC，et al. Vitamin E function and requirements in relation to PUFA [J]. Br J Nutr，2015，114（8）：1113-1122.
[15] Kaur G，Mishra S，Sehgal A，et al. Alterations in lipid peroxidation and antioxidant status in pregnancy with preeclampsia [J]. Mol Cell Biochem，2008，313（1/2）：37-44.
[16] Gilboa SM，Lee KA，Cogswell ME，et al. Maternal intake of vitamin E and birth defects，National Birth Defects Prevention Study，1997-2005 [J]. Birth Defects Res A Clin Mol Teratol，2014，100（9）：647-657.
[17] AbdelHameed Mirghani Dirar，John Doupis. Gestational diabetes from A to Z [J]. World J Diabetes，2017，8（12）：489-511.
[18] Smedts HP，de Vries JH，Rakhshandehroo M，et al. High maternal vitamin E intake by diet or supplements is associated with congenital heart defects in the offspring [J]. BJOG，2009，116（3）：416-423.
[19] 张露平，王歆莉，李燕蓉，等.妊娠早期血清维生素A、E水平的临床观察[J].首都医科大学学报，2013，34（5）：756-758.
[20] 蒋红清，陈寒，倪君君，等.北京市孕妇常规保健下血清维生素A、E水平现状[J].解放军医学院学报，2015，36（11）：1118-1121.
[21] Marozio L，Picardo E，Filippini C，et al. Maternal age over 40 years and pregnancy outcome：a hospital-based survey [J]. J Matern Fetal Neonatal Med，2017，12（7）：1-7.
[22] 中华人民共和国国家卫生健康委员会.中国居民膳食营养素参考摄入量第4部分：脂溶性维生素.中华人民共和国卫生行业标准WS/T578.4-2018[S]. 2018-04-27.
[23] 杨月欣，王光亚，潘兴昌.中国食物成分表[M].2版.北京：北京大学医学出版社，2010. |
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